Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism

Journal of Virology

Volumn 83, Issue 22, 2009, Pages 11665-11672

  Dunn, Ewan F ^a   Fearns, Rachel ^a   Connor, John H ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN KINASE B INHIBITOR IV; UNCLASSIFIED DRUG; WORTMANNIN;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RHABDOVIRUS; SIGNAL TRANSDUCTION; VACCINIA VIRUS; VESICULAR STOMATITIS VIRUS; VIRUS REPLICATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANTIVIRAL AGENTS; CHROMONES; MORPHOLINES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; VESICULOVIRUS; VIRUS REPLICATION;

RESPIRATORY SYNCYTIAL VIRUS; RHABDOVIRIDAE; VACCINIA VIRUS; VESICULAR STOMATITIS VIRUS;

EID: 70350316061     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01092-09     Document Type: Article

References (47)

1. Ahmed, N. N., T. F. Franke, A. Bellacosa, K. Datta, M. E. Gonzalez-Portal, T. Taguchi, J. R. Testa, and P. N. Tsichlis. 1993. The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential. Oncogene 8:1957-1963. (Pubitemid 23212429)
2. Arroyo, J. D., and W. C. Hahn. 2005. Involvement of PP2A in viral and cellular transformation. Oncogene 24:7746-7755.
3. Autret, A., S. Martin-Latil, C. Brisac, L. Mousson, F. Colbere-Garapin, and B. Blondel. 2008. Early phosphatidylinositol 3-kinase/Akt pathway activation limits poliovirus-induced JNK-mediated cell death. J. Virol. 82:3796-3802.
4. Avota, E., A. Avots, S. Niewiesk, L. P. Kane, U. Bommhardt, V. ter Meulen, and S. Schneider-Schaulies. 2001. Disruption of Akt kinase activation is important for immunosuppression induced by measles virus. Nat. Med. 7:725-731.
5. Bain, J., H. McLauchlan, M. Elliott, and P. Cohen. 2003. The specificities of protein kinase inhibitors: an update. Biochem. J. 371:199-204. (Pubitemid 36458094)
6. Bain, J., L. Plater, M. Elliott, N. Shpiro, C. J. Hastie, H. McLauchlan, I. Klevernic, J. S. Arthur, D. R. Alessi, and P. Cohen. 2007. The selectivity of protein kinase inhibitors: a further update. Biochem. J. 408:297-315.
7. Brehmer, D., Z. Greff, K. Godl, S. Blencke, A. Kurtenbach, M. Weber, S. Muller, B. Klebl, M. Cotten, G. Keri, J. Wissing, and H. Daub. 2005. Cellular targets of gefitinib. Cancer Res. 65:379-382.
8. Buchkovich, N. J., Y. Yu, C. A. Zampieri, and J. C. Alwine. 2008. The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt- mTOR signalling pathway. Nat. Rev. Microbiol. 6:266-275.
9. Calleja, V., M. Laguerre, P. J. Parker, and B. Larijani. 2009. Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition. PLoS Biol. 7:e17.
10. Chugh, P., B. Bradel-Tretheway, C. M. Monteiro-Filho, V. Planelles, S. B. Maggirwar, S. Dewhurst, and B. Kim. 2008. Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy. Retrovirology 5:11.
11. Cooray, S. 2004. The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival. J. Gen. Virol. 85:1065-1076.
12. Davies, S. P., H. Reddy, M. Caivano, and P. Cohen. 2000. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351:95-105.
13. Ehrhardt, C., T. Wolff, S. Pleschka, O. Planz, W. Beermann, J. G. Bode, M. Schmolke, and S. Ludwig. 2007. Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses. J. Virol. 81:3058-3067. (Pubitemid 46456615)
14. Franke, T. F. 2008. Intracellular signaling by Akt: bound to be specific. Sci. Signal. 1:pe29.
15. Godl, K., J. Wissing, A. Kurtenbach, P. Habenberger, S. Blencke, H. Gutbrod, K. Salassidis, M. Stein-Gerlach, A. Missio, M. Cotten, and H. Daub. 2003. An efficient proteomics method to identify the cellular targets of protein kinase inhibitors. Proc. Natl. Acad. Sci. USA 100:15434-15439.
16. Gruenberg, J., and F. G. van der Goot. 2006. Mechanisms of pathogen entry through the endosomal compartments. Nat. Rev. Mol. Cell Biol. 7:495-504.
17. Han, E. K., J. D. Leverson, T. McGonigal, O. J. Shah, K. W. Woods, T. Hunter, V. L. Giranda, and Y. Luo. 2007. Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition. Oncogene 26:5655-5661.
18. Karst, A. M., D. L. Dai, J. Q. Cheng, and G. Li. 2006. Role of p53 upregulated modulator of apoptosis and phosphorylated Akt in melanoma cell growth, apoptosis, and patient survival. Cancer Res. 66:9221-9226.
19. Kau, T. R., F. Schroeder, S. Ramaswamy, C. L. Wojciechowski, J. J. Zhao, T. M. Roberts, J. Clardy, W. R. Sellers, and P. A. Silver. 2003. A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell 4:463-476.
20. Kaur, S., A. Sassano, B. Dolniak, S. Joshi, B. Majchrzak-Kita, D. P. Baker, N. Hay, E. N. Fish, and L. C. Platanias. 2008. Role of the Akt pathway in mRNA translation of interferon-stimulated genes. Proc. Natl. Acad. Sci. USA 105:4808-4813.
21. Krishnamoorthy, J., Z. Mounir, J. F. Raven, and A. E. Koromilas. 2008. The eIF2α kinases inhibit vesicular stomatitis virus replication independently of eIF2α phosphorylation. Cell Cycle 7:2346-2351.
22. Lefrancios, L., and D. S. Lyles. 1982. The interaction of antibody with the major surface glycoprotein of vesicular stomatitis virus. I. Analysis of neutralizing epitopes with monoclonal antibodies. Virology 121:157-167.
23. Liu, T. C., H. Wakimoto, R. L. Martuza, and S. D. Rabkin. 2007. Herpes simplex virus Us3(-) mutant as oncolytic strategy and synergizes with phosphatidylinositol 3-kinase-Akt-targeting molecular therapeutics. Clin. Cancer Res. 13:5897-5902.
24. Luo, Y., A. R. Shoemaker, X. Liu, K. W. Woods, S. A. Thomas, R. de Jong, E. K. Han, T. Li, V. S. Stoll, J. A. Powlas, A. Oleksijew, M. J. Mitten, Y. Shi, R. Guan, T. P. McGonigal, V. Klinghofer, E. F. Johnson, J. D. Leverson, J. J. Bouska, M. Mamo, R. A. Smith, E. E. Gramling-Evans, B. A. Zinker, A. K. Mika, P. T. Nguyen, T. Oltersdorf, S. H. Rosenberg, Q. Li, and V. L. Giranda. 2005. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol. Cancer Ther. 4:977-986.
25. Lyles, D. S., M. O. McKenzie, P. E. Kaptur, K. W. Grant, and W. G. Jerome. 1996. Complementation of M gene mutants of vesicular stomatitis virus by plasmid-derived M protein converts spherical extracellular particles into native bullet shapes. Virology 217:76-87.
26. Minami, K., Y. Tambe, R. Watanabe, T. Isono, M. Haneda, K. Isobe, T. Kobayashi, O. Hino, H. Okabe, T. Chano, and H. Inoue. 2007. Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway. J. Virol. 81:11106-11115. (Pubitemid 47536083)
27. Ong, S. E., M. Schenone, A. A. Margolin, X. Li, K. Do, M. K. Doud, D. R. Mani, L. Kuai, X. Wang, J. L. Wood, N. J. Tolliday, A. N. Koehler, L. A. Marcaurelle, T. R. Golub, R. J. Gould, S. L. Schreiber, and S. A. Carr. 2009. Identifying the proteins to which small-molecule probes and drugs bind in cells. Proc. Natl. Acad. Sci. USA 106:4617-4622.
28. Peters, K., S. Chattopadhyay, and G. C. Sen. 2008. IRF-3 activation by Sendai virus infection is required for cellular apoptosis and avoidance of persistence. J. Virol. 82:3500-3508.
29. Ramaswamy, S., N. Nakamura, F. Vazquez, D. B. Batt, S. Perera, T. M. Roberts, and W. R. Sellers. 1999. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc. Natl. Acad. Sci. USA 96:2110-2115.
30. Schabbauer, G., J. Luyendyk, K. Crozat, Z. Jiang, N. Mackman, S. Bahram, and P. Georgel. 2008. TLR4/CD14-mediated PI3K activation is an essential component of interferon-dependent VSV resistance in macrophages. Mol. Immunol. 45:2790-2796.
31. Shelly, S., N. Lukinova, S. Bambina, A. Berman, and S. Cherry. 2009. Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus. Immunity 30:588-598.
32. Shpetner, H., M. Joly, D. Hartley, and S. Corvera. 1996. Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmannin. J. Cell Biol. 132:595-605. (Pubitemid 26069241)
33. Soares, J. A. P., F. G. G. Leite, L. G. Andrade, A. A. Torres, L. P. De Sousa, L. S. Barcelos, M. M. Teixeira, P. C. P. Ferreira, E. G. Kroon, T. Souto- Padron, and C. A. Bonjardim. 2009. Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infection is required for both host survival and viral replication. J. Virol. 83:6883-6899.
34. Song, Y. S., P. Narasimhan, G. S. Kim, J. E. Jung, E. H. Park, and P. H. Chan. 2008. The role of Akt signaling in oxidative stress mediates NF-κB activation in mild transient focal cerebral ischemia. J. Cereb. Blood Flow Metab. 28:1917-1926.
35. Sun, M., S. M. Fuentes, K. Timani, D. Sun, C. Murphy, Y. Lin, A. August, M. N. Teng, and B. He. 2008. Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses. J. Virol. 82:105-114.
36. Sun, S. Y., L. M. Rosenberg, X. Wang, Z. Zhou, P. Yue, H. Fu, and F. R. Khuri. 2005. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res. 65:7052-7058.
37. Thomas, K. W., M. M. Monick, J. M. Staber, T. Yarovinsky, A. B. Carter, and G. W. Hunninghake. 2002. Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway. J. Biol. Chem. 277:492-501.
38. Walker, E. H., M. E. Pacold, O. Perisic, L. Stephens, P. T. Hawkins, M. P. Wymann, and R. L. Williams. 2000. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol. Cell 6:909-919.
39. Werden, S. J., J. W. Barrett, G. Wang, M. M. Stanford, and G. McFadden. 2007. M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A. J. Virol. 81:2340-2348.
40. Widenmaier, S. B., A. V. Sampaio, T. M. Underhill, and C. H. McIntosh. 2009. Noncanonical activation of Akt/protein kinase B in β-cells by the incretin hormone glucose-dependent insulinotropic polypeptide. J. Biol. Chem. 284:10764-10773.
41. Wullschleger, S., R. Loewith, and M. N. Hall. 2006. TOR signaling in growth and metabolism. Cell 124:471-484.
42. Xu, J. T., H. Y. Tu, W. J. Xin, X. G. Liu, G. H. Zhang, and C. H. Zhai. 2007. Activation of phosphatidylinositol 3-kinase and protein kinase B/Akt in dorsal root ganglia and spinal cord contributes to the neuropathic pain induced by spinal nerve ligation in rats. Exp. Neurol. 206:269-279.
43. Yang, L., H. C. Dan, M. Sun, Q. Liu, X. M. Sun, R. I. Feldman, A. D. Hamilton, M. Polokoff, S. V. Nicosia, M. Herlyn, S. M. Sebti, and J. Q. Cheng. 2004. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res. 64:4394-4399. (Pubitemid 38856907)
44. Yu, Y., S. B. Kudchodkar, and J. C. Alwine. 2005. Effects of simian virus 40 large and small tumor antigens on mammalian target of rapamycin signaling: small tumor antigen mediates hypophosphorylation of eIF4E-binding protein 1 late in infection. J. Virol. 79:6882-6889. (Pubitemid 40677320)
45. Zaborowska, I., and D. Walsh. 2009. PI3K signaling regulates rapamycinin-sensitive translation initiation complex formation in vaccinia virus-infected cells. J. Virol. 83:3988-3992.
46. Zhirnov, O. P., and H. D. Klenk. 2007. Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling. Apoptosis 12:1419-1432.
47. Zhu, Q. S., W. Ren, B. Korchin, G. Lahat, A. Dicker, Y. Lu, G. Mills, R. E. Pollock, and D. Lev. 2008. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer Res. 68:2895-2903.