Occludin is overexpressed in Alzheimer's disease and vascular dementia

Journal of Cellular and Molecular Medicine

Volumn 11, Issue 3, 2007, Pages 569-579

  Romanitan, Mihaela Oana ^a,b   Popescu, Bogdan O ^b,c   Winblad, Bengt ^a   Bajenaru, Ovidiu Alexandru ^b   Bogdanovic, Nenad ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c VICTOR BABES NATIONAL INSTITUTE OF PATHOLOGY   (Romania)

Author keywords

Alzheimer; Blood brain barrier; CADASIL; Cerebral angiopathy; Intercellular tight junctions; Occludin; Quantification stereology; Vascular dementia

Indexed keywords

EID: 34547260411     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2007.00047.x     Document Type: Article

References (61)

1. Ballabh P, Braun A, Nedergaard M. The blood-brain barrier: an overview: structure, regulation and clinical implications. Neurobiol Dis. 2004 16 : 1 13.
2. Hawkins BT, Davis TP. The blood brain barrier/neu-rovascular unit in health and disease. Pharmacol Rev. 2005 57 : 173 85.
3. Verkhratsky A, Toescu EC. Neuronal-glial networks as substrate for CNS integration. J Cell Mol Med. 2006 10 : 826 36.
4. Schneeberger EE, Lynch RD. The tight junction: a multi-functional complex. Am J Physiol Cell Physiol. 2004 286 : C1213 28.
5. Kniesel U, Wolburg H. Tight junctions of the blood brain barier. Cell Mol. Neurobiol. 2000 20 : 57 76.
6. Rubin LL. The blood-brain barrier in and out of cell culture. Curr Opin Neurobiol. 1991 1 : 360 3.
7. Nusrat A, Parkos CA, Verkade P, Foley CS, Liang TW, Innis-Whitehouse W, Eastburn KK, Madara JL. Tight junctions are membrane microdomains. J Cell Sci. 2000 113 : 1771 81.
8. Gumbiner B. Structure, biochemistry and assembly of epithelial tight junctions. Am J Physiol. 1987 253 : C749 58.
9. Nagy Z, Peters H, Hüttner I. Fracture faces of cell junctions in cerebral endothelium during normal and hyperosmotic conditions. Lab Invest. 1984 50 : 313 22.
10. Vorbrodt AW, Dobrogowska DH. Molecular anatomy of interendothelial junctions in human blood-brain barrier microvessels. Folia Histochem Cytobiol. 2004 42 : 67 75.
11. Bazzoni G, Martinez Estrada O, Dejana E. Molecular structure and functional role of vascular tight junctions. Trends Cardiovasc Med. 1999 9 : 147 52.
12. Cereijido M, Valdes J, Shoshani L, Contreras RG. Role of tight junctions in establishing and maintaining cell polarity. Annu Rev Physiol. 1998 60 : 161 77.
13. Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S. Occludin: a novel integral membrane protein localizing at the tight junctions. J Cell Biol. 1993 123 : 1777 88.
14. Hirase T, Staddon JM, Saitou M, Ando-Akatsuka Y, Itoh M, Furuse M, Fujimoto K, Tsukita S, Rubin LL. Occludin as a possible determinant of tight junction permeability in endothelial cells. J Cell Sci. 1997 110 : 1603 13.
15. Yang Y, Estrada EY, Thompson JF, Liu W, Rosenberg G. Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metallopro-teinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab. 2007 27 : 697 709.
16. Willis CL, Nolan CC, Reith SN, Lister T, Prior MJ, Guerin CJ, Mavroudis G, Ray DE. Focal astrocyte loss is followed by microvascular damage, with subsequent repair of the blood-brain barrier in the apparent absence of direct astrocytic contact. Glia 2004 45 : 325 37.
17. Dallasta LM, Pisarov LA, Esplen JE, Werley JV, Moses AV, Nelson JA, Achim CL. Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis. Am J Pathol. 1999 155 : 1915 27.
18. Davies DC. Blood-brain barrier breakdown in septic encephalopathy and brain tumors. J Anat. 2002 200 : 639 46.
19. Mark KS, Davis TP. Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation. Am J Physiol Heart Circ Physiol. 2002 282 : H1485 94.
20. Plumb J, McQuaid S, Mirakhur M, Kirk J. Abnormal endothelial tight junctions in active lesions and normal-appearing white matter in multiple sclerosis. Brain Pathol. 2002 12 : 154 69.
21. Bauer H, Stelzhammer W, Fuchs R, Weiger TM, Danninger C, Probst G, Krizbai IA. Astrocytes and neurons express the tight junction-specific protein occludin in vitro. Exp Cell Res. 1999 250 : 434 8.
22. Mooradian AD. Potential mechanisms of the age-related changes in the blood-brain barrier. Neurobiol Aging. 1994 15 : 751 5.
23. Mooradian AD. Effect of aging on the blood-brain barrier. Neurobiol. Aging 1988 9 : 31 9.
24. Jorm AF, Jolley D. The incidence of dementia - a meta-analysis. Neurology 1998 51 : 728 33.
25. Nag S. Pathophysiology of blood-brain barrier break-down. Methods Mol Med. 2003, 89 : 97 119.
26. Kalaria RN. Vascular factors in Alzheimer's disease. Int Psychogeriatr. 2003 15 : 47 52.
27. Kalaria RN. Cerebral vessels in ageing and Alzheimer's disease. Pharmacol Ther. 1996 72 : 193 214.
28. Marco S, Skaper SD. Amyloid beta-peptide 1-42 alters tight junction protein distribution and expression in brain microvessel endothelial cells. Neurosci Lett. 2006 401 : 219 24.
29. Lippoldt A, Kniesel U, Liebner S, Kalbacher H, Kirsch T, Wolburg H, Haller H. Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood-brain barrier endothelial cells. Brain Res. 2000 885 : 251 61.
30. Forero DA, Casadesus G, Perry G, Arboleda H. Synaptic dysfunction and oxidative stress in Alzheimerz's disease: emerging mechanisms. J Cell Mol Med. 2006 10 : 796 805.
31. Krizbai IA, Bauer H, Bresgen N, Eckl PM, Farkas A, Szatmári E, Traweger A, Wejksza K, Bauer HC. Effect of oxidative stress on the junctional proteins of cultured cerebral endothelial cells. Cell Mol Neurobiol. 2005 25 : 129 39.
32. Nagy Z. The last neuronal division: a unifying hypothesis for the pathogenesis of Alzheimer's disease. J Cell Mol Med. 2005 9 : 531 41.
33. American Psychiatric Association : Committee on Nomenclature and Statistics. Diagnostic and statistical manual of mental disorders (DSM) 4th ed. Washington DC 1994.
34. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984 34 : 939 44.
35. Bogdanovic N, Morris JH. Diagnostic criteria for Alzheimer's disease in multi-centre brain banking. In : Cruz-Sanches FF, Ravid R, Cuzner ML, editors. Neuropathological diagnostic criteria for brain banking, Amsterdam, IOS press 1995. p. 20 9.
36. National Institute on Aging and Reagan Institute Working Group on diagnostic criteria for the neu-ropathological assessment o Alzheimer disease. Consensus recommendations for the post-mortem diagnosis of Alzheimer's disease. Neurobiol Aging. 1997 18 : S1 2.
37. West MJ, Slomianka L, Gundersen HJ. Unbiased stereological estimation of the total number of neurons in the subdivisions of rat hippocampus using the optical fractionator. Anat Rec. 1991 231 : 482 97.
38. Lasn H, Winblad B, Bogdanovic N. Neuroglia in the inferior olivary nucleus during normal aging and Alzheimer's disease. J Cell Mol Med. 2006 10 : 145 56.
39. Dawson TP, Neal JW, Llewellyn L, Thomas C. Neuropathology techniques. London : Oxford University Press 2003.
40. Hawkins BT, Abbruscato TJ, Egleton RD, Brown RC, Huber JD, Campos CR, Davis TP. Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution. Brain Res. 2004 1027 : 48 58.
41. Bolton SJ, Anthony DC, Perry VH. Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo. Neuroscience 1998 86 : 1245 57.
42. Brown RC, Davis TP. Calcium modulation of adherens and tight junction function: a potential mechanism for blood-brain barrier disruption after stroke. Stroke 2002 33 : 1706 11.
43. Schiera G, Bono E, Raffa MP, Gallo A, Pitarresi GL, Di Liegro I, Savettieri G. Synergistic effects of neurons and astrocytes on the differentiation of brain capillary endothelial cells in culture. J Cell Mol Med. 2003 7 : 165 70.
44. Schiera G, Sala S, Gallo A, Raffa MP, Pitarresi GL, Savettieri G, Di Liegro I. Permeability properties of a three-cell type in vitro model of blood-brain barrier. J Cell Mol Med. 2005 9 : 373 9.
45. Hussar P, Tserentsoodol N, Koyama H, Yokoo-Sugawara M, Matsuzaki T, Takami S, Takata K. The glucose transporter GLUT1 and the tight junction protein occludin in nasal olfactory mucosa. Chem Senses. 2002 27 : 7 11.
46. Hirakawa H, Okajima S, Nagaoka T, Takamatsu T, Oyamada M. Loss and recovery of the blood-nerve barrier in the rat sciatic nerve after crush injury are associated with expression of intercellular junctional proteins. Exp Cell Res. 2003 284 : 196 210.
47. Aaku-Saraste E, Hellwig A, Huttner WB. Loss of occludin and functional tight junctions, but not ZO-1, during neural tube closure-remodelling of the neuroepithelium prior to neurogenesis. Dev Biol. 1996 180 : 664 79.
48. Garcia JH, Liu K-F, Ho K-L. Neuronal necrosis after middle cerebral artery occlusion in Wistar rats progresses at different time intervals in the caudatoputamen and cortex. Stroke 1995 26 : 636 43.
49. Feekes JA, Hsu SW, Chaloupka JC, Cassel MD. Tertiary microvascular territories define lacunar infarcts in the basal ganglia. Ann Neurol. 2005 58 : 18 30.
50. Thal DR, Ghebremedhin E, Orantes M, Wiestler OD. Vascular pathology in Alzheimer disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline. J Neuropathol Exp Neurol. 2003 62 : 1287 301.
51. Zhu X, Lee HG, Raina AK, Perry G, Smith MA. The role of mitogen-activated protein kinase pathways in Alzheimer's disease. Neurosignals. 2002 11 : 270 81.
52. Campbell M, Collery R, McEvoy A, Gardiner TA, Stitt AW, Brankin B. Involvement of MAPKs in endo-statin-mediated regulation of blood-retinal barrier function. Curr Eye Res. 2006 31 : 1033 45.
53. Stopa EG, Gonzalez AM, Chorsky R, Corona RJ, Alvarez J, Bird ED, Baird A. Basic fibroblast growth factor in Alzheimer's disease. Biochem Biophys Res Commun. 1990 171 : 690 6.
54. Reuss B, Dono R, Unsicker K. Functions of fibrob-last growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants. J Neurosci. 2003 23 : 6404 12.
55. Tarkowski E, Issa R, Sjogren M, Wallin A, Blennow K, Tarkowski A, Kumar P. Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia. Neurobiol Aging. 2002 23 : 237 43.
56. Del Bo R, Scarlato M, Ghezzi S, Martinelli Boneschi F, Fenoglio C, Galbiati S, Virgilio R, Galimberti D, Galimberti G, Crimi M, Ferrarese C, Scarpini E, Bresolin N, Comi GP. Vascular endothelial growth factor gene variability is associated with increased risk for AD. Ann Neurol. 2005 57 : 373 80.
57. Yang SP, Bae DG, Kang HJ, Gwag BJ, Gho YS, Chae CB. Co-accumulation of vascular endothelial growth factor with beta-amyloid in the brain of patients with Alzheimer's disease. Neurobiol Aging. 2004 25 : 283 90.
58. Harhaj NS, Felinski EA, Wolpert EB, Sundstrom JM, Gardner TW, Antonetti DA. VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability. Invest Ophthalmol Vis Sci. 2006 47 : 5106 15.
59. Mungrue IN, Bredt DS. nNOS at a glance: implications for brain and brawn. J Cell Sci. 2004 117 : 2627 29.
60. Ghassemifar MR, Sheth B, Papenbrock T, Leese HJ, Houghton FD, Fleming TP. Occludin TM4-: an isoforms of the tight junction protein present in primates lacking the fourth transmembrane domain. J Cell Sci. 2002 115 : 3171 80.
61. Muresan Z, Paul DL, Goodenough DA. Occludin 1B, a variant of the tight junction protein occludin. Mol Biol Cell. 2000 11 : 627 34.