Characterization of the role of Sp1 and NF-Y in differential regulation of PTTG/securin expression in tumor cells

Gene

Volumn 322, Issue 1-2, 2003, Pages 113-121

  Clem, Amy L ^a   Hamid, Tariq ^a   Kakar, Sham S ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Cancer; Gene expression; NF Y; PTTG; Securin; Sp1

Indexed keywords

LUCIFERASE; NUCLEAR FACTOR Y; NUCLEOTIDE; SECURIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CHROMATIN; CONTROLLED STUDY; DNA FLANKING REGION; FIBROBLAST CULTURE; GEL MOBILITY SHIFT ASSAY; GENE CONSTRUCT; GENE CONTROL; GENE DELETION; GENE FUSION; GENE MAPPING; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOPHYSIS TUMOR; IMMUNOPRECIPITATION; IN VIVO STUDY; MALE; NUCLEOTIDE SEQUENCE; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CARCINOMA; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPORTER GENE; SITE DIRECTED MUTAGENESIS; TISSUE SPECIFICITY; TRANSCRIPTION INITIATION; TRANSLATION INITIATION; TUMOR CELL; WESTERN BLOTTING;

EID: 0344872679     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2003.08.012     Document Type: Article

References (33)

1. Chang Z.F., Huang D.Y., Hu S.F. NF-Y-mediated trans-activation of the human thymidine kinase promoter is closely linked to activation of cyclin-dependent kinase. J. Cell. Biochem. 75:1999;300-309.
2. Chien W., Pei L. A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product. J. Biol. Chem. 275:2000;19422-19427.
3. Dominguez A., Ramos-Morales F., Romero F., Rios R.M., Dreyfus F., Tortolero M., Pintor-Toro J.A. hPTTG, a human homologue of rat PTTG, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG. Oncogene. 17:1998;2187-2193.
4. Heaney A.P., Singson R., McCabe C.J., Nelson V., Nakashima M., Melmed S. Expression of pituitary-tumour transforming gene in colorectal tumours. Lancet. 355:2000;716-719.
5. Heaney A.P., Nelson V., Fernando M., Horwitz G. Transforming events in thyroid tumorigenesis and their association with follicular lesions. J. Clin. Endocrinol. Metab. 86:2001;5025-5032.
6. Hu Z., Jin S., Scotto K.W. Transcriptional activation of the MDR1 gene by UV irradiation. Role of NF-Y and Sp1. J. Biol. Chem. 275:2000;2979-2985.
7. Inoue T., Kamiyama J., Sakai T. Sp1 and NF-Y synergistically mediate the effect of vitamin D(3) in the p27(Kip1) gene promoter that lacks vitamin D response elements. J. Biol. Chem. 274:1999;32309-32317.
8. Joun H., Lanske B., Karperien M., Qian F., Defize L., Abou-Samra A. Tissue-specific transcription start sites and alternative splicing of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor gene: a new PTH/PTHrP receptor splice variant that lacks the signal peptide. Endocrinology. 138:1997;1742-1749.
9. Kadonaga J.T., Carner K.R., Masiarz F.R., Tjian R. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell. 51:1987;1079-1090.
10. Kakar S.S. Molecular structure of the human gonadotropin-releasing hormone receptor gene. Eur. J. Endocrinol. 137:1997;183-192.
11. Kakar S.S. Assignment of the human tumor transforming gene TUTR1 to chromosome band 5q35.1 by fluorescence in situ hybridization. Cytogenet. Cell Genet. 83:1998;93-95.
12. Kakar S.S. Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG). Gene. 240:1999;317-324.
13. Kakar S.S., Jennes L. Molecular cloning and characterization of the tumor transforming gene (TUTR1): a novel gene in human tumorigenesis. Cytogenet. Cell Genet. 84:1999;211-216.
14. Kakar S.S., Chen L., Puri R., Flynn S.E., Jennes L. Characterization of a polyclonal antibody to human pituitary tumor transforming gene 1 (PTTG1) protein. J. Histochem. Cytochem. 49:2001;1537-1546.
15. Kim J.H., Lee J.N., Paik Y.K. Cholesterol biosynthesis from lanosterol. A concerted role for Sp1 and NF-Y-binding sites for sterol-mediated regulation of rat 7-dehydrocholesterol reductase gene expression. J. Biol. Chem. 276:2001;18153-18160.
16. Land H., Parada L.F., Weinberg R.A. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature. 304:1983;596-602.
17. Luo R.X., Postigo A.A., Dean D.C. Rb interacts with histone deacetylase to repress transcription. Cell. 92:1998;463-473.
18. Maity S.N., de Crombrugghe B. Role of the CCAAT-binding protein CBF/NF-Y in transcription. Trends Biochem. Sci. 23:1998;174-178.
19. Mantovani R. The molecular biology of the CCAAT-binding factor NF-Y. Gene. 239:1999;15-27.
20. Pei L. Genomic organization and identification of an enhancer element containing binding sites for multiple proteins in rat pituitary tumor-transforming gene. J. Biol. Chem. 273:1998;5219-5225.
21. Pei L. Activation of mitogen-activated protein kinase cascade regulates pituitary tumor-transforming gene transactivation function. J. Biol. Chem. 275:2000;31191-31198.
22. Pei L., Melmed S. Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol. Endocrinol. 11:1997;433-441.
23. Puri R., Tousson A., Chen L., Kakar S.S. Molecular cloning of pituitary tumor transforming gene 1 from ovarian tumors and its expression in tumors. Cancer Lett. 163:2001;131-139.
24. Ramos-Morales F., Dominguez A., Romero F., Luna R., Multon M.C., Pintor-Toro J.A., Tortolero M. Cell cycle regulated expression and phosphorylation of hpttg proto-oncogene product. Oncogene. 19:2000;403-409.
25. Roder K., Wolf S.S., Larkin K.J., Schweizer M. Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1. Gene. 234:1999;61-69.
26. Schneider G., Oswald F., Wahl C., Greten F.R., Adler G., Schmid R.M. Cyclosporine inhibits growth through the activating transcription factor/cAMP-responsive element-binding protein binding site in the cyclin D1 promoter. J. Biol. Chem. 277:2002;43599-43607.
27. Schwab M., Varmus H.E., Bishop J.M. Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture. Nature. 316:1985;160-162.
28. Wang Z., Yu R., Melmed S. Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division. Mol. Endocrinol. 15:2001;1870-1879.
29. Xiong S., Chirala S.S., Wakil S.J. Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites. Proc. Natl. Acad. Sci. U. S. A. 97:2000;3948-3953.
30. Yamada K., Tanaka T., Miyamoto K., Noguchi T. Sp family members and nuclear factor-Y cooperatively stimulate transcription from the rat pyruvate kinase M gene distal promoter region via their direct interactions. J. Biol. Chem. 275:2000;18129-18137.
31. Yu R., Ren S.G., Horwitz G.A., Wang Z., Melmed S. Pituitary tumor transforming gene (PTTG) regulates placental JEG-3 cell division and survival: evidence from live cell imaging. Mol. Endocrinol. 14:2000;1137-1146.
32. Zhang X., Horwitz G.A., Prezant T.R., Valentini A., Nakashima M., Bronstein M.D., Melmed S. Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). Mol. Endocrinol. 13:1999;156-166.
33. Zou H., McGarry T.J., Bernal T., Kirschner M.W. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science. 285:1999;418-422.