Strong HIV-1-specific T cell responses in HIV-1-exposed uninfected infants and neonates revealed after regulatory T cell removal

PLoS ONE

Volumn 1, Issue 1, 2006, Pages

  Legrand, Fatema A ^a   Nixon, Douglas F ^a   Loo, Christopher P ^a   Ono, Erika ^b   Chapman, Joan M ^a   Miyamoto, Maristela ^b   Diaz, Ricardo S ^b   Santos, Amélia M N ^b   Succi, Regina C M ^b   Abadi, Jacob ^c   Rosenberg, Michael G ^c   de Moraes Pinto, Maria Isabel ^b   Kallas, Esper G ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR PLUS LAMIVUDINE PLUS ZIDOVUDINE; DIDANOSINE; EFAVIRENZ; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; NELFINAVIR; STAVUDINE; ZIDOVUDINE; GAG PROTEIN;

ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL SPECIFICITY; CELLULAR IMMUNITY; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INFANT; LYMPHOCYTE DEPLETION; NEWBORN; PRENATAL CARE; PRENATAL EXPOSURE; QUANTITATIVE ANALYSIS; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UMBILICAL CORD BLOOD; VERTICAL TRANSMISSION; VIRUS INACTIVATION; VIRUS LOAD; VIRUS TRANSMISSION; ADULT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOLOGY; DISEASE TRANSMISSION; FETUS BLOOD; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PREGNANCY; PREGNANCY COMPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; FEMALE; FETAL BLOOD; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, CELLULAR; INFANT; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; T-LYMPHOCYTES, REGULATORY;

EID: 34548042128     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000102     Document Type: Article

References (53)

1. Magder LS, Mofenson L, Paul ME, Zorrilla CD, Blattner WA, et al. (2005) Risk factors for in utero and intrapartum transmission of HIV. J Acquir Immune Defic Syndr 38: 87-95.
2. Connor EM, McSherry G (1994) Immune-based interventions in perinatal human immunodeficiency virus infection. Pediatr Infect Dis J 13: 440-448.
3. Luzuriaga K, Sullivan JL (2002) Pediatric HIV-1 infection: advances and remaining challenges. AIDS Rev 4: 21-26.
4. Mother-to-child transmission of HIV infection in the era of highly active antiretroviral therapy. Clin Infect Dis 40: 458-465.
5. Luzuriaga K, Sullivan JL (2005) Prevention of mother-to-child transmission of HIV infection. Clin Infect Dis 40: 466-467.
6. McGowan JP, Shah SS (2000) Prevention of perinatal HIV transmission during pregnancy. J Antimicrob Chemother 46: 657-668.
7. Borrow P, Lewicki H, Hahn BH, Shaw GM, Oldstone MB (1994) Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol 68: 6103-6110.
8. Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, et al. (1994) Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 68: 4650-4655.
9. Klein MR, van Baalen CA, Holwerda AM, Kerkhof Garde SR, Bende RJ, et al. (1995) Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics. J Exp Med 181: 1365-1372.
10. Jin X, Bauer DE, Tuttleton SE, Lewin S, Gettie A, et al. (1999) Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med 189: 991-998.
11. Schmitz JE, Kuroda MJ, Santra S, Sasseville VG, Simon MA, et al. (1999) Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 283: 857-860.
12. Rinaldo C, Huang XL, Fan ZF, Ding M, Beltz L, et al. (1995) High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors. J Virol 69: 5838-5842.
13. Pantaleo G, Menzo S, Vaccarezza M, Graziosi C, Cohen OJ, et al. (1995) Studies in subjects with long-term nonprogressive human immunodeficiency virus infection. N Engl J Med 332: 209-216.
14. Kalams SA, Goulder PJ, Shea AK, Jones NG, Trocha AK, et al. (1999) Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy. J Virol 73: 6721-6728.
15. Pitcher CJ, Quittner C, Peterson DM, Connors M, Koup RA, et al. (1999) HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression. Nat Med 5: 518-525.
16. Phillips RE, Rowland-Jones S, Nixon DF, Gotch FM, Edwards JP, et al. (1991) Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 354: 453-459.
17. Price DA, Goulder PJ, Klenerman P, Sewell AK, Easterbrook PJ, et al. (1997) Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc Natl Acad Sci U S A 94: 1890-1895.
18. Luzuriaga K, Koup RA, Pikora CA, Brettler DB, Sullivan JL (1991) Deficient human immunodeficiency virus type 1-specific cytotoxic T cell responses in vertically infected children. J Pediatr 119: 230-236.
19. Cheynier R, Langlade-Demoyen P, Marescot MR, Blanche S, Blondin G, et al. (1992) Cytotoxic T lymphocyte responses in the peripheral blood of children born to human immunodeficiency virus-1-infected mothers. Eur J Immunol 22: 2211-2217.
20. Rowland-Jones SL, Nixon DF, Aldhous MC, Gotch F, Ariyoshi K, et al. (1993) HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant. Lancet 341: 860-861.
21. Buseyne F, Blanche S, Schmitt D, Griscelli C, Riviere Y (1993) Detection of HIV-specific cell-mediated cytotoxicity in the peripheral blood from infected children. J Immunol 150: 3569-3581.
22. Clerici M, Sison AV, Berzofsky JA, Rakusan TA, Brandt CD, et al. (1993) Cellular immune factors associated with mother-to-infant transmission of HIV. Aids 7: 1427-1433.
23. De Maria A, Cirillo C, Moretta L (1994) Occurrence of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic T cell activity in apparently uninfected children born to HIV-1-infected mothers. J Infect Dis 170: 1296-1299.
24. McFarland EJ, Harding PA, Luckey D, Conway B, Young RK, et al. (1994) High frequency of Gag- and envelope-specific cytotoxic T lymphocyte precursors in children with vertically acquired human immunodeficiency virus type 1 infection. J Infect Dis 170: 766-774.
25. Spiegel HM, Chandwani R, Sheehy ME, Dobroszycki J, Fennelly G, et al. (2000) The impact of early initiation of highly active antiretroviral therapy on the human immunodeficiency virus type 1-specific CD8 T cell response in children. J Infect Dis 182: 88-95.
26. Scott-Algara D, Buseyne F, Blanche S, Rouzioux C, Jouanne C, et al. (2001) Frequency and phenotyping of human immunodeficiency virus (HIV)-specific CD8+ T cells in HIV-infected children, using major histocompatibility complex class I peptide tetramers. J Infect Dis 183: 1565-1573.
27. Sandberg JK, Fast NM, Jordan KA, Furlan SN, Barbour JD, et al. (2003) HIV-specific CD8+ T cell function in children with vertically acquired HIV-1 infection is critically influenced by age and the state of the CD4+ T cell compartment. J Immunol 170: 4403-4410.
28. Lohman BL, Slyker JA, Richardson BA, Farquhar C, Mabuka JM, et al. (2005) Longitudinal assessment of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon responses during the first year of life in HIV-1-infected infants. J Virol 79: 8121-8130.
29. Chakraborty R, Morel AS, Sutton JK, Appay V, Ripley RM, et al. (2005) Correlates of delayed disease progression in HIV-1-infected Kenyan children. J Immunol 174: 8191-8199.
30. Zhang Q, Pettitt E, Burkinshaw R, Race G, Shaw L, et al. (2002) Mucosal immune responses to meningococcal conjugate polysaccharide vaccines in infants. Pediatr Infect Dis J 21: 209-213.
31. Gibson L, Piccinini G, Lilleri D, Revello MG, Wang Z, et al. (2004) Human cytomegalovirus proteins pp65 and immediate early protein 1 are common targets for CD8+ T cell responses in children with congenital or postnatal human cytomegalovirus infection. J Immunol 172: 2256-2264.
32. Marchant A, Appay V, Van Der Sande M, Dulphy N, Liesnard C, et al. (2003) Mature CD8(+) T lymphocyte response to viral infection during fetal life. J Clin Invest 111: 1747-1755.
33. Marchant A, Goldman M (2005) T cell-mediated immune responses in human newborns: ready to learn? Clin Exp Immunol 141: 10-18.
34. Hermann E, Truyens C, Alonso-Vega C, Even J, Rodriguez P, et al. (2002) Human fetuses are able to mount an adultlike CD8 T-cell response. Blood 100: 2153-2158.
35. Mascart F, Verscheure V, Malfroot A, Hainaut M, Pierard D, et al. (2003) Bordetella pertussis infection in 2-month-old infants promotes type 1 T cell responses. J Immunol 170: 1504-1509.
36. Burchett SK, Corey L, Mohan KM, Westall J, Ashley R, et al. (1992) Diminished interferon-gamma and lymphocyte proliferation in neonatal and postpartum primary herpes simplex virus infection. J Infect Dis 165: 813-818.
37. Malhotra I, Mungai P, Wamachi A, Kioko J, Ouma JH, et al. (1999) Helminthand Bacillus Calmette-Guerin-induced immunity in children sensitized in utero to filariasis and schistosomiasis. J Immunol 162: 6843-6848.
38. Aandahl EM, Michaelsson J, Moretto WJ, Hecht FM, Nixon DF (2004) Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens. J Virol 78: 2454-2459.
39. Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, et al. (2005) Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22: 329-341.
40. Fontenot JD, Rudensky AY (2005) A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 6: 331-337.
41. Sakaguchi S (2005) Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 6: 345-352.
42. Michaelsson J, Mold JE, McCune JM, Nixon DF (2006) Regulation of T cell responses in the developing human fetus. J Immunol 176: 5741-5748.
43. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, et al. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med.
44. Hofmeister R, Khaled AR, Benbernou N, Rajnavolgyi E, Muegge K, et al. (1999) Interleukin-7: physiological roles and mechanisms of action. Cytokine Growth Factor Rev 10: 41-60.
45. Betts MR, Nason MC, West SM, De Rosa SC, Migueles SA, et al. (2006) HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood 107: 4781-4789.
46. Lichterfeld M, Yu XG, Waring MT, Mui SK, Johnston MN, et al. (2004) HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha. Blood 104: 487-494.
47. Zimmerli SC, Harari A, Cellerai C, Vallelian F, Bart PA, et al. (2005) HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells. Proc Natl Acad Sci U S A 102: 7239-7244.
48. Frenkel LM, Mullins JI, Learn GH, Manns-Arcuino L, Herring BL, et al. (1998) Genetic evaluation of suspected cases of transient HIV-1 infection of infants. Science 280: 1073-1077.
49. Oswald-Richter K, Grill SM, Shariat N, Leelawong M, Sundrud MS, et al. (2004) HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells. PLoS Biol 2: E198.
50. Kinter AL, Hennessey M, Bell A, Kern S, Lin Y, et al. (2004) CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J Exp Med 200: 331-343.
51. Eggena MP, Barugahare B, Jones N, Okello M, Mutalya S, et al. (2005) Depletion of Regulatory T Cells in HIV Infection Is Associated with Immune Activation. J Immunol 174: 4407-4414.
52. Tsaknaridis L, Spencer L, Culbertson N, Hicks K, LaTocha D, et al. (2003) Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity. J Neurosci Res 74: 296-308.
53. Somerset DA, Zheng Y, Kilby MD, Sansom DM, Drayson MT (2004) Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset. Immunology 112: 38-43.