Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices

British Journal of Pharmacology

Volumn 117, Issue 4, 1996, Pages 689-697

  Frankiewicz, Tadeusz ^a   Potier, Brigitte ^b,c   Bashir, Zafar I ^b,d   Collingridge, Graham L ^b,d   Parsons, Chris G ^a  

^a MERZ PHARMACEUTICALS GMBH   (Germany)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c INSERM   (France)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Area CA1; Hippocampal slice; Kinetics; LTP (long term potentiation); Memantine (1 amino 3,5 dimethyladmantane); MK 801 (dizocilpine); NMDA (N methyl D aspartate); Patch clamp; Superior colliculus culture; Voltage dependency

Indexed keywords

DIZOCILPINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DEPOLARIZATION; DRUG EFFECT; FEMALE; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; NERVE CELL CULTURE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SUPERIOR COLLICULUS; SYNAPTIC TRANSMISSION;

EID: 0030029425     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15245.x     Document Type: Article

References (60)

1. ANDINE, P., SANDBERG, M., BAGENHOLM, R., LEHMANN, A. & HAGBERG, H. (1991). Intra- and extracellular changes of amino acids in the cerebral cortex of the neonatal rat during hypoxic-ischaemia. Dev. Brain Res., 64, 115-120.
2. APLAND, J.P. & CANN, F.J. (1995). Anticonvulsant effects of memantine and MK-801 in guinea pig hippocampal slices. Brain. Res. Bull., 37, 311-316.
3. BARNES, C.A., DANYSZ, W. & PARSONS, C.G. (1995). Effects of the uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist memantine (1-amino-3,5-dimethyl-adamantane) on hippocampal long-term potentiation (LTP), short-term exploratory modulation (STEM) and spatial memory in awake, freely moving rats. Eur. J. Neurosci. (in press).
4. BASHIR, Z.I. & COLLINGRIDGE, G.L. (1992). NMDA receptor-dependent transient homosynaptic and heterosynaptic depression in picrotoxin-treated hippocampal slices. Eur. J. Neurosci., 4, 485-490.
5. BENVENISTE, H., DREJER, J., SCHUSBOE, A. & DIEMER, N.H. (1984). Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem., 43, 1369-1374.
6. BLISS, T.V.P. & COLLINGRIDGE, G.L. (1993). A synaptic model of memory - long-term potentiation in the hippocampus. Nature, 361, 31-39.
7. BORMANN, J. (1989). Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels. Eur. J. Pharmacol., 166, 591-592.
8. BOULTON, C.L., IRVING, A.J., SOUTHAM, E., POTIER, B., GARTHWAITE, J. & COLLINGRIDGE, G.L. (1994). The nitric oxide-cyclic GMP pathway and synaptic depression in rat hippocampal slices. Eur. J. Neurosci., 6, 1528-1535.
9. BRESINK, I., DANYSZ, W., PARSONS, C.G. & MUTSCHLER, E. (1995). Different binding affinities of NMDA receptor channel blockers in various brain regions - indication of NMDA receptor heterogeneity. Neuropharmacol., 34, 533-540.
10. BUISSON, A., CALLEBERT, J. MATHIEU, E., PLOTKINE, M. & BOULU, R.G. (1992). Striatal protection induced by lesioning the substantia-nigra of rats subjected to focal ischemia. J. Neurochem., 59, 1153-1157.
11. CHEN, H-S.V., PELLEGRINI, J.W., AGGARWAL, S.K., LEI, S.Z., WARACH, S., JENSEN, F.E. & LIPTON, S.A. (1992). Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J. Neurosci., 12, 4427-4436.
12. CLEMENTS, J.D., LESTER, R.A.J., TONG, G., JAHR, C.E. & WESTBROOK, G.L. (1992). The time course of glutamate in the synaptic cleft. Science, 258, 1498-1501.
13. COAN, E.J. & COLLINGRIDGE, G.L. (1987a). Effects of phencyclidine, SKF 10,047 and related psychomimetic agents on N-methyl-D-aspartate receptor-mediated synaptic responses in rat hippocampal slices. Br. J. Pharmacol., 91, 547-556.
14. COAN, E.J. & COLLINGRIDGE, G.L. (1987b). Characterisation of an N-methyl-D-aspartate receptor component of synaptic transmission in rat hipocampal slices. Neuroscience, 22, 1-8.
15. COAN, E.J., SAYWOOD, W. & COLLINGRIDGE, G.L. (1987). MK-801 blocks NMDA receptor-mediated synaptic transmission and long-term potentiation in rat hippocampal slices. Neurosci. Lett., 80, 111-114.
16. COLLINGRIDGE, G.L., KEHL, S.J. & MCLENNAN, H. (1983). Excitatory amino acids in synaptic transmission in the Schaffer-commissural pathway of the rat hippocampus. J. Physiol., 334, 33-46.
17. DANYSZ, W. & ARCHER, T. (1994). Glutamate, learning and dementia - selection of evidence. Amino Acids, 7, 147-163.
18. DANYSZ, W., GOSSEL, M., ZAJACZKOWSKI, W., DILL, D. & QUACK, G. (1994a). Are NMDA antagonistic properties relevant for antiparkinsonian activity in rats? case of amantadine and memantine. J. Neural Transm. - Parkinsons Sect., 7, 155-166.
19. DANYSZ, W., MISZTAL, M., FILIPKOWSKI, K., KACZMAREK, L. & SKANGIELKRAMSKA, J. (1994b). Learning impairment induced by chronic infusion of quinolinic acid - protection by memantine. Neurosci. Abs., 20, 1722.
20. DANYSZ, W., PARSONS, C.G., BRESINK, I. & QUACK, G. (1995a). Glutamate in CNS disorders - a revived target for drug development? Drug News Perspect., 8, 261-277.
21. DANYSZ, W., ZAJACZKOWSKI, W. & PARSONS, C.G. (1995b). Modulation of learning processes by ionotropic glutamate receptor ligands. Behav. Pharmacol., 6, 455-474.
22. DAVIES, S.N., MARTIN, D., MILLAR, J.D., ARAM, J.A., CHURCH, J. & LODGE, D. (1988). Differences in results from in vivo and in vitro studies on the use-dependency of N-methylaspartate antagonism by MK-801 and other phencyclidine receptor ligands. Eur. J. Pharmacol., 145, 141-151.
23. DIMPFEL, W. (1995). Effects of memantine on synaptic transmission in the hippocampus in vitro. Arzneim. Forsch./Drug Res., 45, 1-5.
24. DITZLER, K. (1991). Efficacy and tolerability of memantine in patients with dementia syndrome. Arzneim. Forsch./Drug Res 41, 773-780.
25. GLOBUS, M.Y.T., BUSTO, R., DIETRICH, W.D., MARTINEZ, E., VALDES, I. & GINSBERG, M.D. (1988). Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and γ-aminobutyric acid studied in intracerebral microdialysis. J. Neurochem., 51, 1455-1464.
26. GLOBUS, M.Y.T., BUSTO, R., MARTINEZ, E., VALDES, I., DIETRICH, W.D. & GINSBERG, M.D. (1991). Comparative effect of transient global ischemia on extracellular levels of glutamate, glycine, and gamma-aminobutyric acid in vulnerable and nonvulnerable brain regions in the rat. J. Neurochem., 57, 470-478.
27. GÖRTELMEYER, R. & ERBLER, H. (1992). Memantine in the treatment of mild to moderate dementia syndrome. A double-blind placebo-controlled study. Arzneim. Forsch./Drug Res., 42, 904-913.
28. GROSSMANN, W. & SCHUTZ, W. (1982). Memantine and neurogenic bladder dysfunction in spastic conditions. Arzneim. Forsch./Drug Res., 32, 1273-1276.
29. HALLIWELL, R.F., PETERS, J.A. & LAMBERT, J.J. (1989). The mechanism of action and pharmacological specificity of the anticonvulsant NMDA antagonist MK-801: a voltage clamp study on neuronal cells in culture. Br. J. Pharmacol., 96, 480-494.
30. HASHIMOTO, N., MATSUMOTO, T., MABE, H., HASHITANI, T. & NISHINO, H. (1994). Dopamine has inhibitory and accelerating effects on ischemia-induced neuronal cell damage in the rat striatum. Brain Res. Bull., 33, 281-288.
31. HERRON, C.E., LESTER, R.A., COAN, E.J. & COLLINGRIDGE, G.L. (1986). Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism. Nature, 322, 265-268.
32. HESSLER, N.A., SHIRKE, A.M. & MALINOW, R. (1993). The probability of transmitter release at a mammalian central synapse. Nature, 366, 569-572.
33. HUETTNER, J.E. & BEAN, B.P, (1988). Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels. Proc. Natl. Acad. Sci. U.S.A., 85, 1307-1311.
34. KARSCHIN, A., AIZENMAN, E. & LIPTON, S.A. (1988). The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro. J. Neurosci., 8, 2895-2906.
35. KORNHUBER, J., BORMANN, J., HUBERS, M., RUSCHE, K. & RIEDERER, P. (1991). Effects of the 1-amino-adamantanes at the (+)-MK-801-binding site of the NMDA-receptor-gated ion channel - a human postmortem brain study. Eur. J. Pharmacol., 206, 297-300.
36. 3H]-MK-801 at therapeutic concentrations in postmortem human frontal cortex. Eur. J. Pharmacol., 166, 589-590.
37. KORNHUBER, J. & QUACK, G. (1995). Cerebrospinal fluid and serum concentrations of the N-methyl-D-aspartate (NMDA) receptor antagonist memantine in man. Neurosci. Lett., 195, 137-139.
38. KORNHUBER, J., WELLER, M., SCHOPPMEYER, K. & RIEDERER, P. (1994). Amantadine and memantine are NMDA receptor antagonists. J. Neural. Transm. - Gen. Sect., 43, 91-104.
39. MACDONALD, J.F. & NOWAK, L.M. (1990). Mechanisms of blockade of excitatory amino acid receptor channels. Trends Pharmacol. Sci., 11, 167-172.
40. 2+ of NMDA responses in spinal cord neurons. Nature, 309, 261-263.
41. MISZTAL, M., FILIPKOWSKI, R.K., KACZMAREK, L., SKANGIEL-KRAMSKA, J. & DANYSZ, W. (1994). Learning impairment induced by chronic intraventricular infusion of quinolinic acid -a model of progressive excitotoxicity. Behav. Pharmacol., 5, (suppl 1.) 55.
42. MISZTAL, M., FRANKIEWICZ, T., PARSONS, C.G. & DANYSZ, W. (1995). Learning deficit induced by chronic intraventricular infusion of quinolinic acid - protection by MK-801 and memantine. Eur. J. Pharmacol. (in press).
43. MITANI, A., ANDOU, Y. & KATAOKA, K. (1992). Selective vulnerability of hippocampal area CA1 neurons cannot be explained in terms of an increase in glutamate concentration during ischemia in the gerbil: Brain microdialysis study. Neuroscience, 48, 307-313.
44. MORRIS, R.G.M., ANDERSON, E., LYNCH, G.S. & BAUDRY, M. (1986). Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature, 319, 774-776.
45. NOWAK, L., BREGESTOVSKI, P., ASCHER, P., HERBERT, A. & PROCHIANTZ, A. (1984). Magnesium gates glutamate-activated channels in mouse central neurons. Nature, 307, 462-465.
46. PANTEV, M., RITTER, R. & GÖRTELMEYER, R. (1993). Clinical and behavioural evaluation in long-term care patients with mild to moderate dementia under Memantine treatment. Zeitschr. Gerontol. Psychiat., 6, 103-117.
47. PARSONS, C.G., GRUNER, R., ROZENTAL, J., MILLAR, J. & LODGE, D. (1993). Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan). Neuropharmacol., 32, 1337-1350.
48. PARSONS, C.G., KRISHTAL, O.A. & MISGELD, U. (1994). Comparative studies on NMDA receptor antagonism by amantadine (1-amino-adamantane) and memantine (l-amino-3,5-dimethyl-adamantane). Soc. Neurosci. Abs., 20, 1144.
49. PARSONS, C.G., PANCHENKO, V.A., PINCHENKO, V.O., TSYNDRENKO, A.Y. & KRISHTAL, O.A. (1995a). Comparative patch clamp studies with freshly dissociated rat hippocampal and striatal neurones on the NMDA receptor antagonistic effects of amantadine and memantine. Eur. J. Neurosci., (in press).
50. PARSONS, C.G., QUACK, G., BRESINK, I., BARAN, L., PRZEGALINSKI, E., KOSTOWSKI, W., KRZASCIK, P., HARTMANN, S. & DANYSZ, W. (1995b). Comparison of the potency, kinetics and voltage-dependency of open channel blockade for a series of uncompetitive NMDA antagonists in vitro with anticonvulsive and motor impairment activity in vivo. Neuropharmacol., 34, 1239-1258.
51. PONGRACZ, F., POOLOS, N.P., KOCSIS, J.D. & SHEPHERD, G.M. (1992). A model of NMDA receptor-mediated activity in dendrites of hippocampal area CA1 pyramidal neurons. J. Neurophysiol., 68, 2248-2259.
52. ROSENMUND, C., CLEMENTS, J.D. & WESTBROOK, G.L. (1993). Nonuniform probability of glutamate release at a hippocampal synapse. Science, 262, 754-757.
53. SCHNEIDER, E., FISCHER, P.A., CLEMENS, R., BALZEREIT, F., FÜFGELD, E.W. & HAASE, H.J. (1984). Effects of oral memantine on symptoms of Parkinson's disease. Dtsch. Medizin. Wochenzt. Schr., 109, 987-990.
54. STIEG, P.E., SATHI, S., ALVARADO, S.P., JACKSON, P.S., PELLIGRINI, J.W., CHEN, H.-S.V., LIPTON, S.A. & JENSEN, F.E. (1993). Post-stroke neuroprotection by memantine minimally affects behaviour and does not block LTP. Neurosci. Abs., 19, 1503.
55. WENK, G.L., DANYSZ, W. & MOBLEY, S.L. (1994). Investigations of neurotoxicity and neuroprotection within the nucleus basalis of the rat. Brain Res., 655, 7-11.
56. WENK, G.L., DANYSZ, W. & MOBLEY, S.L. (1995). MK-801, memantine and amantadine show neuroprotective activity against NMDA toxicity in the nucleus basalis - a dose response study. Eur. J. Pharmacol. 293, 267-270
57. WESEMANN, W., SONTAG, K.H. & MAJ, J. (1983). On the pharmacodynamics and pharmacokinetics of memantine. Arzneim. Forsch./Drug Res., 33, 1122-1134.
58. WONG, E.H.F., KEMP, J.A., PRIESTLEY, T., KNIGHT, A.R., WOODRUFF, G.N. & IVERSEN, L.L. (1986). The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc. Natl. Acad. Sci. U.S.A., 83, 7104-7108.
59. WOODHILL, A.M. (1973). Ionic blockage of sodium channels in nerve. J. Gen. Physiol., 61, 687-708.
60. ZAJACZKOWSKI, W., QUACK, G. & DANYSZ, W. (1995). Infusion of (+)-MK-801 and memantine -contrasting effects on radial maze learning in rats with entorhinal cortex lesion. Eur. J. Pharmacol., (in press).