메뉴 건너뛰기




Volumn 109, Issue 4, 2007, Pages 1559-1567

Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: Evidence for antigen-driven intraclonal diversification

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IMMUNOGLOBULIN RECEPTOR;

EID: 33846916636     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-05-020644     Document Type: Article
Times cited : (30)

References (48)
  • 1
    • 0035822263 scopus 로고    scopus 로고
    • How immunology is reshaping clinical disciplines: The example of haematology
    • Caligaris-Cappio F. How immunology is reshaping clinical disciplines: the example of haematology. Lancet. 2001;358:49-55.
    • (2001) Lancet , vol.358 , pp. 49-55
    • Caligaris-Cappio, F.1
  • 4
    • 0033567968 scopus 로고    scopus 로고
    • Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    • Damle RN, Wasil T, Fais F, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999;94:1840-1847.
    • (1999) Blood , vol.94 , pp. 1840-1847
    • Damle, R.N.1    Wasil, T.2    Fais, F.3
  • 5
    • 0032532668 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
    • Fais F, Ghiotto F, Hashimoto S, et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest. 1998;102:1515-1525.
    • (1998) J Clin Invest , vol.102 , pp. 1515-1525
    • Fais, F.1    Ghiotto, F.2    Hashimoto, S.3
  • 6
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94:1848-1854.
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 7
    • 0028355650 scopus 로고
    • The pathogenesis of chronic lymphocytic leukemia: Analysis of the antibody repertoire
    • Schroeder HW Jr, Dighiero G. The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire. Immunol Today. 1994;15:288-294.
    • (1994) Immunol Today , vol.15 , pp. 288-294
    • Schroeder Jr, H.W.1    Dighiero, G.2
  • 8
    • 0035803464 scopus 로고    scopus 로고
    • Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells
    • Klein U, Tu Y, Stolovitzky GA, et al. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med. 2001;194:1625-1638.
    • (2001) J Exp Med , vol.194 , pp. 1625-1638
    • Klein, U.1    Tu, Y.2    Stolovitzky, G.A.3
  • 9
    • 0035803371 scopus 로고    scopus 로고
    • Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia
    • Rosenwald A, Alizadeh AA, Widhopf G, et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med. 2001;194:1639-1647.
    • (2001) J Exp Med , vol.194 , pp. 1639-1647
    • Rosenwald, A.1    Alizadeh, A.A.2    Widhopf, G.3
  • 10
    • 0036624881 scopus 로고    scopus 로고
    • B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes
    • Damle RN, Ghiotto F, Valetto A, et al. B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood. 2002;99:4087-4093.
    • (2002) Blood , vol.99 , pp. 4087-4093
    • Damle, R.N.1    Ghiotto, F.2    Valetto, A.3
  • 11
    • 0031985902 scopus 로고    scopus 로고
    • Lack of intraclonal diversification in Ig heavy and light chain V region genes expressed by CD5+IgM+ chronic lymphocytic leukemia B cells: A multiple time point analysis
    • Schettino EW, Cerutti A, Chiorazzi N, Casali P. Lack of intraclonal diversification in Ig heavy and light chain V region genes expressed by CD5+IgM+ chronic lymphocytic leukemia B cells: a multiple time point analysis. J Immunol. 1998;160:820-830.
    • (1998) J Immunol , vol.160 , pp. 820-830
    • Schettino, E.W.1    Cerutti, A.2    Chiorazzi, N.3    Casali, P.4
  • 12
  • 13
    • 0034651628 scopus 로고    scopus 로고
    • Analysis of expressed immunoglobulin heavy chain genes in familial B-CLL
    • Sakai A, Marti GE, Caproaso N, et al. Analysis of expressed immunoglobulin heavy chain genes in familial B-CLL. Blood. 2000;95:1413-1419.
    • (2000) Blood , vol.95 , pp. 1413-1419
    • Sakai, A.1    Marti, G.E.2    Caproaso, N.3
  • 14
    • 13344278693 scopus 로고    scopus 로고
    • Evidence for progenitors of chronic lymphocytic leukemia B cells that undergo intraclonal differentiation and diversification
    • Dono M, Hashimoto S, Fais F, et al. Evidence for progenitors of chronic lymphocytic leukemia B cells that undergo intraclonal differentiation and diversification. Blood. 1996;87:1586-1594.
    • (1996) Blood , vol.87 , pp. 1586-1594
    • Dono, M.1    Hashimoto, S.2    Fais, F.3
  • 15
    • 0028341211 scopus 로고
    • Molecular analysis of rearranged VH genes during B cell chronic lymphocytic leukemia: Intraclonal stability is frequent but not constant
    • Korganow AS, Martin T, Weber JC, et al. Molecular analysis of rearranged VH genes during B cell chronic lymphocytic leukemia: intraclonal stability is frequent but not constant. Leuk Lymphoma. 1994;14:55-69.
    • (1994) Leuk Lymphoma , vol.14 , pp. 55-69
    • Korganow, A.S.1    Martin, T.2    Weber, J.C.3
  • 16
    • 0025193558 scopus 로고
    • Intraclonal diversity in the VH genes expressed by CD5-chronic lymphocytic leukemia-producing pathologic IgM rheumatoid factor
    • Roudier J, Silverman GJ, Chen PP, Carson DA, Kipps TJ. Intraclonal diversity in the VH genes expressed by CD5-chronic lymphocytic leukemia-producing pathologic IgM rheumatoid factor. J Immunol. 1990;144:1526-1530.
    • (1990) J Immunol , vol.144 , pp. 1526-1530
    • Roudier, J.1    Silverman, G.J.2    Chen, P.P.3    Carson, D.A.4    Kipps, T.J.5
  • 17
    • 0029742040 scopus 로고    scopus 로고
    • Evidence for immunoglobulin heavy chain variable region gene replacement in a patient with B cell chronic lymphocytic leukemia
    • Stamatopoulos K, Kosmas C, Stavroyianni N, Loukopoulos D. Evidence for immunoglobulin heavy chain variable region gene replacement in a patient with B cell chronic lymphocytic leukemia. Leukemia. 1996;10:1551-1556.
    • (1996) Leukemia , vol.10 , pp. 1551-1556
    • Stamatopoulos, K.1    Kosmas, C.2    Stavroyianni, N.3    Loukopoulos, D.4
  • 18
    • 0036884414 scopus 로고    scopus 로고
    • Ongoing in vivo class switch DNA recombination in chronic lymphocytic leukemia B cells
    • Cerutti A, Zan H, Shah S, Schattner E, Schaffer A, Casali P. Ongoing in vivo class switch DNA recombination in chronic lymphocytic leukemia B cells. J Immunol. 2002;169:6594-603.
    • (2002) J Immunol , vol.169 , pp. 6594-6603
    • Cerutti, A.1    Zan, H.2    Shah, S.3    Schattner, E.4    Schaffer, A.5    Casali, P.6
  • 19
    • 33644650266 scopus 로고    scopus 로고
    • IgV gene intraclonal diversification and clonal evolution in B-cell chronic lymphocytic leukemia
    • Bagnara D, Callea V, Stelitano C, et al. IgV gene intraclonal diversification and clonal evolution in B-cell chronic lymphocytic leukemia. Br J Haematol. 2006;133:50-58.
    • (2006) Br J Haematol , vol.133 , pp. 50-58
    • Bagnara, D.1    Callea, V.2    Stelitano, C.3
  • 20
    • 0029981025 scopus 로고    scopus 로고
    • National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment
    • Cheson BD, Bennett JM, Grever M, et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood. 1996;87:4990-4997.
    • (1996) Blood , vol.87 , pp. 4990-4997
    • Cheson, B.D.1    Bennett, J.M.2    Grever, M.3
  • 21
    • 0014385564 scopus 로고
    • Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g
    • Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl. 1968;97:77-89.
    • (1968) Scand J Clin Lab Invest Suppl , vol.97 , pp. 77-89
    • Boyum, A.1
  • 22
    • 0029063311 scopus 로고
    • Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction
    • Brezinschek HP, Brezinschek RI, Lipsky PE. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J Immunol. 1995;155:190-202.
    • (1995) J Immunol , vol.155 , pp. 190-202
    • Brezinschek, H.P.1    Brezinschek, R.I.2    Lipsky, P.E.3
  • 23
    • 0026567277 scopus 로고
    • Use of family specific leader region primers for PCR amplification of the human heavy chain variable region gene repertoire
    • Campbell MJ, Zelenetz AD, Levy S, Levy R. Use of family specific leader region primers for PCR amplification of the human heavy chain variable region gene repertoire. Mol Immunol. 1992;29:193-203.
    • (1992) Mol Immunol , vol.29 , pp. 193-203
    • Campbell, M.J.1    Zelenetz, A.D.2    Levy, S.3    Levy, R.4
  • 24
    • 0030985603 scopus 로고    scopus 로고
    • Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells
    • Foster SJ, Brezinschek H-P, Brezinschek RI, Lipsky PE. Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells. J Clin Invest. 1997;99:1614-1627.
    • (1997) J Clin Invest , vol.99 , pp. 1614-1627
    • Foster, S.J.1    Brezinschek, H.-P.2    Brezinschek, R.I.3    Lipsky, P.E.4
  • 25
    • 33846910943 scopus 로고    scopus 로고
    • Tomlinson IM, Williams SJ, Corbett SJ, Cox JBL, Winter G. V BASE sequence directory. 2002. Cambridge, United Kingdom: MRC Centre for Protein Engineering; 1996.
    • Tomlinson IM, Williams SJ, Corbett SJ, Cox JBL, Winter G. V BASE sequence directory. Vol 2002. Cambridge, United Kingdom: MRC Centre for Protein Engineering; 1996.
  • 26
    • 33846923441 scopus 로고    scopus 로고
    • MRC Centre for Protein Engineering, Accessed April 28
    • MRC Centre for Protein Engineering. V Base: database of human antibody genes. http://vbase.mrc-cpe.cam.ac.uk. Accessed April 28, 2006.
    • (2006) V Base: Database of human antibody genes
  • 27
    • 33846917021 scopus 로고    scopus 로고
    • National Center for Biotechnology Information, Accessed April 28
    • National Center for Biotechnology Information. IgBLAST: immunoglobulin basic local alignment search tool. http://www.ncbi.nlm.nih.gov/igblast. Accessed April 28, 2006.
    • (2006) IgBLAST: Immunoglobulin basic local alignment search tool
  • 28
  • 29
    • 0008476550 scopus 로고
    • Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin
    • McKean D, Huppi K, Bell M, Staudt L, Gerhard W, Weigert M. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc Natl Acad Sci U S A. 1984;81:3180-3184.
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 3180-3184
    • McKean, D.1    Huppi, K.2    Bell, M.3    Staudt, L.4    Gerhard, W.5    Weigert, M.6
  • 30
    • 0022018911 scopus 로고
    • Somatic mutation and clonal expansion of B cells in an antigen-driven immune response
    • Sablitzky F, Wildner G, Rajewsky K. Somatic mutation and clonal expansion of B cells in an antigen-driven immune response. EMBO J. 1985;4:345-350.
    • (1985) EMBO J , vol.4 , pp. 345-350
    • Sablitzky, F.1    Wildner, G.2    Rajewsky, K.3
  • 31
    • 0142149019 scopus 로고    scopus 로고
    • Estimating hypermutation rates from clonal tree data
    • Kleinstein SH, Louzoun Y, Shlomchik MJ. Estimating hypermutation rates from clonal tree data. J Immunol. 2003;171:4639-4649.
    • (2003) J Immunol , vol.171 , pp. 4639-4649
    • Kleinstein, S.H.1    Louzoun, Y.2    Shlomchik, M.J.3
  • 32
    • 0000634555 scopus 로고
    • Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia
    • Kipps TJ, Tomhave E, Pratt LF, Duffy S, Chen PP, Carson DA. Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 1989;86:5913-5917.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 5913-5917
    • Kipps, T.J.1    Tomhave, E.2    Pratt, L.F.3    Duffy, S.4    Chen, P.P.5    Carson, D.A.6
  • 33
    • 0024590614 scopus 로고
    • Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia
    • Sthoeger ZM, Wakai M, Tse DB, et al. Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia. J Exp Med. 1989;169:255-268.
    • (1989) J Exp Med , vol.169 , pp. 255-268
    • Sthoeger, Z.M.1    Wakai, M.2    Tse, D.B.3
  • 34
    • 0025035702 scopus 로고
    • Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies
    • Borche L, Lim A, Binet JL, Dighiero G. Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies. Blood. 1990;76:562-569.
    • (1990) Blood , vol.76 , pp. 562-569
    • Borche, L.1    Lim, A.2    Binet, J.L.3    Dighiero, G.4
  • 35
    • 0030639650 scopus 로고    scopus 로고
    • Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features
    • Johnson TA, Rassenti LZ, Kipps TJ. Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features. J Immunol. 1997;158:235-246.
    • (1997) J Immunol , vol.158 , pp. 235-246
    • Johnson, T.A.1    Rassenti, L.Z.2    Kipps, T.J.3
  • 36
    • 0037085801 scopus 로고    scopus 로고
    • Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia
    • Tobin G, Thunberg U, Johnson A, et al. Somatically mutated Ig V(H)3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood. 2002;99:2262-2264.
    • (2002) Blood , vol.99 , pp. 2262-2264
    • Tobin, G.1    Thunberg, U.2    Johnson, A.3
  • 37
    • 4344704897 scopus 로고    scopus 로고
    • Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia
    • Messmer BT, Albesiano E, Efremov DG, et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med. 2004;200:519-525.
    • (2004) J Exp Med , vol.200 , pp. 519-525
    • Messmer, B.T.1    Albesiano, E.2    Efremov, D.G.3
  • 38
    • 11144356992 scopus 로고    scopus 로고
    • Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia
    • Ghiotto F, Fais F, Valetto A, et al. Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia. J Clin Invest. 2004;113:1008-1016.
    • (2004) J Clin Invest , vol.113 , pp. 1008-1016
    • Ghiotto, F.1    Fais, F.2    Valetto, A.3
  • 39
    • 20444454585 scopus 로고    scopus 로고
    • Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity
    • Herve M, Xu K, Ng YS, et al. Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. J Clin Invest. 2005;115:1636-1643.
    • (2005) J Clin Invest , vol.115 , pp. 1636-1643
    • Herve, M.1    Xu, K.2    Ng, Y.S.3
  • 41
    • 33745826284 scopus 로고    scopus 로고
    • Is chronic lymphocytic leukemia a response to infectious agents?
    • Hamblin T. Is chronic lymphocytic leukemia a response to infectious agents? Leuk Res. 2006;30:1063-1064.
    • (2006) Leuk Res , vol.30 , pp. 1063-1064
    • Hamblin, T.1
  • 42
    • 33745824962 scopus 로고    scopus 로고
    • Immunophenotypic characterization of IgVH3-72 B-cell chronic lymphocytic leukaemia (B-CLL)
    • Capello D, Zucchetto A, Degan M, et al. Immunophenotypic characterization of IgVH3-72 B-cell chronic lymphocytic leukaemia (B-CLL). Leuk Res. 2006;30:1197-1199.
    • (2006) Leuk Res , vol.30 , pp. 1197-1199
    • Capello, D.1    Zucchetto, A.2    Degan, M.3
  • 43
    • 12344338189 scopus 로고    scopus 로고
    • Second malignancies and Richter's syndrome in patients with chronic lymphocytic leukemia
    • Robak T. Second malignancies and Richter's syndrome in patients with chronic lymphocytic leukemia. Hematology. 2004;9:387-400.
    • (2004) Hematology , vol.9 , pp. 387-400
    • Robak, T.1
  • 44
    • 0016858575 scopus 로고
    • Subsequent neoplasia in chronic lymphocytic leukemia
    • Manusow D, Weinerman BH. Subsequent neoplasia in chronic lymphocytic leukemia. JAMA. 1975;232:267-269.
    • (1975) JAMA , vol.232 , pp. 267-269
    • Manusow, D.1    Weinerman, B.H.2
  • 46
    • 1042280347 scopus 로고    scopus 로고
    • Veterans with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) have a markedly increased rate of second malignancy, which is the most common cause of death
    • Kyasa MJ, Hazlett L, Parrish RS, Schichman SA, Zent CS. Veterans with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) have a markedly increased rate of second malignancy, which is the most common cause of death. Leuk Lymphoma. 2004;45:507-513.
    • (2004) Leuk Lymphoma , vol.45 , pp. 507-513
    • Kyasa, M.J.1    Hazlett, L.2    Parrish, R.S.3    Schichman, S.A.4    Zent, C.S.5
  • 47
    • 3543066288 scopus 로고    scopus 로고
    • MALT lymphoma: From morphology to molecules
    • Isaacson PG, Du MQ. MALT lymphoma: from morphology to molecules. Nat Rev Cancer. 2004;4:644-653.
    • (2004) Nat Rev Cancer , vol.4 , pp. 644-653
    • Isaacson, P.G.1    MQ, D.2
  • 48
    • 3042829782 scopus 로고    scopus 로고
    • Analysis of IgVH gene mutations in B cell chronic lymphocytic leukaemia according to antigen-driven selection identifies subgroups with different prognosis and usage of the canonical somatic hypermutation machinery
    • Degan M, Bomben R, Dal Bo M, et al. Analysis of IgVH gene mutations in B cell chronic lymphocytic leukaemia according to antigen-driven selection identifies subgroups with different prognosis and usage of the canonical somatic hypermutation machinery. Br J Haematol. 2004;126:29-42.
    • (2004) Br J Haematol , vol.126 , pp. 29-42
    • Degan, M.1    Bomben, R.2    Dal, B.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.