Immunologic aspects of monoclonal B-cell lymphocytosis

Immunologic Research

Volumn 49, Issue 1-3, 2011, Pages 269-280

  Lanasa, Mark C ^a   Weinberg, J Brice ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

Author keywords

B cell development; B cell receptor; Chronic lymphocytic leukemia; Monoclonal B lymphocytosis; Non Hodgkin's lymphoma

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD19 ANTIGEN; CD20 ANTIGEN; CD23 ANTIGEN; CD5 ANTIGEN; CD79B ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN M; INTERLEUKIN 10;

B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COMPARTMENTALIZATION; CELL MATURATION; CHRONIC LYMPHATIC LEUKEMIA; DISEASE ASSOCIATION; FLOW CYTOMETRY; HELPER CELL; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; LYMPHOCYTOSIS; LYMPHOPROLIFERATIVE DISEASE; MANTLE CELL LYMPHOMA; MONOCLONAL B LYMPHOCYTOSIS; NATURAL KILLER CELL; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

B-LYMPHOCYTES; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPHOCYTOSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, ANTIGEN, B-CELL; T-LYMPHOCYTES;

EID: 79952695392     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12026-010-8188-4     Document Type: Review

References (56)

1. Altekruse SF, Kosary CL, Krapcho M, Neyman N, Aminou R, Waldron W, Ruhl J, Howlader N, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Cronin K, Chen HS, Feuer EJ, Stinchcomb DG, Edwards BK (eds). SEER cancer statistics review, 1975-2007. 2010. Bethesda, MD: National Cancer Institute. http://seer.cancer.gov/csr/1975-2007/, based on November 2009 SEER data submission, posted to the SEER web site.
2. Chiorazzi N, Rai KR, Ferrarini M. Chronic lymphocytic leukemia. N Engl J Med. 2005;352(8):804-15.
3. Rawstron AC, et al. Monoclonal B lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Blood. 2002;100(2):635-9.
4. Rawstron AC, et al. Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N Engl J Med. 2008;359(6):575-83.
5. Landgren O, et al. B-cell clones as early markers for chronic lymphocytic leukemia. N Engl J Med. 2009;360(7):659-67.
6. Rawstron AC, et al. Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion. Blood. 2002;100(7):2289-90.
7. Ghia P, et al. Monoclonal CD5 + and CD5 - B-lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood. 2004;103(6):2337-42. (Pubitemid 38326255)
8. Shim YK, et al. Prevalence and natural history of monoclonal and polyclonal B-cell lymphocytosis in a residential adult population. Cytometry B Clin Cytom. 2007;72(5):344-53. (Pubitemid 350194351)
9. Nieto WG, et al. Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach. Blood. 2009;114(1):33-7.
10. Nieto WG, et al. Commentary: Comparison of current flow cytometry methods for monoclonal B cell lymphocytosis detection. Cytometry B Clin Cytom. 2010;78 Suppl 1:S4-9.
11. Shim YK, et al. Prevalence of monoclonal B-cell lymphocytosis: a systematic review. Cytometry B Clin Cytom. 2010;78 Suppl 1:S10-8.
12. Lanasa MC, et al. Single-cell analysis reveals oligoclonality among 'low-count' monoclonal B-cell lymphocytosis. Leukemia. 2010;24(1):133-40.
13. Marti GE, et al. B-cell monoclonal lymphocytosis and B-cell abnormalities in the setting of familial B-cell chronic lymphocytic leukemia. Cytometry B Clin Cytom. 2003;52(1):1-12. (Pubitemid 38297638)
14. Goldin LR et al. Common occurrence of monoclonal B-cell lymphocytosis among members of high-risk CLL families. Br J Haematol. 2010 (in press).
15. Matos DM, Ismael SJ, Scrideli CA, de Oliveira FM, Rego EM, Falcao RP. Monoclonal B-cell lymphocytosis in first-degree relatives of patients with sporadic (non-familial) chronic lymphocytic leukaemia. Br J Haematol. 2009;147:339-46.
16. Crowther-Swanepoel D et al. Inherited genetic susceptibility to monoclonal B-cell lymphocytosis. Blood. 2010 (in press).
17. Goldin LR, et al. Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin's lymphomas among relatives of patients with chronic lymphocytic leukemia. Haematologica. 2009;94(5):647-53.
18. Shanafelt TD et al. Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management. Leukemia. 2010;24(3):512-20.
19. Marti GE, et al. Diagnostic criteria for monoclonal B-cell lymphocytosis. Br J Haematol. 2005;130(3):325-32. (Pubitemid 43899581)
20. Cheson BD, et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood. 1996;87(12):4990-7. (Pubitemid 26189840)
21. Hallek M, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the international workshop on chronic lymphocytic leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111(12):5446-56.
22. Shanafelt TD, et al. B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcome. Blood. 2009;113(18):4188-96.
23. Shanafelt TD, et al. Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia. J Clin Oncol. 2009;27(24):3959-63.
24. Rawstron AC, et al. Different biology and clinical outcome according to the absolute numbers of clonal B-cells in monoclonal B-cell lymphocytosis (MBL). Cytometry B Clin Cytom. 2010;78 Suppl 1:S19-23.
25. Hauswirth A et al. Monoclonal B-cell lymphocytosis (MBL) with normal whole lymphocyte counts is associated with reduced numbers of normal circulating immature and mature B-lymphocytes. Hematologica. 95(Suppl 2):324 (abstract).
26. Dagklis A, et al. The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring. Blood. 2009;114(1):26-32.
27. Caligaris-Cappio F, Ghia P. Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease? J Clin Oncol. 2008;26(27):4497-503.
28. Fais F, et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest. 1998;102(8):1515-25. (Pubitemid 28492218)
29. Widhopf GF II, et al. Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins. Blood. 2004;104(8):2499-504.
30. Tobin G, et al. Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood. 2004;104(9):2879-85. (Pubitemid 39434975)
31. Messmer BT, et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med. 2004;200(4):519-25. (Pubitemid 39121908)
32. Hamblin TJ, et al. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94(6):1848-54. (Pubitemid 29430400)
33. Rosenwald A, et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med. 2001;194(11):1639-47. (Pubitemid 33126814)
34. Klein U, et al. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med. 2001;194(11):1625-38. (Pubitemid 33126813)
35. Guarini A, et al. BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgVHunmutated chronic lymphocytic leukemia (CLL) cells. Blood. 2008;112(3):782-92.
36. Volkheimer AD, et al. Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification. Blood. 2007;109(4):1559-67. (Pubitemid 46239589)
37. Lossos IS, et al. The inference of antigen selection on Ig genes. J Immunol. 2000;165(9):5122-6.
38. Bagnara D, et al. IgV gene intraclonal diversification and clonal evolution in B-cell chronic lymphocytic leukaemia. Br J Haematol. 2006;133(1):50-8. (Pubitemid 43327197)
39. Gurrieri C, et al. Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification. J Exp Med. 2002;196(5):629-39. (Pubitemid 35024441)
40. Markey GM, et al. Enumeration of absolute numbers of T lymphocyte subsets in B-chronic lymphocytic leukaemia using an immunoperoxidase technique: relation to clinical stage. Br J Haematol. 1986;62(2):257-73. (Pubitemid 16212075)
41. Kimby E, et al. T lymphocyte subpopulations in chronic lymphocytic leukemia of B cell type in relation to immunoglobulin isotype(s) on the leukemic clone and to clinical features. Eur J Haematol. 1987;38(3):261-7.
42. Ghia P, Caligaris-Cappio F. The indispensable role of microenvironment in the natural history of lowgrade B-cell neoplasms. Adv Cancer Res. 2000;79:157-73. (Pubitemid 30228123)
43. Gorgun G, et al. Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells. J Clin Invest. 2005;115(7):1797-805. (Pubitemid 40979718)
44. Ramsay AG, et al. Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest. 2008;118(7):2427-37. (Pubitemid 351949771)
45. Lotz M, Ranheim E, Kipps TJ. Transforming growth factor beta as endogenous growth inhibitor of chronic lymphocytic leukemia B cells. J Exp Med. 1994;179(3):999-1004. (Pubitemid 24065658)
46. Fayad L, et al. Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: correlation with phenotypic characteristics and outcome. Blood. 2001;97(1):256-63. (Pubitemid 32061268)
47. Beyer M, et al. Reduced frequencies and suppressive function of CD4 + CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. Blood. 2005;106(6):2018-25. (Pubitemid 41291715)
48. Motta M, et al. Increased expression of CD152 (CTLA-4) by normal T lymphocytes in untreated patients with B-cell chronic lymphocytic leukemia. Leukemia. 2005;19(10):1788-93. (Pubitemid 41486157)
49. Rezvany MR, et al. Oligoclonal TCRBV gene usage in B-cell chronic lymphocytic leukemia: major perturbations are preferentially seen within the CD4 T-cell subset. Blood. 1999;94(3):1063-9.
50. Goolsby CL, et al. Expansions of clonal and oligoclonal T cells in B-cell chronic lymphocytic leukemia are primarily restricted to the CD3(+)CD8(+) T-cell population. Cytometry. 2000;42(3):188-95. (Pubitemid 30451719)
51. Serrano D, et al. Clonal expansion within the CD4 + CD57 + and CD8 + CD57 + T cell subsets in chronic lymphocytic leukemia. J Immunol. 1997;158(3):1482-9. (Pubitemid 127469977)
52. Miller C, et al. Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes. J Exp Med. 1995;181(4):1319-31.
53. Fischer M, Klein U, Kuppers R. Molecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation. J Clin Invest. 1997;100(7):1667-76.
54. Palmer S, et al. Prognostic importance of T and NK-cells in a consecutive series of newly diagnosed patients with chronic lymphocytic leukaemia. Br J Haematol. 2008;141(5):607-14. (Pubitemid 351667615)
55. Lanasa MC, et al. Oligoclonal TRBV gene usage among CD8(+) T cells in monoclonal B lymphocytosis and CLL. Br J Haematol. 2009;145(4):535-7.
56. Kepler TB, et al. Statistical analysis of antigen receptor spectratype data. Bioinformatics. 2005;21(16): 3394-400. (Pubitemid 41222444)