Functional CB2 type cannabinoid receptors at CNS synapses

Neuropharmacology

Volumn 57, Issue 4, 2009, Pages 356-368

  Morgan, Nicola H ^a   Stanford, Ian M ^a   Woodhall, Gavin L ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

Cannabinoid; Entorhinal; GABA; Inhibition; IPSC

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 4 [6 METHOXY 2 (4 METHOXYPHENYL) 3 BENZOFURANYLCARBONYL]BENZONITRILE; 4 AMINOBUTYRIC ACID; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; CANNABINOID 2 RECEPTOR;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SELECTIVITY; ENTORHINAL CORTEX; GABAERGIC TRANSMISSION; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; GENE REPRESSION; NONHUMAN; PHARMACOLOGICAL BLOCKING; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; SYNAPSE; SYNAPTIC INHIBITION;

ANIMALS; ARACHIDONIC ACIDS; BENZOFURANS; CANNABINOIDS; CENTRAL NERVOUS SYSTEM AGENTS; DIOXOLES; ENDOCANNABINOIDS; ENTORHINAL CORTEX; GAMMA-AMINOBUTYRIC ACID; GLYCERIDES; HIPPOCAMPUS; INDOLES; MALE; NEURAL INHIBITION; NEURONS; QUINOLONES; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 68749110973     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2009.07.017     Document Type: Article

References (66)

1. Alger B.E., Pitler T.A., Wagner J.J., Martin L.A., Morishita W., Kirov S.A., and Lenz R.A. Retrograde signalling in depolarization-induced suppression of inhibition in rat hippocampal CA1 cells. J. Physiol. 496 (1996) 197-209
2. Baker D., Pryce G., Davies W.L., and Hiley C.R. In silico patent searching reveals a new cannabinoid receptor. Trends Pharmacol. Sci. 27 (2006) 1-3
3. Beltramo M., Bernardini N., Bertorelli R., Campanella M., Nicolussi E., Fredduzzi S., and Reggiani A. CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms. Eur. J. Neurosci. 23 6 (2006) 1530-1538
4. Benito B., Núñex E., Tolón R.M., Carrier E.J., Rábano A., Hillard C.J., and Romero J. Cannabinoid CB2 receptors and fatty acid hydrolase are selectively over expressed in neuritic plaque associated glia in Alzheimer's disease brains. J. Neurosci. 3 (2003) 11136-11141
5. Berretta N., and Jones R.S. A comparison of spontaneous EPSCs in layer II and layer IV-V neurons of the rat entorhinal cortex in vitro. J. Neurophysiol. 76 2 (1996) 1089-1100
6. Breivogel C.S., Griffin G., Di Marzo V., and Martin B.R. Evidence for a new G protein-coupled cannabinoid receptor in mouse brain. Mol. Pharmacol. 60 (2001) 155-163
7. Brusco A., Tagliaferro P., Saez T., and Onaivi E.S. Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus. Synapse 62 12 (2008) 944-949
8. Cabral G.A., and Dove Pettit D.A. Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease. J. Neuroimmunol. 83 (1998) 116-123
9. Chan P.K., Chan S.C., and Yung W.H. Presynaptic inhibition of GABAergic inputs to rat substantia nigra pars reticulata neurones by a cannabinoid agonist. Neuroreport 9 4 (1998) 671-675
10. Devane W.A., Dysarz III F.A., Johnson M.R., Melvin L.S., and Howlett A.C. Determination and characterization of a cannabinoid receptor in rat brain. Mol. Pharmacol. 34 5 (1988) 605-613
11. Devane W.A., Hanus L., Breuer A., Pertwee R.G., Stevenson L.A., Griffin G., Gibson D., Mandelbaum A., Etinger A., and Mechoulam R. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258 5090 (1992) 1946-1949
12. Felder C.C., Joyce K.E., Briley E.M., Glass M., Mackie K.P., Fahey K.J., Cullinan G.J., Hunden D.C., Johnson D.W., Chaney M.O., Koppel G.A., and Brownstein M. LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation. J. Pharmacol. Exp. Ther. 284 1 (1998) 291-297
13. Freund T.F., Katona I., and Piomelli D. Role of endogenous cannabinoids in synaptic signaling. Physiol. Rev. 83 (2003) 1017-1066
14. Fredj N.B., and Burrone J. A resting pool of vesicles is responsible for spontaneous vesicle fusion at the synapse. Nat. Neurosci. 12 6 (2009) 751-758
15. Glass M., Dragunow M., and Faull R.L.M. Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience 77 (1997) 299-318
16. Gong J.P., Onaivi E.S., Ishiguro H., Liu Q.R., Tagliaferro P.A., Brusco A., and Uhl G.R. Cannabinoid CB2 receptors: immunhistochemical localization in rat brain. Brain Res. 1071 (2006) 10-23
17. 2 receptor absence in the rat central nervous system. Eur. J. Pharmacol. 377 (1999) 117-125
18. Hájos N., Katona I., Naiem S.S., MacKie K., Ledent C., Mody I., and Freund T.F. Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations. Eur. J. Neurosci. 12 9 (2000) 3239-3249
19. Hajos N., Ledent C., and Freund T.F. Novel cannabinoid sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus. Neuroscience 106 (2001) 1-4
20. Hentges S.T., Low M.J., and Williams J.T. Differential regulation of synaptic inputs by constitutively released endocannabinoids and exogenous cannabinoids. J. Neurosci. 25 42 (2005) 9746-9751
21. Hollrigel G.S., and Soltesz I. Slow kinetics of miniature IPSCs during early postnatal development in granule cells of the dentate gyrus. J. Neurosci. 17 13 (1997) 5119-5128
22. Hosohata Y., Quock R.M., Hosohata K., Makriyannis A., Consroe P., Roeske W.R., and Yamamura H.I. AM630 antagonism of cannabinoid-stimulated [35S]GTP gamma S binding in the mouse brain. Eur. J. Pharmacol. 321 1 (1997) R1-R3
23. Huffman J.W., Liddle J., Yu S., Aung M.M., Abood M.E., Wiley J.L., and Martin B.R. 3-(1′,1′-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorg. Med. Chem. 7 12 (1999) 2905-2914
24. 2 receptor. J. Pharmacol. Exp. Ther. 296 (2001) 420-425
25. Klausberger T., Marton L.F., O'Neill J., Huck J.H.J., Dalezios Y., Fuentealba P., Suen W.Y., Papp E., Kaneko T., Watanabe M., Csicsvari J., and Somogyi P. Complementary roles of cholecystokinin-and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations. J. Neurosci. 25 (2005) 9782-9793
26. Kreitzer A.C., and Regehr W.G. Cerebellar depolarization-induced suppression of inhibition is mediated by endogenous cannabinoids. J. Neurosci. 21 20 (2001) RC174
27. Liu P., Bilkey D.K., Darlington C.L., and Smith P.F. Cannabinoid CB1 receptor protein expression in the rat hippocampus and entorhinal, perirhinal, postrhinal and temporal cortices: regional variations and age-related changes. Brain Res. 979 1-2 (2003) 235-239
28. Llano I., Leresche N., and Marty A. Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currents. Neuron 6 (1991) 565-574
29. Lynn A.B., and Herkenham M. Localization of cannabinoid receptors and nonsaturable high-density cannabinoid binding sites in peripheral tissues of the rat: implications for receptor-mediated immune modulation by cannabinoids. J. Pharmacol. Exp. Ther. 268 3 (1994) 1612-1623
30. 2+-assisted metabotropic glutamate receptor subtype 1 to phospholipase C β4 signaling cascade in the cerebellum. J. Neurosci. 25 (2005) 6826-6835
31. Marriott K.S., and Huffman J.W. Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor. Curr. Top. Med. Chem. 8 3 (2008) 187-204
32. Mato S., Pazos A., and Valdizán E.M. Cannabinoid receptor antagonism and inverse agonism in response to SR141716A on cAMP production in human and rat brain. Eur. J. Pharmacol. 443 (2002) 43-46
33. Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., and Bonner T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346 (1990) 561-564
34. Miklaszewska A.E., Gaubrusiewilz K., Kaminska B., and Konarska L. Distinctive pattern of cannabinoid receptor type II (CB2) expression in adult and paediatric brain tumours. Brain Res. 1137 (2007) 161-169
35. Moldrich G., and Wenger T. Localization of the CB1 cannabinoid receptor in the rat brain. An immunohistochemical study. Peptides 21 11 (2000) 1735-1742
36. Morgan N.H., Stanford I.M., and Woodhall G.L. Modulation of network oscillatory activity and GABAergic synaptic transmission by CB1 cannabinoid receptors in the rat medial entorhinal cortex. Neural Plast. 2008 (2008) 808564
37. Mechoulam R., Ben-Shabat S., Hanus L., Ligumsky M., Kaminski N.E., Schatz A.R., Gopher A., Almog S., Martin B.R., Compton D.R., et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 50 1 (1995) 83-90
38. Munro S., Thomas K.L., and Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365 6441 (1993) 61-65
39. New D.C., and Wong Y.H. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. FEBS Lett. 536 1-3 (2003) 157-160
40. Núñez E., Benito C., Tolón R.M., Hillard C.J., Griffin W.S.T., and Romero J. Glial expression of cannabinoid CB2 receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndrome. Neuroscience 151 (2008) 104-110
41. 2 receptors in brain. Ann. NY Acad. Sci. 1074 (2006) 514-536
42. Oz M. Receptor-independent effects of endocannabinoids on ion channels. Curr. Pharm. Des. 12 2 (2006) 227-239
43. Pan P.Y., Tian J.H., and Sheng Z.H. Snapin facilitates the synchronization of synaptic vesicle fusion. Neuron 61 3 (2009) 412-424
44. Pattij T., Wiskerke J., and Schoffelmeer A.N. Cannabinoid modulation of executive functions. Eur. J. Pharmacol. 585 2-3 (2008) 458-463
45. Pertwee R.G. Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development. Expert Opin. Investig. Drugs 9 7 (2000) 1553-1571
46. Pitler T.A., and Alger B.E. Postsynaptic spike firing reduces synaptic GABAA responses in hippocampal pyramidal cells. J. Neurosci. 12 10 (1992) 4122-4132
47. Rinaldi-Carmona M., Barth F., Héaulme M., Alonso R., Shire D., Congy C., Soubrié P., Brelière J.C., and Le Fur G. Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonist. Life Sci. 56 23-24 (1995) 1941-1947
48. Rosell S., and Agurell S. Effects of 7-hydroxy-delta-6-tetrahydrocannabinol and some related cannabinoids on the guinea pig isolated ileum. Acta Physiol. Scand. 94 1 (1975) 142-144
49. Ross R.A., Coutts A.A., McFarlane S.M., Anavi-Goffer S., Irving A.J., Pertwee R.G., MacEwan D.J., and Scott R.H. Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception. Neuropharmacology 40 2 (2001) 221-232
50. Ryberg E., Larsson N., Sjögren S., Leonova J., Elebring T., Nilsson K., Drmota T., and Greasley P.J. The orphan receptor GPR55 is a novel cannabinoid receptor. Br. J. Pharm. 152 (2007) 1092-1101
51. Savinainen J.R., Kokkola T., Salo O.M., Poso A., Järvinen T., and Laitinen J.T. Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor. Br. J. Pharmacol. 145 5 (2005) 636-645
52. 2: a characterization of expression and adenylate cyclase modulation with in the immune system. Toxicol. Appl. Pharmacol. 142 (1996) 278-287
53. Ständer S., Schmelz M., Metze D., Luger T., and Rukwied R. Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin. J. Dermatol. Sci. 38 3 (2005) 177-188
54. Suárez J., Bermúdez-Silva F.J., Mackie K., Ledent C., Zimmer A., Cravatt B.F., and de Fonseca F.R. Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei. J. Comp. Neurol. 509 4 (2008) 400-421
55. Sugiura T., Kodaka T., Nakane S., Miyashita T., Kondo S., Suhara Y., Takayama H., Waku K., Seki C., Baba N., and Ishima Y. Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonylglycerol, ether-linked analogues and related compounds. J. Biol. Chem. 274 (1999) 2794-2801
56. 2 receptor. Comparison of the agonist activities of various cannabinoid receptor ligands in HL-60 cells. J. Biol. Chem. 275 (2000) 605-612
57. Szabo B., Dörner L., Pfreundtner C., Nörenberg W., and Starke K. Inhibition of GABAergic inhibitory postsynaptic currents by cannabinoids in rat corpus striatum. Neuroscience 85 2 (1998) 395-403
58. Tsou K., Brown S., Sañudo-Peña M.C., Mackie K., and Walker J.M. Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience 83 2 (1998) 393-411
59. Van Sickle M.D., Duncan M., Kingsley P.J., Mouihate A., Urbani P., Mackie K., Stella N., Makriyannis A., Piomelli D., Davison J.S., Marnett L.J., Di Marzo V., Pittman Q.J., Patel K.D., and Sharkey K.A. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science 310 5746 (2005) 329-332
60. Viveros M.P., Marco E.M., Llorente R., and López-Gallardo M. Endocannabinoid system and synaptic plasticity: implications for emotional responses. Neural Plast. 2007 (2007) 52908
61. Wilson R.I., and Nicoll R.A. Endogenous cannabinoids mediate retrograde signaling at hippocampal synapses. Nature 410 (2001) 588-592
62. Wilson R.I., Kunos G., and Nicoll R.A. Presynaptic specificity of endocannabinoid signaling in the hippocampus. Neuron 31 3 (2001) 453-462
63. Woodhall G., Evans D.I., Cunningham M.O., and Jones R.S. NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons. J. Neurophysiol. 86 4 (2001) 1644-1651
64. Woodhall G.L., Bailey S.J., Thompson S.E., Evans D.I.P., and Jones R.S.G. Fundamental differences in spontaneous synaptic inhibition between deep and superficial layers of the rat entorhinal cortex. Hippocampus 15 (2005) 232-245
65. Woodhall G.L., Ayman G., and Jones R.S. Differential control of two forms of glutamate release by group III metabotropic glutamate receptors at rat entorhinal synapses. Neuroscience 148 1 (2007) 7-21
66. 2+ rise are selectively suppressed by cannabinoid receptor activation in cerebellar Purkinje cells. J. Neurosci. 26 1 (2006) 86-95