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Volumn 54, Issue 1, 2011, Pages 16-25

Monitoring lentiviral vector production kinetics using online permittivity measurements

Author keywords

Dielectric spectroscopy; HEK293; Lentiviral vector production; Online monitoring; Perfusion culture; Permittivity measurements; Process Analytical Technology (PAT)

Indexed keywords

HEK-293; LENTIVIRAL VECTOR PRODUCTION; ONLINE MONITORING; PERFUSION CULTURE; PROCESS ANALYTICAL TECHNOLOGY (PAT);

EID: 79952725447     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2011.01.002     Document Type: Article
Times cited : (23)

References (67)
  • 1
    • 36249015420 scopus 로고    scopus 로고
    • Gene delivery by lentivirus vectors
    • Cockrell A.S., Kafri T. Gene delivery by lentivirus vectors. Mol. Biotechnol. 2007, 36(3):184-204.
    • (2007) Mol. Biotechnol. , vol.36 , Issue.3 , pp. 184-204
    • Cockrell, A.S.1    Kafri, T.2
  • 2
    • 34548303952 scopus 로고    scopus 로고
    • Lentiviral vectors encoding tetracycline-dependent repressors and transactivators for reversible knockdown of gene expression: a comparative study
    • Pluta K., Diehl W., Zhang X.Y., Kutner R., Bialkowska A., Reiser J. Lentiviral vectors encoding tetracycline-dependent repressors and transactivators for reversible knockdown of gene expression: a comparative study. BMC Biotechnol. 2007, 7:41.
    • (2007) BMC Biotechnol. , vol.7 , pp. 41
    • Pluta, K.1    Diehl, W.2    Zhang, X.Y.3    Kutner, R.4    Bialkowska, A.5    Reiser, J.6
  • 3
    • 0034278156 scopus 로고    scopus 로고
    • Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy
    • Vigna E., Naldini L. Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy. J. Gene Med. 2000, 2(5):308-316.
    • (2000) J. Gene Med. , vol.2 , Issue.5 , pp. 308-316
    • Vigna, E.1    Naldini, L.2
  • 4
    • 75349106422 scopus 로고    scopus 로고
    • Recent progress in lentiviral vector mass production
    • Ansorge S., Henry O., Kamen A. Recent progress in lentiviral vector mass production. Biochem. Eng. J. 2010, 48(3):362-377.
    • (2010) Biochem. Eng. J. , vol.48 , Issue.3 , pp. 362-377
    • Ansorge, S.1    Henry, O.2    Kamen, A.3
  • 5
    • 4644323951 scopus 로고    scopus 로고
    • State-of-the-art of the production of retroviral vectors
    • Merten O.W. State-of-the-art of the production of retroviral vectors. J. Gene Med. 2004, 6(S1):S105-S124.
    • (2004) J. Gene Med. , vol.6 , Issue.S1
    • Merten, O.W.1
  • 7
    • 68949202566 scopus 로고    scopus 로고
    • Transient transfection methods for clinical adeno-associated viral vector production
    • Wright J.F. Transient transfection methods for clinical adeno-associated viral vector production. Hum. Gene Ther. 2009, 20:1-9.
    • (2009) Hum. Gene Ther. , vol.20 , pp. 1-9
    • Wright, J.F.1
  • 8
    • 33646543920 scopus 로고    scopus 로고
    • Scalable production of adeno-associated virus type 2 vectors via suspension transfection
    • Park J.Y., Lim B.P., Lee K., Kim Y.G., Jo E.C. Scalable production of adeno-associated virus type 2 vectors via suspension transfection. Biotechnol. Bioeng. 2006, 94(3):416-430.
    • (2006) Biotechnol. Bioeng. , vol.94 , Issue.3 , pp. 416-430
    • Park, J.Y.1    Lim, B.P.2    Lee, K.3    Kim, Y.G.4    Jo, E.C.5
  • 9
    • 34147125994 scopus 로고    scopus 로고
    • Recombinant protein production by large-scale transient gene expression in mammalian cells: state of the art and future perspectives
    • Baldi L., Hacker D., Adam M., Wurm F. Recombinant protein production by large-scale transient gene expression in mammalian cells: state of the art and future perspectives. Biotechnol. Lett. 2007, 29(5):677-684.
    • (2007) Biotechnol. Lett. , vol.29 , Issue.5 , pp. 677-684
    • Baldi, L.1    Hacker, D.2    Adam, M.3    Wurm, F.4
  • 11
    • 34848876973 scopus 로고    scopus 로고
    • High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells
    • Hildinger M., Baldi L., Stettler M., Wurm F. High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells. Biotechnol. Lett. 2007.
    • (2007) Biotechnol. Lett.
    • Hildinger, M.1    Baldi, L.2    Stettler, M.3    Wurm, F.4
  • 12
    • 58749101153 scopus 로고    scopus 로고
    • Reflections on more than 10 years of TGE approaches
    • Geisse S. Reflections on more than 10 years of TGE approaches. Protein Expr. Purif. 2009, 64(2):99-107.
    • (2009) Protein Expr. Purif. , vol.64 , Issue.2 , pp. 99-107
    • Geisse, S.1
  • 13
    • 33748938728 scopus 로고    scopus 로고
    • Bioprocess monitoring and computer control: key roots of the current PAT initiative
    • Junker B.H., Wang H.Y. Bioprocess monitoring and computer control: key roots of the current PAT initiative. Biotechnol. Bioeng. 2006, 95(2):226-261.
    • (2006) Biotechnol. Bioeng. , vol.95 , Issue.2 , pp. 226-261
    • Junker, B.H.1    Wang, H.Y.2
  • 14
    • 70349949073 scopus 로고    scopus 로고
    • Advances in on-line monitoring and control of mammalian cell cultures: supporting the PAT initiative
    • Teixeira A.P., Olivera R., Alves P.M., Carrondo M.J.T. Advances in on-line monitoring and control of mammalian cell cultures: supporting the PAT initiative. Biotechnol. Adv. 2009, 27(6):726-732.
    • (2009) Biotechnol. Adv. , vol.27 , Issue.6 , pp. 726-732
    • Teixeira, A.P.1    Olivera, R.2    Alves, P.M.3    Carrondo, M.J.T.4
  • 16
    • 0031543428 scopus 로고    scopus 로고
    • On-line and in situ monitoring of biomass in submerged cultivations
    • Olsson L., Nielsen J. On-line and in situ monitoring of biomass in submerged cultivations. Trends Biotechnol. 1997, (15):517-522.
    • (1997) Trends Biotechnol. , Issue.15 , pp. 517-522
    • Olsson, L.1    Nielsen, J.2
  • 18
    • 0039136064 scopus 로고    scopus 로고
    • On-line monitoring of the progress of infection in Sf-9 insect cell cultures using relative permittivity measurements
    • Zeiser A., Bedard C., Voyer R., Jardin B., Tom R., Kamen A.A. On-line monitoring of the progress of infection in Sf-9 insect cell cultures using relative permittivity measurements. Biotechnol. Bioeng. 1999, 63(1):122-126.
    • (1999) Biotechnol. Bioeng. , vol.63 , Issue.1 , pp. 122-126
    • Zeiser, A.1    Bedard, C.2    Voyer, R.3    Jardin, B.4    Tom, R.5    Kamen, A.A.6
  • 19
    • 0034281764 scopus 로고    scopus 로고
    • On-line monitoring of physiological parameters of insect cell cultures during the growth and infection process
    • Zeiser A., Elias C.B., Voyer R., Jardin B., Kamen A.A. On-line monitoring of physiological parameters of insect cell cultures during the growth and infection process. Biotechnol. Prog. 2000, 16(5):803-808.
    • (2000) Biotechnol. Prog. , vol.16 , Issue.5 , pp. 803-808
    • Zeiser, A.1    Elias, C.B.2    Voyer, R.3    Jardin, B.4    Kamen, A.A.5
  • 20
    • 0038731394 scopus 로고    scopus 로고
    • On-line biomass monitoring of CHO perfusion culture with scanning dielectric spectroscopy
    • Cannizzaro C., Gugerli R., Marison I., von Stockar U. On-line biomass monitoring of CHO perfusion culture with scanning dielectric spectroscopy. Biotechnol. Bioeng. 2003, 84(5):597-610.
    • (2003) Biotechnol. Bioeng. , vol.84 , Issue.5 , pp. 597-610
    • Cannizzaro, C.1    Gugerli, R.2    Marison, I.3    von Stockar, U.4
  • 21
    • 76849104099 scopus 로고    scopus 로고
    • Multifrequency permittivity measurements enable on-line monitoring of changes in intracellular conductivity due to nutrient limitations during batch cultivations of CHO cells
    • Ansorge S., Esteban G., Schmid G. Multifrequency permittivity measurements enable on-line monitoring of changes in intracellular conductivity due to nutrient limitations during batch cultivations of CHO cells. Biotechnol. Prog. 2010, 26(1):272-283.
    • (2010) Biotechnol. Prog. , vol.26 , Issue.1 , pp. 272-283
    • Ansorge, S.1    Esteban, G.2    Schmid, G.3
  • 22
    • 0033064937 scopus 로고    scopus 로고
    • Electrorotation studies of baby hamster kidney fibroblasts infected with herpes simplex virus type 1
    • Archer S., Morgan H., Rixon F.J. Electrorotation studies of baby hamster kidney fibroblasts infected with herpes simplex virus type 1. Biophys. J. 1999, 76(5):2833.
    • (1999) Biophys. J. , vol.76 , Issue.5 , pp. 2833
    • Archer, S.1    Morgan, H.2    Rixon, F.J.3
  • 23
    • 67349274284 scopus 로고    scopus 로고
    • Alterations of the plasma membrane caused by murine polyomavirus proliferation: an electrorotation study
    • Berardi V., Aiello C., Bonincontro A., Risuleo G. Alterations of the plasma membrane caused by murine polyomavirus proliferation: an electrorotation study. J. Membr. Biol. 2009, 229(1):19-25.
    • (2009) J. Membr. Biol. , vol.229 , Issue.1 , pp. 19-25
    • Berardi, V.1    Aiello, C.2    Bonincontro, A.3    Risuleo, G.4
  • 24
    • 0003054229 scopus 로고    scopus 로고
    • Measurements of changes in cell size distribution to monitor Baculovirus infection of insect cells
    • Kluwer Academic Publishers, Dordrecht, O.W. Merten, P. Perrin, B. Griffiths (Eds.)
    • Chico E., Jäger V. Measurements of changes in cell size distribution to monitor Baculovirus infection of insect cells. New Developments and New Applications in Animal Cell Technology 1998, 329-331. Kluwer Academic Publishers, Dordrecht. O.W. Merten, P. Perrin, B. Griffiths (Eds.).
    • (1998) New Developments and New Applications in Animal Cell Technology , pp. 329-331
    • Chico, E.1    Jäger, V.2
  • 25
    • 0035119844 scopus 로고    scopus 로고
    • Cell size as a tool to predict the production of recombinant protein by the insect-cell baculovirus expression system
    • Palomares L., Pedroza J., Ramirez O. Cell size as a tool to predict the production of recombinant protein by the insect-cell baculovirus expression system. Biotechnol. Lett. 2001, 23(5):359.
    • (2001) Biotechnol. Lett. , vol.23 , Issue.5 , pp. 359
    • Palomares, L.1    Pedroza, J.2    Ramirez, O.3
  • 26
    • 34548314442 scopus 로고    scopus 로고
    • Process optimization of large-scale production of recombinant adeno-associated vectors using dielectric spectroscopy
    • Negrete A., Esteban G., Kotin R.M. Process optimization of large-scale production of recombinant adeno-associated vectors using dielectric spectroscopy. Appl. Microbiol. Biotechnol. 2007, 76(4):761-772.
    • (2007) Appl. Microbiol. Biotechnol. , vol.76 , Issue.4 , pp. 761-772
    • Negrete, A.1    Esteban, G.2    Kotin, R.M.3
  • 27
    • 44049085243 scopus 로고    scopus 로고
    • Toward exascale production of recombinant adeno-associated virus for gene transfer applications
    • Cecchini S., Negrete A., Kotin R.M. Toward exascale production of recombinant adeno-associated virus for gene transfer applications. Gene Ther. 2008, 15(11):823-830.
    • (2008) Gene Ther. , vol.15 , Issue.11 , pp. 823-830
    • Cecchini, S.1    Negrete, A.2    Kotin, R.M.3
  • 28
    • 2642647059 scopus 로고    scopus 로고
    • Serum-free production of recombinant proteins and adenoviral vector by 293-SF-3F6 cells
    • Côté J., Garnier A., Massie B., Kamen A. Serum-free production of recombinant proteins and adenoviral vector by 293-SF-3F6 cells. Biotechnol. Bioeng. 1998, 59:567-575.
    • (1998) Biotechnol. Bioeng. , vol.59 , pp. 567-575
    • Côté, J.1    Garnier, A.2    Massie, B.3    Kamen, A.4
  • 29
    • 72449162211 scopus 로고    scopus 로고
    • Development of a scalable process for high-yield lentiviral vector production by transient transfection of HEK293 suspension cultures
    • Ansorge S., Lanthier S., Transfiguracion J., Durocher Y., Henry O., Kamen A. Development of a scalable process for high-yield lentiviral vector production by transient transfection of HEK293 suspension cultures. J. Gene Med. 2009, 11(10):868-876.
    • (2009) J. Gene Med. , vol.11 , Issue.10 , pp. 868-876
    • Ansorge, S.1    Lanthier, S.2    Transfiguracion, J.3    Durocher, Y.4    Henry, O.5    Kamen, A.6
  • 30
  • 31
  • 32
    • 35648981154 scopus 로고    scopus 로고
    • Production of lentiviral vectors by large-scale transient transfection of suspension cultures and affinity chromatography purification
    • Segura M.M., Garnier A., Durocher Y., Coelho H., Kamen A. Production of lentiviral vectors by large-scale transient transfection of suspension cultures and affinity chromatography purification. Biotechnol. Bioeng. 2007, 98(4):789-799.
    • (2007) Biotechnol. Bioeng. , vol.98 , Issue.4 , pp. 789-799
    • Segura, M.M.1    Garnier, A.2    Durocher, Y.3    Coelho, H.4    Kamen, A.5
  • 33
    • 2942618534 scopus 로고    scopus 로고
    • Insights into adenoviral vector production kinetics in acoustic filter-based perfusion cultures
    • Henry O., Dormond E., Perrier M., Kamen A. Insights into adenoviral vector production kinetics in acoustic filter-based perfusion cultures. Biotechnol. Bioeng. 2004, 86(7):765-774.
    • (2004) Biotechnol. Bioeng. , vol.86 , Issue.7 , pp. 765-774
    • Henry, O.1    Dormond, E.2    Perrier, M.3    Kamen, A.4
  • 34
    • 0030431007 scopus 로고    scopus 로고
    • Dissolved carbon dioxide accumulation in a large scale and high density production of TGFβ receptor with baculovirus infected Sf-9 cells
    • Garnier A., Voyer R., Tom R., Perret S., Jardin B., Kamen A. Dissolved carbon dioxide accumulation in a large scale and high density production of TGFβ receptor with baculovirus infected Sf-9 cells. Cytotechnology 1996, 22:53-63.
    • (1996) Cytotechnology , vol.22 , pp. 53-63
    • Garnier, A.1    Voyer, R.2    Tom, R.3    Perret, S.4    Jardin, B.5    Kamen, A.6
  • 35
    • 0001206002 scopus 로고
    • Quantification of cytotoxicity by cell volume and cell proliferation
    • Winkelmeier P., Glauner B., Lindl T. Quantification of cytotoxicity by cell volume and cell proliferation. ATLA 1993, 21:269-280.
    • (1993) ATLA , vol.21 , pp. 269-280
    • Winkelmeier, P.1    Glauner, B.2    Lindl, T.3
  • 36
    • 0025438136 scopus 로고
    • Cell volume measurement as an estimation of mammalian cell biomass
    • Frame K., Hu W.-S. Cell volume measurement as an estimation of mammalian cell biomass. Biotechnol. Bioeng. 1990, 36:191-197.
    • (1990) Biotechnol. Bioeng. , vol.36 , pp. 191-197
    • Frame, K.1    Hu, W.-S.2
  • 37
    • 84907040752 scopus 로고
    • Dielectric spectroscopy and membrane organization
    • Kell D.B., Harris C.M. Dielectric spectroscopy and membrane organization. J. Bioelectricity 1985, 4:317-348.
    • (1985) J. Bioelectricity , vol.4 , pp. 317-348
    • Kell, D.B.1    Harris, C.M.2
  • 38
    • 0023306390 scopus 로고
    • Dielectric permittivity of microbial suspensions at radio frequencies: a novel method for the real-time estimation of microbial biomass
    • Harris C.M., Todd R.W., Bungard S.J., Lovitt J.G.M., Kell D.B. Dielectric permittivity of microbial suspensions at radio frequencies: a novel method for the real-time estimation of microbial biomass. Enzyme Microb. Technol. 1987, 9:181-186.
    • (1987) Enzyme Microb. Technol. , vol.9 , pp. 181-186
    • Harris, C.M.1    Todd, R.W.2    Bungard, S.J.3    Lovitt, J.G.M.4    Kell, D.B.5
  • 39
    • 0023636426 scopus 로고
    • The passive electrical properties of biological systems: their significance in physiology, biophysics and biotechnology
    • Pethig R., Kell D.B. The passive electrical properties of biological systems: their significance in physiology, biophysics and biotechnology. Phys. Med. Biol. 1987, 32:933-970.
    • (1987) Phys. Med. Biol. , vol.32 , pp. 933-970
    • Pethig, R.1    Kell, D.B.2
  • 40
    • 0033180019 scopus 로고    scopus 로고
    • The dielectric properties of biological cells at radiofrequencies: applications in biotechnology
    • Markx G.H., Davey C.L. The dielectric properties of biological cells at radiofrequencies: applications in biotechnology. Enzyme Microb. Technol. 1999, 25:161-171.
    • (1999) Enzyme Microb. Technol. , vol.25 , pp. 161-171
    • Markx, G.H.1    Davey, C.L.2
  • 41
    • 54949152106 scopus 로고
    • Electrical properties of tissue and cell suspensions
    • Schwan H.P. Electrical properties of tissue and cell suspensions. Adv. Biol. Med. Phys. 1957, 5:147-208.
    • (1957) Adv. Biol. Med. Phys. , vol.5 , pp. 147-208
    • Schwan, H.P.1
  • 42
    • 55949087943 scopus 로고    scopus 로고
    • Dielectric measurement of cell death
    • Patel P.M., Markx G.H. Dielectric measurement of cell death. Enzyme Microb. Technol. 2008, 43(7):463-470.
    • (2008) Enzyme Microb. Technol. , vol.43 , Issue.7 , pp. 463-470
    • Patel, P.M.1    Markx, G.H.2
  • 43
    • 33748565282 scopus 로고
    • Dispersion and absorption in dielectrics: 1 - alternating current characteristics
    • Cole K.S., Cole R.H. Dispersion and absorption in dielectrics: 1 - alternating current characteristics. J. Chem. Phys. 1929, 9:341-351.
    • (1929) J. Chem. Phys. , vol.9 , pp. 341-351
    • Cole, K.S.1    Cole, R.H.2
  • 44
    • 0004048707 scopus 로고
    • Aberystwyth, Department of Biological Sciences, University of Wales
    • Davey C.L. The Biomass Monitor Source Book 1993, Aberystwyth, Department of Biological Sciences, University of Wales.
    • (1993) The Biomass Monitor Source Book
    • Davey, C.L.1
  • 45
    • 0035261902 scopus 로고    scopus 로고
    • Kinetic analyses of stability of simple and complex retroviral vectors
    • Higashikawa F., Chang L.-J. Kinetic analyses of stability of simple and complex retroviral vectors. Virology 2001, 280(1):124-131.
    • (2001) Virology , vol.280 , Issue.1 , pp. 124-131
    • Higashikawa, F.1    Chang, L.-J.2
  • 46
    • 0029051806 scopus 로고
    • Monitoring of mammalian cell growth and virus production process using on-line oxygen uptake rate measurement
    • Kussow C.M., et al. Monitoring of mammalian cell growth and virus production process using on-line oxygen uptake rate measurement. Enzyme Microb. Technol. 1995, 17(9):779.
    • (1995) Enzyme Microb. Technol. , vol.17 , Issue.9 , pp. 779
    • Kussow, C.M.1
  • 47
    • 0030570089 scopus 로고    scopus 로고
    • On-line monitoring of respiration in recombinant-baculovirus infected and uninfected insect cell bioreactor cultures
    • Kamen A.A., Bédard C., Tom R., Perret S., Jardin B. On-line monitoring of respiration in recombinant-baculovirus infected and uninfected insect cell bioreactor cultures. Biotechnol. Bioeng. 1996, (50):36-48.
    • (1996) Biotechnol. Bioeng. , Issue.50 , pp. 36-48
    • Kamen, A.A.1    Bédard, C.2    Tom, R.3    Perret, S.4    Jardin, B.5
  • 48
    • 33747098170 scopus 로고    scopus 로고
    • Application of on-line OUR measurements to detect actions points to improve baculovirus-insect cell cultures in bioreactors
    • Lecina M., Soley A., Gràcia J., Espunya E., Lázaro B., Cairó J.J., Gòdia F. Application of on-line OUR measurements to detect actions points to improve baculovirus-insect cell cultures in bioreactors. J. Biotechnol. 2006, 125(3):385-394.
    • (2006) J. Biotechnol. , vol.125 , Issue.3 , pp. 385-394
    • Lecina, M.1    Soley, A.2    Gràcia, J.3    Espunya, E.4    Lázaro, B.5    Cairó, J.J.6    Gòdia, F.7
  • 49
    • 3042704538 scopus 로고    scopus 로고
    • Development and optimization of an adenovirus production process
    • Kamen A., Henry O. Development and optimization of an adenovirus production process. J. Gene Med. 2004, 6(S1):S184-S192.
    • (2004) J. Gene Med. , vol.6 , Issue.S1
    • Kamen, A.1    Henry, O.2
  • 52
    • 0034024242 scopus 로고    scopus 로고
    • On-line measurement of green fluorescent protein (GFP) fluorescence for the monitoring of recombinant adenovirus production
    • Gilbert P.-A., Garnier A., Jacob D., Kamen A. On-line measurement of green fluorescent protein (GFP) fluorescence for the monitoring of recombinant adenovirus production. Biotechnol. Lett. 2000, 22(7):561-567.
    • (2000) Biotechnol. Lett. , vol.22 , Issue.7 , pp. 561-567
    • Gilbert, P.-A.1    Garnier, A.2    Jacob, D.3    Kamen, A.4
  • 53
    • 36749020097 scopus 로고    scopus 로고
    • On-line monitoring of infected Sf-9 insect cell cultures by scanning permittivity measurements and comparison with off-line biovolume measurements
    • Ansorge S., Esteban G., Schmid G. On-line monitoring of infected Sf-9 insect cell cultures by scanning permittivity measurements and comparison with off-line biovolume measurements. Cytotechnology 2007, 55:115-124.
    • (2007) Cytotechnology , vol.55 , pp. 115-124
    • Ansorge, S.1    Esteban, G.2    Schmid, G.3
  • 54
    • 0034090316 scopus 로고    scopus 로고
    • Expression of human immunodeficiency virus type 1 Gag protein precursor and envelope proteins from a vesicular stomatitis virus recombinant: high-level production of virus-like particles containing HIV envelope
    • Haglund K., Forman J., Kräusslich H.-G., Rose J.K. Expression of human immunodeficiency virus type 1 Gag protein precursor and envelope proteins from a vesicular stomatitis virus recombinant: high-level production of virus-like particles containing HIV envelope. Virology 2000, 268(1):112-121.
    • (2000) Virology , vol.268 , Issue.1 , pp. 112-121
    • Haglund, K.1    Forman, J.2    Kräusslich, H.-G.3    Rose, J.K.4
  • 55
    • 0035659634 scopus 로고    scopus 로고
    • The HIV-1 assembly machine
    • Göttlinger H. The HIV-1 assembly machine. AIDS 2001, 15(Suppl. 5):S13-20.
    • (2001) AIDS , vol.15 , Issue.SUPPL. 5
    • Göttlinger, H.1
  • 57
    • 28444441522 scopus 로고    scopus 로고
    • Detailed design and comparative analysis of protocols for optimized production of high-performance HIV-1-derived lentiviral particles
    • Mitta B., Rimann M., Fussenegger M. Detailed design and comparative analysis of protocols for optimized production of high-performance HIV-1-derived lentiviral particles. Metab. Eng. 2005, 7(5-6):426-436.
    • (2005) Metab. Eng. , vol.7 , Issue.5-6 , pp. 426-436
    • Mitta, B.1    Rimann, M.2    Fussenegger, M.3
  • 58
    • 33846081072 scopus 로고    scopus 로고
    • Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via Toll-like receptor 9
    • Pichlmair A., Diebold S.S., Gschmeissner S., Takeuchi Y., Ikeda Y., Collins M.K., Reis e Sousa C. Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via Toll-like receptor 9. J. Virol. 2007, 81:539-547.
    • (2007) J. Virol. , vol.81 , pp. 539-547
    • Pichlmair, A.1    Diebold, S.S.2    Gschmeissner, S.3    Takeuchi, Y.4    Ikeda, Y.5    Collins, M.K.6    Reis e Sousa, C.7
  • 59
    • 44349138765 scopus 로고    scopus 로고
    • Characterization of complete particles (VSV-G/SIN-GFP) and empty particles (VSV-G/EMPTY) in human immunodeficiency virus type 1-based lentiviral products for gene therapy: potential applications for improvement of product quality and safety
    • Zhao Y., Keating K., Dolman C., Thorpe R. Characterization of complete particles (VSV-G/SIN-GFP) and empty particles (VSV-G/EMPTY) in human immunodeficiency virus type 1-based lentiviral products for gene therapy: potential applications for improvement of product quality and safety. Hum. Gene Ther. 2008, 19(5):475-486.
    • (2008) Hum. Gene Ther. , vol.19 , Issue.5 , pp. 475-486
    • Zhao, Y.1    Keating, K.2    Dolman, C.3    Thorpe, R.4
  • 60
    • 0027264118 scopus 로고
    • Mutational analysis of the vesicular stomatitis virus glycoprotein G for membrane fusion domains
    • Li Y., Drone C., Sat E., Ghosh H.P. Mutational analysis of the vesicular stomatitis virus glycoprotein G for membrane fusion domains. J. Virol. 1993, 67(7):4070-4077.
    • (1993) J. Virol. , vol.67 , Issue.7 , pp. 4070-4077
    • Li, Y.1    Drone, C.2    Sat, E.3    Ghosh, H.P.4
  • 61
    • 0036968555 scopus 로고    scopus 로고
    • Lentiviral vectors for gene delivery into cells
    • Quinonez R., Sutton R.E. Lentiviral vectors for gene delivery into cells. DNA Cell Biol. 2002, 21(12):937-951.
    • (2002) DNA Cell Biol. , vol.21 , Issue.12 , pp. 937-951
    • Quinonez, R.1    Sutton, R.E.2
  • 63
    • 0035809236 scopus 로고    scopus 로고
    • On-line determination of animal cell concentration in two industrial high-density culture processes by dielectric spectroscopy
    • Ducommun P., Kadouri A., von Stockar U., Marison I.W. On-line determination of animal cell concentration in two industrial high-density culture processes by dielectric spectroscopy. Biotechnol. Bioeng. 2002, 77(3):316-323.
    • (2002) Biotechnol. Bioeng. , vol.77 , Issue.3 , pp. 316-323
    • Ducommun, P.1    Kadouri, A.2    von Stockar, U.3    Marison, I.W.4
  • 65
    • 55949121863 scopus 로고    scopus 로고
    • A comparative study of cell death using electrical capacitance measurements and dielectrophoresis
    • Patel P.M., Bhat A., Markx G.H. A comparative study of cell death using electrical capacitance measurements and dielectrophoresis. Enzyme Microb. Technol. 2008, 43(7):523-530.
    • (2008) Enzyme Microb. Technol. , vol.43 , Issue.7 , pp. 523-530
    • Patel, P.M.1    Bhat, A.2    Markx, G.H.3
  • 66
    • 0025109011 scopus 로고
    • The budding of defective human immunodeficiency virus type 1 (HIV-1) particles from cell clones persistently infected with HIV-1
    • Goto T., Ikuta K., Zhang J.J., Morita C., Sano K., Komatsu M., Fujita H., Kato S., Nakai M. The budding of defective human immunodeficiency virus type 1 (HIV-1) particles from cell clones persistently infected with HIV-1. Arch. Virol. 1990, 111(1):87-101.
    • (1990) Arch. Virol. , vol.111 , Issue.1 , pp. 87-101
    • Goto, T.1    Ikuta, K.2    Zhang, J.J.3    Morita, C.4    Sano, K.5    Komatsu, M.6    Fujita, H.7    Kato, S.8    Nakai, M.9
  • 67
    • 47049130164 scopus 로고    scopus 로고
    • Imaging the biogenesis of individual HIV-1 virions in live cells
    • Jouvenet N., Bieniasz P.D., Simon S.M. Imaging the biogenesis of individual HIV-1 virions in live cells. Nature 2008, 454(7201):236-240.
    • (2008) Nature , vol.454 , Issue.7201 , pp. 236-240
    • Jouvenet, N.1    Bieniasz, P.D.2    Simon, S.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.