An integrated scheme for feature selection and parameter setting in the support vector machine modeling and its application to the prediction of pharmacokinetic properties of drugs

Artificial Intelligence in Medicine

Volumn 46, Issue 2, 2009, Pages 155-163

  Yang, Sheng Yong ^a   Huang, Qi ^a   Li, Lin Li ^b   Ma, Chang Ying ^a   Zhang, Hui ^a   Bai, Ru ^a   Teng, Qi Zhi ^a   Xiang, Ming Li ^a   Wei, Yu Quan ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Conjugate gradient; Genetic algorithm; Pharmacokinetic and pharmacodynamic property of drug; Support vector machine

Indexed keywords

ADMET PROPERTIES; BLOOD-BRAIN BARRIERS; CLASSIFICATION MODELS; CONJUGATE GRADIENT; FEATURE SELECTIONS; FEATURE SUBSETS; HUMAN INTESTINAL ABSORPTIONS; INPUT FEATURES; P GLYCOPROTEINS; PARAMETER OPTIMIZATIONS; PARAMETER SETTINGS; PHARMACOKINETIC PROPERTIES; PREDICTION ACCURACIES; PREDICTIVE MODELS; STATISTICAL LEARNING METHODS; SVM CLASSIFICATIONS;

ABSORPTION; BIOCHEMISTRY; CONJUGATE GRADIENT METHOD; EDUCATION; GENETIC ALGORITHMS; GLYCOPROTEINS; IMAGE RETRIEVAL; PHARMACOKINETICS; PHYSIOLOGY; STRUCTURAL OPTIMIZATION; VECTORS;

SUPPORT VECTOR MACHINES;

GLYCOPROTEIN P;

ARTICLE; BLOOD BRAIN BARRIER; CONJUGATE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG PENETRATION; DRUG TOXICITY; GENETIC ALGORITHM; INTESTINE ABSORPTION; PHARMACOKINETICS; PRIORITY JOURNAL; PROTEIN DETERMINATION; SUPPORT VECTOR MACHINE; TORSADE DES POINTES;

ALGORITHMS; BLOOD-BRAIN BARRIER; HUMANS; INTESTINAL ABSORPTION; MODELS, THEORETICAL; PHARMACOKINETICS; TORSADES DE POINTES;

EID: 67349139293     PISSN: 09333657     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.artmed.2008.07.001     Document Type: Article

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