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Volumn 105, Issue 39, 2008, Pages 15058-15063

Opposing functions of IKKβ during acute and chronic intestinal inflammation

Author keywords

Apoptosis; Colitis; Heat shock protein 70; NF B; STAT3

Indexed keywords

I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; DEXTRAN SULFATE; I KAPPA B KINASE; INTERLEUKIN 1; STAT3 PROTEIN; STAT3 PROTEIN, MOUSE;

EID: 54449091097     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808216105     Document Type: Article
Times cited : (146)

References (37)
  • 1
    • 33745775434 scopus 로고    scopus 로고
    • Mechanisms of disease: Pathogenesis of Crohn's disease and ulcerative colitis
    • Sartor RB (2006) Mechanisms of disease: Pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 3:390-407.
    • (2006) Nat Clin Pract Gastroenterol Hepatol , vol.3 , pp. 390-407
    • Sartor, R.B.1
  • 2
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-κB
    • Hayden MS, Ghosh S (2004) Signaling to NF-κB. Genes Dev 18:2195-2224.
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 3
    • 1942521356 scopus 로고    scopus 로고
    • Transcriptional profiling of IKK2/NF-κB- and p38 MAP kinase-dependent gene expression in TNF-α-stimulated primary human endothelial cells
    • Viemann D, et al. (2004) Transcriptional profiling of IKK2/NF-κB- and p38 MAP kinase-dependent gene expression in TNF-α-stimulated primary human endothelial cells. Blood 103:3365-3373.
    • (2004) Blood , vol.103 , pp. 3365-3373
    • Viemann, D.1
  • 4
    • 0036009115 scopus 로고    scopus 로고
    • NF-κB at the crossroads of life and death
    • Karin M, Lin A (2002) NF-κB at the crossroads of life and death. Nat Immunol 3:221-227.
    • (2002) Nat Immunol , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 5
    • 39049183044 scopus 로고    scopus 로고
    • Regulation and function of IKK and IKK-related kinases
    • Hacker H, Karin M (2006) Regulation and function of IKK and IKK-related kinases. Sci STKE 2006, re13.
    • (2006) Sci STKE , vol.2006
    • Hacker, H.1    Karin, M.2
  • 6
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-κB system: A treasure trove for drug development
    • Karin M, Yamamoto Y, Wang QM (2004) The IKK NF-κB system: A treasure trove for drug development. Nat Rev Drug Discov 3:17-26.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 7
    • 29144479205 scopus 로고    scopus 로고
    • Allergen-induced peribronchial fibrosis and mucus production mediated by IκB kinase β-dependent genes in airway epithelium
    • Broide DH, et al. (2005) Allergen-induced peribronchial fibrosis and mucus production mediated by IκB kinase β-dependent genes in airway epithelium. Proc Natl Acad Sci USA 102:17723-17728.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17723-17728
    • Broide, D.H.1
  • 8
    • 19344374949 scopus 로고    scopus 로고
    • IκB kinase (IKK)β but not IKKα is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
    • Ruocco MG, et al. (2005) IκB kinase (IKK)β but not IKKα is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J Exp Med 201:1677-1687.
    • (2005) J Exp Med , vol.201 , pp. 1677-1687
    • Ruocco, M.G.1
  • 9
    • 0141676361 scopus 로고    scopus 로고
    • A highly selective inhibitor of IκB kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice
    • McIntyre KW, et al. (2003) A highly selective inhibitor of IκB kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis Rheum 48:2652-2659.
    • (2003) Arthritis Rheum , vol.48 , pp. 2652-2659
    • McIntyre, K.W.1
  • 10
    • 0344792632 scopus 로고    scopus 로고
    • A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-κB
    • Lawrance IC, et al. (2003) A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-κB. Gastroenterology 125:1750-1761.
    • (2003) Gastroenterology , vol.125 , pp. 1750-1761
    • Lawrance, I.C.1
  • 11
    • 0029836444 scopus 로고    scopus 로고
    • Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice
    • Neurath MF, Pettersson S, Meyer zum Buschenfelde KH, Strober W (1996) Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-κB abrogates established experimental colitis in mice. Nat Med 2:998-1004.
    • (1996) Nat Med , vol.2 , pp. 998-1004
    • Neurath, M.F.1    Pettersson, S.2    Meyer zum Buschenfelde, K.H.3    Strober, W.4
  • 12
    • 0346095203 scopus 로고    scopus 로고
    • An inhibitor of IκB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice
    • MacMaster JF, et al. (2003) An inhibitor of IκB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. Inflamm Res 52:508-511.
    • (2003) Inflamm Res , vol.52 , pp. 508-511
    • MacMaster, J.F.1
  • 13
    • 4043088499 scopus 로고    scopus 로고
    • IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten FR, et al. (2004) IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118:285-296.
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1
  • 14
    • 34047173496 scopus 로고    scopus 로고
    • Epithelial NEMO links innate immunity to chronic intestinal inflammation
    • Nenci A, et al. (2007) Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446:557-561.
    • (2007) Nature , vol.446 , pp. 557-561
    • Nenci, A.1
  • 15
    • 34548225362 scopus 로고    scopus 로고
    • NF-κB is a negative regulator of IL-1β secretion as revealed by genetic and pharmacological inhibition of IKKβ
    • Greten FR, et al. (2007) NF-κB is a negative regulator of IL-1β secretion as revealed by genetic and pharmacological inhibition of IKKβ. Cell 130:918-931.
    • (2007) Cell , vol.130 , pp. 918-931
    • Greten, F.R.1
  • 16
    • 33847168466 scopus 로고    scopus 로고
    • IκB kinase inhibitors for treating autoimmune and inflammatory disorders: Potential and challenges
    • Strnad J, Burke JR (2007) IκB kinase inhibitors for treating autoimmune and inflammatory disorders: Potential and challenges. Trends Pharmacol Sci 28:142-148.
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 142-148
    • Strnad, J.1    Burke, J.R.2
  • 17
    • 1442306054 scopus 로고    scopus 로고
    • IκB-kinaseβ-dependent NF-κB activation provides radioprotection to the intestinal epithelium
    • Egan LJ, et al. (2004) IκB-kinaseβ-dependent NF-κB activation provides radioprotection to the intestinal epithelium. Proc Natl Acad Sci USA 101:2452-2457.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2452-2457
    • Egan, L.J.1
  • 18
    • 0038587747 scopus 로고    scopus 로고
    • The two faces of IKK and NF-κB inhibition: Prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
    • Chen LW, et al. (2003) The two faces of IKK and NF-κB inhibition: Prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 9:575-581.
    • (2003) Nat Med , vol.9 , pp. 575-581
    • Chen, L.W.1
  • 19
    • 0142052933 scopus 로고    scopus 로고
    • Nuclear factor-κB activation promotes restitution of wounded intestinal epithelial monolayers
    • Egan LJ, et al. (2003) Nuclear factor-κB activation promotes restitution of wounded intestinal epithelial monolayers. Am J Physiol 285:C1028-C1035.
    • (2003) Am J Physiol , vol.285
    • Egan, L.J.1
  • 20
    • 33744502595 scopus 로고    scopus 로고
    • Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKβ
    • Nagashima K, et al. (2006) Rapid TNFR1-dependent lymphocyte depletion in vivo with a selective chemical inhibitor of IKKβ. Blood 107:4266-4273.
    • (2006) Blood , vol.107 , pp. 4266-4273
    • Nagashima, K.1
  • 21
    • 0037159513 scopus 로고    scopus 로고
    • IKKα, IKKβ, and NEMO/IKKγ are each required for the NF-κB-mediated inflammatory response program
    • Li X, et al. (2002) IKKα, IKKβ, and NEMO/IKKγ are each required for the NF-κB-mediated inflammatory response program. J Biol Chem 277:45129-45140.
    • (2002) J Biol Chem , vol.277 , pp. 45129-45140
    • Li, X.1
  • 22
    • 38449104349 scopus 로고    scopus 로고
    • Differential expression of inflammatory and fibrogenic genes and their regulation by NF-κB inhibition in a mouse model of chronic colitis
    • Wu F, Chakravarti S (2007) Differential expression of inflammatory and fibrogenic genes and their regulation by NF-κB inhibition in a mouse model of chronic colitis. J Immunol 179:6988-7000.
    • (2007) J Immunol , vol.179 , pp. 6988-7000
    • Wu, F.1    Chakravarti, S.2
  • 23
    • 34548171423 scopus 로고    scopus 로고
    • Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis
    • Tanaka K, et al. (2007) Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis. J Biol Chem 282:23240-23252.
    • (2007) J Biol Chem , vol.282 , pp. 23240-23252
    • Tanaka, K.1
  • 24
    • 0032812761 scopus 로고    scopus 로고
    • Transcriptional regulation of the heat shock protein genes by STAT family transcription factors
    • Stephanou A, Latchman DS (1999) Transcriptional regulation of the heat shock protein genes by STAT family transcription factors. Gene Expression 7:311-319.
    • (1999) Gene Expression , vol.7 , pp. 311-319
    • Stephanou, A.1    Latchman, D.S.2
  • 25
    • 4043059169 scopus 로고    scopus 로고
    • Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
    • el Marjou F, et al. (2004) Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 39:186-193.
    • (2004) Genesis , vol.39 , pp. 186-193
    • el Marjou, F.1
  • 26
    • 0242416989 scopus 로고    scopus 로고
    • IKKβ is required for peripheral B cell survival and proliferation
    • Li ZW, et al. (2003) IKKβ is required for peripheral B cell survival and proliferation. J Immunol 170:4630-4637.
    • (2003) J Immunol , vol.170 , pp. 4630-4637
    • Li, Z.W.1
  • 27
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn R, et al. (1993) Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263-274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1
  • 28
    • 20844463064 scopus 로고    scopus 로고
    • A synthetic TLR4 antagonist has antiinflammatory effects in two murine models of inflammatory bowel disease
    • Fort MM, et al. (2005) A synthetic TLR4 antagonist has antiinflammatory effects in two murine models of inflammatory bowel disease. J Immunol 174:6416-6423.
    • (2005) J Immunol , vol.174 , pp. 6416-6423
    • Fort, M.M.1
  • 29
    • 0032407805 scopus 로고    scopus 로고
    • Molecular effects of recombinant human interleukin-11 in the HLA-B27 rat model of inflammatory bowel disease
    • Peterson RL, et al. (1998) Molecular effects of recombinant human interleukin-11 in the HLA-B27 rat model of inflammatory bowel disease. Lab Invest 78:1503-1512.
    • (1998) Lab Invest , vol.78 , pp. 1503-1512
    • Peterson, R.L.1
  • 30
    • 33751549013 scopus 로고    scopus 로고
    • Suppression of experimental colitis by intestinal mononuclear phagocytes
    • Qualls JE, Kaplan AM, van Rooijen N, Cohen DA (2006) Suppression of experimental colitis by intestinal mononuclear phagocytes. J Leukocyte Biol 80:802-815.
    • (2006) J Leukocyte Biol , vol.80 , pp. 802-815
    • Qualls, J.E.1    Kaplan, A.M.2    van Rooijen, N.3    Cohen, D.A.4
  • 31
    • 34948858508 scopus 로고    scopus 로고
    • Heat shock response in gastrointestinal tract
    • Sikora A, Grzesiuk E (2007) Heat shock response in gastrointestinal tract. J Physiol Pharmacol 58(Suppl 3):43- 62.
    • (2007) J Physiol Pharmacol , vol.58 , Issue.SUPPL. 3 , pp. 43-62
    • Sikora, A.1    Grzesiuk, E.2
  • 32
    • 33747584864 scopus 로고    scopus 로고
    • Gut myoelectrical activity induces heat shock response in Escherichia coli and Caco-2 cells
    • Laubitz D, et al. (2006) Gut myoelectrical activity induces heat shock response in Escherichia coli and Caco-2 cells. Exp Physiol 91:867-875.
    • (2006) Exp Physiol , vol.91 , pp. 867-875
    • Laubitz, D.1
  • 34
    • 25844459154 scopus 로고    scopus 로고
    • NF-κB: Linking inflammation and immunity to cancer development and progression
    • Karin M, Greten FR (2005) NF-κB: Linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5:749-759.
    • (2005) Nat Rev Immunol , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 35
    • 0037031856 scopus 로고    scopus 로고
    • Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine
    • Madison BB, et al. (2002) Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem 277:33275-33283.
    • (2002) J Biol Chem , vol.277 , pp. 33275-33283
    • Madison, B.B.1
  • 36
    • 14644403009 scopus 로고    scopus 로고
    • Toll-like receptor 9-induced type I IFN protects mice from experimental colitis
    • Katakura K, et al. (2005) Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest 115:695-702.
    • (2005) J Clin Invest , vol.115 , pp. 695-702
    • Katakura, K.1
  • 37
    • 31344475056 scopus 로고    scopus 로고
    • Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock
    • Hammer M, et al. (2006) Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. J Exp Med 203:15-20.
    • (2006) J Exp Med , vol.203 , pp. 15-20
    • Hammer, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.