Stromal genes discriminate preinvasive from invasivedisease, predict outcome, and highlight inflammatory pathways in digestive cancers

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 5, 2010, Pages 2177-2182

  Saadi, Amel ^a   Shannon, Nicholas B ^a   Lao Sirieix, Pierre ^a   O'Donovan, Maria ^a,b   Walker, Elaine ^a   Clemons, Nicholas J ^a   Hardwick, James S ^c   Zhang, Chunsheng ^c   Das, Madhumita ^a   Save, Vicki ^b   Novelli, Marco ^d   Balkwill, Frances ^e   Fitzgerald, Rebecca C ^a  

^a HUTCHISON MRC RESEARCH CENTRE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c MERCK RESEARCH LABORATORIES   (United States)

^d ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Barrett's esophagus; Gene set enrichment; Inflammation; Intraepithelial neoplasia; Microarray

Indexed keywords

CYTOKINE RECEPTOR; PROTEIN BCL 6; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BARRETT ESOPHAGUS; CANCER GROWTH; CANCER STAGING; CLINICAL ARTICLE; CONTROLLED STUDY; DYSPLASIA; ESOPHAGEAL ADENOCARCINOMA; GASTROINTESTINAL TUMOR; GENE; GENE IDENTIFICATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; JMY GENE; MICRODISSECTION; PRIORITY JOURNAL; PROGNOSIS; STROMA; TMEPAI GENE; UPREGULATION;

ADENOCARCINOMA; BARRETT ESOPHAGUS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CYTOKINES; DIGESTIVE SYSTEM NEOPLASMS; DNA-BINDING PROTEINS; ESOPHAGEAL NEOPLASMS; GELATINASES; HUMANS; INFLAMMATION; MEMBRANE PROTEINS; METAPLASIA; NEOPLASM INVASIVENESS; NUCLEAR PROTEINS; ONCOGENES; PRECANCEROUS CONDITIONS; PROGNOSIS; RECEPTORS, CYTOKINE; SERINE ENDOPEPTIDASES; STROMAL CELLS; TRANS-ACTIVATORS;

EID: 76649134465     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0909797107     Document Type: Article

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