Pharmacophore modeling study based on known Spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 7, 2009, Pages 1944-1949

  Xie, Huan Zhang ^a   Li, Lin Li ^a   Ren, Ji Xia ^a   Zou, Jun ^a   Yang, Li ^a   Wei, Yu Quan ^a   Yang, Sheng Yong ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Kinase inhibitor; Pharmacophore model; Spleen tyrosine kinase (Syk); Virtual screening

Indexed keywords

AK 968; AK 968 1209687; AK 968 15361771; PROTEIN KINASE SYK; PROTEIN KINASE SYK INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DATA BASE; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROGEN BOND; IC 50; IN VITRO STUDY; MOLECULAR MODEL; PHARMACOPHORE; QUANTITATIVE ANALYSIS;

COMPUTER SIMULATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; SMALL MOLECULE LIBRARIES; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 61849149464     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.049     Document Type: Article

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