-
1
-
-
0141532262
-
Toll-like receptor signaling
-
Akira, S. (2003) Toll-like receptor signaling. J. Biol. Chem. 278, 38105-38108
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 38105-38108
-
-
Akira, S.1
-
2
-
-
0037313578
-
Interleukin-12 and the regulation of innate resistance and adaptive immunity
-
Trinchieri, G. (2003) Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3, 133-146
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 133-146
-
-
Trinchieri, G.1
-
3
-
-
0028970060
-
Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
-
Trinchieri, G. (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13, 251-276
-
(1995)
Annu. Rev. Immunol.
, vol.13
, pp. 251-276
-
-
Trinchieri, G.1
-
4
-
-
0035089760
-
Regulation of interleukin-12 production by G-protein-coupled receptors
-
DOI 10.1016/S1286-4579(00)01357-5
-
Braun, M.C. and Kelsall, B.L. (2001) Regulation of interleukin-12 production by G-protein-coupled receptors. Microbes Infect. 3, 99-107 (Pubitemid 32209327)
-
(2001)
Microbes and Infection
, vol.3
, Issue.2
, pp. 99-107
-
-
Braun, M.C.1
Kelsall, B.L.2
-
5
-
-
0027521572
-
Interleukin-10-deficient mice develop chronic enterocolitis
-
DOI 10.1016/0092-8674(93)80068-P
-
Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K., and Muller, W. (1993) Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75, 263-274 (Pubitemid 23320290)
-
(1993)
Cell
, vol.75
, Issue.2
, pp. 263-274
-
-
Kuhn, R.1
Lohler, J.2
Rennick, D.3
Rajewsky, K.4
Muller, W.5
-
6
-
-
0033152662
-
C5a suppresses the production of IL-12 by IFN-γ-primed and lipopolysaccharide-challenged human monocytes
-
Wittmann, M., Zwirner, J., Larsson, V.A., Kirchhoff, K., Begemann, G., Kapp, A., Gotze, O., and Werfel, T. (1999) C5a suppresses the production of IL-12 by IFN-γ-primed and lipopolysaccharide-challenged human monocytes. J. Immunol. 162, 6763-6769 (Pubitemid 29309403)
-
(1999)
Journal of Immunology
, vol.162
, Issue.11
, pp. 6763-6769
-
-
Wittmann, M.1
Zwirner, J.2
Larsson, V.-A.3
Kirchhoff, K.4
Begemann, G.5
Kapp, A.6
Gotze, O.7
Werfel, T.8
-
7
-
-
0034653895
-
Selective suppression of IL-12 production by chemoattractants
-
Braun, M.C., Lahey, E., and Kelsall, B.L. (2000) Selective suppression of IL-12 production by chemoattractants. J. Immunol. 164, 3009-3017 (Pubitemid 30148960)
-
(2000)
Journal of Immunology
, vol.164
, Issue.6
, pp. 3009-3017
-
-
Braun, M.C.1
Lahey, E.2
Kelsall, B.L.3
-
8
-
-
17444403917
-
C5a negatively regulates toll-like receptor 4-induced immune responses
-
DOI 10.1016/j.immuni.2005.02.006
-
Hawlisch, H., Belkaid, Y., Baelder, R., Hildeman, D., Gerard, C., and Kohl, J. (2005) C5a negatively regulates toll-like receptor 4-induced immune responses. Immunity 22, 415-426 (Pubitemid 40545108)
-
(2005)
Immunity
, vol.22
, Issue.4
, pp. 415-426
-
-
Hawlisch, H.1
Belkaid, Y.2
Baelder, R.3
Hildeman, D.4
Gerard, C.5
Kohl, J.6
-
9
-
-
23844434887
-
G(i)-protein-dependent inhibition of IL-12 production is mediated by activation of the phosphatidylinositol 3-kinase-protein 3 kinase B/Akt pathway and JNK
-
la Sala, A., Gadina, M., and Kelsall, B.L. (2005) G(i)-protein-dependent inhibition of IL-12 production is mediated by activation of the phosphatidylinositol 3-kinase-protein 3 kinase B/Akt pathway and JNK. J. Immunol. 175, 2994-2999
-
(2005)
J. Immunol.
, vol.175
, pp. 2994-2999
-
-
La Sala, A.1
Gadina, M.2
Kelsall, B.L.3
-
10
-
-
0036707521
-
PI3K-mediated negative feedback regulation of IL-12 production in DCs
-
Fukao, T., Tanabe, M., Terauchi, Y., Ota, T., Matsuda, S., Asano, T., Kadowaki, T., Takeuchi, T., and Koyasu, S. (2002) PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat. Immunol. 3, 875-881
-
(2002)
Nat. Immunol.
, vol.3
, pp. 875-881
-
-
Fukao, T.1
Tanabe, M.2
Terauchi, Y.3
Ota, T.4
Matsuda, S.5
Asano, T.6
Kadowaki, T.7
Takeuchi, T.8
Koyasu, S.9
-
11
-
-
0035865058
-
Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by toll-like receptor 2: Role of N-terminal hydrophobic portion in its multiple functions
-
Nishiguchi, M., Matsumoto, M., Takao, T., Hoshino, M., Shimonishi, Y., Tsuji, S., Begum, N.A., Takeuchi, O., Akira, S., Toyoshima, K., and Seya, T. (2001) Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by Toll-like receptor 2: role of N-terminal hydrophobic portion in its multiple functions. J. Immunol. 166, 2610-2616 (Pubitemid 32173499)
-
(2001)
Journal of Immunology
, vol.166
, Issue.4
, pp. 2610-2616
-
-
Nishiguchi, M.1
Matsumoto, M.2
Takao, T.3
Hoshino, M.4
Shimonishi, Y.5
Tsuji, S.6
Begum, N.A.7
Takeuchi, O.8
Akira, S.9
Toyoshima, K.10
Seya, T.11
-
12
-
-
0034635264
-
Function of PI3Kg in thymocyte development, T cell activation, and neutrophil migration
-
Sasaki, T., Irie-Sasaki, J., Jones, R.G., Oliveira-dos-Santos, A.J., Stanford, W.L., Bolon, B., Wakeham, A., Itie, A., Bouchard, D., Kozieradzki, I., Joza, N., Mak, T.W., Ohashi, P.S., Suzuki, A., and Penninger, J.M. (2000) Function of PI3Kg in thymocyte development, T cell activation, and neutrophil migration. Science 287, 1040-1046
-
(2000)
Science
, vol.287
, pp. 1040-1046
-
-
Sasaki, T.1
Irie-Sasaki, J.2
Jones, R.G.3
Oliveira-dos-Santos, A.J.4
Stanford, W.L.5
Bolon, B.6
Wakeham, A.7
Itie, A.8
Bouchard, D.9
Kozieradzki, I.10
Joza, N.11
Mak, T.W.12
Ohashi, P.S.13
Suzuki, A.14
Penninger, J.M.15
-
13
-
-
0032909703
-
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85a subunit of phosphoinositide 3-kinase
-
Terauchi, Y., Tsuji, Y., Satoh, S., Minoura, H., Murakami, K., Okuno, A., Inukai, K., Asano, T., Kaburagi, Y., Ueki, K., Nakajima, H., Hanafusa, T., Matsuzawa, Y., Sekihara, H., Yin, Y., Barrett, J.C., Oda, H., Ishikawa, T., Akanuma, Y., Komuro, I., Suzuki, M., Yamamura, K., Kodama, T., Suzuki, H., Koyasu, S., Aizawa, S., Tobe, K., Fukui, Y., Yazaki, Y., and Kadowaki, T. (1999) Increased insulin sensitivity and hypoglycaemia in mice lacking the p85a subunit of phosphoinositide 3-kinase. Nat. Genet. 21, 230-235
-
(1999)
Nat. Genet.
, vol.21
, pp. 230-235
-
-
Terauchi, Y.1
Tsuji, Y.2
Satoh, S.3
Minoura, H.4
Murakami, K.5
Okuno, A.6
Inukai, K.7
Asano, T.8
Kaburagi, Y.9
Ueki, K.10
Nakajima, H.11
Hanafusa, T.12
Matsuzawa, Y.13
Sekihara, H.14
Yin, Y.15
Barrett, J.C.16
Oda, H.17
Ishikawa, T.18
Akanuma, Y.19
Komuro, I.20
Suzuki, M.21
Yamamura, K.22
Kodama, T.23
Suzuki, H.24
Koyasu, S.25
Aizawa, S.26
Tobe, K.27
Fukui, Y.28
Yazaki, Y.29
Kadowaki, T.30
more..
-
14
-
-
0033555829
-
Xid-like immunodeficiency in mice with disruption of the p85a subunit of phosphoinositide 3-kinase
-
Suzuki, H., Terauchi, Y., Fujiwara, M., Aizawa, S., Yazaki, Y., Kadowaki, T., and Koyasu, S. (1999) Xid-like immunodeficiency in mice with disruption of the p85a subunit of phosphoinositide 3-kinase. Science 283, 390-392
-
(1999)
Science
, vol.283
, pp. 390-392
-
-
Suzuki, H.1
Terauchi, Y.2
Fujiwara, M.3
Aizawa, S.4
Yazaki, Y.5
Kadowaki, T.6
Koyasu, S.7
-
15
-
-
0034193331
-
Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses
-
He, J., Gurunathan, S., Iwasaki, A., Ash-Shaheed, B., and Kelsall, B.L. (2000) Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responses. J. Exp. Med. 191, 1605-1610
-
(2000)
J. Exp. Med.
, vol.191
, pp. 1605-1610
-
-
He, J.1
Gurunathan, S.2
Iwasaki, A.3
Ash-Shaheed, B.4
Kelsall, B.L.5
-
16
-
-
42149110310
-
Critical roles of the p110b subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells
-
Tsukamoto, K., Hazeki, K., Hoshi, M., Nigorikawa, K., Inoue, N., Sasaki, T., and Hazeki, O. (2008) Critical roles of the p110b subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells. J. Immunol. 180, 2054-2061
-
(2008)
J. Immunol.
, vol.180
, pp. 2054-2061
-
-
Tsukamoto, K.1
Hazeki, K.2
Hoshi, M.3
Nigorikawa, K.4
Inoue, N.5
Sasaki, T.6
Hazeki, O.7
-
17
-
-
34548649547
-
Role of phosphoinositide 3-kinase in innate immunity
-
Hazeki, K., Nigorikawa, K., and Hazeki, O. (2007) Role of phosphoinositide 3-kinase in innate immunity. Biol. Pharm. Bull. 30, 1617-1623
-
(2007)
Biol. Pharm. Bull.
, vol.30
, pp. 1617-1623
-
-
Hazeki, K.1
Nigorikawa, K.2
Hazeki, O.3
-
18
-
-
0029090212
-
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
-
Stoyanov, B., Volinia, S., Hanck, T., Rubio, I., Loubtchenkov, M., Malek, D., Stoyanova, S., Vanhaesebroeck, B., Dhand, R., Nurnberg, B., Gierschik, P., Seedorf, K., Hsuan, J. J., Waterfield, M. D., and Wetzker, R. (1995) Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 269, 690-693
-
(1995)
Science
, vol.269
, pp. 690-693
-
-
Stoyanov, B.1
Volinia, S.2
Hanck, T.3
Rubio, I.4
Loubtchenkov, M.5
Malek, D.6
Stoyanova, S.7
Vanhaesebroeck, B.8
Dhand, R.9
Nurnberg, B.10
Gierschik, P.11
Seedorf, K.12
Hsuan, J.J.13
Waterfield, M.D.14
Wetzker, R.15
-
19
-
-
0030869757
-
Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide
-
Kurosu, H., Maehama, T., Okada, T., Yamamoto, T., Hoshino, S., Fukui, Y., Ui, M., Hazeki, O., and Katada, T. (1997) Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide. J. Biol. Chem. 272, 24252-24256
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24252-24256
-
-
Kurosu, H.1
Maehama, T.2
Okada, T.3
Yamamoto, T.4
Hoshino, S.5
Fukui, Y.6
Ui, M.7
Hazeki, O.8
Katada, T.9
-
20
-
-
0032828890
-
Roles of non-catalytic subunits in Γβγ-induced activation of class I phosphoinositide 3-kinase isoforms β and γ
-
Maier, U., Babich, A., and Nurnberg, B. (1999) Roles of non-catalytic subunits in Γβγ-induced activation of class I phosphoinositide 3-kinase isoforms β and γ. J. Biol. Chem. 274, 29311-29317
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 29311-29317
-
-
Maier, U.1
Babich, A.2
Nurnberg, B.3
-
21
-
-
29644446699
-
Specific role for p85/p110β in GTP-binding-protein-mediated activation of Akt
-
DOI 10.1042/BJ20050671
-
Kubo, H., Hazeki, K., Takasuga, S., and Hazeki, O. (2005) Specific role for p85/p110β in GTP-binding-protein-mediated activation of Akt. Biochem. J. 392, 607-614 (Pubitemid 43022741)
-
(2005)
Biochemical Journal
, vol.392
, Issue.3
, pp. 607-614
-
-
Kubo, H.1
Hazeki, K.2
Takasuga, S.3
Hazeki, O.4
-
22
-
-
46149106818
-
The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ
-
Guillermet-Guibert, J., Bjorklof, K., Salpekar, A., Gonella, C., Ramadani, F., Bilancio, A., Meek, S., Smith, A.J., Okkenhaug, K., and Vanhaesebroeck, B. (2008) The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ. Proc. Natl Acad. Sci. USA 105, 8292-8297
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 8292-8297
-
-
Guillermet-Guibert, J.1
Bjorklof, K.2
Salpekar, A.3
Gonella, C.4
Ramadani, F.5
Bilancio, A.6
Meek, S.7
Smith, A.J.8
Okkenhaug, K.9
Vanhaesebroeck, B.10
-
23
-
-
49649087385
-
Essential roles of PI(3)K-p110b in cell growth, metabolism and tumorigenesis
-
Jia, S., Liu, Z., Zhang, S., Liu, P., Zhang, L., Lee, S. H., Zhang, J., Signoretti, S., Loda, M., Roberts, T.M., and Zhao, J.J. (2008) Essential roles of PI(3)K-p110b in cell growth, metabolism and tumorigenesis. Nature 454, 776-779
-
(2008)
Nature
, vol.454
, pp. 776-779
-
-
Jia, S.1
Liu, Z.2
Zhang, S.3
Liu, P.4
Zhang, L.5
Lee, S.H.6
Zhang, J.7
Signoretti, S.8
Loda, M.9
Roberts, T.M.10
Zhao, J.J.11
-
24
-
-
34347400796
-
Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo
-
DOI 10.1182/blood-2006-12-063636
-
Zhang, X., Kimura, Y., Fang, C., Zhou, L., Sfyroera, G., Lambris, J.D., Wetsel, R.A., Miwa, T., and Song, W.C. (2007) Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood 110, 228-236 (Pubitemid 47026839)
-
(2007)
Blood
, vol.110
, Issue.1
, pp. 228-236
-
-
Zhang, X.1
Kimura, Y.2
Fang, C.3
Zhou, L.4
Sfyroera, G.5
Lambris, J.D.6
Wetsel, R.A.7
Miwa, T.8
Song, W.-C.9
-
25
-
-
21244502077
-
ERK activation following macrophage FcγR ligation leads to chromatin modifications at the IL-10 locus
-
Lucas, M., Zhang, X., Prasanna, V., and Mosser, D.M. (2005) ERK activation following macrophage FcγR ligation leads to chromatin modifications at the IL-10 locus. J. Immunol. 175, 469-477 (Pubitemid 40884351)
-
(2005)
Journal of Immunology
, vol.175
, Issue.1
, pp. 469-477
-
-
Lucas, M.1
Zhang, X.2
Prasanna, V.3
Mosser, D.M.4
-
26
-
-
23944486750
-
Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
-
Martin, M., Rehani, K., Jope, R.S., and Michalek, S.M. (2005) Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat. Immunol. 6, 777-784
-
(2005)
Nat. Immunol.
, vol.6
, pp. 777-784
-
-
Martin, M.1
Rehani, K.2
Jope, R.S.3
Michalek, S.M.4
-
27
-
-
0346103719
-
Modulation of the Phosphoinositide 3-Kinase Pathway Alters Innate Resistance to Polymicrobial Sepsis
-
Williams, D., Li, C., Ha, T., Ozment-Skelton, T., Kalbfleisch, J., Preiszner, J., Brooks, L., and Schweitzer, J.B. (2004) Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis. J. Immunol. 172, 449-456 (Pubitemid 38020500)
-
(2004)
Journal of Immunology
, vol.172
, Issue.1
, pp. 449-456
-
-
Williams, D.L.1
Li, C.2
Ha, T.3
Ozment-Skelton, T.4
Kalbfleisch, J.H.5
Preiszner, J.6
Brooks, L.7
Breuel, K.8
Schweitzer, J.B.9
-
28
-
-
33645801404
-
Opposite effects of wortmannin and 2-(4-morpholinyl)-8-phenyl-1(4H)- benzopyran-4-one hydrochloride on toll-like receptor-mediated nitric oxide production: Negative regulation of nuclear factor-kB by phosphoinositide 3-kinase
-
Hazeki, K., Kinoshita, S., Matsumura, T., Nigorikawa, K., Kubo, H., and Hazeki, O. (2006) Opposite effects of wortmannin and 2-(4-morpholinyl)-8-phenyl- 1(4H)-benzopyran-4-one hydrochloride on toll-like receptor-mediated nitric oxide production: negative regulation of nuclear factor-kB by phosphoinositide 3-kinase. Mol. Pharmacol. 69, 1717-1724
-
(2006)
Mol. Pharmacol.
, vol.69
, pp. 1717-1724
-
-
Hazeki, K.1
Kinoshita, S.2
Matsumura, T.3
Nigorikawa, K.4
Kubo, H.5
Hazeki, O.6
-
29
-
-
1542314248
-
Interleukin-10 inhibits interleukin-12 p40 gene transcription by targeting a late event in the activation pathway
-
Zhou, L., Nazarian, A.A., and Smale, S. T. (2004) Interleukin-10 inhibits interleukin-12 p40 gene transcription by targeting a late event in the activation pathway. Mol. Cell. Biol. 24, 2385-2396
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 2385-2396
-
-
Zhou, L.1
Nazarian, A.A.2
Smale, S.T.3
-
30
-
-
0035062021
-
Interleukin-10 and the interleukin-10 receptor
-
Moore, K.W., de Waal Malefyt, R., Coffman, R.L., and O'Garra, A. (2001) Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19, 683-765
-
(2001)
Annu. Rev. Immunol.
, vol.19
, pp. 683-765
-
-
Moore, K.W.1
De Waal Malefyt, R.2
Coffman, R.L.3
O'Garra, A.4
-
31
-
-
56749174940
-
Exploring the full spectrum of macrophage activation
-
Mosser, D.M. and Edwards, J.P. (2008) Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8, 958-969
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 958-969
-
-
Mosser, D.M.1
Edwards, J.P.2
|