메뉴 건너뛰기




Volumn 32, Issue 2, 2011, Pages 195-201

Prescription of lipophilic statins to Alzheimer's disease patients: Some controversies to consider

Author keywords

Alzheimer's disease; Blood brain barrier (BBB); Cholesterol; Statins

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E4; ATORVASTATIN; CERIVASTATIN; CHOLESTEROL; FLUINDOSTATIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVALONIC ACID; MEVINOLIN; PRAVASTATIN; PROBUCOL; SIMVASTATIN; TRIACYLGLYCEROL;

EID: 79952860352     PISSN: 15901874     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10072-010-0440-0     Document Type: Review
Times cited : (18)

References (58)
  • 1
    • 33645384019 scopus 로고    scopus 로고
    • Effects of statins beyond lipid lowering: Potential for clinical benefits
    • 16054715 10.1016/j.ijcard.2005.05.056
    • K Almuti R Rimawi D Spevack R Ostfeld 2006 Effects of statins beyond lipid lowering: potential for clinical benefits Int J Cardiol 109 7 15 16054715 10.1016/j.ijcard.2005.05.056
    • (2006) Int J Cardiol , vol.109 , pp. 7-15
    • Almuti, K.1    Rimawi, R.2    Spevack, D.3    Ostfeld, R.4
  • 2
    • 0036793543 scopus 로고    scopus 로고
    • Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AβP (1-40) and (1-42) peptides
    • DOI 10.1096/fj.02-0829com
    • N Arispe M Doh 2002 Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AβP (1-40) and (1-42) peptides Faseb J 16 1526 1535 12374775 10.1096/fj.02-0829com 1:CAS:528:DC%2BD38XnvFWntrs%3D (Pubitemid 35154635)
    • (2002) FASEB Journal , vol.16 , Issue.12 , pp. 1526-1536
    • Arispe, N.1    Doh, M.2
  • 3
    • 43249094747 scopus 로고    scopus 로고
    • Statins, incident Alzheimer disease, change in cognitive function, and neuropathology
    • DOI 10.1212/01.wnl.0000288181.00826.63
    • Z Arvanitakis JA Schneider RS Wilson JL Bienras JF Kelly DA Evans DA Bennet 2008 Statins, incident Alzheimer disease, change in cognitive function, and neuropathology Neurology 70 1795 1802 18199831 10.1212/01.wnl.0000288181. 00826.63 1:CAS:528:DC%2BD1cXhtFahu7vO (Pubitemid 351653958)
    • (2008) Neurology , vol.70 , Issue.19 PART 2 , pp. 1795-1802
    • Arvanitakis, Z.1    Schneider, J.A.2    Wilson, R.S.3    Bienias, J.L.4    Kelly, J.F.5    Evans, D.A.6    Bennett, D.A.7
  • 6
    • 0142028254 scopus 로고    scopus 로고
    • The cholesterol-lowering drug Probucol increases apolipoprotein E production in the hippocampus of aged rats: Implications for Alzheimer's disease
    • DOI 10.1016/S0306-4522(03)00361-0
    • D Champagne D Pearson D Dea J Rochford J Poirier 2003 The cholesterol-lowering drug Probucol increases apolipoprotein E production in the hippocampus of aged rats: implications for Alzheimer's disease Neuroscience 121 99 110 12946703 10.1016/S0306-4522(03)00361-0 1:CAS:528:DC%2BD3sXmslehtrY%3D (Pubitemid 37297617)
    • (2003) Neuroscience , vol.121 , Issue.1 , pp. 99-110
    • Champagne, D.1    Pearson, D.2    Dea, D.3    Rochford, J.4    Poirier, J.5
  • 8
  • 9
    • 0035478637 scopus 로고    scopus 로고
    • Clinically relevant differences between the statins: Implications for therapeutic selection
    • DOI 10.1016/S0002-9343(01)00870-1, PII S0002934301008701
    • PH Chong JD Seeger C Franklin 2001 Clinically relevant differences between the statins: implications for therapeutic selection Am J Med 111 390 400 11583643 10.1016/S0002-9343(01)00870-1 1:CAS:528:DC%2BD3MXnt1Shtbw%3D (Pubitemid 32913673)
    • (2001) American Journal of Medicine , vol.111 , Issue.5 , pp. 390-400
    • Chong, P.H.1    Seeger, J.D.2    Franklin, C.3
  • 11
    • 28844474981 scopus 로고    scopus 로고
    • Statin therapy in the treatment of Alzheimer disease: What is the rationale?
    • DOI 10.1016/j.amjmed.2005.09.006, PII S0002934305008004
    • ST DeKosky 2005 Statin therapy in the treatment of Alzheimer disease: what is the rationale? Am J Med 118 12A 48S 53S 10.1016/j.amjmed.2005.09.006 1:CAS:528:DC%2BD28XmvFGjuw%3D%3D (Pubitemid 41779427)
    • (2005) American Journal of Medicine , vol.118 , Issue.12 SUPPL.
    • DeKosky, S.T.1
  • 13
    • 57749083174 scopus 로고    scopus 로고
    • Neuroprotective effects of the Alzheimer's Disease related gene seladin-1
    • 18768664 10.1677/JME-08-0071 1:CAS:528:DC%2BD1cXhsFaktr3P
    • A Peri M Serio 2008 Neuroprotective effects of the Alzheimer's Disease related gene seladin-1 J Mol Endocrinol 41 251 261 18768664 10.1677/JME-08-0071 1:CAS:528:DC%2BD1cXhsFaktr3P
    • (2008) J Mol Endocrinol , vol.41 , pp. 251-261
    • Peri, A.1    Serio, M.2
  • 14
    • 0034125199 scopus 로고    scopus 로고
    • Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: Specific changes in Alzheimer's disease
    • GP Eckert NJ Cairns A Maras WF Gattaz WE Müller 2000 Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer's disease Dement Geriatr Cogn Disord 11 181 186 10867442 10.1159/000017234 1:CAS:528:DC%2BD3cXls1Ojur4%3D (Pubitemid 30416021)
    • (2000) Dementia and Geriatric Cognitive Disorders , vol.11 , Issue.4 , pp. 181-186
    • Eckert, G.P.1    Cairns, N.J.2    Maras, A.3    Gattaz, W.F.4    Muller, W.E.5
  • 15
    • 0035901715 scopus 로고    scopus 로고
    • Differential effects of lovastatin treatment on brain cholesterol levels in normal and ApoE-deficient mice
    • GP Eckert C Kirsch WE Mueller 2001 Differential effects of lovastatin treatment on brain cholesterol levels in normal and apoE-deficient mice NeuroReport 12 883 887 11303752 10.1097/00001756-200104170-00003 1:CAS:528:DC%2BD3MXjtVWhurk%3D (Pubitemid 32281439)
    • (2001) NeuroReport , vol.12 , Issue.5 , pp. 883-887
    • Eckert, G.P.1    Kirsch, C.2    Mueller, W.E.3
  • 16
    • 12344334775 scopus 로고    scopus 로고
    • A new approach to the treatment of osteoporosis
    • 15682577
    • B Erdemli S Kilicoglu-Serin E Erdemli 2005 A new approach to the treatment of osteoporosis Orthopedics 28 59 62 15682577
    • (2005) Orthopedics , vol.28 , pp. 59-62
    • Erdemli, B.1    Kilicoglu-Serin, S.2    Erdemli, E.3
  • 18
    • 0034887738 scopus 로고    scopus 로고
    • Lipid-lowering drugs and risk of myopathy: A population-based follow-up study
    • DOI 10.1097/00001648-200109000-00017
    • D Gaist LA Rodriguez C Huerta J Hallas SH Sindrup 2001 Lipid-lowering drugs and risk of myopathy: a population-based follow-up study Epidemiology 12 5 565 569 11505177 10.1097/00001648-200109000-00017 1:STN:280: DC%2BD3MvlvVyrtA%3D%3D (Pubitemid 32761999)
    • (2001) Epidemiology , vol.12 , Issue.5 , pp. 565-569
    • Gaist, D.1    Garcia Rodriguez, L.A.2    Huerta, C.3    Hallas, J.4    Sindrup, S.H.5
  • 19
    • 0035834416 scopus 로고    scopus 로고
    • CNS synaptogenesis promoted by glia-derived cholesterol
    • DOI 10.1126/science.294.5545.1354
    • DH Mauch K Nagler C Schumacher C Goritz EC Muller A Otto 2001 CNS synaptogenesis promoted by glia-derived cholesterol Science 294 1354 1357 11701931 10.1126/science.294.5545.1354 1:CAS:528:DC%2BD3MXotlKmu7c%3D (Pubitemid 33063104)
    • (2001) Science , vol.294 , Issue.5545 , pp. 1354-1357
    • Mauch, D.H.1    Nagier, K.2    Schumacher, S.3    Goritz, C.4    Muller, E.-C.5    Otto, A.6    Pfrieger, F.W.7
  • 20
    • 0035114219 scopus 로고    scopus 로고
    • Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: Involvement of nonsterol isoprenoid biosynthesis inhibition
    • DOI 10.1006/mcne.2000.0904
    • N García-Román AM Alvarez MJ Toro A Montes MJ Lorenzo 2001 Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition Mol Cell Neuros 17 329 341 10.1006/mcne.2000.0904 (Pubitemid 32176489)
    • (2001) Molecular and Cellular Neuroscience , vol.17 , Issue.2 , pp. 329-341
    • Garcia-Roman, N.1    Alvarez, A.M.2    Toro, M.J.3    Montes, A.4    Lorenzo, M.J.5
  • 21
    • 3242777802 scopus 로고    scopus 로고
    • Does aggressive statin therapy offer improved cholesterol-independent benefits compared to conventional statin treatment?
    • DOI 10.1016/j.ijcard.2003.10.013, PII S0167527303006119
    • S Gupta 2004 Does aggressive statin therapy offer improved cholesterol-independent benefits compared to conventional statin treatment? Int J Cardiol 96 131 139 15262025 10.1016/j.ijcard.2003.10.013 (Pubitemid 38979890)
    • (2004) International Journal of Cardiology , vol.96 , Issue.2 , pp. 131-139
    • Gupta, S.1
  • 22
    • 33947593576 scopus 로고    scopus 로고
    • Alzheimer disease - No target for statin treatment. A mini review
    • DOI 10.1007/s11064-006-9168-x
    • S Hoyer P Riederer 2007 Alzheimer disease - no target for statin treatment. A mini review Neurochem Res 32 695 706 17063393 10.1007/s11064-006- 9168-x 1:CAS:528:DC%2BD2sXjtlyms7w%3D (Pubitemid 46481299)
    • (2007) Neurochemical Research , vol.32 , Issue.4-5 , pp. 695-706
    • Hoyer, S.1    Riederer, P.2
  • 23
    • 67650128395 scopus 로고    scopus 로고
    • Therapeutic potential of statins in Alzheimer's disease
    • 19321181 10.1016/j.jns.2009.02.352 1:CAS:528:DC%2BD1MXoslSitro%3D
    • N Kandiah H Feldman 2009 Therapeutic potential of statins in Alzheimer's disease J Neurol Sci 283 230 234 19321181 10.1016/j.jns.2009.02.352 1:CAS:528:DC%2BD1MXoslSitro%3D
    • (2009) J Neurol Sci , vol.283 , pp. 230-234
    • Kandiah, N.1    Feldman, H.2
  • 24
    • 0036750004 scopus 로고    scopus 로고
    • Cholesterol attenuates the membrane perturbing properties of β-amyloid peptides
    • C Kirsch GP Eckert WE Mueller 2002 Cholesterol attenuates the membrane perturbing properties of beta-amyloid peptides Amyloid 9 149 159 12408677 10.3109/13506120209114816 1:CAS:528:DC%2BD38XovVGksrY%3D (Pubitemid 35205204)
    • (2002) Amyloid , vol.9 , Issue.3 , pp. 149-159
    • Kirsch, C.1    Eckert, G.P.2    Mueller, W.E.3
  • 25
    • 0032450855 scopus 로고    scopus 로고
    • Metabolic alterations in postmortem Alzheimer's disease brain are exaggerated by Apo-E4
    • DOI 10.1016/S0197-4580(98)00105-5, PII S0197458098001055
    • WE Klunk K Panchalingam RJ McClure JA Stanley JW Pettergrew 1998 Metabolic alterations in postmortem Alzheimer's disease brain are exaggerated by Apo-E4 Neurobiol Aging 19 6 511 515 10192209 10.1016/S0197-4580(98)00105-5 1:CAS:528:DyaK1MXitFamtLY%3D (Pubitemid 29117117)
    • (1998) Neurobiology of Aging , vol.19 , Issue.6 , pp. 511-515
    • Klunk, W.E.1    Panchalingam, K.2    McClure, R.J.3    Stanley, J.A.4    Pettegrew, J.W.5
  • 27
    • 0028929262 scopus 로고
    • Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and accross the tissues of the mouse
    • 7883961 10.1172/JCI117760 1:CAS:528:DyaK2MXktlKhtbs%3D
    • Y Osono LA Woollett J Herz JM Dietschy 1995 Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and accross the tissues of the mouse J Clin Invest 95 3 1124 1132 7883961 10.1172/JCI117760 1:CAS:528:DyaK2MXktlKhtbs%3D
    • (1995) J Clin Invest , vol.95 , Issue.3 , pp. 1124-1132
    • Osono, Y.1    Woollett, L.A.2    Herz, J.3    Dietschy, J.M.4
  • 28
    • 3042640736 scopus 로고    scopus 로고
    • High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs
    • DOI 10.1016/j.steroids.2004.03.012, PII S0039128X04000601
    • D Lütjohann M Stroick T Bertsch S Kühl B Lindenthal K Thelen U Andersson I Björkhem K von Bergmann K Fassbender 2004 High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs Steroids 69 431 438 15219793 10.1016/j.steroids.2004.03.012 (Pubitemid 38829339)
    • (2004) Steroids , vol.69 , Issue.6 , pp. 431-438
    • Lutjohann, D.1    Stroick, M.2    Bertsch, T.3    Kuhl, S.4    Lindenthal, B.5    Thelen, K.6    Andersson, U.7    Bjorkhem, I.8    Von Bergmann, K.9    Fassbender, K.10
  • 29
    • 11844285607 scopus 로고    scopus 로고
    • Cholesterol, transferrin saturation, and the development of dementia and Alzheimer's disease: Results from an 18-year population-based cohort
    • AG Mainous III SL Eschenbach BJ Well CJ Everett JM Gill 2005 Cholesterol, transferrin saturation, and the development of dementia and Alzheimer's disease: results from an 18-year population-based cohort Fam Med 37 36 42 15619154 (Pubitemid 40094090)
    • (2005) Family Medicine , vol.37 , Issue.1 , pp. 36-42
    • Mainous III, A.G.1    Eschenbach, S.L.2    Wells, B.J.3    Everett, C.J.4    Gill, J.M.5
  • 31
    • 0026524681 scopus 로고
    • Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol
    • 1625771 10.1016/0197-4580(92)90116-F 1:STN:280:DyaK38zis12msg%3D%3D
    • RP Mason WJ Shoemaker L Shajenko TE Chambers LG Herbette 1992 Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol Neurobiol Aging 13 3 413 419 1625771 10.1016/0197-4580(92)90116-F 1:STN:280:DyaK38zis12msg%3D%3D
    • (1992) Neurobiol Aging , vol.13 , Issue.3 , pp. 413-419
    • Mason, R.P.1    Shoemaker, W.J.2    Shajenko, L.3    Chambers, T.E.4    Herbette, L.G.5
  • 32
    • 18844457544 scopus 로고    scopus 로고
    • High total cholesterol levels in late life associated with a reduced risk of dementia
    • DOI 10.1212/01.WNL.0000161870.78572.A5
    • MM Mielke PP Zandi M Sjogren D Gustafson S Ostling B Steen I Skoog 2005 High total cholesterol levels in late life associated with a reduced risk of dementia Neurology 64 1689 1695 15911792 10.1212/01.WNL.0000161870.78572.A5 1:CAS:528:DC%2BD2MXktVKrurY%3D (Pubitemid 40695799)
    • (2005) Neurology , vol.64 , Issue.10 , pp. 1689-1695
    • Mielke, M.M.1    Zandi, P.P.2    Sjogren, M.3    Gustafson, D.4    Ostling, S.5    Steen, B.6    Skoog, I.7
  • 34
  • 35
    • 36949033817 scopus 로고    scopus 로고
    • Emerging indications for statins: A pluripotent family of agents with several potential applications
    • DOI 10.2174/138161207782794194
    • K Paraskevas AA Tzovaras DD Briana DP Mikhailidis 2007 Emerging indications for statins: a pluripotent family of agents with several potential applications Curr Pharm Des 13 3622 3636 18220799 10.2174/138161207782794194 1:CAS:528:DC%2BD1cXnsVOgsw%3D%3D (Pubitemid 350238933)
    • (2007) Current Pharmaceutical Design , vol.13 , Issue.35 , pp. 3622-3636
    • Paraskevas, K.I.1    Tzovaras, A.A.2    Briana, D.D.3    Mikhailidis, D.P.4
  • 38
    • 4644361588 scopus 로고    scopus 로고
    • ABCA1 is required for normal central nervous system apoE levels and for lipidation of astrocyte-secreted apoE
    • DOI 10.1074/jbc.M407963200
    • SE Wahrle H Jiang M Parsadanian J Legleiter X Han JD Fryer T Kowalewski DM Holtzman 2004 ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted ApoE J Biol Chem 279 40987 40993 15269217 10.1074/jbc.M407963200 1:CAS:528:DC%2BD2cXnslWnu78%3D (Pubitemid 39287699)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.39 , pp. 40987-40993
    • Wahrle, S.E.1    Jiang, H.2    Parsadanian, M.3    Legleiter, J.4    Han, X.5    Fryer, J.D.6    Kowalewski, T.7    Holtzman, D.M.8
  • 41
    • 0028281788 scopus 로고
    • In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors
    • DOI 10.1023/A:1018975928974
    • A Saheki T Terasaki I Tamai A Tsuji 1994 In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors Pharm Res 11 2 305 311 8165193 10.1023/A:1018975928974 1:CAS:528:DyaK2cXitVOrtLs%3D (Pubitemid 24076229)
    • (1994) Pharmaceutical Research , vol.11 , Issue.2 , pp. 305-311
    • Saheki, A.1    Terasaki, T.2    Tamai, I.3    Tsuji, A.4
  • 42
    • 29944441329 scopus 로고    scopus 로고
    • Statins and osteoporosis: New role for old drugs
    • BJ Satyawan J Girish Kumar 2006 Statins and osteoporosis: new role for old drugs JPP 58 3 18
    • (2006) JPP , vol.58 , pp. 3-18
    • Satyawan, B.J.1    Girish Kumar, J.2
  • 43
    • 66349136255 scopus 로고    scopus 로고
    • Are side-chain oxidized oxysterols regulators also in vivo?
    • 18952574 10.1194/jlr.R800025-JLR200
    • I Bjorkhem 2009 Are side-chain oxidized oxysterols regulators also in vivo? J Lipid Res 50 Suppl S213 S218 18952574 10.1194/jlr.R800025-JLR200
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Bjorkhem, I.1
  • 44
    • 6444230927 scopus 로고    scopus 로고
    • Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: A p53-independent mitochondrial-mediated apoptotic mechanism
    • DOI 10.1093/carcin/bgh201
    • MA Shibata Y Ito J Morimoto Y Otsuki 2004 Lovastatin inhibits tumor growth and lung metastasis in mouse mammary carcinoma model: a p53-independent mitochondrial-mediated apoptotic mechanism Carcinogenesis 25 1887 1898 15180944 10.1093/carcin/bgh201 1:CAS:528:DC%2BD2cXnvVOqt74%3D (Pubitemid 39405908)
    • (2004) Carcinogenesis , vol.25 , Issue.10 , pp. 1887-1898
    • Shibata, M.-A.1    Ito, Y.2    Morimoto, J.3    Otsuki, Y.4
  • 45
    • 34147174373 scopus 로고    scopus 로고
    • Atorvastatin attenuates transplant-associated coronary arteriosclerosis in a murine model of cardiac transplantation
    • DOI 10.1016/j.biopha.2006.09.017, PII S0753332206003520
    • I Shirakawa M Sata A Saiura Y Kaneda H Yasshiro Y Hirata 2007 Atorvastatin attenuates transplant-associated coronary arteriosclerosis in a murine model of cardiac transplantation Biomed Pharmacother 61 154 159 17258886 10.1016/j.biopha.2006.09.017 1:CAS:528:DC%2BD2sXkt1akur0%3D (Pubitemid 46562557)
    • (2007) Biomedicine and Pharmacotherapy , vol.61 , Issue.2-3 , pp. 154-159
    • Shirakawa, I.1    Sata, M.2    Saiura, A.3    Kaneda, Y.4    Yashiro, H.5    Hirata, Y.6    Makuuchi, M.7    Nagai, R.8
  • 46
    • 0036714243 scopus 로고    scopus 로고
    • Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial
    • DOI 10.1002/ana.10292
    • M Simons F Schwarzler D Lütjohann K von Bergmann K Beyreuther J Dichgans H Wormstall T Hartmann JB Schulz 2002 Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: a 26-week randomized, placebo-controlled, double-blind trial Ann Neurol 52 346 350 12205648 10.1002/ana.10292 1:CAS:528:DC%2BD38Xns1amtr4%3D (Pubitemid 35001502)
    • (2002) Annals of Neurology , vol.52 , Issue.3 , pp. 346-350
    • Simons, M.1    Schwarzler, F.2    Lutjohann, D.3    Von Bergmann, K.4    Beyreuther, K.5    Dichgans, J.6    Wormstall, H.7    Hartmann, T.8    Schulz, J.B.9
  • 47
    • 0037159465 scopus 로고    scopus 로고
    • Simvastatin treatment in the SLO syndrome: A safe approach?
    • DOI 10.1002/ajmg.10722
    • L Starck A Lövgren-Sandblom I Björkhem 2002 Simvastatin treatment in the SLO syndrome: a safe approach? Am J Med Genet 113 183 189 12407710 10.1002/ajmg.10722 (Pubitemid 35231551)
    • (2002) American Journal of Medical Genetics , vol.113 , Issue.2 , pp. 183-189
    • Starck, L.1    Lovgren-Sandblom, A.2    Bjorkhem, I.3
  • 48
    • 34047238791 scopus 로고    scopus 로고
    • Do statins reduce blood pressure? A meta-analysis of randomized, controlled trials
    • DOI 10.1161/01.HYP.0000259737.43916.42
    • P Strazzullo SM Kerry A Barbato M Versiero L D'Elia FP Cappuccio 2007 Do statins reduce blood pressure?: a meta-analysis of randomized, controlled trials Hypertension 49 792 798 17309949 10.1161/01.HYP.0000259737.43916.42 1:CAS:528:DC%2BD2sXivVamt7w%3D (Pubitemid 351664226)
    • (2007) Hypertension , vol.49 , Issue.4 , pp. 792-798
    • Strazzullo, P.1    Kerry, S.M.2    Barbato, A.3    Versiero, M.4    D'Elia, L.5    Cappuccio, F.P.6
  • 50
    • 0035856407 scopus 로고    scopus 로고
    • On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells
    • DOI 10.1016/S0304-3940(01)02277-7, PII S0304394001022777
    • N Bogdanovic L Bretillon EG Lund 2001 On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells Neurosci Lett 314 45 48 11698143 10.1016/S0304-3940(01)02277-7 1:CAS:528:DC%2BD3MXotFSrsr8%3D (Pubitemid 33043802)
    • (2001) Neuroscience Letters , vol.314 , Issue.1-2 , pp. 45-48
    • Bogdanovic, N.1    Bretillon, L.2    Lund, E.G.3    Diczfalusy, U.4    Lannfelt, L.5    Winblad, B.6    Russell, D.W.7    Bjorkhem, I.8
  • 52
    • 0034705221 scopus 로고    scopus 로고
    • Better outcome after stroke with higher serum cholesterol levels
    • 10822434 1:STN:280:DC%2BD3c3osVWgsQ%3D%3D
    • C Vauthey GR de Freitas G van Melle 2000 Better outcome after stroke with higher serum cholesterol levels Neurology 54 1944 1949 10822434 1:STN:280:DC%2BD3c3osVWgsQ%3D%3D
    • (2000) Neurology , vol.54 , pp. 1944-1949
    • Vauthey, C.1    De Freitas, G.R.2    Van Melle, G.3
  • 53
    • 20344381348 scopus 로고    scopus 로고
    • Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitro
    • DOI 10.1002/jnr.20458
    • S Vuletic ER Peskind SM Marcovina JF Quinn MC Cheung H Kennedy JA Kaye L Jin JJ Albers 2005 Reduced CSF PLTP activity in Alzheimer's disease and other neurologic diseases; PLTP induces ApoE secretion in primary human astrocytes in vitro J Neuros Res 80 406 413 10.1002/jnr.20458 1:CAS:528:DC%2BD2MXjvFakt74%3D (Pubitemid 40780829)
    • (2005) Journal of Neuroscience Research , vol.80 , Issue.3 , pp. 406-413
    • Vuletic, S.1    Peskind, E.R.2    Marcovina, S.M.3    Quinn, J.F.4    Cheung, M.C.5    Kennedy, H.6    Kaye, J.A.7    Jin, L.-W.8    Albers, J.J.9
  • 54
    • 69049083465 scopus 로고    scopus 로고
    • Executive function and attention are preserved in older surgically menopausal monkeys receiving estrogen or estrogen plus progesterone
    • 19692611 10.1523/JNEUROSCI.1591-09.2009 1:CAS:528:DC%2BD1MXhtVKqt7fP
    • ML Voytko R Murray CJ Higgs 2009 Executive function and attention are preserved in older surgically menopausal monkeys receiving estrogen or estrogen plus progesterone J Neurosci 29 10362 10370 19692611 10.1523/JNEUROSCI.1591-09. 2009 1:CAS:528:DC%2BD1MXhtVKqt7fP
    • (2009) J Neurosci , vol.29 , pp. 10362-10370
    • Voytko, M.L.1    Murray, R.2    Higgs, C.J.3
  • 57
    • 0024990330 scopus 로고
    • Neurotrophic and neurotoxic effects of amyloid beta protein: Reversal by tachykinin neuropeptides
    • 2218531 10.1126/science.2218531 1:CAS:528:DyaK3MXlslansg%3D%3D
    • BA Yankner LK Duffy DA Kirschner 1990 Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides Science 250 279 282 2218531 10.1126/science.2218531 1:CAS:528:DyaK3MXlslansg%3D%3D
    • (1990) Science , vol.250 , pp. 279-282
    • Yankner, B.A.1    Duffy, L.K.2    Kirschner, D.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.