At the edge of translation - materials to program cells for directed differentiation

Oral Diseases

Volumn 17, Issue 3, 2011, Pages 241-251

  Arany, P R ^a,b,c,d   Mooney, D J ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

^c HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Biomaterials; Scaffolds; Stem cells; Tissue engineering; Translational medicine

Indexed keywords

BIOMATERIAL; BONE MORPHOGENETIC PROTEIN; ENDOTHELIAL CELL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; MORPHOGEN; NUCLEIC ACID; PLATELET DERIVED GROWTH FACTOR; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; CELL ADHESION; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TRANSLATIONAL RESEARCH;

BIOCOMPATIBLE MATERIALS; CELL ADHESION; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; CELL PHYSIOLOGICAL PROCESSES; GUIDED TISSUE REGENERATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; NUCLEIC ACIDS; STEM CELLS; TISSUE ENGINEERING;

EID: 79952585523     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/j.1601-0825.2010.01735.x     Document Type: Review

References (95)

1. Agrawal V, Johnson SA, Reing J et al (2010). Epimorphic regeneration approach to tissue replacement in adult mammals. Proc Natl Acad Sci USA 107: 3351-3355.
2. Aldridge BB, Burke JM, Lauffenburger DA, Sorger PK (2006). Physicochemical modelling of cell signalling pathways. Nat Cell Biol 8: 1195-1203.
3. Ali OA, Emerich D, Dranoff G, Mooney DJ (2009a). In situ regulation of DC subsets and T cells mediates tumor regression in mice. Sci Translation Med 1: 8ra19.
4. Ali OA, Huebsch N, Cao L, Dranoff G, Mooney DJ (2009b). Infection-mimicking materials to program dendritic cells in situ. Nat Mater 8: 151-158.
5. Alsberg E, Anderson KW, Albeiruti A, Franceschi RT, Mooney DJ (2001a). Cell-interactive alginate hydrogels for bone tissue engineering. J Dent Res 80: 2025-2029.
6. Alsberg E, Hill EE, Mooney DJ (2001b). Craniofacial tissue engineering. Crit Rev Oral Biol Med 12: 64-75.
7. Alsberg E, Anderson KW, Albeiruti A, Rowley JA, Mooney DJ (2002). Engineering growing tissues. Proc Natl Acad Sci USA 99: 12025-12030.
8. van Amerongen MJ, Harmsen MC, Petersen AH, Kors G, van Luyn MJ (2006). The enzymatic degradation of scaffolds and their replacement by vascularized extracellular matrix in the murine myocardium. Biomaterials 27: 2247-2257.
9. Bohl KS, Shon J, Rutherford B, Mooney DJ (1998). Role of synthetic extracellular matrix in development of engineered dental pulp. J Biomater Sci 9: 749-764.
10. Bonadio J, Smiley E, Patil P, Goldstein S (1999). Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration. Nat Med 5: 753-759.
11. Borselli C, Storrie H, Benesch-Lee F et al (2009). Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors. Proc Natl Acad Sci USA 107: 3287-3292.
12. Bosshardt DD (2008). Biological mediators and periodontal regeneration: a review of enamel matrix proteins at the cellular and molecular levels. J Clin Periodontol 35: 87-105.
13. Bouhadir KH, Lee KY, Alsberg E, Damm KL, Anderson KW, Mooney DJ (2001). Degradation of partially oxidized alginate and its potential application for tissue engineering. Biotechnol Prog 17: 945-950.
14. Brambrink T, Hochedlinger K, Bell G, Jaenisch R (2006). ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable. Proc Natl Acad Sci USA 103: 933-938.
15. Campbell KH, McWhir J, Ritchie WA, Wilmut I (1996). Sheep cloned by nuclear transfer from a cultured cell line. Nature 380: 64-66.
16. Cao R, Brakenhielm E, Pawliuk R et al (2003). Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2. Nat Med 9: 604-613.
17. Cao L, Arany PR, Wang WS, Mooney DJ (2009). Promoting angiogenesis via manipulation of VEGF responsiveness with Notch signaling. Biomaterials 30: 4085-4093.
18. Chen CS, Mrksich M, Huang S, Whitesides GM, Ingber DE (1997). Geometric control of cell life and death. Science (New York, NY) 276: 1425-1428.
19. Chen RR, Silva EA, Yuen WW, Mooney DJ (2007). Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Pharmaceut Res 24: 258-264.
20. Comisar WA, Hsiong SX, Kong HJ, Mooney DJ, Linderman JJ (2006). Multi-scale modeling to predict ligand presentation within RGD nanopatterned hydrogels. Biomaterials 27: 2322-2329.
21. Comisar WA, Kazmers NH, Mooney DJ, Linderman JJ (2007). Engineering RGD nanopatterned hydrogels to control preosteoblast behavior: a combined computational and experimental approach. Biomaterials 28: 4409-4417.
22. Cutler SM, Garcia AJ (2003). Engineering cell adhesive surfaces that direct integrin alpha5beta1 binding using a recombinant fragment of fibronectin. Biomaterials 24: 1759-1770.
23. Discher DE, Mooney DJ, Zandstra PW (2009). Growth factors, matrices, and forces combine and control stem cells. Science (New York, NY) 324: 1673-1677.
24. Driever W, Siegel V, Nusslein-Volhard C (1990). Autonomous determination of anterior structures in the early Drosophila embryo by the bicoid morphogen. Development 109: 811-820.
25. Eid K, Chen K, Griffith L, Glowacki J (2001). Effect of RGD coating on osteocompatibility of PLGA-polymerdisks in rat tibial wound. J Biomed Mat Res 57: 224-231.
26. El-Backly RM, Massoud AG, El-Badry AM, Sherif RA, Marei MK (2008). Regeneration of dentine/pulp-like tissue using a dental pulp stem cell/poly(lactic-co-glycolic) acid scaffold construct in New Zealand white rabbits. Aust Endod J 34: 52-67.
27. Engler AJ, Sen S, Sweeney HL, Discher DE (2006). Matrix elasticity directs stem cell lineage specification. Cell 126: 677-689.
28. Esposito M, Grusovin MG, Papanikolaou N, Coulthard P, Worthington HV (2009). Enamel matrix derivative (Emdogain(R)) for periodontal tissue regeneration in intrabony defects. Cochrane Database System Rev (Online) CD003875.
29. Fang J, Zhu YY, Smiley E et al (1996). Stimulation of new bone formation by direct transfer of osteogenic plasmid genes. Proc Natl Acad Sci USA 93: 5753-5758.
30. Firestone AJ, Chen JK (2010). Controlling destiny through chemistry: small-molecule regulators of cell fate. ACS Chem Biol 5: 15-34.
31. Furth ME, Atala A, Van Dyke ME (2007). Smart biomaterials design for tissue engineering and regenerative medicine. Biomaterials 28: 5068-5073.
32. Geiger B, Bershadsky A, Pankov R, Yamada KM (2001). Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk. Nat Rev 2: 793-805.
33. Gurdon JB (1964). The transplantation of living cell nuclei. Adv Morphogen 4: 1-43.
34. Hadorn E (1968). Transdetermination in cells. Scien Am 219: 110-114. passim.
35. Hill E, Boontheekul T, Mooney DJ (2006). Designing scaffolds to enhance transplanted myoblast survival and migration. Tissue Eng 12: 1295-1304.
36. Hu Z, Luo F, Pan Y et al (2008). Arg-Gly-Asp (RGD) peptide conjugated poly(lactic acid)-poly(ethylene oxide) micelle for targeted drug delivery. J Biomed Mater Res 85: 797-807.
37. Huang YC, Kaigler D, Rice KG, Krebsbach PH, Mooney DJ (2005a). Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration. J Bone Miner Res 20: 848-857.
38. Huang YC, Simmons C, Kaigler D, Rice KG, Mooney DJ (2005b). Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4). Gene Ther 12: 418-426.
39. Huebsch N, Mooney DJ (2009). Inspiration and application in the evolution of biomaterials. Nature 462: 426-432.
40. Huebsch N, Arany PR, Mao AS et al (2010). Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. Nat Mater 9: 518-526.
41. Ichida JK, Blanchard J, Lam K et al (2009). A small-molecule inhibitor of TGF-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell 5: 491-503.
42. Jung RE, Glauser R, Scharer P, Hammerle CH, Sailer HF, Weber FE (2003). Effect of rhBMP-2 on guided bone regeneration in humans. Clin Oral Implants Res 14: 556-568.
43. Kaigler D, Krebsbach PH, West ER, Horger K, Huang YC, Mooney DJ (2005). Endothelial cell modulation of bone marrow stromal cell osteogenic potential. FASEB J 19: 665-667.
44. Kaigler D, Krebsbach PH, Wang Z, West ER, Horger K, Mooney DJ (2006). Transplanted endothelial cells enhance orthotopic bone regeneration. J Dent Res 85: 633-637.
45. Kandziora F, Schmidmaier G, Schollmeier G et al (2002). IGF-I and TGF-beta1 application by a poly-(D, L-lactide)-coated cage promotes intervertebral bone matrix formation in the sheep cervical spine. Spine 27: 1710-1723.
46. Kawamata Y, Nagayama Y, Nakao K et al (2002). Receptor independent augmentation of adenovirus-mediated gene transfer with chitosan in vitro. Biomaterials 23: 4573-4579.
47. Keeney M, van den Beucken JJ, van der Kraan PM, Jansen JA, Pandit A (2010). The ability of a collagen/calcium phosphate scaffold to act as its own vector for gene delivery and to promote bone formation via transfection with VEGF(165). Biomaterials 31: 2893-2902.
48. Khetani SR, Bhatia SN (2008). Microscale culture of human liver cells for drug development. Nat Biotech 26: 120-126.
49. Kim JB, Sebastiano V, Wu G et al (2009). Oct4-induced pluripotency in adult neural stem cells. Cell 136: 411-419.
50. Kim K, Lee CH, Kim BK, Mao JJ (2010). Anatomically shaped tooth and periodontal regeneration by cell homing. J Dent Res. May 6 2010. [Epub ahead of print]
51. King GN, Cochran DL (2002). Factors that modulate the effects of bone morphogenetic protein induced periodontal regeneration: a critical review. J Periodontol 73: 925-936.
52. Kitamura M, Nakashima K, Kowashi Y et al (2008). Periodontal tissue regeneration using fibroblast growth factor-2: randomized controlled phase II clinical trial. PLoS ONE 3: e2611.
53. Kong HJ, Kaigler D, Kim K, Mooney DJ (2004). Controlling rigidity and degradation of alginate hydrogels via molecular weight distribution. Biomacromolecules 5: 1720-1727.
54. Kong HJ, Polte TR, Alsberg E, Mooney DJ (2005). FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness. Proc Natl Acad Sci USA 102: 4300-4305.
55. Koo LY, Irvine DJ, Mayes AM, Lauffenburger DA, Griffith LG (2002). Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus. J Cell Sci 115: 1423-1433.
56. Lander ES, Linton LM, Birren B et al (2001). Initial sequencing and analysis of the human genome. Nature 409: 860-921.
57. Langer R, Vacanti JP (1993). Tissue engineering. Science (New York, NY) 260: 920-926.
58. Lieberman-Aiden E, van Berkum NL, Williams L et al (2009). Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (New York, NY) 326: 289-293.
59. von Lindern JJ, Niederhagen B, Appel T, Berge S (2002). Treatment of soft tissue defects with exposed bone in the head and face region with alginates and hydrocolloid dressings. J Oral Maxillofac Surg 60: 1126-1130.
60. Mann BK, West JL (2002). Cell adhesion peptides alter smooth muscle cell adhesion, proliferation, migration, and matrix protein synthesis on modified surfaces and in polymer scaffolds. J Biomed Mater Res 60: 86-93.
61. Mao JJ, Giannobile WV, Helms JA et al (2006). Craniofacial tissue engineering by stem cells. J Dent Res 85: 966-979.
62. Massia SP, Stark J (2001). Immobilized RGD peptides on surface-grafted dextran promote biospecific cell attachment. J Biomed Mater Res 56: 390-399.
63. Meissner A, Wernig M, Jaenisch R (2007). Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol 25: 1177-1181.
64. Mierisch CM, Cohen SB, Jordan LC, Robertson PG, Balian G, Diduch DR (2002). Transforming growth factor-beta in calcium alginate beads for the treatment of articular cartilage defects in the rabbit. Arthroscopy 18: 892-900.
65. Misteli T, Soutoglou E (2009). The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat Rev 10: 243-254.
66. Moioli EK, Clark PA, Chen M et al (2008). Synergistic actions of hematopoietic and mesenchymal stem/progenitor cells in vascularizing bioengineered tissues. PLoS ONE 3: e3922.
67. Mooney DJ, Vandenburgh H (2008). Cell delivery mechanisms for tissue repair. Cell Stem Cell 2: 205-213.
68. Mooney DJ, Baldwin DF, Suh NP, Vacanti JP, Langer R (1996). Novel approach to fabricate porous sponges of poly(D, L-lactic-co-glycolic acid) without the use of organic solvents. Biomaterials 17: 1417-1422.
69. Munger JS, Huang X, Kawakatsu H et al (1999). The integrin alpha V beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 96: 319-328.
70. Murakami S, Takayama S, Ikezawa K et al (1999). Regeneration of periodontal tissues by basic fibroblast growth factor. J Periodon Res 34: 425-430.
71. Okano F, Merad M, Furumoto K, Engleman EG (2005). In vivo manipulation of dendritic cells overcomes tolerance to unmodified tumor-associated self antigens and induces potent antitumor immunity. J Immunol 174: 2645-2652.
72. Orkin SH, Zon LI (2008). Hematopoiesis: an evolving paradigm for stem cell biology. Cell 132: 631-644.
73. Parrish LC, Miyamoto T, Fong N, Mattson JS, Cerutis DR (2009). Non-bioabsorbable vs. bioabsorbable membrane: assessment of their clinical efficacy in guided tissue regeneration technique. A systematic review. J Oral Sci 51: 383-400.
74. Poondra RR, Kumar NN, Bijian K et al (2009). Discovery of indoline-based, natural-product-like compounds as probes of focal adhesion kinase signaling pathways. J Combinator Chem 9: 303-309.
75. Quirk RA, Chan WC, Davies MC, Tendler SJ, Shakesheff KM (2001). Poly(L-lysine)-GRGDS as a biomimetic surface modifier for poly(lactic acid). Biomaterials 22: 865-872.
76. Richardson TP, Peters MC, Ennett AB, Mooney DJ (2001). Polymeric system for dual growth factor delivery. Nat Biotechnol 19: 1029-1034.
77. Schense JC, Hubbell JA (1999). Cross-linking exogenous bifunctional peptides into fibrin gels with factor XIIIa. Bioconjug Chem 10: 75-81.
78. Schuettengruber B, Chourrout D, Vervoort M, Leblanc B, Cavalli G (2007). Genome regulation by polycomb and trithorax proteins. Cell 128: 735-745.
79. Schuler M, Owen GR, Hamilton DW et al (2006). Biomimetic modification of titanium dental implant model surfaces using the RGDSP-peptide sequence: a cell morphology study. Biomaterials 27: 4003-4015.
80. Schwartz YB, Pirrotta V (2007). Polycomb silencing mechanisms and the management of genomic programmes. Nat Rev 8: 9-22.
81. Shin S, Salvay DM, Shea LD (2010). Lentivirus delivery by adsorption to tissue engineering scaffolds. J Biomed Mater Res 93: 1252-1259.
82. Silva EA, Mooney DJ (2007). Spatiotemporal control of vascular endothelial growth factor delivery from injectable hydrogels enhances angiogenesis. J Thromb Haemost 5: 590-598.
83. Silva EA, Kim ES, Kong HJ, Mooney DJ (2008). Material-based deployment enhances efficacy of endothelial progenitor cells. Proc Natl Acad Sci USA 105: 14347-14352.
84. Slack JM (2009). Metaplasia and somatic cell reprogramming. J Pathol 217: 161-168.
85. Sohier J, Moroni L, van Blitterswijk C, de Groot K, Bezemer JM (2008). Critical factors in the design of growth factor releasing scaffolds for cartilage tissue engineering. Expert Opin Drug Deliv 5: 543-566.
86. Sporn MB, Roberts AB (1986). Peptide growth factors and inflammation, tissue repair, and cancer. J Clin Invest 78: 329-332.
87. Struhl G, Johnston P, Lawrence P A (1992). Control of Drosophila body pattern by the hunchback morphogen gradient. Cell 69: 237-249.
88. Sun Q, Silva EA, Wang A et al (2010). Sustained release of multiple growth factors from injectable polymeric system as a novel therapeutic approach towards angiogenesis. Pharmaceu Res 27: 264-271.
89. Taba M Jr, Jin Q, Sugai JV, Giannobile WV (2005). Current concepts in periodontal bioengineering. Orthodon Craniofac Res 8: 292-302.
90. Takahashi K, Yamanaka S (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663-676.
91. Tosatti S, Schwartz Z, Campbell C et al (2004). RGD-containing peptide GCRGYGRGDSPG reduces enhancement of osteoblast differentiation by poly(L-lysine)-graft-poly(ethylene glycol)-coated titanium surfaces. J Biomed Mater Res 68: 458-472.
92. Valarmathi MT, Goodwin RL, Fuseler JW, Davis JM, Yost MJ, Potts JD (2010). A 3-D cardiac muscle construct for exploring adult marrow stem cell based myocardial regeneration. Biomaterials 31: 3185-3200.
93. Venter JC, Adams MD, Myers EW et al (2001). The sequence of the human genome. Science (New York, NY) 291: 1304-1351.
94. Yung CW, Fiering J, Mueller AJ, Ingber DE (2009). Micromagnetic-microfluidic blood cleansing device. Lab Chip 9: 1171-1177.
95. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA (2008). In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455: 627-632.