The p53 inhibitor MDM2 facilitates Sonic hedgehog-mediated tumorigenesis and influences cerebellar foliation

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Malek, Reem ^a   Matta, Jennifer ^b   Taylor, Natalie ^a   Perry, Mary Ellen ^b   Mendrysa, Susan M ^a  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN P53; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; CELL SURFACE RECEPTOR; GLI PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; MDM2 PROTEIN, MOUSE; PATCHED RECEPTORS; SHH PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN WEIGHT; CARCINOGENESIS; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CEREBELLUM HYPOPLASIA; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GRANULAR NEURONAL PRECURSOR; GROWTH DISORDER; IN VIVO STUDY; INTRACELLULAR SIGNALING; MALE; MEDULLOBLASTOMA; MOTOR COORDINATION; MOUSE; NEURAL STEM CELL; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; WILD TYPE; AGING; ALLELE; ANIMAL; CELL SURVIVAL; CEREBELLUM; CEREBELLUM TUMOR; CONGENITAL MALFORMATION; DRUG ANTAGONISM; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; NERVE CELL; PATHOLOGY; PRECANCER; SIGNAL TRANSDUCTION;

EPICOCCUM; ERINACEIDAE; MUS;

AGING; ALLELES; ANIMALS; APOPTOSIS; CELL PROLIFERATION; CELL SURVIVAL; CEREBELLAR NEOPLASMS; CEREBELLUM; HEDGEHOG PROTEINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; NEURAL STEM CELLS; NEURONS; PRECANCEROUS CONDITIONS; PROTO-ONCOGENE PROTEINS C-MDM2; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79952776026     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017884     Document Type: Article

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