B-Cell Monoclonal Lymphocytosis and B-Cell Abnormalities in the Setting of familial B-Cell Chronic Lymphocytic Leukemia

Cytometry Part B - Clinical Cytometry

Volumn 52, Issue 1, 2003, Pages 1-12

  Marti, Gerald E ^a,g   Carter, Patricia ^a   Abbasi, Fatima ^a   Washington, Glennelle C ^a   Jain, Nisha ^a   Zenger, Vincent E ^a   Ishibe, Naoko ^b   Goldin, Lynn ^b   Fontaine, Laura ^b   Weissman, Nancy ^b   Sgambati, Maria ^b   Fauget, Guy ^c   Bertin, Pablo ^d   Vogt Jr , Robert F ^e   Slade, Barbara ^f   Noguchi, Philip D ^a   Stetler Stevenson, M A ^g   Caporaso, Neil ^b  

^a Center for Biologics Evaluation and Research   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^e CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^f AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY   (United States)

^g NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Absolute lymphocyte count; B cell monoclonal lymphocytosis; CD20; CD5; Cell cycle analysis; Familial B cell chronic leukemia; Flow cytometry; Immunophenotyping;

Indexed keywords

CD19 ANTIGEN; CD20 ANTIBODY; CD23 ANTIGEN; CD5 ANTIGEN; DNA;

ARTICLE; B CELL LEUKEMIA; B CELL MONOCLONAL LYMPHOCYTOSIS; B LYMPHOCYTE; CANCER REGISTRY; CELL CYCLE; CHRONIC LYMPHATIC LEUKEMIA; CLONAL VARIATION; CLONE; DISEASE COURSE; EARLY DIAGNOSIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; LYMPHOCYTOSIS; PATHOGENESIS; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; RELATIVE; CELL CLONE; FEMALE; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; INCIDENCE; MALE; PATHOLOGY; PEDIGREE; RISK FACTOR;

B-LYMPHOCYTES; CELL CYCLE; CLONE CELLS; FEMALE; FLOW CYTOMETRY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOPHENOTYPING; INCIDENCE; LEUKEMIA, LYMPHOCYTIC, CHRONIC; LYMPHOCYTOSIS; MALE; PEDIGREE; POLYMERASE CHAIN REACTION; RISK FACTORS;

EID: 10744230599     PISSN: 15524949     EISSN: None     Source Type: Journal    
DOI: 10.1002/cyto.b.10013     Document Type: Article

References (59)

1. Weiss NS. Geographical variation in the incidence of the leukemia and lymphomas. Natl Cancer Inst Monogr 1979;53:139-142.
2. Linet MS, Cartwright RA. Chronic lymphocytic leukemia: epidemiology and etiologic findings. Nouv Rev Fr Hematol 1988;30:353-357.
3. Capalbo S, Trerotoli P, Ciancio A, Battista C, Serio G, Liso V. Increased risk of lymphoproliferative disorders in relatives of patients with B-cell chronic lymphocytic leukemia: relevance of the degree of familial linkage. Eur J Haematol 2000;65:114-117.
4. Goldin LR, Sgambati M, Marti GE, Fontaine L, Ishibe N, Caporaso N. Anticipation in familial chronic lymphocytic leukemia. Am J Hum Genet 1999;65:265-269.
5. Gunz FW, Dameshek W. Chronic lymphocytic leukemia in a family, including twin brothers and a son. JAMA 1957;164:1323-1325.
6. Gunz FW, Gunz JP, Veale AM, Chapman CJ, Houston IB. Familial leukaemia: a study of 909 families. Scand J Haematol 1975;15:117-131.
7. Horwitz M, Goode EL, Jarvik GP. Anticipation in familial leukemia. Am J Hum Genet 1996;59:990-998.
8. Yuille MR, Houlston RS, Catovsky D. Anticipation in familial chronic lymphocytic leukaernia. Leukemia 1998;12:1696-1698.
9. Yuille MR, Matutes E, Marossy A, Hilditch B, Catovsky D, Houlston RS. Familial chronic lymphocytic leukaemia: a survey and review of published studies. Br J Haematol 2000;109:794-799.
10. Ardashnikov SN. Genetics of leukemia in man. J Hyg 1937;37:286-289.
11. Conley CL, Misiti J, Laster AJ. Genetic factors predisposing to chronic lymphocytic leukemia and to autoimmune disease. Medicine 1980;59:323-334.
12. Goldgar DE, Easton DF, Cannon-Albright LA, Skolnick MH. Systematic population based assessment of cancer risk in first-degree relatives of cancer probands. J Natl Cancer Inst 1994;86:1600-1608.
13. Ishibe N, Sgambati MT, Fontaine L, Goldin LR, Jain N, Weissman N, Marti G, Caporaso NE. Clinical characteristics of familial B-CLL in the National Cancer Institute Familial Registry. Leuk Lymphoma 2001;42:99-108.
14. Linet MS, Van Natta ML, Brookmeyer R, Khoury MJ, McCaffrey LD, Humphrey RL, Szklo M. Familial cancer history and chronic lymphocytic leukemia: a case-control study. Am J Epidemiol 1989;130:655-664.
15. Wiernik PH, Ashwin M, Hu XP, Paietta E, Brown K. Anticipation in familial chronic lymphocytic leukaemia. Br J Haematol 2001;113:407-414.
16. Dohner H, Stilgenbauer S, Benne A, Leupol E, Kröbe A, Bullinge L, Döhne K, Bent M, Lichter P. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2001;343:1910-1911.
17. Kyle RA, Rajkumar SV. Monoclonal gammaopathies of undetermined significance. Hematol Oncol Clin North Am 1999;13:1181-1202.
18. Kyle RA, Therneau TM, Rajkumar SV, Offord JR, Larson DR, Plevak MF, Melton LJ III. A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N Engl J Med 2002;346:564-569.
19. Jack A, Richards S, Evans P, Wilks C. Population screening for B-cell monoclonal lymphocytosis using PCR and flow cytometry to determine immunophenotypes. In: Marti GE, Vogt RF, Zenger VE, editors. Proceedings of a USPHS workshop on laboratory approaches to determining the role of environmental exposures as risk factors for B-cell chronic lymphocytic leukemia and other B-cell lymphoproliferative disorders. Atlanta, GA; 1997. p 93-96.
20. Maiese RL, Braylan RC. Detection of low levels of B-cell lymphoproliferative disorders. In: Marti GE, Vogt RF, Zenger VE, editors. Proceedings of a USPHS workshop on laboratory approaches to determining the role of environmental exposures as risk factors for B-cell chronic lymphocytic leukemia and other B-cell lymphoproliferative disorders. Atlanta, GA; 1997. p 61-68.
21. Marti GE, Muller J, Stetler-Stevenson M, Caporaso N. B-cell monoclonal lymphocytosis in three individuals living near a hazardous waste site. In: Marti GE, Vogt RF, Zenger VE, editors. Proceedings of a USPHS workshop on laboratory approaches to determining the role of environmental exposures as risk factors for B-cell chronic lymphocytic leukemia and other B-cell lymphoproliferative disorders. Atlanta, GA; 1997. p 37-50.
22. Sarasua SM, Vogt RF, Middleton DC, et al. 'CLL-like' B-cell phenotypes detected in superfund studies: epidemiologic methods and findings. In: Marti GE, Vogt RF, Zenger VE, editors. Proceedings of a USPHS workshop on laboratory approaches to determining the role of environmental exposures as risk factors for B-cell chronic lymphocytic leukemia and other B-cell lymphoproliferative disorders. Atlanta, GA; 1997. p 7-18.
23. Vogt RF, Meredith MNK, Powell J, et al. Results in eleven individuals with B-CLL-like phenotypes detected in environmental health studies. In: Marti GE, Vogt RF, Zenger VE, editors. Proceedings of a USPHS workshop on laboratory approaches to determining the role of environmental exposures as risk factors for B-cell chronic lymphocytic leukemia and other B-cell lymphoproliferative disorders. Atlanta, GA; 1997. p 19-35.
24. Cartwright RA. Summary of epidemiology and immunobiology. In: Marti GE, Vogt RF, Zenger VE, editors. Proceedings of a USPHS workshop on laboratory approaches to determining the role of environmental exposures as risk factors for B-cell chronic lymphocytic leukemia and other B-cell lymphoproliferative disorders. Atlanta, GA; 1997. p 215-222.
25. Slade BA. Follow-up investigation of B-cell abnormalities identified in previous ATSDR health studies. Publication PB99-138331. Bethesda: US Department of Health and Human Services, Public Health Service; 1999.
26. Caporaso N, Fontaine L, Whitehouse J, Marti GE. Familial BCLL: review of literature and the NCI Familial BCLL Registry. In: Marti GE, Vogt RF, Zenger VE, editors. Proceedings of a USPHS workshop on laboratory approaches to determining the role of environmental exposures as risk factors for B-cell chronic lymphocytic leukemia and other B-cell lymphoproliferative disorders. Atlanta, GA; 1997. p.173-180.
27. Caporaso NE, Whitehouse J, Bertin P, Amos C, Papadopoulos N, Muller J, Whang-Peng J, Tucker MA, Fleisher TA, Marti GE. A 20 year clinical and laboratory study of familial B-chronic lymphocytic leukemia in a single kindred. Leuk Lymphoma 1991;3:331-342.
28. Cheson BD, Bennett JM, Grever M, et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996;87:4990-4997.
29. Zwiebel JA, Cheson BD. Chronic lymphocytic leukemia: staging and prognostic factors. Semin Oncol 1998;25:42-59.
30. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick H, Sultan C. Proposals for the classification of chronic (mature) B and T lymphoid leukemias. J Clin Pathol 1989;42:567-584.
31. Carter PH, Resto-Ruiz S, Washington GC, Ethridge S, Palini A, Vogt R, Waxdal M, Fleisher T, Noguchi P, Marti GE. Whole blood lysis: a flow cytometric analysis of three anticoagulants and five cell preparations. Cytometry 1992;13:68-74.
32. Duque RE, Andreeff M, Braylan RC, Diamond LW, Peiper SC. Consensus review of the clinical utility of DNA flow cytometry in neoplastic hematopathology. Cytometry 1993;14:492-496.
33. Fleisher TA, Marti GE. Detection of unseparated human lymphocytes by flow cytometry. In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W, editors. Current protocols in immunology. Volume 1. New York: John Wiley & Sons; 1991. p 7.9.1-7.9.7.
34. Kamihira, S, Matutes E, Marco JG, Hoda S, Morilla R, Owusu-Ankomah K, Crawford A, Ellis J, Catovsky D. Flow cytometry detection of minimal DNA aneuploidy in mature lymphoid leukemias: Comparison with metaphase and interphase cytogenetics. Int J Oncol 1994;5:211-214.
35. Zenger VE, Vogt R, Mandy F, Schwartz A, Marti GE. Quantitative Flow Cytometry: Inter-Laboratory Variation. Cytometry 1998;33:138-145.
36. Nicholson JKA, Rao PE, Calvelli T, Stetler-Stevenson M, Browning SW, Marti G. Artifactual staining of monoclonal antibodies in two-color combinations is due to an immunoglobulin in the serum and plasma. Cytometry 1994;18:140-146.
37. Shankey TV, Rabinovitch PS, Bagwell B, Bower KD, Duque RE, Hedley DW, Myall BH, Wheeless L, Cox C. Guidelines for implementation of clinical DNA cytometry, International Society for Analytical Cytology. Cytometry 1993;14:472-477.
38. Vindelov LL. Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. A new method for rapid isolation and straining of nuclei. Virchows Arch B Cell Pathol 1977;24:227-242.
39. McCarthy KP, Sloan JP, Wiedemann LM. Rapid method for distinguishing clonal from polyclonal B-cell populations in surgical biopsy specimens. J Clin Pathol 1990;43:429-432.
40. Griesser H. Applied molecular genetics in the diagnosis of malignant non-Hodgkins lymphoma. Diagn Mol Pathol 1993;2:177-191.
41. Melo JV, Brito-Babapulle V, Foroni L, Robinson DS, Luzzatto L, Catovsky D. Two new cell lines from B-prolymphocytic leukaemia: characterization by morphology, immunological markers, karyotype and Ig gene rearrangement. Int J Cancer 1986;38:531-538.
42. Marti GE. Mechanisms of a B cell neoplasia. In: Potter M, Melchers F, editors. Mechanisms of B cell neoplasia. Basel, Switzerland: Editiones Roche; 1993. p 129-136.
43. Marti GE, Faguet G, Bertin P, Agee J, Washington G, Ruiz S, Carter P, Zenger V, Vogt R, Noguchi P. CD20 and CD5 expression in B chronic lymphocytic leukemia (B-CLL). Proc N Y Acad Sci 1992;651:480-483.
44. Marti GE, Faguet GB, Stewart C, Branham P, Carter PH, Washington GC, Bertin P, Muller J, Zenger V, Caporosa N, Whitehouse J, Amos CI, Fleisher TA, Vogt R. Evolution of leukemic heterogeneity of human B-CLL lymphocytes between and within patients. Curr Topics Microbiol Immunol 1992;182:303-311.
45. Rachel JM, Zucker ML, Plapp FV, Fox CM, Marti GE, Abassi F, Menitove JE. B cell monoclonal lymphocytosis in blood donors (abstract). Blood 2002;100:590a.
46. Rawstron AC, Green MJ, Kuzmicki A, Kennedy B, Fenton JAL, Evans PAS, O'Connor SJM, Richards SJ, Morgan GJ, Jack AS, Hillmen P. Monoclonal B lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Blood 2002;100:635-639.
47. Rawstron AC, Yuille MR, Fuller J, Cullen M, Kennedy B, Richards SJ, Jack AS, Matutes E, Catovsky D, Hillmen P, Houlston RS. Inherited predisposition to CLL is detectable as sub-clinical monoclonal B-lymphocyte expansion. Blood. 2002;100:2289-2291.
48. Faguet GB, Agee JF, Marti GE. Clone emergence and evolution in chronic lymphocytic leukemia: characterization of clinical, laboratory, and immunophenotypic profiles of 25 patients. Leuk Lymphoma 1992;6:345-356.
49. Bassan R, Buzzetti M, Marini B, Rambaldi A, Allavena P, Barbui T. Investigation of chronic lymphocytosis in adults. Am J Clin Pathol 1988;89:783-787.
50. Han T, Ozer H, Gavigan M, Gajera R, Minowada J, Bloom ML, Sadamori N, Sandberg AA, Gomez GA, Henderson ES. Benign monoclonal B cell lymphocytosis-a benign variant of CLL: clinical, immunologic, phenotypic, and cytogenetic studies in 20 patients. Blood 1984;64:244-252.
51. Mandelli F, De Rossi G, Mancini P, Alberti A, Cajozzo A, Grignani F, Leoni P, Liso V, Martelli M, Neri A. Progression in chronic lymphocytic leukemia: a retrospective multicentric study from the GIMEMA group. J Clin Oncol 1987;5:398-404.
52. Wang C, Amato D, Fernandes B. CD5-negative phenotype of monoclonal B-lymphocytosis of undetermined significance (MLUS). Am J Hematol 2002;69:147-149.
53. Yakhnina EI, Nikitin EA, Astsaturov IA, Varlamova EY, Kobzev YN, Kovaleva LG, Kremenetskaya AM, Melikyan AL, Pivnik AV, Samoilova RS, Vorobyev AI. A benign form of chronic lymphoid leukemia. Ter Arkh 1997;69:11-17.
54. Byrd J. Clonal lymphocytosis of uncertain significance (CLUS): what clues will CLUS yield? Blood 2002;100:2277.
55. Levine PH, Hoover RN. The emerging epidemic of non-Hodgkin's lymphoma: current knowledge regarding etiologic factors. Cancer Res 1992;52:5425S-5574S.
56. Rosenwald A, Alizadeh AA, Widhopf G, Simon R, Davis RE, Yu X, Yang L, Pickeral OK, Rassenti LZ, Powell J, Botstein D, Byrd JC, Grever MR, Cheson BD, Chiorazzi N, Wilson WH, Kipps TJ, Brown PO, Staudt LM. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. J Exp Med 2001;194:1639-1647.
57. Stratowa C, Loffler G, Lichter P, Stilgenbauer S, Haberl P, Schweifer N, Döhner H, Wilgenbus KK. CDNA microarray gene expression analysis of B-cell chronic lymphocytic leukemia proposes potential new prognostic markers involved in lymphocyte trafficking. Int J Cancer 2001;91:474-480.
58. Voss T, Ahorn H, Haberl P, Dohner H, Wilgenbus K. Correlation of clinical data with proteomics profiles in 24 patients with B-cell chronic lymphocytic leukemia. Int J Cancer 2001;91:180-186.
59. Fukushima PI, Nguyen PK, O'Grady P, Stetler-Stevenson M. Flow cytometric analysis of kappa and lambda light chain expression. Cytometry 1996;26:243-252.