Pituitary tumor-transforming gene and its binding factor in endocrine cancer

Expert Reviews in Molecular Medicine

Volumn 12, Issue , 2010, Pages

  Smith, Vicki E ^a   Franklyn, Jayne A ^a   McCabe, Christopher J ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BINDING PROTEIN; ESTROGEN; FIBROBLAST GROWTH FACTOR 2; GROWTH FACTOR; NUCLEAR FACTOR Y; OCTAMER TRANSCRIPTION FACTOR 1; PITUITARY TUMOR TRANSFORMING GENE BINDING FACTOR; PLAKOGLOBIN; PROTEIN P53; SECURIN; TRANSCRIPTION FACTOR SP1; TUMOR MARKER; UNCLASSIFIED DRUG; VASCULOTROPIN; MEMBRANE PROTEIN; PITUITARY TUMOR TRANSFORMING PROTEINS; PITUITARY TUMOR-TRANSFORMING PROTEINS; PTTG1IP PROTEIN, HUMAN; TUMOR PROTEIN;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ANEUPLOIDY; ANGIOGENESIS; APOPTOSIS; BREAST CANCER; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELLULAR DISTRIBUTION; COLORECTAL CARCINOMA; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; ENDOCRINE TUMOR; EPIGENETICS; G2 PHASE CELL CYCLE CHECKPOINT; GENE DELETION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENOMIC INSTABILITY; HUMAN; HYPOPHYSIS TUMOR; INTRACELLULAR SIGNALING; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; ONCOGENE C MYC; OVARY CANCER; PITUITARY TUMOR TRANSFORMING GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; PROTO ONCOGENE; REVIEW; THYROID CANCER; TRANSACTIVATION; UPREGULATION; UTERUS MYOMA; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; FEMALE; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; PHYSIOLOGY; RAT;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; ENDOCRINE GLAND NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION; GENOMIC INSTABILITY; HUMANS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; RATS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79952279243     PISSN: 14623994     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1462399410001699     Document Type: Review

References (139)

1. Pei, L. and Melmed, S. (1997) Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Molecular Endocrinology 11, 433-441 (Pubitemid 27147011)
2. Zou, H. et al. (1999) Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science 285, 418-422
3. Hamid, T., Malik, M.T. and Kakar, S.S. (2005) Ectopic expression of PTTG1/securin promotes tumorigenesis in human embryonic kidney cells. Molecular Cancer 4, 3
4. Ramaswamy, S. et al. (2003) A molecular signature of metastasis in primary solid tumors. Nature Genetics 33, 49-54 (Pubitemid 36068681)
5. Chien, W. and Pei, L. (2000) A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product. Journal of Biological Chemistry 275, 19422-19427 (Pubitemid 30422919)
6. McCabe, C.J. et al. (2003) Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour. Clinical Endocrinology 58, 141-150 (Pubitemid 36194267)
7. Stratford, A.L. et al. (2005) Pituitary tumor transforming gene binding factor: a novel transforming gene in thyroid tumorigenesis. Journal of Clinical Endocrinology and Metabolism 90, 4341-4349 (Pubitemid 41058217)
8. Watkins, R.J. et al. (2010) Pituitary tumor transforming gene binding factor: a new gene in breast cancer. Cancer Research 70, 3739-3749
9. Dominguez, A. et al. (1998) hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG. Oncogene 17, 2187-2193 (Pubitemid 28515372)
10. Zhang, X. et al. (1999) Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). Molecular Endocrinology 13, 156-166 (Pubitemid 29022288)
11. Lee, I.A., Seong, C. and Choe, I.S. (1999) Cloning and expression of human cDNA encoding human homologue of pituitary tumor transforming gene. Biochemistry and Molecular Biology International 47, 891-897 (Pubitemid 29240508)
12. Kakar, S.S. and Jennes, L. (1999) Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis. Cytogenetics and Cell Genetics 84, 211-216 (Pubitemid 29294968)
13. Saez, C. et al. (1999) hpttg is over-expressed in pituitary adenomas and other primary epithelial neoplasias. Oncogene 18, 5473-5476 (Pubitemid 29469235)
14. Hunter, J.A. et al. (2003) The relationship between pituitary tumour transforming gene (PTTG) expression and in vitro hormone and vascular endothelial growth factor (VEGF) secretion from human pituitary adenomas. European Journal of Endocrinology 148, 203-211 (Pubitemid 36305686)
15. Zhang, X. et al. (1999) Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. Journal of Clinical Endocrinology and Metabolism 84, 761-767 (Pubitemid 29075718)
16. Heaney, A.P. et al. (2001) Transforming events in thyroid tumorigenesis and their association with follicular lesions. Journal of Clinical Endocrinology and Metabolism 86, 5025-5032 (Pubitemid 33020559)
17. Boelaert, K. et al. (2003)Pituitary tumor transforming gene and fibroblast growth factor-2 expression: potential prognostic indicators in differentiated thyroid cancer. Journal of Clinical Endocrinology and Metabolism 88, 2341-2347 (Pubitemid 36549916)
18. Kim, D.S. et al. (2006) Pituitary tumor-transforming gene regulates multiple downstream angiogenic genes in thyroid cancer. Journal of Clinical Endocrinology and Metabolism 91, 1119-1128 (Pubitemid 43357790)
19. Heaney, A.P. et al. (2000) Expression of pituitary-tumour transforming gene in colorectal tumours. Lancet 355, 716-719 (Pubitemid 30107628)
20. Kim, D.S. et al. (2007) Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity. Carcinogenesis 28, 749-759 (Pubitemid 46523373)
21. Puri, R. et al. (2001) Molecular cloning of pituitary tumor transforming gene 1 from ovarian tumors and its expression in tumors. Cancer Letters 163, 131-139 (Pubitemid 32121839)
22. Solbach, C. et al. (2004) PTTG mRNA expression in primary breast cancer: a prognostic marker for lymph node invasion and tumor recurrence. Breast 13, 80-81 (Pubitemid 38228595)
23. Ogbagabriel, S. et al. (2005) Securin is overexpressed in breast cancer. Modern Pathology 18, 985-990 (Pubitemid 41059961)
24. Cho-Rok, J. et al. (2006) Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo. Hepatology 43, 1042-1052
25. Kakar, S.S. and Malik, M.T. (2006) Suppression of lung cancer with siRNA targeting PTTG. International Journal of Oncology 29, 387-395
26. Shibata, Y. et al. (2002) Expression of PTTG (pituitary tumor transforming gene) in esophageal cancer. Japanese Journal of Clinical Oncology 32, 233-237 (Pubitemid 43102805)
27. Saez, C. et al. (2002) Expression of hpttg proto-oncogene in lymphoid neoplasias. Oncogene 21, 8173-8177 (Pubitemid 35454420)
28. Tfelt-Hansen, J. et al. (2004) Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells. Endocrinology 145, 4222-4231 (Pubitemid 39120571)
29. Prezant, T.R., Kadioglu, P. and Melmed, S. (1999) An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: evidence for hPTTG family. Journal of Clinical Endocrinology and Metabolism 84, 1149-1152 (Pubitemid 29138258)
30. Chen, L. et al. (2000) Identification of the human pituitary tumor transforming gene (hPTTG) family: molecular structure, expression, and chromosomal localization. Gene 248, 41-50 (Pubitemid 30259200)
31. Heaney, A.P. et al. (1999) Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Nature Medicine 5, 1317-1321 (Pubitemid 29535612)
32. Yin, H. et al. (2001) Strain difference in regulation of pituitary tumor transforming gene (PTTG) in estrogen-induced pituitary tumorigenesis in rats. Japanese Journal of Cancer Research 92, 1034-1040 (Pubitemid 33041172)
33. Marqusee, E. et al. (2000) The effect of droloxifene and estrogen on thyroid function in postmenopausal women. Journal of Clinical Endocrinology and Metabolism 85, 4407-4410 (Pubitemid 32055406)
34. Pei, L. (1998) Genomic organization and identification of an enhancer element containing binding sites for multiple proteins in rat pituitary tumor-transforming gene. Journal of Biological Chemistry 273, 5219-5225
35. Kakar, S.S. (1999) Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG). Gene 240, 317-324
36. Wang, Z. and Melmed, S. (2000) Characterization of the murine pituitary tumor transforming gene (PTTG) and its promoter. Endocrinology 141, 763-771 (Pubitemid 32250501)
37. Clem, A.L., Hamid, T. and Kakar, S.S. (2003) Characterization of the role of Sp1 and NF-Y in differential regulation of PTTG/securin expression in tumor cells. Gene 322, 113-121 (Pubitemid 37485988)
38. Zhou, Y. et al. (2003) DNA damage-induced inhibition of securin expression is mediated by p53. Journal of Biological Chemistry 278, 462-470 (Pubitemid 36043597)
39. Chen, R.N. et al. (2008) Thyroid hormone receptors suppress pituitary tumor transforming gene 1 activity in hepatoma. Cancer Research 68, 1697-1706
40. Rajamannan, N.M. et al. (2007) TGFbeta inducible early gene-1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathway. Journal of Cellular Biochemistry 100, 315-325 (Pubitemid 46146082)
41. Zhou, C. et al. (2008) Oct-1 induces pituitary tumor transforming gene expression in endocrine tumors. Endocrine-related Cancer 15, 817-831
42. Zhou, C. et al. (2005) Overexpression of human pituitary tumor transforming gene (hPTTG), is regulated by beta-catenin /TCF pathway in human esophageal squamous cell carcinoma. International Journal of Cancer 113, 891-898 (Pubitemid 40096868)
43. Hlubek, F. et al. (2006) Securin (hPTTG1) expression is regulated by beta-catenin/TCF in human colorectal carcinoma. British Journal of Cancer 94, 1672-1677 (Pubitemid 43924931)
44. Pan, H. et al. (2007) Aberrant activation of gammacatenin promotes genomic instability and oncogenic effects during tumor progression. Cancer Biology and Therapy 6, 1638-1643 (Pubitemid 351590337)
45. Thompson, A.D., III and Kakar, S.S. (2005) Insulin and IGF-1 regulate the expression of the pituitary tumor transforming gene (PTTG) in breast tumor cells. FEBS Letters 579, 3195-3200
46. Chamaon, K. et al. (2005) Regulation of the pituitary tumor transforming gene by insulin-like-growth factor-I and insulin differs between malignant and non-neoplastic astrocytes. Biochemical and Biophysics Research Communications 331, 86-92 (Pubitemid 40545146)
47. Chamaon, K. et al. (2010) Transcripts of PTTG and growth factors bFGF and IGF-1 are correlated in pituitary adenomas. Experimental and Clinical Endocrinology and Diabetes 118, 121-126
48. Tsai, S.J. et al. (2005) Expression and functional analysis of pituitary tumor transforming gene-1 [corrected] in uterine leiomyomas. Journal of Clinical Endocrinology and Metabolism 90, 3715-3723
49. Vlotides, G. et al. (2006) Mechanisms for growth factor-induced pituitary tumor transforming gene-1 expression in pituitary folliculostellate TtT/GF cells. Molecular Endocrinology 20, 3321-3335 (Pubitemid 44834329)
50. Kanakis, D. et al. (2003) Promoter mutations are no major cause of PTTG overexpression in pituitary adenomas. Clinical Endocrinology 58, 151-155 (Pubitemid 36194268)
51. Hidalgo, M. et al. (2008) Methylation alterations are not a major cause of PTTG1 misregulation. BMC Cancer 8, 110
52. Li, T. et al. (2009) Histone acetyltransferase p300 regulates the expression of human pituitary tumor transforming gene (hPTTG). Journal of Genetics and Genomics 36, 335-342
53. Zur, A. and Brandeis, M. (2001) Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis. EMBO Journal 20, 792-801 (Pubitemid 32167643)
54. Sanchez-Puig, N., Veprintsev, D.B. and Fersht, A.R. (2005) Human full-length securin is a natively unfolded protein. Protein Science 14, 1410-1418 (Pubitemid 41014813)
55. Csizmok, V. et al. (2008) Structural and dynamic characterization of intrinsically disordered human securin by NMR spectroscopy. Journal of the American Chemical Society 130, 16873-16879
56. Yu, R. et al. (2000) Pituitary tumor transforming gene (PTTG) regulates placental JEG-3 cell division and survival: evidence from live cell imaging. Molecular Endocrinology 14, 1137-1146 (Pubitemid 32260476)
57. Ramos-Morales, F. et al. (2000) Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product. Oncogene 19, 403-409 (Pubitemid 30077341)
58. Boelaert, K. et al. (2004) PTTG's C-terminal PXXP motifs modulate critical cellular processes in vitro. Journal of Molecular Endocrinology 33, 663-677 (Pubitemid 40057561)
59. Romero, F. et al. (2001) Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase. Nucleic Acids Research 29, 1300-1307 (Pubitemid 32229457)
60. Mu, Y.M. et al. (2003) Human pituitary tumor transforming gene (hPTTG) inhibits human lung cancer A549 cell growth through activation of p21(WAF1/CIP1). Endocrine Journal 50, 771-781
61. Yu, R. et al. (2003) Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells. Endocrinology 144, 4991-4998
62. Minematsu, T. et al. (2007) PTTG is a secretory protein in human pituitary adenomas and in mouse pituitary tumor cell lines. Endocrine Pathology 18, 8-15 (Pubitemid 47345624)
63. Nasmyth, K. (2002) Segregating sister genomes: the molecular biology of chromosome separation. Science 297, 559-565
64. Waizenegger, I.C. et al. (2000) Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase. Cell 103, 399-410
65. Losada, A., Hirano, M. and Hirano, T. (2002) Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis. Genes and Development 16, 3004-3016 (Pubitemid 35424189)
66. Sumara, I. et al. (2002) The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Molecular Cell 9, 515-525 (Pubitemid 34273783)
67. Peters, J.M. (2006) The anaphase promoting complex/cyclosome: a machine designed to destroy. Nature Reviews. Molecular Cell Biology 7, 644-656
68. Jallepalli, P.V. et al. (2001) Securin is required for chromosomal stability in human cells. Cell 105, 445-457 (Pubitemid 32520851)
69. Stemmann, O. et al. (2001) Dual inhibition of sister chromatid separation at metaphase. Cell 107, 715-726 (Pubitemid 34033665)
70. Gorr, I.H., Boos, D. and Stemmann, O. (2005) Mutual inhibition of separase and Cdk1 by two-step complex formation. Molecular Cell 19, 135-141 (Pubitemid 40884664)
71. Holland, A.J. and Taylor, S.S. (2006) Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction. Journal of Cell Science 119, 3325-3336 (Pubitemid 44405218)
72. Baumgarten, A.J., Felthaus, J. and Wasch, R. (2009) Strong inducible knockdown of APC/CCdc20 does not cause mitotic arrest in human somatic cells. Cell Cycle 8, 643-646
73. Kim, H.S. et al. (2009) Functional interaction between BubR1 and securin in an anaphase-promoting complex/cyclosomeCdc20-independent manner. Cancer Research 69, 27-36
74. Tong, Y. et al. (2007) Pituitary tumor transforming gene interacts with Sp1 to modulate G1/S cell phase transition. Oncogene 26, 5596-5605 (Pubitemid 47267833)
75. Marangos, P. and Carroll, J. (2008) Securin regulates entry into M-phase by modulating the stability of cyclin B. Nat Cell Biol 10, 445-451
76. Yu, R. et al. (2000) Pituitary tumor transforming gene causes aneuploidy and p53-dependent and p53-independent apoptosis. Journal of Biological Chemistry 275, 36502-36505 (Pubitemid 32002045)
77. Hagting, A. et al. (2002) Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J Cell Biol 157, 1125-1137 (Pubitemid 34847784)
78. Winnepenninckx, V. et al. (2006) Expression and possible role of hPTTG1/securin in cutaneous malignant melanoma. Modern Pathology 19, 1170-1180 (Pubitemid 44268187)
79. Kim, D. et al. (2005) Pituitary tumour transforming gene (PTTG) induces genetic instability in thyroid cells. Oncogene 24, 4861-4866 (Pubitemid 41076304)
80. Wang, Z., Yu, R. and Melmed, S. (2001) Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division. Molecular Endocrinology 15, 1870-1879 (Pubitemid 33022528)
81. Mei, J., Huang, X. and Zhang, P. (2001) Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts. Curr Biol 11, 1197-1201 (Pubitemid 32722574)
82. Pfleghaar, K. et al. (2005) Securin is not required for chromosomal stability in human cells. PLoS Biol 3, e416
83. Huang, X. et al. (2005) Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells. Mol Biol Cell 16, 4725-4732 (Pubitemid 41416455)
84. Tong, Y. et al. (2008) Pituitary tumor transforming gene 1 regulates Aurora kinase A activity. Oncogene 27, 6385-6395
85. Wang, Z. et al. (2003) Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes. Proceedings of the National Academy of Sciences of the United States of America 100, 3428-3432 (Pubitemid 36356600)
86. Chesnokova, V. et al. (2009) Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence. Endocrinology 150, 2603-2610
87. Vousden, K.H. (2006) Outcomes of p53 activation-spoilt for choice. Journal of Cell Science 119, 5015-5020
88. Hamid, T. and Kakar, S.S. (2004) PTTG/securin activates expression of p53 and modulates its function. Molecular Cancer 3, 18
89. Bernal, J.A. et al. (2002) Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis. Nature Genetics 32, 306-311
90. Lai, Y. et al. (2007) The important anti-apoptotic role and its regulation mechanism of PTTG1 in UV-induced apoptosis. Journal of Biochemistry and Molecular Biology 40, 966-972 (Pubitemid 350242283)
91. Kho, P.S. et al. (2004) p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis. Journal of Biological Chemistry 279, 21183-21192 (Pubitemid 38656522)
92. Romero, F. et al. (2004) Securin is a target of the UV response pathway in mammalian cells. Molecular and Cellular Biology 24, 2720-2733 (Pubitemid 38381264)
93. Limon-Mortes, M.C. et al. (2008) UV-induced degradation of securin is mediated by SKP1-CUL1-beta TrCP E3 ubiquitin ligase. Journal of Cell Science 121, 1825-1831 (Pubitemid 351943375)
94. Bernal, J.A. et al. (2008) Proliferative potential after DNAdamage and non-homologous end joining are affected by loss of securin. Cell Death and Differentiation 15, 202-212 (Pubitemid 350286188)
95. Wang, Z. and Melmed, S. (2000) Pituitary tumor transforming gene (PTTG) transforming and transactivation activity. Journal of Biological Chemistry 275, 7459-7461 (Pubitemid 30159638)
96. Ishikawa, H. et al. (2001) Human pituitary tumor-transforming gene induces angiogenesis. Journal of Clinical Endocrinology and Metabolism 86, 867-874 (Pubitemid 32207508)
97. McCabe, C.J. et al. (2002) Vascular endothelial growth factor, its receptor KDR/Flk-1, and pituitary tumor transforming gene in pituitary tumors. Journal of Clinical Endocrinology and Metabolism 87, 4238-4244
98. Fujii, T. et al. (2006) Overexpression of pituitary tumor transforming gene 1 in HCC is associated with angiogenesis and poor prognosis. Hepatology 43, 1267-1275 (Pubitemid 43980105)
99. Wang, Y.K. et al. (2004) [Expression of pituitary tumor-transforming gene in endometrial carcinoma]. Zhonghua Fu Chan Ke Za Zhi 39, 538-542
100. Minematsu, T. et al. (2006) PTTG overexpression is correlated with angiogenesis in human pituitary adenomas. Endocrine Pathology 17, 143-153 (Pubitemid 44965903)
101. Kim, D.S. et al. (2006) Pituitary tumor transforming gene (PTTG) stimulates thyroid cell proliferation via a vascular endothelial growth factor/kinase insert domain receptor/inhibitor of DNA binding-3 autocrine pathway. Journal of Clinical Endocrinology and Metabolism 91, 4603-4611 (Pubitemid 44833445)
102. Malik, M.T. and Kakar, S.S. (2006) Regulation of angiogenesis and invasion by human Pituitary tumor transforming gene (PTTG) through increased expression and secretion of matrix metalloproteinase-2 (MMP-2). Molecular Cancer 5, 61
103. Horwitz, G.A. et al. (2003) Human pituitary tumor-transforming gene (PTTG1) motif suppresses prolactin expression. Molecular Endocrinology 17, 600-609 (Pubitemid 36403573)
104. Pei, L. (2001) Identification of c-myc as a downstream target for pituitary tumor-transforming gene. Journal of Biological Chemistry 276, 8484-8491
105. Pei, L. (1999) Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells. Journal of Biological Chemistry 274, 3151-3158
106. Tong, Y. and Eigler, T. (2009) Transcriptional targets for pituitary tumor-transforming gene-1. Journal of Molecular Endocrinology 43, 179-185
107. Yaspo, M.L. et al. (1998) Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3. Genomics 49, 133-136
108. Bork, P. et al. (1999) Domains in plexins: links to integrins and transcription factors. Trends in Biochemical Sciences 24, 261-263 (Pubitemid 29301688)
109. Stock, M. et al. (2004) Identification of novel genes of the bone-specific transcription factor Runx2. Journal of Bone and Mineral Research 19, 959-972 (Pubitemid 41103453)
110. Smith, V.E. et al. (2009) A novel mechanism of sodium iodide symporter repression in differentiated thyroid cancer. Journal of Cell Science 122, 3393-3402
111. Filippella, M. et al. (2006) Pituitary tumour transforming gene (PTTG) expression correlates with the proliferative activity and recurrence status of pituitary adenomas: a clinical and immunohistochemical study. Clinical Endocrinology 65, 536-543 (Pubitemid 44414280)
112. Wierinckx, A. et al. (2007) A diagnostic marker set for invasion, proliferation, and aggressiveness of prolactin pituitary tumors. Endocrine-related Cancer 14, 887-900 (Pubitemid 350074076)
113. Raverot, G. et al. (2010) Prognostic factors in prolactin pituitary tumors: clinical, histological, and molecular data from a series of 94 patients with a long postoperative follow-up. Journal of Clinical Endocrinology and Metabolism 95, 1708-1716
114. Noh, T.W. et al. (2009) Predicting recurrence of nonfunctioning pituitary adenomas. Journal of Clinical Endocrinology and Metabolism 94, 4406-4413
115. Chesnokova, V. et al. (2005) Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/- pituitary tumorigenesis. Molecular Endocrinology 19, 2371-2379 (Pubitemid 41252829)
116. Chesnokova, V. et al. (2007) Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth. Cancer Research 67, 10564-10572 (Pubitemid 350070833)
117. Chesnokova, V. et al. (2008) p21(Cip1) restrains pituitary tumor growth. Proceedings of the National Academy of Sciences of the United States of America 105, 17498-17503
118. Hsu, Y.H. et al. (2010) Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human fibroblasts. Journal of Biological Chemistry 285, 22630-22638
119. Abbud, R.A. et al. (2005) Early multipotential pituitary focal hyperplasia in the alpha-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice. Molecular Endocrinology 19, 1383-1391 (Pubitemid 40594132)
120. Donangelo, I. et al. (2006) Pituitary tumor transforming gene overexpression facilitates pituitary tumor development. Endocrinology 147, 4781-4791 (Pubitemid 44402185)
121. Zhou, C. et al. (2009) E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors. Molecular Endocrinology 23, 2000-2012
122. Heaney, A.P., Fernando, M. and Melmed, S. (2002) Functional role of estrogen in pituitary tumor pathogenesis. Journal of Clinical Investigation 109, 277-283 (Pubitemid 34083748)
123. Saez, C. et al. (2006) Prognostic significance of human pituitary tumor-transforming gene immunohistochemical expression in differentiated thyroid cancer. Journal of Clinical Endocrinology and Metabolism 91, 1404-1409
124. Ying, H. et al. (2006) Aberrant accumulation of PTTG1induced bya mutated thyroid hormone beta receptor inhibits mitotic progression. Journal of Clinical Investigation 116, 2972-2984 (Pubitemid 44684482)
125. Kim, C.S. et al. (2007) The pituitary tumor-transforming gene promotes angiogenesis in a mouse model of follicular thyroid cancer. Carcinogenesis 28, 932-939 (Pubitemid 47072175)
126. Boelaert, K. et al. (2007) PTTG and PBF repress the human sodium iodide symporter. Oncogene 26, 4344-4356 (Pubitemid 47014460)
127. Chen, G. et al. (2004) Inhibitory effects of anti-sense PTTG on malignant phenotype of human ovarian carcinoma cell line SK-OV-3. Journal of Huazhong University of Science and Technology. Medical Sciences 24, 369-372 (Pubitemid 41559599)
128. El Naggar, S.M. et al. (2007) Development of cystic glandular hyperplasia of the endometrium in Mullerian inhibitory substance type II receptor-pituitary tumor transforming gene transgenic mice. Journal of Endocrinology 194, 179-191
129. Talvinen, K. et al. (2008) Proliferation marker securin identifies favourable outcome in invasive ductal breast cancer. British Journal of Cancer 99, 335-340
130. Talvinen, K. et al. (2009) Securin promotes the identification of favourable outcome in invasive breast cancer. British Journal of Cancer 101, 1005-1010
131. Lo, Y.L. et al. (2007) Breast cancer risk associated with genotypic polymorphism of the mitotic checkpoint genes: a multigenic study on cancer susceptibility. Carcinogenesis 28, 1079-1086
132. Brendle, A. et al. (2009) Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study. European Journal of Cancer 45, 435-442
133. Chen, C.C. et al. (2006) Combination of multiple mRNA markers (PTTG1, Survivin, UbcH10 and TK1) in the diagnosis of Taiwanese patients with breast cancer by membrane array. Oncology 70, 438-446
134. Ghayad, S.E. et al. (2009) Identification of TACC1, NOV, and PTTG1 as newcandidate genes associated with endocrine therapy resistance in breast cancer. Journal of Molecular Endocrinology 42, 87-103
135. Ito, T. et al. (2008) Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma. Cancer Research 68, 3214-3224
136. Rehfeld, N. et al. (2006) The influence of the pituitary tumor transforming gene-1 (PTTG-1) on survival of patients with small cell lung cancer and non-small cell lung cancer. Journal of Carcinogenesis 5, 4
137. El Naggar, S.M., Malik, M.T. and Kakar, S.S. (2007) Small interfering RNA against PTTG: a novel therapy for ovarian cancer. International Journal of Oncology 31, 137-143
138. Solbach, C. et al. (2005) Pituitary tumor-transforming gene (PTTG): a novel target for anti-tumor therapy. Anticancer Research 25, 121-125 (Pubitemid 40470100)
139. Mo, Z. et al. (2009) Antitumor effect of F-PBF(beta-TrCP)-induced targeted PTTG1 degradation in HeLa cells. Journal of Biotechnology 139, 6-11