Meta-analysis of the effect of HHEX gene polymorphism on the risk of type 2 diabetes

Mutagenesis

Volumn 26, Issue 2, 2011, Pages 309-314

  Cai, Yu ^a   Yi, Jiayong ^a   Ma, Yushui ^a   Fu, Da ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HEMATOPOIETICALLY EXPRESSED HOMEOBOX PROTEIN; HOMEODOMAIN PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; ASIAN; CAUCASIAN; DISEASE ASSOCIATION; ETHNICITY; GENETIC HETEROGENEITY; GENETIC POLYMORPHISM; HAPLOTYPE; HETEROZYGOSITY; HUMAN; META ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; CONTINENTAL POPULATION GROUPS; DIABETES MELLITUS, TYPE 2; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMEODOMAIN PROTEINS; HUMANS; POLYMORPHISM, GENETIC; RISK FACTORS; TRANSCRIPTION FACTORS;

EID: 79952309502     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/geq095     Document Type: Article

References (47)

1. Stumvoll, M., Goldstein, B. J. and Van Haeften, T. W. (2005) Type 2 diabetes principles of pathogenesis and therapy. Lancet, 365, 1333-1346.
2. Wild, S., Roglic, G., Green, A., Sicree, R. and King, H. (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care, 27, 1047-1053. (Pubitemid 38579764)
3. Altshuler, D., Hirschhorn, J. N., Klannemark, M. et al. (2000) The common PPAR gamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat. Genet., 26, 76-80.
4. Gloyn, A. L., Weedon, M. N., Owen, K. R. et al. (2003) Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes, 52, 568-572. (Pubitemid 36173218)
5. Grant, S. F., Thorleifsson, G., Reynisdottir, I. et al. (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat. Genet., 38, 320-323.
6. Saxena, R., Voight, B. F., Lyssenko, V. et al. (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science, 316, 1331-1336. (Pubitemid 46871653)
7. Frayling, T. M., Timpson, N. J., Weedon, M. N. et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316, 889-894. (Pubitemid 46764279)
8. Sandhu, M. S., Weedon, M. N., Fawcett, K. A. et al. (2007) Common variants in WFS1 confer risk of type 2 diabetes. Nat. Genet., 39, 951-953.
9. Scott, L. J., Mohlke, K. L., Bonnycastle, L. L. et al. (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science, 316, 1341-1345. (Pubitemid 46871655)
10. Sladek, R., Rocheleau, G., Rung, J. et al. (2007) A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature, 445, 881-885.
11. Bort, R., Martinez-Barbera, J. P., Beddington, R. S. and Zaret, K. S. (2004) Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development, 131, 797-806. (Pubitemid 38263195)
12. Hunter, M. P., Wilson, C. M., Jiang, X. et al. (2007) The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis. Dev. Biol., 308, 355-367.
13. Staiger, H., Stancáková, A., Zilinskaite, J. et al. (2008) A candidate type2 diabetes polymorphism near the HHEX locus affects acute glucosestimulated insulin release in European populations: results from the EUGENE2 study. Diabetes, 57, 514-517.
14. Pascoe, L., Tura, A., Patel, S. K. et al. (2007) Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes, 56, 3101-3104. (Pubitemid 350223648)
15. Rudovich, N. N., Rochlitz, H. J. and Pfeiffer, A. F. H. P. (2007) Reduced hepatic insulin extraction in response to gastric inhibitory polypeptide compensates for reduced insulin secretion in normal-weight and normal glucose tolerant first-degree relatives of type 2 diabetic patients. Diabetes, 53, 2359-2365.
16. Higgins, J. P., Thompson, S. G., Deeks, J. J. and Altman, D. G. (2003) Measuring inconsistency in meta-analyses. BMJ, 327, 557-560.
17. DerSimonian, R. and Laird, N. (1986) Meta-analysis in clinical trials. Control. Clin. Trials, 7, 177-188.
18. Mantel, N. and Haenszel, W. (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl Cancer Inst., 22, 719-748.
19. Woolf, B. (1955) On estimating the relation between blood group and disease. Ann. Hum. Genet., 19, 251-253.
20. Egger, M., Davey Smith, G., Schneider, M. and Minder, C. (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-634. (Pubitemid 27387172)
21. Begg, C. B. and Mazumdar, M. (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-1101.
22. Hedrick, P. W. (1987) Gametic disequilibrium measures: proceed with caution. Genetics, 117, 331-341.
23. Gabriel, S. B., Schaffner, S. F., Nguyen, H. et al. (2002) The structure of haplotype blocks in the human genome. Science, 296, 2225-2229. (Pubitemid 34680308)
24. Tan, J. T., Ng, D. P., Nurbaya, S. et al. (2010) Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore. J. Clin. Endocrinol. Metab., 95, 390-397.
25. Hu, C., Zhang, R., Wang, C. et al. (2009) PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. PLoS One, 4, e7643.
26. Pivovarova, O., Nikiforova, V. J., Pfeiffer, A. F. and Rudovich, N. (2009) The influence of genetic variations in HHEX gene on insulin metabolism in the German MESYBEPO cohort. Diabetes Metab. Res. Rev., 25, 156-162.
27. Tabara, Y., Osawa, H., Kawamoto, R., Onuma, H., Shimizu, I., Miki, T., Kohara, K. and Makino, H. (2009) Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening. Diabetes, 58, 493-498.
28. Lyssenko, V., Jonsson, A., Almgren, P. et al. (2008) Clinical risk factors, DNA variants, and the development of type 2 diabetes. N. Engl. J. Med., 359, 2220-2232.
29. Rong, R., Hanson, R. L., Ortiz, D., Wiedrich, C., Kobes, S., Knowler, W. C., Bogardus, C. and Baier, L. J. (2009) Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. Diabetes, 58, 478-488.
30. Lee, Y. H., Kang, E. S., Kim, S. H. et al. (2008) Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population. J. Hum. Genet., 53, 991-998.
31. Wu, Y., Li, H., Loos, R. J., Yu, Z., Ye, X., Chen, L., Pan, A., Hu, F. B. and Lin, X. (2008) Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes, 57, 2834-2842.
32. Sanghera, D. K., Ortega, L., Han, S. et al. (2008) Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med. Genet., 9, 59.
33. Horikawa, Y., Miyake, K., Yasuda, K. et al. (2008) Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. J. Clin. Endocrinol. Metab., 93, 3136-41.
34. Ng, M. C., Park, K. S., Oh, B. et al. (2008) Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes, 57, 2226-2233.
35. Lewis, J. P., Palmer, N. D., Hicks, P. J., Sale, M. M., Langefeld, C. D., Freedman, B. I., Divers, J. and Bowden, D. W. (2008) Association analysis in African Americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes, 57, 2220-2225.
36. Hertel, J. K., Johansson, S., Raeder, H., Midthjell, K., Lyssenko, V., Groop, L., Molven, A. and Njølstad, P. R. (2008) Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study). Diabetologia, 51, 971-977.
37. Ezzidi, I., Mtiraoui, N., Cauchi, S. et al. (2009) Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study. BMC Med. Genet., 10, 33.
38. Takeuchi, F., Serizawa, M., Yamamoto, K. et al. (2009) Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Diabetes, 58, 1690-9.
39. van Vliet-Ostaptchouk, J. V., Onland-Moret, N. C., van Haeften, T. W., Franke, L., Elbers, C. C., Shiri-Sverdlov, R., van der Schouw, Y. T., Hofker, M. H. and Wijmenga, C. (2008) HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort. Eur. J. Hum. Genet., 16, 652-656.
40. Furukawa, Y., Shimada, T., Furuta, H. et al. (2008) Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population. J. Clin. Endocrinol. Metab., 93, 310-314.
41. Horikoshi, M., Hara, K., Ito, C., Shojima, N., Nagai, R., Ueki, K., Froguel, P. and Kadowaki, T. (2007) Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia, 50, 2461-2466. (Pubitemid 350060646)
42. Zeggini, E., Weedon, M. N., Lindgren, C. M. et al. (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science, 316, 1336-1341. (Pubitemid 46871654)
43. Schulze, M. B., Al-Hasani, H., Boeing, H., Fisher, E., Döring, F. and Joost, H. G. (2007) Variation in the HHEX-IDE gene region predisposes to type 2 diabetes in the prospective, population-based EPIC-Potsdam cohort. Diabetologia, 50, 2405-2407. (Pubitemid 47512391)
44. Grarup, N., Rose, C. S., Andersson, E. A. et al. (2007) Studies of association of variants near the HHEX, CDKN2A/B and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects validation and extension of genome-wide association studies. Diabetes, 56, 3105-3111. (Pubitemid 350223649)
45. Tanaka, H., Yamamoto, T., Ban, T. et al. (2005) Hex stimulates the hepatocyte nuclear factor 1α-mediated activation of transcription. Arch. Biochem. Biophys., 442, 117-124.
46. Hattersly, A. T., Freathy, R. M., Bennett, A. J. et al. (2008) Direct evidence to support the fetal insulin hypothesis as the type 2 diabetes risk alleles at the CDKAL1 and HHEX-IDE gene loci reduce birth weight. Diabetologia, 51(Suppl. 1), 127.
47. Baier, L. J. and Hanson, R. L. (2004) Genetic studies of the etiology of type 2 diabetes in Pima Indians: hunting for pieces to a complicated puzzle. Diabetes, 53, 1181-1186.