Targeting cell division: Small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 32, 2004, Pages 11821-11826

  Margalit, Danielle N ^a   Romberg, Laura ^a,c   Mets, Rebecca B ^b,d   Hebert, Alan M ^a   Mitchison, Timothy J ^a   Kirschner, Marc W ^a   RayChaudhuri, Debabrata ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c OBERLIN COLLEGE   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE; ENZYME INHIBITOR; FTSZ PROTEIN; GUANOSINE TRIPHOSPHATASE; PACLITAXEL; POLYMER; TUBULIN; UNCLASSIFIED DRUG; ZANTRIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; CELL DIVISION; CELL KINETICS; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVITY; ESCHERICHIA COLI; HYDROLYSIS; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROKARYOSIS; PROTEIN ASSEMBLY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOPOLYMERS; CYTOSKELETAL PROTEINS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; PROKARYOTA;

EID: 4143110291     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0404439101     Document Type: Article

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