Very low level of major BCR-ABL expression in blood of some healthy individuals

Bone Marrow Transplantation

Volumn 17, Issue SUPPL. 3, 1996, Pages

  Biernaux, C ^a   Sels, A ^a   Huez, G ^a   Stryckmans, P ^b  

^a Laboratory of Biological Chemistry   (Belgium)

^b JULES BORDET INSTITUTE   (Belgium)

Author keywords

CML; Healthy individuals; M bcr abl; RT PCR

Indexed keywords

BCR ABL PROTEIN;

BLOOD; BLOOD CELL; CONFERENCE PAPER; HUMAN; HUMAN CELL; LEUKOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL CORD BLOOD;

EID: 0029954751     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (9)

1. Maurer J, Janssen JWG, Thiel E et al. Detection of chimeric BCR-ABL genes in acute lymphoblastic leukemia by polymerase chain reaction. Lancet 1991; 337: 1055.
2. Kantarjian HM, Deisseroth A, Kurzrock R, Estrov Z, Talpaz M. Chronic myelogenous leukemia: a concise update. Blood 1993; 82: 691-703.
3. Lee M, Khouri I, Champlin R et at. Detection of minimal residual disease by polymerase chain reaction of bcr-abl transcripts in chronic myelogenous leukaemia following allogeneic bone marrow transplantation. Br J Haematol 1992; 82: 708.
4. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ. Isolation of biological active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 1979; 18: 5294.
5. Cross NCP, Melo JV, Feng L, Goldman JM. An optimized multiplex polymerase chain reaction (PCR) for detection of bcr-abl fusion mRNAs in haematological disorders. Leukemia 1994; 8: 186.
6. Brernaux C, Loos M, Sels A, Huez G, Stryckmans P. Detection of major BCR-ABL gene expression at a very low level in blood cells of some healthy individuals. Blood 1995; 86: 3118-3122.
7. Gaiger A, Lion T, Kalhs P et al. Frequent detection of bcr-abl specific mRNA in patients with chronic myeloid leukemia (CML) following allogeneic and syngeneic bone marrow transplantation (BMT). Leukemia 1993; 7: 1766.
8. Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia by the P210 bcr/abl gene of the Philadelphia chromosome. Science 1990; 247: 824.
9. Liu Y, Hernandez AM, Shibata D, Cortopassi G. Bcl2 translocation frequency rises with age in humans. Proc Natl Acad Sci USA 1994; 91: 8910.