Synthesis and biological evaluation of analogues of AKT (protein kinase B) inhibitor-IV

Journal of Medicinal Chemistry

Volumn 54, Issue 5, 2011, Pages 1126-1139

  Sun, Qi ^a   Wu, Runzhi ^a   Cai, Sutang ^a   Lin, Yuan ^b   Sellers, Llewlyn ^b   Sakamoto, Kaori ^b   He, Biao ^b   Peterson, Blake R ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(2 NITROPHENYL)PHENYLAMINE; (4 BENZOOXAZOL 2 YL 2 NITROPHENYL)PHENYLAMINE; (4 BENZOTHIAZOL 2 YL 2 NITROPHENYL)PHENYLAMINE; 1 ETHYL 2 [2 (METHYLPHENYLAMINO)ETHENYL] 3 PHENYL 3H BENZOIMIDAZOL 1 IUM IODINE; 1 ETHYL 6 METHOXYCARBONYL 2 [2 (METHYLPHENYLAMINO)ETHENYL] 3 PHENYL 3H BENZOIMIDAZOL 1 IUM IODINE; 2 (1 PHENYL 2 STYRYL 1H BENZOIMIDAZOL 5 YL)BENZOTHIAZOLE; 2 (1,2 DIPHENYL 1H BENZOIMIDAZOL 5 YL)BENZOTHIAZOLE; 2 (2 NONA 1,3 DIENYL 1 PHENYL 1H BENZOIMIDAZOL 5 YL)BENZOTHIAZOLE; 2 (4 CHLORO 3 NITROPHENYL)BENZOTHIAZOLE; 2 (5 BENZOTHIAZOL 2 YL 1 PHENYL 1H BENZOIMIDAZOL 2 YL)METHYL PHENYLAMINE; 2 [2 (METHYLPHENYLAMINO)ETHENYL] 1 PHENYL 1H BENZOIMIDAZOLE 5 CARBOXYLIC ACID METHYL ESTER; 2 [2 (METHYLPHENYLAMINO)ETHENYL] 1 PHENYL 1H BENZOIMIDAZOLE 5 CARBOXYLIC ACID PHENYLAMIDE; 3 AMINO 4 PHENYLAMINOBENZOIC ACID METHYL ESTER; 3 AMINO N PHENYL 4 PHENYLAMINOBENZAMIDE; 3 ETHYL 2 [2 (METHYLPHENYLAMINO)ETHENYL] 1 PHENYL 5 PHENYLCARBAMOYL 3H BENZOIMIDAZOL 1 IUM IODINE; 3 NITRO 4 PHENYLAMINOBENZOIC ACID METHYL ESTER; 3 NITRO N PHENYL 4 PHENYLAMINOBENZAMINE; 4 BENZOOXAZOL 2 YL N1 PHENYLBENZENE 1,2 DIAMINE; 4 BENZOTHIAZOL 2 YL N1 PHENYLBENZENE 1,2 DIAMINE; 5 BENZOOXAZOL 2 YL 3 ETHYL 2 [2 (METHYLPHENYLAMINO)ETHENYL] 1 PHENYL 3H BENZOIMIDAZOL 1 IUM IODINE; 5 BENZOTHIAZOL 2 YL 3 ETHYL 2 [2 (METHYLPHENYLAMINO)ETHENYL] 1 PHENYL 3H BENZOIMIDAZOL 1 IUM IODINE; [2 (5 BENZOOXAZOL 2 YL 1 PHENYL 1H BENZOIMIDAZOL 2 YL)ETHENYL]METHYLPHENYLAMINE; [2 (5 BENZOTHIAZOL 2 YL 1 PHENYL 1H BENZOIMIDAZOL 2 YL)ETHENYL]METHYLPHENYLAMINE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; METHYLPHENYL[2 (1 PHENYL 1H BENZOIMIDAZOL 2 YL)ETHENYL]AMINE; N PHENYLBENZENE 1,2 DIAMINE; PROTEIN KINASE B INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CATALYSIS; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN NHBE; CELL VIABILITY; CONTROLLED STUDY; CYCLIZATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; DRUG TARGETING; HELA CELL; HUMAN; HUMAN CELL; MYCOBACTERIUM FORTUITUM; NONHUMAN; PARAINFLUENZA VIRUS 5; VIRUS CELL INTERACTION; VIRUS RECOMBINANT; VIRUS REPLICATION;

ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; BENZIMIDAZOLES; BRONCHI; CELLS, CULTURED; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; MYCOBACTERIUM FORTUITUM; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RESPIRATORY MUCOSA; RUBULAVIRUS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TRACHEA; VIRUS REPLICATION;

EID: 79952259137     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100912b     Document Type: Article

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