Pituitary tumour transforming gene (PTTG) expression correlates with the proliferative activity and recurrence status of pituitary adenomas: A clinical and immunohistochemical study

Clinical Endocrinology

Volumn 65, Issue 4, 2006, Pages 536-543

  Filippella, Mariagiovanna ^a,e   Galland, Françoise ^a   Kujas, Michèle ^d   Young, Jacques ^a,b,c   Faggiano, Antongiulio ^e   Lombardi, Gaetano ^e   Colao, Annamaria ^e   Meduri, Geri ^c   Chanson, Philippe ^a,b,c  

^a BICÊTRE HOSPITAL   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c INSERM   (France)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; GENE PRODUCT; KI 67 ANTIGEN; PITUITARY TUMOR TRANSFORMING PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BIODIVERSITY; CANCER INVASION; CANCER RECURRENCE; CANCER SURGERY; CARCINOGENESIS; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL OBSERVATION; CLINICAL STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE FREE INTERVAL; DISEASE SEVERITY; EVALUATION; FEMALE; FOLLOW UP; GENDER; GENE EXPRESSION; GROUPS BY AGE; HISTOLOGY; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; IMMUNOHISTOCHEMISTRY; MALE; MICROADENOMA; MULTIVARIATE ANALYSIS; POSTOPERATIVE PERIOD; PREDICTOR VARIABLE; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; PROGNOSIS; RELIABILITY; ROC CURVE; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TRANSSPHENOIDAL SURGERY; TUMOR CELL; TUMOR VOLUME;

ADENOMA; ADULT; AGED; CHI-SQUARE DISTRIBUTION; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASM RECURRENCE, LOCAL; PITUITARY NEOPLASMS; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; ROC CURVE; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 33748807072     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2006.02630.x     Document Type: Article

References (57)

1. Melmed, S. (2003) Mechanisms for pituitary tumorigenesis: the plastic pituitary. Journal of Clinical Investigation, 112, 1603-1618.
2. Asa, S.L. & Ezzat, S. (2005) Genetics and proteomics of pituitary tumors. Endocrine, 28, 43-47.
3. Musat, M., Vax, V.V., Borboli, N., Gueorguiev, M., Bonner, S., Korbonits, M. & Grossman, A.B. (2004) Cell cycle dysregulation in pituitary oncogenesis. Frontiers of Hormone Research, 32, 34-62.
4. Farrell, W.E. & Clayton, R.N. (2000) Molecular pathogenesis of pituitary tumors. Frontiers in Neuroendocrinology, 21, 174-198.
5. Suhardja, A.S., Kovacs, K.T. & Rutka, J.T. (1999) Molecular pathogenesis of pituitary adenomas: a review. Acta Neurochirurgica (Wien), 141, 729-736.
6. Pei, L. & Melmed, S. (1997) Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Molecular Endocrinology, 11, 433-441.
7. YuR. & Melmed, S. (2001) Oncogene activation in pituitary tumors. Brain Pathology, 1, 328-341.
8. Spada, A., Arosio, M., Bochicchio, D., Bazzorini, N., Vallar, L., Bassetti, M. & Faglia, G. (1990) Clinical, biochemical and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenyl cyclase. Journal of Clinical Endocrinology and Metabolism, 71, 1421-1426.
9. Karga, H.J., Alexander, J.M., Hedley-Whyte, E.T., Klibanski, A. & Jameson, J.L. (1992) Ras mutations in human pituitary tumors. Journal of Clinical Endocrinology and Metabolism, 74, 914-919.
10. Cai, J.H., Alexander, J.M., Hedley-Whyte, E.T., Scheithauer, B.W., Jameson, J.L., Zervas, N.T. & Klibanski, A. (1994) ras Mutations in human prolactinomas and pituitary carcinomas. Journal of Clinical Endocrinology and Metabolism, 78, 89-93.
11. Pei, L., Melmed, S., Scheithauer, B., Kovacs, K. & Prager, D. (1994) H-ras mutations in human pituitary carcinoma metastases. Journal of Clinical Endocrinology and Metabolism, 78, 842-846.
12. Zou, H., McGarry, T.J., Bernal, T. & Kirschner, M.W. (1999) Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science, 285, 418-422.
13. YuR., Heaney, A., Lu, W., Chen, J. & Melmed, S. (2000) Pituitary tumor transforming gene (PTTG) causes aneuploidy and p53-dependent and p53-independent apoptosis. Journal of Biological Chemistry, 275, 36502-36505.
14. Zhang, X., Horwitz, G.A., Prezant, T.R., Valentini, A., Nakashima, M., Bronstein, M.D. & Melmed, S. (1999) Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). Molecular Endocrinology, 13, 156-166.
15. Zur, A. & Brandeis, M. (2001) Securin degradation is mediated by fzy znd fzr, and is required for complete chromatid separation but for cytokinesis. EMBO Journal, 20, 792-801.
16. Zhang, X., Horwitz, G.A., Heaney, A.P., Nakashima, M., Prezant, T.R., Bronstein, M.D. & Melmed, S. (1999) Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. Journal of Clinical Endocrinology and Metabolism, 84, 761-767.
17. Romero, F., Multon, M.C., Ramos-Morales, F., Dominguez, A., Bernal, J.A., Pintor-Toro, J.A. & Tortolero, M. (2001) Human securing, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase. Nucleic Acids Research, 29, 1300-1307.
18. Pei, L. (2001) Identification of c-myc as down-stream target for pituitary tumor-transforming gene. Journal of Biological Chemistry, 276, 8484-8491.
19. McCabe, C.J., Boelaert, K., Tannahill, L.A., Heaney, A.P., Stratford, A.L., Khaira, J.S., Hussain, S., Sheppard, M.C., Franklyn, J.A. & Gittoes, N.J. (2002) Vascular endothelial growth factor (VEGF), its receptor KDR and pituitary tumor transforming gene in pituitary tumors. Journal of Clinical Endocrinology and Metabolism, 87, 4238-4244.
20. Ishikawa, H. & Heaney, A.P., YuR., Horwitz, G.A. & Melmed, S. (2001) Human pituitary tumor-transforming gene induce angiogenesis. Journal of Clinical Endocrinology and Metabolism, 86, 867-874.
21. Saez, C., Pereda, T., Borrero, J.J., Espina, A., Romero, F., Tortolero, M., Pintor-Toro, J.A., Seguera, D.I. & Japon, A.M. (2002) Expression of hpttg proto-oncogene in lymphoid neoplasias. Oncogene, 2, 8173-8177.
22. Cattoretti, G., Becker, M.H., Key, G., Duchrow, M., Schluter, C., Galle, J. & Gerdes, J. (1992) Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB1 and MIB3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. Journal of Pathology, 168, 357-363.
23. Gerdes, J. (1990) Ki-67 and other proliferation markers useful for immunohistological diagnostic and prognostic evaluations in human malignancies. Seminars in Cancer Biology, 1, 199-206.
24. Landolt, A.M., Shibata, T. & Kleihues, P. (1987) Growth rate of human pituitary adenomas. Journal of Neurosurgery, 67, 803-806.
25. Knosp, E., Kitz, K., Steiner, E. & Matula, C. (1991) Pituitary adenomas with parasellar invasion. Acta Neurochirurgica (Wien), 53, 65-71.
26. Thapar, K., Kovacs, K., Scheithauer, B.W., Stefaneanu, L., Horvath, E., Pernicone, P.J., Murray, D. & Laws, E.R. Jr (1996) Proliferative activity and invasiveness among pituitary adenomas and carcinomas: an analysis using the MIB-1 antibody. Neurosurgery, 38, 99-107.
27. Mastronardi, L., Guiducci, A., Spera, C., Puzzilli, F., Liberati, F. & Maira, G. (1999) Ki-67 labelling index and invasiveness among anterior pituitary adenomas: analysis of 103 cases using the MIB-1 monoclonal antibody. Journal of Clinical Pathology, 52, 107-111.
28. Zhao, D., Tomono, Y. & Nose, T. (1999) Expression of p27Kip1 and ki-67 in pituitary adenomas: an investigation of marker of adenoma invasiveness. Acta Neurochirurgica (Wien), 141, 187-192.
29. Jaffrain-Rea, M.L., Di Stefano, D., Minniti, G., Esposito, V., Bultrini, A., Ferretti, E., Santoro, A., Faticanti Scucchi, L., Gulino, A. & Cantore, G. (2002) A critical reappraisal of MIB-1 labelling index significance in a large series of pituitary tumours: secreting versus non-secreting adenomas. Endocrine Related Cancer, 9, 103-113.
30. Pizarro, C.B., Oliveira, M.C., Coutinho, L.B. & Ferreira, N.P. (2004) Measurement of ki-67 antigen in 159 pituitary adenomas using the MIB-1 monoclonal antibody. Brazilian Journal of Medical Biology Research, 37, 235-243.
31. Paek, K.I., Kim, S.H., Song, S.H., Choi, S.W., Koh, H.S., Youm, J.Y. & Kim, Y. (2005) Clinical significance of Ki-67 labelling index in pituitary macroadenomas. Journal of Korean Medical Science, 20, 489-494.
32. Gandour-Edwards, R., Kapadia, S.B., Janecka, I.P., Martinez, A.J. & Barnes, L. (1995) Biologic markers of invasive pituitary adenomas involving the sphenoid sinus. Modern Pathology, 8, 160-164.
33. Kawamoto, H., Uozumi, T., Kawamoto, K., Arita, K., Yano, T. & Hirohita, T. (1995) Analysis of the growth rate and cavernous sinus invasion of pituitary adenomas. Acta Neurochirurgica (Wien), 136, 37-43.
34. Pegolo. G., Buckwalter, J.G., Weiss, M.H. & Hinton, D.R. (1995) Pituitary adenoma. Correlation of the cytologic appearance with biologic behavior. Acta Cytologica, 39, 887-892.
35. Yonezawa, K., Tamaki, N. & Kokunai, T. (1997) Clinical features and growth fractions of pituitary adenomas. Surgical Neurology, 48, 494-500.
36. Losa, M., Franzin, A., Mangili, F., Terreni, M.R., Barzaghi, R., Veglia, F., Mortini, P. & Giovanelli, M. (2000) Proliferation index in nonfunctioning pituitary adenomas: correlations with clinical characteristics and long-term follow-up. Neurosurgery, 47, 1313-1318.
37. Honegger, J., Prettin, C., Feuerhake, F., Petrik, M., Schulte-Monting, J. & Reincke, M. (2003) Expression of Ki-67 antigen in nonfunctioning pituitary adenomas: correlation with growth velocity and invasiveness. Journal of Neurosurgery, 99, 674-679.
38. Chanson, P., Pantel, J., Young, J., Couzinet, B., Bidart, J.-M. & Schaison, G. (1997) Free luteinizing hormone beta-subunit in normal subjects and patients with pituitary adenomas. Journal of Clinical Endocrinology and Metabolism, 82, 1397-1402.
39. Polak, M., Bertherat, J., Li, J.Y., Kujas, M., Le Dafniet, M., Weizan, H., Van Effenterre, R., Epelbaum, J. & Turpin, G. (1991) A human TSH-secreting adenoma: endocrine, biochemical and morphological studies. Evidence of somatostatin receptors by using quantitative autoradiography. Clinical and biological improvement by SMS 201-995 treatment. Acta Endocrinologica, 124, 479-486.
40. Couzinet, B., Young, J., Kujas, M., Meduri, G., Brailly, S., Thomas, J.L., Chanson, P. & Schaison, G. (1999) The antigonadotropic activity of 19-nor-progesterone derivate is exerted both at the hypothalamic and pituitary levels in women. Journal of Clinical Endocrinology and Metabolism, 84, 4191-4196.
41. Chanson, P., Daujat, F., Young, J., Bellucci, A., Kujas, M., Doyon, D. & Schaison, G. (2001) Normal pituitary hypertrophy as a frequent cause of pituitary incidentaloma: a follow-up study. Journal of Clinical Endocrinology and Metabolism, 86, 3009-3015.
42. Knosp, E., Kitz, K. & Perneczky, A. (1989) Proliferation activity in pituitary adenomas: measurement by monoclonal antibody Ki-67. Neurosurgery, 25, 927-930.
43. Mastronardi, L., Guiducci, A. & Puzzilli, F. (2001) Lack of correlation between Ki-67 labeling index and tumor size of anterior pituitary adenomas. BioMed Central Cancer, 1, 12-16.
44. Yokoyama, S., Hirano, H., Moroki, K., Goto, M., Imamura, S. & Kuratsu, J.I. (2001) Are nonfunctioning pituitary adenomas extending into the cavernous sinus aggressive and/or invasive? Neurosurgery, 49, 857-863.
45. Turner, H.E. & Wass, J.A.H. (1999) Are markers of proliferation valuable in the histological assessment of pituitary tumors? Pituitary, 1, 147-151.
46. Heaney, A.P., Horwitz, G.A., Wang, Z., Singson, R. & Melmed, S. (1999) Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Nature Medicine, 5, 1317-1321.
47. Chesnokova, V., Kovacs, K., Castro, A.V., Zonis, S. & Melmed, S. (2005) Pituitary hypoplasia in Pttg-/- mice is protective for Rb+/-pituitary tumorigenesis. Molecular Endocrinology, 19, 2371-2379.
48. Heaney, A.P., Nelson, V., Fernando, M. & Horwitz, G. (2001) Transforming events in thyroid tumorigenesis and their association with follicular lesion. Journal of Clinical Endocrinology and Metabolism, 86, 5025-5032.
49. Kakar, S.S. (1999) Molecular cloning, genomic organization, and identification of the promoter of the human tumor transforming gene (PTTG). Gene, 240, 317-324.
50. Heaney, A.P., Singson, R., McCabe, C.J., Nelson, V., Nakashima, M. & Melmed, S. (2000) Pituitary tumour transforming gene: a novel marker in colorectal tumours. Lancet, 355, 716-719.
51. Friend, K.E., Chiou, Y.K., Lopes, M.B., Laws, E.R. Jr, Hughes, K.M. & Shupnik, M.A. (1994) Estrogen receptor expression in human pituitary: correlation with immunohistochemistry in normal tissue, and immunohistochemistry and morphology in macroadenomas. Journal of Clinical Endocrinology and Metabolism, 78, 1497-1504.
52. Stefaneanu, L., Kovacs, K., Horvath, E., Lloyd, R.V., Buchfelder, M., Fahlbusch, R. & Smyth, H. (1994) In situ hybridization study of estrogen receptor messenger ribonucleic acid in human adenohypophysial cells and pituitary adenomas. Journal of Clinical Endocrinology and Metabolism, 78, 83-88.
53. Zafar, M., Ezzat, S., Ramyar, L., Pan, N., Smyth, H.S. & Asa, S.L. (1995) Cell-specific expression of estrogen in the human pituitary and its adenomas. Journal of Clinical Endocrinology and Metabolism, 80, 3621-3627.
54. Dominguez, A., Ramos-Morales, F., Romero, F., Rios, R.M., Tortolero, M. & Pintor-Toro, J.A. (1998) hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasm. Evidence for a transcriptional activation function of hPTTG. Oncogene, 17, 2187-2193.
55. McCabe, C.J., Khaira, J.S., Boelaert, K., Heaney, A.P., Tannahill, L.A., Hussain, S., Mitchell, R., Olliff, J., Sheppard, M.C., Franklyn, J.A. & Gittoes, N.J. (2003) Expression of pituitary tumour transforming gene (PTTG) and fibroblast growth factor-2 (FGF-2) in human pituitary adenomas: relationships to clinical tumour behaviour. Clinical Endocrinology, 58, 141-150.
56. Abbud, R.A., Takumi, I., Barker, E.M., Ren, S.G., Chen, D.Y., Wawrowsky, K. & Melmed, S. (2005) Early multipotential pituitary focal hyperplasia in the alpha-subunit of glycoprotein hormone-driven pituitary tumor-transforming gene transgenic mice. Molecular Endocrinology, 19, 1383-1391.
57. Saez, C., Japon, M.A., Ramos-Morales, F., Romero, F., Segura, D.I., Tortolero, M. & Pintor-Toro, J.A. (1999) hpttg is over-expressed in pituitary adenomas and other primary epithelial neoplasias. Oncogene, 18, 5473-5476.