Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly

Blood

Volumn 103, Issue 6, 2004, Pages 2337-2342

  Ghia, Paolo ^a   Prato, Giuseppina ^b   Scielzo, Cristina ^b   Stella, Stefania ^b   Geuna, Massimo ^b   Guida, Giuseppe ^b   Caligaris Cappio, Federico ^b  

^a CANDIOLO CANCER INSTITUTE   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD20 ANTIGEN; CD23 ANTIGEN; CD5 ANTIGEN; CD79B ANTIGEN; IMMUNOGLOBULIN; PARAPROTEIN; PROTEIN BCL 2;

AGED; AGING; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; BLOOD CELL; CHRONIC LYMPHATIC LEUKEMIA; CLONAL VARIATION; CONTROLLED STUDY; FEMALE; GENE REARRANGEMENT; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTOSIS; LYMPHOPROLIFERATIVE DISEASE; MALE; NORMAL HUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 1542283720     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-09-3277     Document Type: Article

References (30)

1. LeMaoult J, Delassus S, Dyall R, Nikolic-Zugic J, Kourilsky P, Weksler ME. Clonal expansions of B lymphocytes in old mice. J Immunol. 1997;159:3866-3874.
2. Rolink A, Haasner D, Nishikawa S, Melchers F. Changes in frequencies of clonable pre B cells during life in different lymphoid organs of mice. Blood. 1993;81:2290-2300.
3. Ghia P, ten Boekel E, Sanz E, de la Hera A, Rolink A, Melchers F. Ordering of human bone narrow B lymphocyte precursors by single-cell polymerase chain reaction analyses of the rearrangement status of the immunoglobulin H and L chain gene loci. J Exp Med. 1996;184:2217-2229.
4. Nunez C, Nishimoto N, Gartland GL, et al. B cells are generated throughout life in humans. J Immunol. 1996;156:866-872.
5. Zharhary D. Age-related changes in the capability of the bone marrow to generate B cells. J Immunol. 1988;141:1863-1869.
6. LeMaoult J, Szabo P, Weksler ME. Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development. Immunol Rev. 1997;160:115-126.
7. Szabo P, Zhao K, Kirman I, et al. Maturation of B cell precursors is impaired in thymic-deprived nude and old mice. J Immunol. 1998;161:2248-2253.
8. Radl J. Age-related monoclonal gammapathies: clinical lessons from the aging C57BL mouse. Immunol Today. 1990;11:234-236.
9. Ligthart GJ, Radl J, Corberand JX, et al. Monoclonal gammopathies in human aging: increased occurrence with age and correlation with health status. Mech Ageing Dev. 1990;52:235-243.
10. + B cells. Mech Ageing Dev. 1998;103:111-121.
11. Stall AM, Farinas MO, Tarlinton DM, Lalor PA, Herzenberg LA, Strober S. Ly-1 B-cell clones similar to human chronic lymphocytic leukemias routinely develop in older normal mice and young autoimmune (New Zealand Black-related) animals. Proc Natl Acad Sci U S A. 1988;85:7312-7316.
12. Rawstron AC, Green MJ, Kuzmicki A, et al. Monoclonal B lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Blood. 2002;100:635-639.
13. Rawstron AC, Yuille MR, Fuller J, et al. Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion. Blood. 2002;100:2289-2290.
14. Capalbo S, Trerotoli P, Ciancio A, Battista C, Serio G, Liso V. Increased risk of lymphoproliferative disorders in relatives of patients with B-cell chronic lymphocytic leukemia: relevance of the degree of familial linkage. Eur J Haematol. 2000;65:114-117.
15. Ramasamy I, Brisco M, Morley A. Improved PCR method for detecting monoclonal immunoglobulin heavy chain rearrangement in B cell neoplasms. J Clin Pathol. 1992;45:770-775.
16. Gribben JG, Neuberg D, Freedman AS, et al. Detection by polymerase chain reaction of residual cells with the bcl-2 translocation is associated with increased risk of relapse after autologous bone marrow transplantation for B-cell lymphoma. Blood. 1993;81:3449-3457.
17. Lazzarino M, Arcaini L, Bernasconi P, et al. A sequence of immuno-chemotherapy with Rituximab, mobilization of in vivo purged stem cells, high-dose chemotherapy and autotransplant is an effective and non-toxic treatment for advanced follicular and mantle cell lymphoma. Br J Haematol. 2002;116:229-235.
18. Provan D, Bartlett-Pandite L, Zwicky C, et al. Eradication of polymerase chain reaction-detectable chronic lymphocytic leukemia cells is associated with improved outcome after bone marrow transplantation. Blood. 1996;88:2228-2235.
19. Rawstron AC, Kennedy B, Evans PA, et al. Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy. Blood. 2001;98:29-35.
20. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J. Lymphoma classification-from controversy to consensus: the R.E.A.L. and WHO classification of lymphoid neoplasms. Ann Oncol. 2000;11(suppl 1):3-10.
21. Sprent J. Lifespans of naive, memory and effector lymphocytes. Curr Opin Immunol. 1993;5:433-438.
22. Klein U, Tu Y, Stolovitzky GA, et al. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med. 2001;194:1625-1638.
23. Damle RN, Ghiotto F, Valetto A, et al. B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood. 2002;99:4087-4093.
24. Maes B, De Wolf-Peeters C. Marginal zone cell lymphoma - an update on recent advances. Histopathology. 2002;40:117-126.
25. Kuppers R, Hajadi M, Plank L, Rajewsky K, Hansmann ML. Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human. Eur J Immunol. 1996;26:1794-1800.
26. Dolken G, Illerhaus G, Hirt C, Mertelsmann R. BCL-2/JH rearrangements in circulating B cells of healthy blood donors and patients with nonmalignant diseases. J Clin Oncol. 1996;14:1333-1344.
27. Ji W, Qu GZ, Ye P, Zhang XY, Halabi S, Ehrlich M. Frequent detection of bcl-2/JH translocations in human blood and organ samples by a quantitative polymerase chain reaction assay. Cancer Res. 1995;55:2876-2882.
28. Bose S, Deininger M, Gora-Tybor J, Goldman JM, Melo JV. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease. Blood. 1998;92:3362-3367.
29. Kyle RA, Therneau TM, Rajkumar SV, et al. A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N Engl J Med. 2002;348:584-589.
30. Stacchini A, Aragno M, Vallario A, et al. MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation. Leuk Res. 1999;23:127-136.