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Volumn 25, Issue 2, 2009, Pages 156-162

The influence of genetic variations in HHEX gene on insulin metabolism in the German MESYBEPO cohort

Author keywords

Genetic association; Hematopoietically expressed homeobox protein gene; Insulin metabolism; Type 2 diabetes mellitus

Indexed keywords

C PEPTIDE; GLUCOSE; HEMATOPOIETICALLY EXPRESSED HOMEOBOX PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMEODOMAIN PROTEIN; INSULIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; HHEX PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

EID: 65549157361     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.926     Document Type: Article
Times cited : (25)

References (17)
  • 1
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007; 445(7130): 881-885.
    • (2007) Nature , vol.445 , Issue.7130 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3
  • 2
    • 35848945259 scopus 로고    scopus 로고
    • Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population
    • HorikoshiM, Hara K, Ito C, et al. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia 2007; 50(12): 2461-2466.
    • (2007) Diabetologia , vol.50 , Issue.12 , pp. 2461-2466
    • Horikoshi, M.1    Hara, K.2    Ito, C.3
  • 3
    • 40749087319 scopus 로고    scopus 로고
    • A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: Results from the EUGENE2 study
    • Staiger H, Stancáková A, Zilinskaite J, et al. A candidate type 2 diabetes polymorphism near the HHEX locus affects acute glucose-stimulated insulin release in European populations: results from the EUGENE2 study. Diabetes 2008; 57(2): 514-517.
    • (2008) Diabetes , vol.57 , Issue.2 , pp. 514-517
    • Staiger, H.1    Stancáková, A.2    Zilinskaite, J.3
  • 4
    • 35449001954 scopus 로고    scopus 로고
    • Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function
    • Pascoe L, Tura A, Patel SK, et al. Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes 2007; 56(12): 3101-3104.
    • (2007) Diabetes , vol.56 , Issue.12 , pp. 3101-3104
    • Pascoe, L.1    Tura, A.2    Patel, S.K.3
  • 5
    • 1342263517 scopus 로고    scopus 로고
    • Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas
    • Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS. Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development 2004; 131(4): 797-806.
    • (2004) Development , vol.131 , Issue.4 , pp. 797-806
    • Bort, R.1    Martinez-Barbera, J.P.2    Beddington, R.S.3    Zaret, K.S.4
  • 6
    • 34547667392 scopus 로고    scopus 로고
    • The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis
    • Hunter MP,Wilson CM, Jiang X, et al. The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis. Dev Biol 2007; 308(2): 355-367.
    • (2007) Dev Biol , vol.308 , Issue.2 , pp. 355-367
    • Hunter, M.P.1    Wilson, C.M.2    Jiang, X.3
  • 7
    • 4344587540 scopus 로고    scopus 로고
    • Reduced hepatic insulin extraction in response to gastric inhibitory polypeptide compensates for reduced insulin secretion in normal-weight and normal glucose tolerant first-degree relatives of type 2 diabetic patients
    • Rudovich NN, Rochlitz HJ, Pfeiffer AFHP. Reduced hepatic insulin extraction in response to gastric inhibitory polypeptide compensates for reduced insulin secretion in normal-weight and normal glucose tolerant first-degree relatives of type 2 diabetic patients. Diabetes 2007; 53(9): 2359-2365.
    • (2007) Diabetes , vol.53 , Issue.9 , pp. 2359-2365
    • Rudovich, N.N.1    Rochlitz, H.J.2    Pfeiffer, A.F.H.P.3
  • 8
    • 0034049630 scopus 로고    scopus 로고
    • Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity
    • Stumvoll M, Mitrakou A, Pimenta W, et al. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 2000; 23(3): 295-301.
    • (2000) Diabetes Care , vol.23 , Issue.3 , pp. 295-301
    • Stumvoll, M.1    Mitrakou, A.2    Pimenta, W.3
  • 9
    • 12244264435 scopus 로고    scopus 로고
    • Genetic Power Calculator: Design of linkage and association genetic mapping studies of complex traits
    • Purcell S, Cherny SS, Sham PC. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003; 19(1): 149-150.
    • (2003) Bioinformatics , vol.19 , Issue.1 , pp. 149-150
    • Purcell, S.1    Cherny, S.S.2    Sham, P.C.3
  • 10
    • 34249895023 scopus 로고    scopus 로고
    • Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    • Zeggini E, Weedon MN, Lindgren CM, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007; 316(5829): 1336-1341.
    • (2007) Science , vol.316 , Issue.5829 , pp. 1336-1341
    • Zeggini, E.1    Weedon, M.N.2    Lindgren, C.M.3
  • 11
    • 36849011549 scopus 로고    scopus 로고
    • Studies of association of variants near the HHEX, CDKN2A/B and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects validation and extension of genome-wide association studies
    • Grarup N, Rose CS, Andersson EA, et al. Studies of association of variants near the HHEX, CDKN2A/B and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects validation and extension of genome-wide association studies. Diabetes 2007; 56(12): 3105-3111.
    • (2007) Diabetes , vol.56 , Issue.12 , pp. 3105-3111
    • Grarup, N.1    Rose, C.S.2    Andersson, E.A.3
  • 12
    • 24944482530 scopus 로고    scopus 로고
    • Hex stimulates the hepatocyte nuclear factor 1α-mediated activation of transcription
    • Tanaka H, Yamamoto T, Ban T, et al. Hex stimulates the hepatocyte nuclear factor 1α-mediated activation of transcription. Arch Biochem Biophys 2005; 442(1): 117-124.
    • (2005) Arch Biochem Biophys , vol.442 , Issue.1 , pp. 117-124
    • Tanaka, H.1    Yamamoto, T.2    Ban, T.3
  • 13
    • 66249121882 scopus 로고    scopus 로고
    • Direct evidence to support the fetal insulin hypothesis as the type 2 diabetes risk alleles at the CDKAL1 and HHEX-IDE gene loci reduce birth weight
    • Hattersly AT, Freathy RM, Bennett AJ, et al. Direct evidence to support the fetal insulin hypothesis as the type 2 diabetes risk alleles at the CDKAL1 and HHEX-IDE gene loci reduce birth weight. Diabetologia 2008; 51(Suppl. 1): 127.
    • (2008) Diabetologia , vol.51 , Issue.SUPPL. 1 , pp. 127
    • Hattersly, A.T.1    Freathy, R.M.2    Bennett, A.J.3
  • 14
    • 34547670061 scopus 로고    scopus 로고
    • Mutations in HHEX are not a common cause of monogenic forms of beta cell dysfunction
    • Minton LA, van de Bunt M, Boustred C, et al. Mutations in HHEX are not a common cause of monogenic forms of beta cell dysfunction. Diabetologia 2007; 50(7): 2019-2022.
    • (2007) Diabetologia , vol.50 , Issue.7 , pp. 2019-2022
    • Minton, L.A.1    van de Bunt, M.2    Boustred, C.3
  • 15
    • 0020539930 scopus 로고
    • Decreased hepatic insulin extraction in subjects with mild glucose intolerance
    • Bonora E, Zavaroni I, Coscelli C, Butturini U. Decreased hepatic insulin extraction in subjects with mild glucose intolerance. Metabolism 1983; 32(5): 438-446.
    • (1983) Metabolism , vol.32 , Issue.5 , pp. 438-446
    • Bonora, E.1    Zavaroni, I.2    Coscelli, C.3    Butturini, U.4
  • 16
    • 0024355499 scopus 로고
    • Defects in insulin-receptor internalization and processing in monocytes of obese subjects and obese NIDDM patients
    • Trischitta V, Brunetti A, Chiavetta A, Benzi L, Papa V, Vigneri R. Defects in insulin-receptor internalization and processing in monocytes of obese subjects and obese NIDDM patients. Diabetes 1989; 38(12): 1579-1584.
    • (1989) Diabetes , vol.38 , Issue.12 , pp. 1579-1584
    • Trischitta, V.1    Brunetti, A.2    Chiavetta, A.3    Benzi, L.4    Papa, V.5    Vigneri, R.6
  • 17
    • 0036787386 scopus 로고    scopus 로고
    • Hyperinsulinemia in African-American children: Decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity
    • Arslanian SA, Saad R, Lewy V, Danadian K, Janosky J. Hyperinsulinemia in African-American children: decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity. Diabetes 2002; 51(10): 3014-3019.
    • (2002) Diabetes , vol.51 , Issue.10 , pp. 3014-3019
    • Arslanian, S.A.1    Saad, R.2    Lewy, V.3    Danadian, K.4    Janosky, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.