Human Pituitary Tumor Transforming Gene (hPTTG) Inhibits Human Lung Cancer A549 Cell Growth through Activation of p21WAF1/CIP1

Endocrine Journal

Volumn 50, Issue 6, 2003, Pages 771-781

  Mu, Yi Ming ^a,b   Oba, Koichi ^a   Yanase, Toshihiko ^a,d   Ito, Takeshi ^a   Ashida, Kenji ^a   Goto, Kiminobu ^a,d   Morinaga, Hidetaka ^d   Ikuyama, Shoichiro ^c   Takayanagi, Ryoichi ^a,d   Nawata, Hajime ^a,d  

^a KYUSHU UNIVERSITY   (Japan)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c KYUSHU UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

A549 cell; P2 WAF 1 CIP 1; Pituitary tumor transforming gene (PTTG)

Indexed keywords

LUCIFERASE; MESSENGER RNA; PROTEIN P21; PROTEIN P53; THYMIDINE; TRITIUM;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL GROWTH; CELL NUCLEUS; CELL STRAIN 3T3; CELL TRANSFORMATION; CELL TYPE; CELLULAR DISTRIBUTION; COLONY FORMATION; CONTROLLED STUDY; CYTOPLASM; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC TRANSFECTION; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; HUMAN PITUITARY TUMOR TRANSFORMING GENE; LUNG CANCER; MOLECULAR CLONING; NONHUMAN; NORTHERN BLOTTING; PROMOTER REGION; PROTEIN LOCALIZATION; PROTO ONCOGENE; RAT; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL DIVISION; CELL LINE; CLONING, MOLECULAR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION; HUMANS; LUNG NEOPLASMS; NEOPLASM PROTEINS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SUBCELLULAR FRACTIONS; TISSUE DISTRIBUTION; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 9144262954     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.50.771     Document Type: Article

References (27)

1. Pei L, Melmed S (1997) Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol Endocrinol 11: 433-441.
2. Zhang X, Horwitz GA, Prezant TR, Valentini A, Nakashima M, Bronstein MD, Melmed S (1999) Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). Mol Endocrinol 13: 156-166.
3. Dominguez A, Ramos-Morales F, Romero F, Rios RM, Dreyfus F, Tortolero M, Pintor-Toro, JA (1998) hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG. Oncogene 17: 2187-2193.
4. Lee IA, Seong C, Choe IS (1999) Cloning and expression of human cDNA encoding human homologue of pituitary tumor transforming gene. Biochem Mol Biol Int 47: 891-897.
5. Heaney AP, Horwitz GA, Wang Z, Singson R, Melmed S (1999) Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Nat Med 5: 1317-1321.
6. Chien W, Pei L (2000) A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product. J Biol Chem 275: 19422-19427.
7. Pei L (2000) Identification of c-Myc as a down-stream target for pituitary tumor-transforming gene. J Biol Chem 275: 31191-98, 2000.
8. Pei L (2000) Activation of mitogen-activated protein kinase cascade regulates pituitary tumor-transforming gene transactivation function. J Biol Chem 275: 31191-31198.
9. Zou H, McGarry TJ, Bernal T, Kirschner MW (1999) Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science 285: 418-422.
10. Yu R, Ren SG, Horwitz GA, Wang Z, Melmed S (2000) Pituitary tumor transforming gene (PTTG) regulates placental JEG-3 cell division and survival: evidence from live cell imaging. Mol Endocrinol 14: 1137-1146.
11. Yu R, Heaney AP, Lu W, Chen J, Melmed S (2000) Pituitary tumor transforming gene causes aneuploidy and p53-dependent and p53-independent apoptosis. J Biol Chem 275: 36502-36505.
12. Pei L (1999) Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells. J Biol Chem 274: 3151-3158.
13. Zhang X, Horwitz GA, Heaney AP, Nakashima M, Prezant TR, Bronstein MD, Melmed S (1999) Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas. J Clin Endocrinol Metab 84: 761-767.
14. Ogawa H, Inouye S, Tsuji FI, Yasuda K, Umesono K (1995) Localization, trafficking, and temperature-dependence of the Aequorea green fluorescent protein in cultured vertebrate cells. Proc Natl Acad Sci USA 92: 11899-11903.
15. Cowley S, Paterson H, Kemp P, Marshall CJ (1994) Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77: 841-852.
16. Cover CM, Hsieh SJ, Cram EJ, Hong C, Riby JE, Bjeldanes LF, Firestone GL (1999) Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells. Cancer Res 59: 1244-1251.
17. Mu Y-M, Yanase T, Nishi Y, Tanaka A, Saito M, Jin C-H, Goto K, Nawata H (2001) Saturated free fatty acids (FFAs), palmitic acid and stearic acid, induce apoptosis in human granulosa cells. Endocrinology (in press).
18. El-Deiry WS, Tokino T, Waldman T, Velculescu V, Oliner JD, Burell M, Hill DE, Healy E, Rees JL, Hamilton SR, Kinzler KW, Vogelstein B (1995) Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues. Cancer Res 55: 2910-2919.
19. Pei L (1998) Genomic organization and identification of an enhancer element containing binding sites for multiple proteins in rat pituitary tumor-transforming gene. J Biol Chem 273: 5219-5225.
20. Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW, Elledge SJ (1995) p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science 267: 1024-1027.
21. Johnson M, Dimitrov D, Vojta PJ, Barrett JC, Noda A, Pereira-Smith OM, Smith JR (1994) Evidence for a p53-independent pathway for upregulation of SDI1/CIP1/WAF1/p21 RNA in human cells. Mol Carcinog 11: 59-64.
22. Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, Vogelstein B, Jacks T (1995) p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev 9: 935-944.
23. Michieli P, Chedid M, Lin D, Pierce JH, Mercer WE, Givol D (1994) Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res 54: 3391-3395.
24. Datto MB, Li Y, Panus JF, Howe DJ, Xiong Y, Wang XF (1995) Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci USA 92: 5545-5549.
25. Datto MB, Yu Y, Wang XF (1995) Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter. J Biol Chem 270: 28623-28628.
26. Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai LH, Zhang P, Dobrowolski S, Bai C, Connell CL, Swindell E, Fox MP, Wei N (1995) Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell 6: 387-400.
27. Niculescu AB 3rd, Chen X, Smeets M, Hengst L, Prives C, Reed SI (1998) Effects of p21Cip1/Waf1 at both the G1/S and the G2/M Cell Cycle Transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol 18: 629-643.