IgV gene intraclonal diversification and clonal evolution in B-cell chronic lymphocytic leukaemia

British Journal of Haematology

Volumn 133, Issue 1, 2006, Pages 50-58

  Bagnara, Davide ^a   Callea, Vincenzo ^b   Stelitano, Caterina ^b   Morabito, Fortunato ^c   Fabris, Sonia ^d   Neri, Antonino ^d   Zanardi, Sabrina ^a   Ghiotto, Fabio ^a   Ciccone, Ermanno ^a   Grossi, Carlo Enrico ^a   Fais, Franco ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b BIANCHI MELACRINO MORELLI HOSPITAL   (Italy)

^c Azienda Ospedaliera di Cosenza   (Italy)

^d FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

Antigen stimulation; B cell chronic lymphocytic leukaemia; Clonal evolution; Immunoglobulin variable region; Somatic hypermutation

Indexed keywords

AMINO ACID; ANTIGEN; NUCLEOTIDE;

AGED; AMINO ACID SUBSTITUTION; ANALYTIC METHOD; ARTICLE; B CELL LEUKEMIA; CASE REPORT; CLONE; COMPARATIVE STUDY; DISEASE COURSE; GENE; GENE AMPLIFICATION; GENE REARRANGEMENT; GENE SEQUENCE; GENEALOGY; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HEAVY CHAIN; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOSTIMULATION; LEUKEMIA CELL; LIGHT CHAIN; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SOMATIC HYPERMUTATION; SOMATIC MUTATION; TUMOR CELL;

AGED; CLONE CELLS; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; EVOLUTION, MOLECULAR; GENE REARRANGEMENT; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMIA, B-CELL, CHRONIC; LYMPHOCYTE ACTIVATION; MALE; RECEPTORS, ANTIGEN, B-CELL; SEQUENCE ALIGNMENT; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; VARIATION (GENETICS);

EID: 33644650266     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2005.05974.x     Document Type: Article

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