메뉴 건너뛰기




Volumn 20, Issue 4, 2010, Pages 159-166

The effects of cytochrome P450 induction by xenobiotics on endobiotic metabolism in pre-clinical safety studies

Author keywords

Cardiovascular effects; Fatty acid metabolism; Steroid metabolism; Vitamin metabolism; Xenoreceptors

Indexed keywords

CYTOCHROME P450; XENOBIOTIC AGENT;

EID: 77955293411     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376511003690307     Document Type: Review
Times cited : (42)

References (63)
  • 1
    • 71249135631 scopus 로고    scopus 로고
    • 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats
    • Aboutabl ME, Zordoky BN, El-Kadi AO. 2009. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Br J Pharmacol 158:1808-1819.
    • (2009) Br J Pharmacol , vol.158 , pp. 1808-1819
    • Aboutabl, M.E.1    Zordoky, B.N.2    El-Kadi, A.O.3
  • 4
    • 0030935086 scopus 로고    scopus 로고
    • Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions
    • Bertz RJ, Granneman GR. 1997. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions. Clin Pharmacokinet 32:210-258. (Pubitemid 27122521)
    • (1997) Clinical Pharmacokinetics , vol.32 , Issue.3 , pp. 210-258
    • Bertz, R.J.1    Granneman, G.R.2
  • 5
    • 64549130038 scopus 로고    scopus 로고
    • Updates on cytochrome P450-mediated cardiovascular drug interactions
    • Cheng JW, Frishman WH, Aronow WS. 2009. Updates on cytochrome P450-mediated cardiovascular drug interactions. Am J Ther 16:155-163.
    • (2009) Am J Ther , vol.16 , pp. 155-163
    • Cheng, J.W.1    Frishman, W.H.2    Aronow, W.S.3
  • 6
    • 0021970479 scopus 로고
    • Changes in thyroidal function and liver UDPglucuronosyltransferase activity in rats following administration of a novel imidazole (SC-37211)
    • DOI 10.1016/0041-008X(85)90387-4
    • Comer CP, Chengelis CP, Levin S, Kotsonis FN. 1985. Changes in thyroidal function and liver UDP-glucuronosyltransferase activity in rats following administration of a novel imidazole (SC-37211). Toxicol Appl Pharmacol 80:427-436. (Pubitemid 15225515)
    • (1985) Toxicology and Applied Pharmacology , vol.80 , Issue.3 , pp. 427-436
    • Comer, C.P.1    Chengelis, C.P.2    Levin, S.3    Kotsonis, F.N.4
  • 7
    • 0028902169 scopus 로고
    • Marketed human pharmaceuticals reported to be tumorigenic in rodents
    • Davies TS, Monro A. 1995. Marketed human pharmaceuticals reported to be tumorigenic in rodents. J Am Coll Toxicol 14:90-107.
    • (1995) J Am Coll Toxicol , vol.14 , pp. 90-107
    • Davies, T.S.1    Monro, A.2
  • 8
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans WE, Relling MV. 1999. Pharmacogenomics: Translating functional genomics into rational therapeutics. Science 286:487-491.
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 9
    • 34547881497 scopus 로고    scopus 로고
    • A gene expression biomarker provides early prediction and mechanistic assessment of hepatic tumor induction by nongenotoxic chemicals
    • DOI 10.1093/toxsci/kfm156
    • Fielden MR, Brennan R, Gollub J. 2007. A gene expression biomarker provides early prediction and mechanistic assessment of hepatic tumor induction by nongenotoxic chemicals. Toxicol Sci 99:90-100. (Pubitemid 47250370)
    • (2007) Toxicological Sciences , vol.99 , Issue.1 , pp. 90-100
    • Fielden, M.R.1    Brennan, R.2    Gollub, J.3
  • 10
    • 65549100013 scopus 로고    scopus 로고
    • Cytochrome P450 and the biological clock in mammals
    • Froy O. 2009. Cytochrome P450 and the biological clock in mammals. Curr Drug Metab 10:104-115.
    • (2009) Curr Drug Metab , vol.10 , pp. 104-115
    • Froy, O.1
  • 11
    • 6944234902 scopus 로고    scopus 로고
    • Regulation of CYP3A4 by the bile acid receptor FXR: Evidence for functional binding sites in the CYP3A4 gene
    • DOI 10.1097/00008571-200410000-00001
    • Gnerre C, Blättler S, Kaufmann MR, Looser R, Meyer UA. 2004. Regulation of CYP3A4 by the bile acid receptor FXR: Evidence for functional binding sites in the CYP3A4 gene. Pharmacogenetics 14:635-645. (Pubitemid 39411263)
    • (2004) Pharmacogenetics , vol.14 , Issue.10 , pp. 635-645
    • Gnerre, C.1    Blattler, S.2    Kaufmann, M.R.3    Looser, R.4    Meyer, U.A.5
  • 14
    • 0034973773 scopus 로고    scopus 로고
    • Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity
    • Guengerich FP. 2001. Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chem Res Toxicol 14:611-650. (Pubitemid 32565712)
    • (2001) Chemical Research in Toxicology , vol.14 , Issue.6 , pp. 611-650
    • Guengerich, F.P.1
  • 15
    • 0344740559 scopus 로고    scopus 로고
    • Induction of drug metabolism: The role of nuclear receptors
    • DOI 10.1124/pr.55.4.2
    • Handschin C, Meyer UA. 2003. Induction of drug metabolism: The role of nuclear receptors. Pharmacol Rev 55:649-673. (Pubitemid 37504978)
    • (2003) Pharmacological Reviews , vol.55 , Issue.4 , pp. 649-673
    • Handschin, C.1    Meyer, U.A.2
  • 17
    • 44249098959 scopus 로고    scopus 로고
    • Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases
    • Hardwick JP. 2008. Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases. Biochem Pharmacol 75:2263-2275.
    • (2008) Biochem Pharmacol , vol.75 , pp. 2263-2275
    • Hardwick, J.P.1
  • 19
    • 70349295631 scopus 로고    scopus 로고
    • Cross-talk between transcription factors AhR and Nrf2: Lessons for cancer chemoprevention from dioxin
    • Hayes JD, Dinkova-Kostova AT, McMahon M. 2009. Cross-talk between transcription factors AhR and Nrf2: Lessons for cancer chemoprevention from dioxin. Toxicol Sci 111:199-201.
    • (2009) Toxicol Sci , vol.111 , pp. 199-201
    • Hayes, J.D.1    Dinkova-Kostova, A.T.2    McMahon, M.3
  • 20
    • 35648976075 scopus 로고    scopus 로고
    • Induction of hepatic cytochrome P450 enzymes: Methods, mechanisms, recommendations, and in vitro-in vivo correlations
    • DOI 10.1080/00498250701534893, PII 783596675, Modelling and Simulation Approaches to in vitro-in vivo, Extrapolation of ADME Properties in Drug Development, Editor: Gordon Gibson, Guest Editor: Amin Rostami-Hodjegan
    • Hewitt NJ, Lecluyse EL, Ferguson SS. 2007. Induction of hepatic cytochrome P450 enzymes: Methods, mechanisms, recommendations, and in vitro-in vivo correlations. Xenobiotica 37:1196-1224. (Pubitemid 350035534)
    • (2007) Xenobiotica , vol.37 , Issue.10-11 , pp. 1196-1224
    • Hewitt, N.J.1    Lecluyse, E.L.2    Ferguson, S.S.3
  • 21
    • 60249090163 scopus 로고    scopus 로고
    • Comparison of the effects of the synthetic pyrethroid metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes
    • Hirose Y, Nagahori H, Yamada T, Deguchi Y, Tomigahara Y, Nishioka K, Uwagawa S, Kawamura S, Isobe N, Lake BG, Okuno Y. 2009. Comparison of the effects of the synthetic pyrethroid metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes. Toxicology 258:64-69.
    • (2009) Toxicology , vol.258 , pp. 64-69
    • Hirose, Y.1    Nagahori, H.2    Yamada, T.3    Deguchi, Y.4    Tomigahara, Y.5    Nishioka, K.6    Uwagawa, S.7    Kawamura, S.8    Isobe, N.9    Lake, B.G.10    Okuno, Y.11
  • 22
    • 33748894676 scopus 로고    scopus 로고
    • Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes
    • DOI 10.1124/dmd.106.010033
    • Jigorel E, Le Vee M, Boursier-Neyret C, Parmentier Y, Fardel O. 2006. Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Drug Metab Dispos 34:1756-1763. (Pubitemid 44427479)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.10 , pp. 1756-1763
    • Jigorel, E.1    Le Vee, M.2    Boursier-Neyret, C.3    Parmentier, Y.4    Fardel, O.5
  • 23
    • 33745683886 scopus 로고    scopus 로고
    • The effect of fenbuconazole on cell proliferation and enzyme induction in the liver of female CD1 mice
    • Juberg DR, Mudra DR, Hazelton GA, Parkinson A. 2006. The effect of fenbuconazole on cell proliferation and enzyme induction in the liver of female CD1 mice. Toxicol Appl Pharmacol 214:178-187.
    • (2006) Toxicol Appl Pharmacol , vol.214 , pp. 178-187
    • Juberg, D.R.1    Mudra, D.R.2    Hazelton, G.A.3    Parkinson, A.4
  • 24
    • 52449108842 scopus 로고    scopus 로고
    • New insights on the xenobiotic-sensing nuclear receptors in liver diseases-CAR and PXR
    • Kakizaki S, Yamazaki Y, Takizawa D, Negishi M. 2008. New insights on the xenobiotic-sensing nuclear receptors in liver diseases-CAR and PXR. Curr Drug Metab 9:614-621.
    • (2008) Curr Drug Metab , vol.9 , pp. 614-621
    • Kakizaki, S.1    Yamazaki, Y.2    Takizawa, D.3    Negishi, M.4
  • 25
    • 0026603890 scopus 로고
    • Predictive assay for rodent carcinogenicity using in vivo biochemical parameters: Operational characteristics and complementarity
    • Kitchin KT, Brown JL, Kulkarni AP. 1992. Predictive assay for rodent carcinogenicity using in vivo biochemical parameters: Operational characteristics and complementarity. Mutat Res 266:253-272.
    • (1992) Mutat Res , vol.266 , pp. 253-272
    • Kitchin, K.T.1    Brown, J.L.2    Kulkarni, A.P.3
  • 26
    • 4444246000 scopus 로고    scopus 로고
    • Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes
    • DOI 10.1128/MCB.24.18.7931-7940.2004
    • Kodama S, Koike C, Negishi M, Yamamoto Y. 2004. Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes. Mol Cell Biol 24:7931-7940. (Pubitemid 39167443)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.18 , pp. 7931-7940
    • Kodama, S.1    Koike, C.2    Negishi, M.3    Yamamoto, Y.4
  • 27
    • 42249111748 scopus 로고    scopus 로고
    • The roles of nuclear receptors CAR and PXR in hepatic energy metabolism
    • Konno Y, Neigishi M, Kodama S. 2008. The roles of nuclear receptors CAR and PXR in hepatic energy metabolism. Drug Metab Pharmacokinet 23:8-13.
    • (2008) Drug Metab Pharmacokinet , vol.23 , pp. 8-13
    • Konno, Y.1    Neigishi, M.2    Kodama, S.3
  • 29
    • 33751579139 scopus 로고    scopus 로고
    • Drug-induced changes in P450 enzyme expression at the gene expression level: A new dimension to the analysis of drug-drug interactions
    • DOI 10.1080/00498250600861785, PII Q6474527J42V7X48
    • Lee MD, Ayanoglu E, Gong L. 2006. Drug-induced changes in P450 enzyme expression at the gene expression level: A new dimension to the analysis of drug-drug interactions. Xenobiotics 36:1013-1080. (Pubitemid 44844112)
    • (2006) Xenobiotica , vol.36 , Issue.10-11 , pp. 1013-1080
    • Lee, M.D.1    Ayanoglu, E.2    Gong, L.3
  • 30
    • 42249102806 scopus 로고    scopus 로고
    • Interplay of pregnane X receptor with other nuclear receptors on gene regulation
    • Lim YP, Huang JD. 2008. Interplay of pregnane X receptor with other nuclear receptors on gene regulation. Drug Metab Pharmacokinet 23:14-21.
    • (2008) Drug Metab Pharmacokinet , vol.23 , pp. 14-21
    • Lim, Y.P.1    Huang, J.D.2
  • 31
    • 45249086547 scopus 로고    scopus 로고
    • Species-specific and age-dependent bile acid composition: Aspects on CYP8B and CYP4A subfamilies in bile acid biosynthesis
    • DOI 10.2174/138920008784220574
    • Lundell K, Wikvall K. 2008. Species-specific and age-dependent bile acid composition: Aspects on CYP8B and CYP4A subfamilies in bile acid biosynthesis. Curr Drug Metab 9:323-331. (Pubitemid 351836421)
    • (2008) Current Drug Metabolism , vol.9 , Issue.4 , pp. 323-331
    • Lundell, K.1    Wikvall, K.2
  • 32
    • 50849145158 scopus 로고    scopus 로고
    • Cytochrome P450 and gene activation-from pharmacology to cholesterol elimination and regression of atherosclerosis
    • Luoma PV. 2008. Cytochrome P450 and gene activation-from pharmacology to cholesterol elimination and regression of atherosclerosis. Eur J Clin Pharmacol. 64:841-850.
    • (2008) Eur J Clin Pharmacol. , vol.64 , pp. 841-850
    • Luoma, P.V.1
  • 33
    • 0019977717 scopus 로고
    • Plasma high-density lipoproteins and hepatic microsomal enzyme induction. Relation to histological changes in the liver
    • DOI 10.1007/BF00547568
    • Luoma PV, Sotaniemi EA, Pelkonen RO, Arranto A, Ehnholm C. 1982. Plasma high-density lipoproteins and hepatic microsomal enzyme induction. Relation to histological changes in the liver. Eur J Clin Pharmacol 23:275-282. (Pubitemid 12028468)
    • (1982) European Journal of Clinical Pharmacology , vol.23 , Issue.3 , pp. 275-282
    • Luoma, P.V.1    Sotaniemi, E.A.2    Pelkonen, R.O.3
  • 35
    • 33845473315 scopus 로고    scopus 로고
    • Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction
    • Martignoni M, Groothius GMM, de Kanter R. 2006. Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol 2:875-994.
    • (2006) Expert Opin Drug Metab Toxicol , vol.2 , pp. 875-994
    • Martignoni, M.1    Groothius, G.M.M.2    De Kanter, R.3
  • 36
    • 65549157442 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages
    • Matsunawa M, Amano Y, Endo K, Uno S, Sakaki T, Yamada S, Makishima M. 2009. The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages. Toxicol Sci 109:50-58.
    • (2009) Toxicol Sci , vol.109 , pp. 50-58
    • Matsunawa, M.1    Amano, Y.2    Endo, K.3    Uno, S.4    Sakaki, T.5    Yamada, S.6    Makishima, M.7
  • 37
    • 0024460524 scopus 로고
    • The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: Implications for thyroid gland neoplasia
    • McClain RM. 1989. The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: Implications for thyroid gland neoplasia. Toxicol Pathol 17:294-306. (Pubitemid 19218939)
    • (1989) Toxicologic Pathology , vol.17 , Issue.2 , pp. 294-306
    • McClain, R.M.1
  • 38
    • 71949119028 scopus 로고    scopus 로고
    • Hepatic OATP1B transporters and nuclear receptors PXR and CAR: Interplay, regulation of drug disposition genes, and single nucleotide polymorphisms
    • Meyer zu Schwabedissen HE, Kim RB. 2009. Hepatic OATP1B transporters and nuclear receptors PXR and CAR: Interplay, regulation of drug disposition genes, and single nucleotide polymorphisms. Mol Pharm 6:1644-1661.
    • (2009) Mol Pharm , vol.6 , pp. 1644-1661
    • Meyer Zu Schwabedissen, H.E.1    Kim, R.B.2
  • 39
    • 0242677815 scopus 로고    scopus 로고
    • Endocrine disruptors induce cytochrome P450 by affecting transcriptional regulation via pregnane X receptor
    • DOI 10.1016/j.taap.2003.08.001
    • Mikamo E, Harada S, Nishikawa J, Nishihara T. 2003. Endocrine disruptors induce cytochrome P450 by affecting transcriptional regulation via pregnane X receptor. Toxicol Appl Pharmacol 193:66-72. (Pubitemid 37373766)
    • (2003) Toxicology and Applied Pharmacology , vol.193 , Issue.1 , pp. 66-72
    • Mikamo, E.1    Harada, S.2    Nishikawa, J.-I.3    Nishihara, T.4
  • 40
    • 50049103631 scopus 로고    scopus 로고
    • Characterization of substrate specificity of dog CYP1A2 using CYP1A2-deficient and wild-type dog liver microsomes
    • Mise M, Hashizume T, Komuro S. 2008. Characterization of substrate specificity of dog CYP1A2 using CYP1A2-deficient and wild-type dog liver microsomes. Drug Metab Dispos 36:1903-1908.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1903-1908
    • Mise, M.1    Hashizume, T.2    Komuro, S.3
  • 41
    • 0842312531 scopus 로고    scopus 로고
    • Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants
    • DOI 10.1097/00008571-200401000-00001
    • Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. 2004. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics 14:1-18. (Pubitemid 38183957)
    • (2004) Pharmacogenetics , vol.14 , Issue.1 , pp. 1-18
    • Nelson, D.R.1    Zeldin, D.C.2    Hoffman, S.M.G.3    Maltais, L.J.4    Wain, H.M.5    Nebert, D.W.6
  • 42
    • 72949114663 scopus 로고    scopus 로고
    • Oxidation of endobiotics mediated by xenobiotic-metabolizing forms of human cytochrome P450
    • (in press)
    • Niwa T, Murayama N, Yamazaki H. 2009. Oxidation of endobiotics mediated by xenobiotic-metabolizing forms of human cytochrome P450. Curr Drug Metab (in press).
    • (2009) Curr Drug Metab
    • Niwa, T.1    Murayama, N.2    Yamazaki, H.3
  • 43
    • 64549162267 scopus 로고    scopus 로고
    • Cardiovascular drug interactions
    • Frishman WH, Sonnenblick EH, Sica DA, editors. 2nd ed. New York: McGraw Hill.
    • Opie LH. 2003. Cardiovascular drug interactions: In: Frishman WH, Sonnenblick EH, Sica DA, editors. Cardiovascular pharmacotherapeutics. 2nd ed. New York: McGraw Hill. pp 875-891.
    • (2003) Cardiovascular Pharmacotherapeutics , pp. 875-891
    • Opie, L.H.1
  • 45
    • 41149102969 scopus 로고    scopus 로고
    • Regulatory cross-talk between drug metabolism and lipid homeostasis: Constitutive androstane receptor and pregnane X receptor increase Insig-1 expression
    • DOI 10.1124/mol.107.041012
    • Roth A, Looser R, Kaufmann M, Blättler SM, Rencurel F, Huang W, Moore DD, Meyer UA. 2008a. Regulatory cross-talk between drug metabolism and lipid homeostasis: Constitutive androstane receptor and pregnane X receptor increase Insig-1 expression. Mol Pharmacol 73:1282-1289. (Pubitemid 351439210)
    • (2008) Molecular Pharmacology , vol.73 , Issue.4 , pp. 1282-1289
    • Roth, A.1    Looser, R.2    Kaufmann, M.3    Blattler, S.M.4    Rencurel, F.5    Huang, W.6    Moore, D.D.7    Meyer, U.A.8
  • 46
    • 40549086299 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes
    • DOI 10.1097/FPC.0b013e3282f706e0, PII 0121301120080400000006
    • Roth A, Looser R, Kaufmann M, Meyer UA. 2008b. Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target gene. Pharmacogenet Genomics 18:325-337. (Pubitemid 351367526)
    • (2008) Pharmacogenetics and Genomics , vol.18 , Issue.4 , pp. 325-337
    • Roth, A.1    Looser, R.2    Kaufmann, M.3    Meyer, U.A.4
  • 48
    • 74549158430 scopus 로고    scopus 로고
    • A comparison of the role of PPAR and RAR on CYP26 regulation
    • Tay S, Dickmann L, Dixit V, Isoherranen N. 2009 A comparison of the role of PPAR and RAR on CYP26 regulation. Mol Pharmacol. 77:218-227.
    • (2009) Mol Pharmacol. , vol.77 , pp. 218-227
    • Tay, S.1    Dickmann, L.2    Dixit, V.3    Isoherranen, N.4
  • 49
    • 0345244260 scopus 로고
    • Antitoxicants and Light Stabilizers: Toxic Effects of 3, 5-di-alkyl-4-Hydroxy-Phenyl Propionic Acid Derivatives in the Rat and Their Relevance for human safety evaluation
    • Thomas H, Hess R, Waechter F, editors. London: Taylor & Francis.
    • Thomas H, Dollenmeier P, Persohn E, Weideli H, Waechter F. 1995. Antitoxicants and light stabilizers: Toxic effects of 3, 5-di-alkyl-4-hydroxy- phenyl propionic acid derivatives in the rat and their relevance for human safety evaluation. In: Thomas H, Hess R, Waechter F, editors. Toxicology of industrial compounds. London: Taylor & Francis. pp 319-339.
    • (1995) Toxicology of Industrial Compounds , pp. 319-339
    • Thomas, H.1    Dollenmeier, P.2    Persohn, E.3    Weideli, H.4    Waechter, F.5
  • 50
    • 0033838338 scopus 로고    scopus 로고
    • Cytochrome P450 mono-oxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat
    • Thum T, Borlak J. 2000. Cytochrome P450 mono-oxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat. Br J Pharmacol 130:1745-1752. (Pubitemid 30655785)
    • (2000) British Journal of Pharmacology , vol.130 , Issue.8 , pp. 1745-1752
    • Thum, T.1    Borlak, J.2
  • 51
    • 34247349605 scopus 로고    scopus 로고
    • Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: Implications for interindividual variability in response to drugs
    • DOI 10.1177/0091270007299930
    • Urquhart BL, Tirona RG, Kim RB. 2007. Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: Implications for interindividual variability in response to drugs. J Clin Pharmacol 47:566-578. (Pubitemid 46632158)
    • (2007) Journal of Clinical Pharmacology , vol.47 , Issue.5 , pp. 566-578
    • Urquhart, B.L.1    Tirona, R.G.2    Kim, R.B.3
  • 52
    • 0032823322 scopus 로고    scopus 로고
    • Subchronic toxicity study with ethylene-bis-(oxyethylene)-bis(3-tert- butyl-4-hydroxy-5-methylhydrocinnamate) in the Cynomolgus monkey: Lack of stimulation of the pituitary-thyroid-liver axis
    • DOI 10.1093/toxsci/51.1.36
    • Waechter F, Beilstein P, Burger AG, O'Connell M, Fabreguettes C, Forster R, Weideli H. 1999. Subchronic toxicity study with ethylene-bis-(oxyethylene)- bis-(3-tert-butyl-4-hydroxy-5-methylhydro cin namate) in the cynomolgus monkey: Lack of stimulation of the pituitary-thyroid-liver axis. Toxicol Sci 51:36-43. (Pubitemid 29439228)
    • (1999) Toxicological Sciences , vol.51 , Issue.1 , pp. 36-43
    • Waechter, F.1    Beilstein, P.2    Burger, A.G.3    O'Connell, M.4    Fabreguettes, C.5    Forster, R.6    Weideli, H.7
  • 53
    • 70450273286 scopus 로고    scopus 로고
    • Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development
    • Wang B, Zhou SF. 2009. Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem 16:4066-4218.
    • (2009) Curr Med Chem , vol.16 , pp. 4066-4218
    • Wang, B.1    Zhou, S.F.2
  • 56
    • 0033199499 scopus 로고    scopus 로고
    • P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR
    • DOI 10.1006/abbi.1999.1351
    • Waxman DJ. 1999. P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR. Arch Biochem Biophys 369:11-23. (Pubitemid 29434534)
    • (1999) Archives of Biochemistry and Biophysics , vol.369 , Issue.1 , pp. 11-23
    • Waxman, D.J.1
  • 58
    • 33646581338 scopus 로고    scopus 로고
    • Preclinical development of new drugs that enhance thyroid hormone metabolism and clearance: Inadequacy of using rats as an animal model for predicting human risks in an IND and NDA
    • Wu KM, Farrelly JG. 2006. Preclinical development of new drugs that enhance thyroid hormone metabolism and clearance: Inadequacy of using rats as an animal model for predicting human risks in an IND and NDA. Am J Ther 13:141-144.
    • (2006) Am J Ther , vol.13 , pp. 141-144
    • Wu, K.M.1    Farrelly, J.G.2
  • 59
    • 2342462928 scopus 로고    scopus 로고
    • Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes
    • DOI 10.1016/j.cbi.2004.01.006, PII S0009279704000080
    • You L. 2004. Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes. Chem Biol Interact 147:233-246. (Pubitemid 38591494)
    • (2004) Chemico-Biological Interactions , vol.147 , Issue.3 , pp. 233-246
    • You, L.1
  • 60
    • 54349101231 scopus 로고    scopus 로고
    • Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats
    • Zordoky BN, Aboutabl ME, El-Kadi AO. 2008. Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats. Drug Metab Dispos 36:2277-2286.
    • (2008) Drug Metab Dispos , vol.36 , pp. 2277-2286
    • Zordoky, B.N.1    Aboutabl, M.E.2    El-Kadi, A.O.3
  • 61
    • 70449529313 scopus 로고    scopus 로고
    • Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats
    • Zordoky BN, Anwar-Mohamed A, Aboutabl ME, El-Kadi AO. 2010. Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats. Toxicol Appl Pharmacol 242:38-46.
    • (2010) Toxicol Appl Pharmacol , vol.242 , pp. 38-46
    • Zordoky, B.N.1    Anwar-Mohamed, A.2    Aboutabl, M.E.3    El-Kadi, A.O.4
  • 62
    • 55049138266 scopus 로고    scopus 로고
    • Induction of several cytochrome P450 genes by doxorubicin in H9c2 cells
    • Zordoky BN, El-Kadi AO. 2008. Induction of several cytochrome P450 genes by doxorubicin in H9c2 cells. Vascul Pharmacol 49:166-172.
    • (2008) Vascul Pharmacol , vol.49 , pp. 166-172
    • Zordoky, B.N.1    El-Kadi, A.O.2
  • 63
    • 65549089505 scopus 로고    scopus 로고
    • Role of NF-kappaB in the regulation of cytochrome P450 enzymes
    • Zordoky BN, El-Kadi AO. 2009. Role of NF-kappaB in the regulation of cytochrome P450 enzymes. Curr Drug Metab 10:164-178.
    • (2009) Curr Drug Metab , vol.10 , pp. 164-178
    • Zordoky, B.N.1    El-Kadi, A.O.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.