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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 6, 2011, Pages 1736-1740

Discovery of novel mGluR1 antagonists: A multistep virtual screening approach based on an SVM model and a pharmacophore hypothesis significantly increases the hit rate and enrichment factor

(8) Li, Guo Bo a,b Yang, Ling Ling a,b Feng, Shan a Zhou, Jian Ping a Huang, Qi a Xie, Huan Zhang a,b Li, Lin Li a Yang, Sheng Yong a

a SICHUAN UNIVERSITY (China)

b SICHUAN UNIVERSITY (China)

Author keywords

A multistep virtual screening approach; mGluR1 antagonist; Pharmacophore; Support vector machine

Indexed keywords

METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR ANTAGONIST;

ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; IC 50; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; PHARMACOPHORE; PREDICTION; SUPPORT VECTOR MACHINE; VIRTUAL REALITY;

DRUG DISCOVERY; MODELS, CHEMICAL; MODELS, MOLECULAR; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 79952363629 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2011.01.087 Document Type: Article

Times cited : (19)

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