Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts

Current Biology

Volumn 11, Issue 15, 2001, Pages 1197-1201

  Mei, Junjie ^a,b   Huang, Xingxu ^a   Zhang, Pumin ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

XENOPUS;

EID: 0035822666     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00325-6     Document Type: Article

References (25)

1. An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast
2. Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast
3. APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5
4. CDC20 and CDH1: A family of substrate-specific activators of APC- dependent proteolysis
5. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1
6. Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s)
7. Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae
8. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis
9. Isolation and characterization of a pituitary tumor-transforming gene (PTTG)
10. Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase
11. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
12. Absence of p53-dependent cell cycle regulation in pluripotent mouse cell lines
13. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2
14. Identification of the human pituitary tumor transforming gene (hPTTG) family: Molecular structure, expression, and chromosomal localization
15. Failure of centromere separation leads to formation of diplochromosomes in next mitosis in okadaic acid treated HeLa cells
16. A novel role of the budding yeast separin Esp1 in anaphase spindle elongation. Evidence that proper spindle association of esp1 is regulated by pds1
17. Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis
18. hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG
19. The fission yeast cut1+ gene regulates spindle pole body duplication and has homology to the budding yeast ESP1 gene
20. Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes
21. Degradation of Drosophila PIM regulates sister chromatid separation during mitosis
22. Separation of sister chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase/anaphase transition
23. Cell cycle mechanisms of sister chromatid separation; roles of Cut1/separin and Cut2/securin
24. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
25. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint