Factors that modulate the effets of bone morphogenetic protein-induced periodontal regeneration: A critical review

Journal of Periodontology

Volumn 73, Issue 8, 2002, Pages 925-936

  King, Gaston N ^a   Cochran, David L ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Ankylosis; Bone morphogenetic proteins; Drug delivery systems; Periodontal regeneration; Tooth root therapy; Wound healing

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; DRUG CARRIER; OSTEOGENIC PROTEIN 1; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; GROWTH PROMOTOR;

BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL GROWTH; CELL POPULATION; CEMENTUM; CLINICAL STUDY; CLINICAL TRIAL; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG RELEASE; HUMAN; MODULATION; NONHUMAN; ORTHODONTICS; OSSIFICATION; PERIODONTAL DISEASE; PERIODONTAL LIGAMENT; PERIODONTICS; PERIODONTIUM; PHENOTYPE; REVIEW; STEM CELL; TISSUE REGENERATION; TOOTH ROOT; WOUND HEALING; ANIMAL; DELAYED RELEASE FORMULATION; DENTAL ACID ETCHING; MASTICATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REGENERATION; TOOTH DEVELOPMENT;

ACID ETCHING, DENTAL; ANIMALS; BITE FORCE; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CEMENTOGENESIS; DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GROWTH SUBSTANCES; HUMANS; OSTEOGENESIS; PERIODONTAL DISEASES; PERIODONTIUM; REGENERATION; STEM CELLS; TOOTH ROOT; WOUND HEALING;

EID: 0036668593     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2002.73.8.925     Document Type: Review

References (80)

1. The pathogenesis of periodontal diseases
2. Origins and functions of cells essential for periodontal repair: The role of fibroblasts in tissue homeostasis
3. Cytokines and cell signaling in the periodontium
4. Periodontal regeneration with polypeptide growth factors
5. Recombinant human bone morphogenetic protein-7 induces healing in a canine long-bone segmental defect model
6. Bone morphogenetic proteins (BMPs): Therapeutic potential in healing bony defects
7. Novel regulators of bone formation: Molecular clones and activities
8. Recombinant human bone morphogenetic protein induces bone formation
9. The bone morphogenetic protein family: Multifunctional cellular regulators in the embryo and adult
10. Controlling TGF beta signaling
11. TGF-beta signal transduction
12. Specific activation of Smad 1 signaling pathways by the BMP7 type 1 receptor, ALK2
13. TGF beta inhibitors: New and unexpected requirements in vertebrate development
14. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
15. Antagonism within and around the organizer: BMP inhibitors in vertebrate body patterning
16. Induction of cementogenesis by recombinant human osteogenic protein-1 (hop-1/bmp-7) in the baboon (Papio ursinus)
17. Periodontal regeneration: Potential role of bone morphogenetic proteins
18. Recombinant human osteogenic protein-1 (OP-1) stimulates periodontal wound healing in Class III furcation defects
19. Intracellular BMP signaling regulation in vertebrates: Pathway or network?
20. Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects
21. Periodontal repair in dogs: Recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration
22. Bone morphogenetic proteins induce periodontal regeneration in baboons (Papio ursinus)
23. Investigation of the expression of the cementoblast phenotype and the modulatory role of cementum matrix in vitro
24. Bone morphogenetic protein-2 stimulates cell recruitment and cementogenesis during early wound healing
25. Periodontal repair in dogs: Evaluation of rhBMP-2 carriers
26. Periodontal repair in dogs: Effect of rhBMP-2 concentration on regeneration of alveolar bone and periodontal attachment
27. Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 to horizontal circumferential defects created by experimental periodontitis in beagle dogs
28. Histologic comparison of regeneration in human intrabony defects when osteogenin is combined with demineralized freeze-dried bone allograft and with purified bovine collagen
29. Periodontal regenerative potential of space-providing expanded polytetrafluoroethylene membranes and recombinant human bone morphogenetic proteins
30. Effects of occlusal loading on ankylosis, bone and cementum formation during bone morphogenetic protein-2 stimulated periodontal regeneration in vivo
31. The effect of root surface demineralization on bone morphogenetic protein-2-induced healing of rat periodontal fenestration defects
32. Effect of two delivery systems for recombinant human bone morphogenetic protein-2 on periodontal regeneration in vivo
33. Recombinant human bone morphogenetic protein-2 stimulation of bone formation around endosseous dental implants
34. Efficacy of bone morphogenetic protein (BMP) with osteopromotive membranes-an experimental study in rat mandibular defects
35. Recombinant bone morphogenetic protein-2 enhances bone healing, guided by osteopromotive e-PTFE membranes: An experimental study in rats
36. Healing of horizontal circumferential periodontal defects following regenerative surgery in beagle dogs
37. Periodontal repair in dogs: Space provision by reinforced ePTFE membranes enhances bone and cementum regeneration in large supraalveolar defects
38. Osteogenic inhibition by rat periodontal ligament cells: Modulation of bone morphogenic protein-7 activity in vivo
39. Effect of masticatory stimulation on dentoalveolar ankylosis after experimental tooth replantation
40. The effect of splinting upon periodontal healing after replantation of permanent incisors in monkeys
41. Ankylosis of the mouse molar after systemic administration of 1-hydroxyethylidene-1,1-bisphosphonate (HEBP)
42. The effect of limited drying or removal of the periodontal ligament. Periodontal healing after replantation of mature permanent inciors in monkeys
43. Repair processes in the periodontium following dentoalveolar ankylosis: The effect of masticatory function
44. Histometric study on the effect of occlusal alteration on periodontal tissue healing after surgical injury
45. Collagen phagocytosis by fibroblasts in the periodontal ligament of the mouse molar during the initial phase of hypofunction
46. Repair of periodontal tissues in vivo and in vitro
47. Evaluation of different types of autotransplanted connective tissues as potential periodontal ligament substitutes. An experimental replantation study in monkeys
48. Quality of periodontal healing. IV. Enzyme histochemical evidence for an osteoblastic origin of reparative cementum
49. Paravascular cells in endosteal spaces of alveolar bone contribute to periodontal ligament cell populations
50. Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes
51. Formation of acellular root cementum in relation to dental and non-dental hard tissues in the rat
52. Formation of reparative acellular extrinsic fiber cementum in relation to implant materials installed in rat periodontium
53. On the dynamics of periodontal tissue formation in degree III furcation defects. An experimental study in dogs
54. Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins
55. Periodontal regeneration with enamel matrix derivative in one human experimental defect. A case report
56. The importance of drug delivery to optimize the effects of bone morphogenetic proteins during periodontal regeneration
57. The effects of recombinant human bone morphogenetic protein-2 in a rat model of periodontal regeneration
58. Human dentin-matrix-derived bone morphogenetic protein
59. Effects of citric acid on diseased root surfaces
60. Cell and fiber attachment to demineralized cementum from normal root surfaces
61. Cell and fiber attachment to demineralized dentin from normal root surfaces
62. Attachment, growth and synthesis by human gingival fibroblasts on demineralized or fibronectin-treated normal and diseased tooth roots
63. Long-time etching at low pH jeopardizes periodontal healing
64. Medium pH modulates matrix mineral, and energy metabolism in cultured chick bones and osteoblast-like cells
65. Root surface etching at neutral pH promotes periodontal healing
66. Root conditioning using EDTA gel as an adjunct to surgical therapy for the treatment of intraosseous periodontal defects
67. Mandibular reconstruction with a recombinant bone-inducing factor. Functional, histologic, and biomechanical evaluation
68. Animal studies of application of rhBMP-2 in maxillofacial reconstruction
69. The potential role of bone morphogenetic proteins in periodontal reconstruction
70. In vitro release of recombinant human osteogenic protein-1 from different carrier materials
71. Application of purified bone morphogenetic protein (BMP) in cranio-maxillo-facial surgery. BMP in compromised surgical reconstructions using titanium implants
72. Effects of carrier release kinetics on bone morphogenetic protein-2-induced periodontal regeneration in vivo
73. Validation and optimization of a polymer system for potential use as a controlled drug delivery system
74. Release of recombinant human bone morphogenetic protein-2 from heterocyclic methacrylate polymer systems
75. The effects of two temporary crown materials on the dental pulp of monkeys (Macaca fascicularis)
76. Biodegradable microspheres: A new delivery system for growth hormone
77. Heterocyclic methacrylates for clinical applications III. Water absorption characteristics
78. Heterocyclic methacrylate-based drug release polymer system
79. The effects of bone morphogenetic protein-2, -4, and -6 on differentiation of rat osteoblast cells in vitro
80. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic differentiation in cells isolated from human periodontal ligament