Distinguished photons: A review of in vivo spectral fluorescence imaging in small animals

Current Pharmaceutical Biotechnology

Volumn 11, Issue 6, 2010, Pages 628-638

  Mansfield, James R ^a  

^a Cambridge Research & Instrumentation Inc   (United States)

Author keywords

Autofluorescence Removal; Fluorescence; In vivo Imaging; Quantitation; Spectral Imaging

Indexed keywords

DOXORUBICIN; FLUORESCENT DYE; NANOPARTICLE; DIAGNOSTIC AGENT;

AUTOFLUORESCENCE; BIOLUMINESCENCE; CLINICAL RESEARCH; FLUORESCENCE IMAGING; IN VIVO STUDY; LIGHT ABSORPTION; MOLECULAR IMAGING; NONHUMAN; PHOTON; REVIEW; SENSITIVITY AND SPECIFICITY; SPECTRAL FLUORESCENCE IMAGING; TECHNOLOGY; ANIMAL; ANIMAL DISEASE; FLUORESCENCE MICROSCOPY; GENETIC PROCEDURES; IMAGE ENHANCEMENT; METHODOLOGY; MOLECULAR PROBE; MOUSE; RAT;

ANIMALIA;

ANIMALS; IMAGE ENHANCEMENT; MICE; MICROSCOPY, FLUORESCENCE; MOLECULAR IMAGING; MOLECULAR PROBE TECHNIQUES; MOLECULAR PROBES; RATS;

EID: 79952115992     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920110792246474     Document Type: Review

References (149)

1. Gilbertson, B.; Longshaw, T.G. Multispectral aerial photography as exploration tool-I: Concepts, techniques and instrumentation. Remote Sens. Environ., 1975-1976, 4. 129-146.
2. Robinove, C. J. The logic of multispectral classification and mapping of land. Remote Sens. Environ., 1981, 11. 231-244.
3. Slate, P.N. Survey of multispectral imaging systems for earth observations. Remote Sens. Environ., 1985, 17 (1), 85-102.
4. Gowen, A.A.; O'Donnell, C.P.; Cullen, P.J.; Downey, G.; Frias, J.M. Hyperspectral imaging-an emerging process analytical tool for food quality and safety control. Trends Food Sci. Technol. 2007, 18 (12) 590-598.
5. Ariana, D.; Guyer, D.E.; Shrestha, B. Integrating multispectral reflectance and fluorescence imaging for defect detection on apples. Comput. Electron. Agric., 2006, 50 (2), 148-161.
6. Roggo, Y.; Ulmschneider, M. Chemical Imaging and Chemometrics: Useful Tools for Process Analytical Technology. Pharmaceutical Manufacturing Handbook. Regulations and Quality, Chapter 4.3, John Wiley, New York, 2009.
7. Lewis, E.N.; Dubois, J. Understanding the potential of near infrared chemical imaging. Am. Lab., 2008, 40 (18), 36-39.
8. Cruz, J; Bautista, M.; Amigo, J.M.; Blanco, M. Nir-chemical imaging study of acetylsalicylic acid in commercial tablets. Talanta, 2009, 80(2), 473-478.
9. Kubik, M. Hyperspectral imaging: A new technique for the noninvasive study of artworks Chapter 5. Phys. Tech. Study Art, Archaeol. Cultural Heritage. 2007, 2. 199-259.
10. Attas, M.; Cloutis, E.; Collins, C.; Goltz, D.; Majzels, C.; Mansfield, J.R.; Mantsch, H.H. Near-infrared spectroscopic imaging in art conservation: investigation of drawing constituents. J. Cultural Heritage. 2003 4(2), 127-136.
11. Levenson, R.L.; Beechem, J.M. Practical Multispectral Fluorescence Imaging. In Practical Fluorescence Imaging, Humana Press: USA, 2004.
12. Garini, Y.; Young, I.T.; McNamara, G. Spectral imaging: principles and applications. Cytometry Part A, 2006, 69A. 735-747
13. Zimmermann, T.; Rietdorf, J.; Pepperkok, R. Spectral imaging and its application in live cell microscopy. FEBS Lett., 2003, 546, 87-92.
14. Levenson, RM; Fornari, A; Loda, M. Multispectral imaging and pathology: seeing and doing more. Expert Opin. Mol. Diagn., 2008, 2(9), 1067-1081.
15. Tholouli, E.; Sweeney, E.; Barrow, E.; Clay, V.; Hoyland, J.A.; Byers, R.J. Quantum dots light up pathology. J. Pathol., 2008, 216(3), 275-285.
16. Dickinson, M.E.; Bearman, G.; Tilie, S.; Lansford, R.; Fraser, S.E. Multi-spectral imaging and linear unmixing add a whole new dimension to laser scanning fluorescence microscopy. Biotechniques, 2001, 31(6),1272-1278.
17. Mansfield, J.R.; Hoyt, C.; Levenson, R.L. Visualization of microscopy-based spectral imaging data from multi-label tissue sections. Curr. Prot. Mol. Biol., 2008, 14,14-19.
18. Chaudhari, A.J.; Darvas, F.; Bading, J.R.; Moats, R.A.; Conti, P.S.; Smith, D.J.; Cherry, S.R.; Leahy, R.M. Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging. Phys. Med. Biol., 2005, 50(23),5421-5441.
19. Qin, C.; Yang, X.; Feng, J.; Liu, K.; Liu, J.; Yan, G.; Zhu, S.; Xu, M.; Tian, J. Adaptive improved element free Galerkin method for quasi-or multi-spectral bioluminescence tomography. Opt. Express, 2009, 17(24), 21925-21934.
20. Farkas DL, Becker D. Applications of spectral imaging: detection and analysis of human melanoma and its precursors. Pig. Cell Res., 2001, 14(1), 2-8.
21. Dhawan, A.P.; D'Alessandro, B.; Patwardhan, S.; Mullani, N. Multispectral optical imaging of skin-lesions for detection of malignant melanomas. Conf. Proc. IEEE Eng. Med. Biol. Soc., 2009, 5352-5355.
22. Klaessens, J.H.G.M.; Noordmans, H.J.; de Roode, R.; Verdaasdonk, R.M. Non-invasive skin oxygenation imaging using a multispectral imaging system, effectiveness of different concentration algorithms applied on human skin. Dössel and W.C. Schlegel Eds., WC 2009, IFMBE Proceedings, 2009, Vol. 25/II, pp. 725-728.
23. Kupriyanov, V.V.; Nighswander-Rempel, S.; Xiang, B. Mapping regional oxygenation and flow in pig hearts in vivo using nearinfrared spectroscopic imaging. J. Mol. Cell. Cardiol. 2004, 37, 5. 947-957.
24. Mansfield, J.R.; Sowa, M.G.; Payette, J.; Badur; Stranc, F.; Mantsch, H.H. A fuzzy C-means clustering approach to the analysis of multispectral images of the rat dorsal skin flap. IEEE Trans. Med. Imaging, 1998, 6. 1011-1018.
25. Cancio, L.C.; Batchinsky, A.I.; Mansfield, J.R.; Panasyuk, S.; Hetz, K.; Martini, D.; Jordan, B.S.; Tracey, B.; Freeman, J.E. Hyperspectral imaging: A new approach to the diagnosis of hemorrhagic shock. J. Trauma. 2006, 60(5),1087-1095.
26. Stamatas, G.N.; Kollias, N. In vivo documentation of cutaneous inflammation using spectral imaging. J. Biomed. Opt., 2007, 12(5), 051603.
27. Attas, M.; Posthumus, T.; Schattka, B.; Sowa, M.; Mantsch, H.H.; Zhang, S. Long-wavelength near-infrared spectroscopic imaging for In vivo skin hydration measurements. Vib. Spectrosc., 2002, 28(1),37-43.
28. Thekkek, N.; Richards-Kortum, R. Optical imaging for cervical cancer detection: solutions for a continuing global problem. Nat. Rev. Cancer, 2008, 8(9), 725-731.
29. Gebhart, S.C.; Stokes, D.L.; Vo-Dinh, T.; Mahadevan-Jansen, A. Instrumentation Considerations in Spectral Imaging for Tissue Demarcation: Comparing Three Methods of Spectral Resolution. In: Spectral Imaging: Instrumentation, Applications, and Analysis III. Bearman, G.H.; Mahadevan-Jansen, A.; Levenson, R.M. Eds. Proc. SPIE, 2005, Vol. 5694. p. 41.
30. Shaner, N.C.; Steinbach, P.A.; Tsien, R.Y. A guide to choosing fluorescent proteins. Nat. Biotechnol., 2005, 12, 905-909.
31. Amos, W.B. The Glow Spreads Throughout Biology: Green Fluorescent Protein: Properties, Applications and Protocols. Chalfie, M.; Kain, S. Eds. Trends in Biochemical Sciences, Elsevier: USA, 1999, Vol. 24(6), p. 251.
32. Tsien, R.Y. The 2009 Lindau Nobel Laureate Meeting: Roger Y. Tsien, Chemistry 2008 J. Vis. Exp., 2010, 13(35), pii: 1575.
33. Graves, E.E.; Weissleder, R.; Ntziachristos, V. Fluorescence molecular imaging of small animal tumor models. Curr. Mol. Med., 2004, 4, 419-430.
34. Choy, G.; Choyke, P.; Libutti, S.K. Current advances in molecular imaging: noninvasive in vivo bioluminescent and fluorescent optical imaging in cancer research. Mol. Imaging, 2003, 2, 303-312.
35. Hilderbrand, S.A.; Weissleder, R. Near-infrared fluorescence: application to in vivo molecular imaging. Curr. Opin Chem. Biol. 2010, 14(1), 71-79.
36. Zhou, L.; El-Deiry, W.S. Multispectral fluorescence imaging. J. Nucl. Med., 2009, 50,1563-1566
37. Levenson, R.L.; Mansfield, J.R. Multispectral imaging in biology and medicine: slices of life. Cytometry Part A, 2006, 69A. 748-758.
38. Troy, T.; Jekic-McMullen, D.; Sambucetti, L.; Rice, B. Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models. Mol. Imaging, 2004, 3. 9-23.
39. Welsh, D.K.; Kay, S.A. Bioluminescence imaging in living organisms. Curr. Opin. Biotechnol., 2005, 16(1), 73-78
40. Troy, T.; Jekic-McMullen, D.; Sambucetti, L.; Rice, B. Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models. Mol. Imaging, 2004, 3. 9-23.
41. Tam, J.M.; Upadhyay R; Pittet MJ; Weissleder R; Mahmood, U. Improved in vivo whole-animal detection limits of green fluorescent protein-expressing tumor lines by spectral fluorescence imaging. Mol. Imaging. 2007, 6. 269-276
42. Frangioni, J.V. In vivo near-infrared fluorescence imaging. Curr. Opin. Chem. Biol., 2003, 7, 626-634.
43. Kovara, J.L.; Simpson, M.A.; Schutz-Geschwendera, A.; Olive, D.M. A systematic approach to the development of fluorescent contrast agents for optical imaging next term of mouse cancer models. Anal. Biochem., 2007, 367(1), 1-12.
44. Mansfield, J.R.; Hoyt, C.C.; Miller, P.M.; Levenson, R.L. Distinguished photons: increased contrast with multispectral in vivo fluorescence imaging. BioTechniques, 2005, 39, S33-S37
45. Neher, R. A.; Neher, E. Optimizing imaging parameters for the separation of multiple labels in a fluorescence image. J. Microsc., 2003, 213, 46-62.
46. Bateson, A.; Curtiss, B. A method for manual endmember selection and spectral unmixing. Remote Sens. Environ. 1996, 55(3), 229-243.
47. Gendrin, C.; Roggo, Y.; Collet, C. Pharmaceutical applications of vibrational chemical imaging and chemometrics: A review. J. Pharm. Biomed. Anal., 2008, 48, (3), 533-553.
48. Mansfield, J.R.; Sowa, M.G.; Scarth, G.B.; Mantsch, H.H. The use of fuzzy C-means clustering in the analysis of spectroscopic imaging data. Anal. Chem., 1997, 69, 3370-3374.
49. Winter, M.E. N-FINDR: an algorithm for fast autonomous spectral end-member determination in hyperspectral data. Proc. SPIE, Imaging Spectrom., 1999, 3753, 266-275.
50. Polder, G.; van der Heijden, G. W. A. M.; Young, I. T. Tomato sorting using independent component analysis on spectral images. Real-Time Imaging. 2003, 9(4), 253-259.
51. Mansfield, J.R.; Gossage, K.W.; Hoyt, C.C.; Levenson, R.L. Autofluorescence removal, multiplexing, and automated analysis methods for In vivo fluorescence imaging. J. Biomed. Opt., 2005, 10(4), 207-1-207-9.
52. Rutan, S.C.; de Juan, A.; Tauler, R. Introduction to multivariate curve resolution. Compr. Chemometrics, 2009, 15. 249-259.
53. Duponchel, L.; Elmi-Rayaleh, W.; Ruckebusch, C.; Huvenne, J.P. Multivariate curve resolution methods in imaging spectroscopy: influence of extraction methods and instrumental perturbations. J. Chem. Inf. Comput. Sci., 2003, 43(6), 2057-2067.
54. Sutherland, V.L.; Timlin, J.A.; Nieman, L.T.; Guzowski, J.F.; Chawla, M.K.; Worley, P.F.; Roysam, B.; McNaughton, B.L.; Sinclair, M.B.; Barnes, C.A. Advanced imaging of multiple mRNAs in brain tissue using a custom hyperspectral imager and multivariate curve resolution. J. Neurosci. Methods, 2007, 160(1), 144-148.
55. Hu, H.; Rice, B.W. In vivo fluorescence imaging with a multivariate curve resolution spectral unmixing technique. J. Biomed. Opt., 2009, 14(6),064011.
56. Budevska, B.O.; Sum, S.T.; Jones, T.J. Application of multivariate curve resolution for analysis of FT-IR microspectroscopic images of in situ plant tissue. Appl. Spectrosc., 2003, 57(2), 124-131.
57. Mansfield, J.R.; Sowa, M.G.; Majzels, C.; Collins, C.; Cloutis, E.; Mantsch, H.H. Near infrared spectroscopic reflectance imaging: supervised vs. unsupervised analysis using an art conservation application. Vib. Spectrosc. 1999 19(1),33-45.
58. Pierna, F.J.A.; Baeten. V.; Dardenne, P.; Dubois, J.; Lewis, E.N.; Burger, J. Comprehensive Chemometrics, In: Spectroscopic Imaging. Brown, S.; Tauler, R.; Walczak, R. Eds., Oxford: Elsevier, 2009, Vol. 4. pp. 173-196
59. Bouchard, M.B.; MacLaurin, S. A; Dwyer, P.J.; Mansfield, J.; Levenson, R.; Krucker, T. Technical considerations in longitudinal multispectral small animal molecular imaging. J. Biomed. Opt., 2007, 12(5),051601.
60. Smith, A.M.; Nie, S. Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv. Drug Deliv. Rev., 2008, 60. 1226-1240.
61. Gao, X.; Dave, S.R. Quantum dots for cancer molecular imaging. Adv. Exp. Med. Biol., 2007, 620, 57-73.
62. Su, J.; Zhang, J.; Liu, L.; Huang, Y.; Mason, R.P. Exploring feasibility of multicolored CdTe quantum dots for in vitro and in vivo fluorescent imaging. J. Nanosci. Nanotechnol., 2008, 8(3),1174-7.
63. Bentolila, L.; Ebenstein, Y.; Weiss, S. Quantum DOTs for in vivo small-animal imaging. J. Nucl. Med., 2009, 50, 493-496
64. Li, Z.B.; Cai, W.; Chen, X. Semiconductor quantum dots for in vivo imaging. J. Nanosci. Nanotechnol., 2007, 7(8), 2567-2581.
65. Longmire, M.; Choyke, P.; Kobayashi, H. Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats. Nanomedicine, 2008, 3(5), 703-717.
66. Yaseen, M.; Yu, J.; Wong, M.S.; Anvari, B. In-vivo fluorescence imaging of mammalian organs using charge-assembled mesocapsule constructs containing indocyanine green. Opt. Express, 2008, 16(25), 20577-20587.
67. Kumar, R.; Roy, I.; Ohulchanskky, T.Y.; Vathy, L.A.; Bergey, E.J.; Sajjad, M.; Prasad, P.N. In vivo biodistribution and clearance studies using multimodal organically modified silica nanoparticles. ACS Nano. 2010, 4(2), 699-708.
68. He, X.; Zhang, P. In Vivo study of biodistribution and urinary excretion of surface-modified silica nanoparticles. Anal. Chem., 2008, 80 (24), pp. 9597-9603.
69. Hama, Y.; Koyama, Y.; Urano, Y.; Choyke, P.L.; Kobayashi, H. Two-color lymphatic mapping using ig-conjugated near infrared optical probes. J. Invest. Dermatol., 2007, 127. 2351-2356.
70. Hama, Y.; Koyama, Y.; Urano, Y.; Choyke, P.L.; Kobayashi, H. Simultaneous two-color spectral fluorescence lymphangiography with near infrared quantum dots to map two lymphatic flows from the breast and the upper extremity. Breast Cancer Res. Treat., 2007, 103, 23-28.
71. Kosaka, N.; Ogawa, M.; Sato, N.; Choyke, P.L.; Kobayashi, H. In vivo real-time, multicolor, quantum dot lymphatic imaging. Soc. Invest. Dermatol., 2009, 129(12), 2818-22.
72. Kobayashi, H.; Ogawa, M.; Kosaka, N.; Choyke, P.L.; Urano, Y. Multicolor imaging of lymphatic function with two nanomaterials: quantum dot-labeled cancer cells and dendrimer-based optical agents. Nanomedicine, 2009, 4(4), 411-419.
73. Kobayashi, H.; Koyama, Y.; Barrett, T.; Hama, Y.; Regino, C.A.; Shin, I.S.; Jang, B.S.; Le, N.; Paik, C.H.; Choyke, P.L.; Urano, Y. Multimodal nanoprobes for radionuclide and five-color nearinfrared optical lymphatic imaging. ACS Nano, 2007,4. 258-264.
74. Kobayashi, H.; Hama, Y.; Koyama, Y.; Barrett, T.; Regino, C.A.; Urano, Y.; Choyke, P.L. Simultaneous multicolor imaging of five different lymphatic basins using quantum dots. Nano Lett., 2007, 6. 1711-1716.
75. Chu, M.; Wan, Y. Sentinel lymph node mapping using nearinfrared fluorescent methylene blue. J. Biosci. Bioeng., 2009, 4. 455-459.
76. Koyama, Y.; Barrett, T.; Hama, Y.; Ravizzini, G.; Choyke, P.L.; Kobayashi, H. In vivo molecular imaging to diagnose and subtype tumors through receptor-targeted optically labeled monoclonal antibodies. Neoplasia, 2007, 12. 1021-1029.
77. Ogawa, M.; Regino, C.A.; Choyke, P.L.; Kobayashi, H. In vivo target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies. Mol. Cancer Ther., 2009, 8(1), 232-239.
78. Barrett, T.; Koyama, Y.; Hama, Y.; Ravizzini, G.; Shin, I.S.; Jang, B.S.; Paik, C.H.; Urano, Y.; Choyke, P.L.; Kobayashi, H. In vivo diagnosis of epidermal growth factor receptor expression using molecular imaging with a cocktail of optically labeled monoclonal antibodies. Clin. Cancer Res., 2007, 13(22), 6639-6648.
79. Chang, S.K.; Rizvi, I.; Solban, N.; Hasan, T. In vivo optical molecular imaging of vascular endothelial growth factor for monitoring cancer treatment. Clin. Cancer Res., 2008, 14(13), 4146-4153.
80. Zhang, H.; Zeng, X.; Li, Q.; Gaillard-Kelly, M.; Wagner, C.R.; Yee, D. Fluorescent tumour imaging of type I IGF receptor in vivo. comparison of antibody-conjugated quantum dots and smallmolecule fluorophore. Br. J. Cancer, 2009 101. 71-79
81. Bogdanov, A.A. Jr.; Lin, C.P.; Kang, H.W. Optical imaging of the adoptive transfer of human endothelial cells in mice using antihuman CD31 monoclonal antibody. Pharm. Res., 2007, 24(6), 1186-92.
82. Manning, H.C.; Merchant, N. P; Foutch, A.C.; Virostko, J.M.; Wyatt, S.K.; Shah, C.; McKinley, E.T.; Xie, J.; Mutic, N.J.; Washington, M.K.; Lafleur, B.; Tantawy, M.N.; Peterson, T.E.; Ansari, M.S.; Baldwin, R.M.; Rothenberg, M.C.; Bornhop, D.J.; Gore, J.C.; Coffey, R.J. Molecular imaging of therapeutic response to EGF receptor blockade in colorectal cancer. Clin. Cancer Res., 2008, 14(22), 7413-7422.
83. Gunn, A.J.; Kobayashi, H.; Choyke, P.L. Targeted optical fluorescence imaging of human ovarian adenocarcinoma using a galactosyl serum albumin-conjugated fluorophore. Cancer Sci., 2007, 98(11),1727-1733.
84. Shah, C.; Miller, T.W.; Wyatt, S.K.; McKinley, E.T.; Olivares, M.G.; Sanchez, V.; Nolting, D.D.; Buck, J.R.; Zhao, P.; Ansari, M.S.; Baldwin, R.M.; Gore, J.C.; Schiff, R.; Arteaga, C.L.; Manning, H.C. Imaging biomarkers predict response toanti-HER2 (ErbB2) therapy in preclinical models of breast cancer. Clin. Cancer Res., 2009, 15(14), 4712-4721.
85. Kosaka, N.; Ogawa, M.; Longmire, M.R.; Choyke, P.L.; Kobayashi, H. Multi-targeted multi-color in vivo optical imaging in a model of disseminated peritoneal ovarian cancer. J. Biomed. Opt., 2009, 14(1), 014023.
86. Hama, Y.; Urano, Y.; Koyama, Y.; Bernardo, M.; Choyke, P.L.; Kobayashi, H. A comparison of the emission efficiency of four common green fluorescence dyes after internalization into cancer cells. Bioconjug. Chem., 2006, 17. 1426-1431.
87. Longmire, M.; Ogawa, M.; Hama, Y.; Kosaka, N.; Regino, C.A.; Choyke, P. L.; Kobayashi, H. Determination of optimal rhodamine fluorophore for in vivo optical imaging. Bioconjug. Chem., 2008, 19. 1735-1742.
88. Backer, M.V.; Levashova, Z.; Levenson, R.; Blankenberg, F.G.; Backer, J.M. Cysteine-containing fusion tag for site-specific conjugation of therapeutic and imaging agents to targeting proteins. Methods Mol. Biol., 494, 275-294.
89. Zhu, S.; Hong, M.; Zhang, L.; Tang, G. Jiang, Y.; Pei, Y. PEGylated PAMAM dendrimer-doxorubicin conjugates: in vitro evaluation and in vivo tumor accumulation. Pharm. Res., 2010, 27(1), 161-174.
90. Urano, Y. Sensitive and selective tumor imaging with novel and highly activatable probes. Anal. Sci., 2008, 24. 51-53.
91. Aguilera, T.A., Olson, E.S.; Timmers, M.M.; Jiang, T.; Tsien, R.Y. Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides. Integr. Biol., 2009, 1(5-6), 371-381.
92. Ogawa, M.; Kosaka, N.; Longmire, M.R.; Urano, Y.; Choyke, P.L.; Kobayashi, H. Fluorophore-quencher based activatable targeted optical probes for detecting in vivo cancer metastases. Mol. Pharm., 2009, 2. 386-395.
93. Ogawa, M.; Kosaka, N.; Choyke, P.L.; Kobayashi, H. In vivo molecular imaging of cancer with a quenching near-infrared fluorescent probe using conjugates of monoclonal antibodies and indocyanine green. Cancer Res., 2009, 69(4), 1268-1272.
94. Ogawa, M.; Kosaka, N.; Choyke, P.L.; Kobayashi, H. H-type dimer formation of fluorophores: a mechanism for activatable, in vivo optical molecular imaging. ACS Chem. Biol., 2009, 4(7), 535-546.
95. Urano, Y.; Asanuma, D.; Hama, Y.; Koyama, Y.; Barrett, T.; Kamiya, M.; Nagano, T.; Watanabe, T.; Hasegawa, A.; Choyke, P.L.; Kobayashi, H. Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes. Nat. Med., 2009, 15(1), 104-109.
96. Raymond, S.B.; Skoch, J.; Hills, I.D.; Nesterov, E.E.; Swager, T.M.; Bacskai, B.J. Smart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology. Eur. J. Nucl. Med. Mol. Imaging, 2008, 35(Suppl 1), S93-98.
97. Kamiya, M.; Kobayashi, H.; Hama, Y.; Koyama, Y.; Bernardo, M.; Nagano, T.; Choyke, P.L.; Urano, Y. An enzymatically activated fluorescence probe for targeted tumor imaging. J. Am. Chem. Soc., 2007, 13. 3918-3929.
98. Hama, Y.; Urano, Y.; Koyama, Y.; Kamiya, M.; Bernardo, M.; Paik, R.S.; Shin, I.S.; Paik, C.H.; Choyke, P.L.; Kobayashi, H. A target cell-specific activatable fluorescence probe for in vivo molecular imaging of cancer based on a self-quenched avidinrhodamine conjugate. Cancer Res., 2007, 67(6), 2791-2799.
99. Lipton, M.J.; Brundage, B.H.; Higgins, C.B.; Boyd, D.P. Clinical applications of dynamic computed tomography. Prog. Cardiovas. Dis., 1986, 28(5), 349-366.
100. Paldino, M.J.; Barboriak, D.P. Fundamentals of quantitative dynamic contrast-enhanced MR imaging. Magn. Reson. Imaging Clin. N. Am., 2009, 17(2), 277-289.
101. Zhou, H.; Luby-Phelps, K.; Mickey, B.E.; Habib, A.A.; Mason, R.P. Dynamic near-infrared optical imaging of 2-deoxyglucose uptake by intracranial glioma of athymic mice. PLoS ONE, 2009, 4(11), e8051.
102. Hama, Y.; Koyama, Y.; Choyke, P.L.; Kobayashi, H. Two-color in vivo dynamic contrast-enhanced pharmacokinetic imaging. J. Biomed. Opt., 2007, 12(3), 034016.
103. Ogawa, M.; Kosaka, N.; Choyke, P.L.; Kobayashi, H. Tumorspecific detection of an optically targeted antibody combined with a quencher-conjugated neutravidin "Quencher-Chaser.: A Dual "Quench and Chase. Strategy to improve target to nontarget ratios for molecular imaging of cancer. Bioconjug. Chem., 2009, 20. 147-154.
104. Hillman, E.M.C.; Moore, A. All-optical anatomic co-registration for molecular imaging of small animals using dynamic contrast. Nat. Photonics, 2007, 1(9), 526-530.
105. Virostko, J.; Xie J, Hallahan, D.E.; Arteaga, C.L.; Gore, J.C.; Manning, H.C. A molecular imaging paradigm to rapidly profile response to angiogenesis-directed therapy in small animals. Mol. Imaging Biol., 2009, 11(3), 204-412.
106. Mayes, P.A.; El-Deiry, W.S. Noninvasive vascular imaging in fluorescent tumors using multispectral imaging. BioTechniques, 2008, 45. 459-464
107. Cai, W.; Shin, D.W.; Chen, K.; Gheysens, O.; Cao, Q.; Wang, S.X.; Gambhir, S.S.; Chen, X. RGD peptide-labeled NIR quantum dots for imaging tumor vasculature in living subjects. Nano Lett., 2006, 6(4),669-676.
108. Thorne, S.H.; Negrin, R.S.; Contag, C.H. Synergistic antitumor effects of immune cell-viral biotherapy. Science, 2006, 311. 1780-1784.
109. Ke, W.; Shao, K.; Huang, R., Han, L.; Liu, Y.; Li, J.; Kuang, Y.; Ye, L.; Lou, J.; Jiang, C. Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. Biomaterials, 2009, 30(36), 6976-6985.
110. Liu, Y.; Huang, R.; Han, L.; Ke, W.; Shao, K.; Ye, L.; Lou, J.; Jiang, C. Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles. Biomaterials. 2009, 30(25), 4195-202.
111. Shu, X.; Royant, A.; Lin, M.Z.; Aguilera, T.A.; Lev-Ram, V.; Steinbach, P.A.; Tsien, R.Y. Mammalian expression of infrared fluorescent proteins engineered from a bactieral phytochrome. Science. 2009, 324. 804-807.
112. Los, G.V.; Wood, K. The HaloTag: a novel technology for cell imaging and protein analysis. Methods Mol. Biol., 2007, 356. 195-208.
113. Kosaka, N.; Ogawa, M.; Choyke, P.L.; Karassina, N.; Corona, C.; McDougall, M.; Lynch, D.T.; Hoyt, C.C.; Levenson, R.M.; Los, G.V.; Kobayashi, H. In vivo stable tumor-specific painting in various colors using dehalogenase-based protein-tag fluorescent ligands. Bioconjug. Chem., 2009, 20(7),1367-1374.
114. Zhang, G.J.; Chen, T.B.; Connolly, B.; Lin, S.A.; Hargreaves, R.; Vanko, A.; Bednar, B.; Macneil, D.J.; Sur, C.; Williams, D.L. In vivo optical imaging of lacz expression using lacz transgenic mice. Assay Drug Dev. Technol., 2009, 4. 391-399.
115. de Vries, B.M.W.; Zeebregts, C.J. Images in cardiovascular medicine. Multispectral near-infrared fluorescence molecular imaging of matrix metalloproteinases in a human carotid plaque using a matrix-degrading metalloproteinase-sensitive activatable fluorescent probe. Images Cardiovasc. Med., 2009, 26,119(20), e534-536.
116. Ma, P.; Liu, S.; Huang, Y.; Chen, X.; Zhang, L.; Jing, X. Lactose mediated liver-targeting effect observed by ex vivo imaging technology. Biomaterials, 2010, 31(9), 2646-2654.
117. Levenson, R.L.; Lynch, D.T.; Kobayashi, H.; Backer, J.M.; Backer, M.V. Multiplexing with multispectral imaging: from mice to microscopy. ILAR J., 2008, 49(1), 78-88.
118. Trede, N.S.; Levenson. R.M. MSI in small (and very small) animals. Screening, 2005, 02. 20-22.
119. Roy, D.; Steyer, G.J.; Gargesha, M.; Stone, M.E.; Wilson, D.L. 3D cryo-imaging: a very high-resolution view of the whole mouse. Anat. Rec., 2009, 292, 342-351.
120. Henriquez, N.V.; van Overveld, P.G.; Que, I.; Buijs, J.T.; Bachelier, R.; Kaijzel, E.L.; Löwik, C.W.; Clezardin, P.; van der Pluijm, G. Advances in optical imaging and novel model systems for cancer metastasis research. Clin. Exp. Metastasis, 2007, 24(8), 699-705.
121. Hama, Y.; Urano, Y.; Koyama, Y.; Choyke, P.L.; Kobayashi, H. Dgalactose receptor-targeted in vivo spectral fluorescence imaging of peritoneal metastasis using galactosamin-conjugated serum albumin-rhodamine green. J. Biomed. Opt., 2007, 12(5),051501.
122. Hama, Y.; Urano, Y.; Koyama, Y.; Choyke, P.L.; Kobayashi, H. Activatable fluorescent molecular imaging of peritoneal metastases following pretargeting with a biotinylated monoclonal antibody. Cancer Res., 2007, 67. (8), 3809-3817.
123. Hama, Y.; Urano, Y.; Koyama, Y.; Gunn, A.J.; Choyke, P.L.; Kobayashi, H. A self-quenched galactosamine-serum albuminrhodaminex conjugate: A "smart. fluorescent molecular imaging probe synthesized with clinically applicable material for detecting peritoneal ovarian cancer metastases. Clin. Cancer Res., 2007, 13(21), 6335-6343.
124. Koyama, Y.; Hama, Y.; Urano, Y.; Nguyen, D.M.; Choyke, P.L.; Kobayashi, H. Spectral fluorescence molecular imaging of lung metastases targeting HER2/neu. Clin. Cancer Res., 2007, 13(10), 2936-2945.
125. Gunn, A.J.; Kobayashi, H.; Choyke, P.L. Tumor-targeted optical imaging in the management of peritoneal carcinomatosis. SD Med., 2007, 60(9),353-357
126. Lin, S.; Xie, X.; Patel, M.R.; Yang, Y.; Li, Z.; Cao, F.; Gheysens, O.; Zhang, Y.; Gambhir, S.S.; Rao, J.H.; Wu, J.C. Quantum dot imaging for embryonic stem cells. BMC Biotechnol., 2007, 7, 67.
127. Yukawa, H.; Kagami, Y.; Watanabe, M.; Oishi, K.; Miyamoto, Y.; Okamoto, Y.; Tokeshi, M.; Kaji, N.; Noguchi, H.; Ono, K.; Sawada, M.; Baba, Y.; Hamajima, N.; Hayashi, S. Quantum dots labeling using octa-arginine peptides for imaging of adipose tissuederived stem cells. Biomaterials, 2010, 31(14), 4094-4103.
128. Snyder, E.L.; Bailey, D.; Shipitsin, M.; Polyak, K.; Loda, M. Identification of CD44v6+/CD24-breast carcinoma cells in primary human tumors by quantum dot-conjugated antibodies. Lab. Investig., 2009, 89. 857-866.
129. Vlashi, E.; Kim, K.; Lagadec, C.; Donna, L.D.; McDonald, J.T.; Eghbali, M.; Sayre, J.W.; Stefani, E.; McBride, W.; Pajonk, F. In vivo imaging, tracking, and targeting of cancer stem cells. J. Natl. Cancer Inst., 2009, 101. 350-359.
130. Hart, L.S.; El-Deiry, W.S. Invincible, but not invisible: imaging approaches toward in vivo detection of cancer stem cells. J. Clin. Oncol., 2008, 17. 2901-2910.
131. Chen, K.; Li, Z.-B.; Wang, H.; Cai, W. Dual-modality optical and positron emission tomography imaging of vascular endothelial growth factor receptor on tumor vasculature using quantum dots. Eur. J. Nucl. Med. Mol. Imaging, 2008, 35,2235-2244
132. Longmire, M.; Choyke, P.; Kobayashi, H. Dendrimer-based contrast agents for molecular imaging. Curr. Top. Med. Chem., 2008, 8, 1180-1186.
133. Koyama, Y.; Talanov, V.S.; Bernardo, M.; Hama, Y.; Regino, C.A.; Brechbiel, M.W.; Choyke, P.L.; Kobayashi, H. A dendrimerbased nanosized contrast agent dual-labeled for magnetic resonance and optical fluorescence imaging to localize the sentinel lymph node in mice. J. Mag. Reson. 2007, 25. 866-871.
134. Olson, E.S.; Jiang, T.; Aguilera, T.A.; Nguyen, Q. T; Ellies, L.G.; Scadeng, M.; Tsien, R.Y. Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc. Natl. Acad. Sci. USA, 2010, 107(9), 4311-4316.
135. Bhushan, K.R.; Misra, P.; Liu, F.; Mathur, S.; Lenkinski, R.E.; Frangioni, J.V. Detection of breast cancer microcalcifications using a dual-modality SPECT/ NIR fluorescent probe. J. Am. Chem. Soc., 2008, 130. 17648-17649.
136. Wang, G.; Cong, W.; Shen, H.; Qian, X.; Henry, M.; Wang, Y. Overview of bioluminescence tomography--a new molecular imaging modality. Front Biosci., 2008, 13, 1281-1293.
137. Lu, Y.; Machado, H.B.; Douraghy, A.; Stout, D.; Herschman, H.; Chatziioannou, A.F. Experimental bioluminescence tomography with fully parallel radiative-transfer-based reconstruction framework. Opt. Express, 2009,17(19), 16681-16695.
138. Hama, Y.; Koyama, Y.; Bernardo, M.; Choyke, P.L.; Kobayashi, H. Spectral near-infrared fluorescence imaging of curved surfaces using projection reconstruction algorithms. Contrast Media Mol. Imaging, 2007, 2. 82-87.
139. Chaudhari, A.J.; Ahn, S.; Levenson, R.; Badawi, R.D.; Cherry, S.R.; Leahy, R.M. Excitation spectroscopy in multispectral optical fluorescence tomography: methodology, feasibility and computer simulation studies. Phys. Med. Biol., 2009, 54, 4687-4704
140. Klose, A. Hyperspectral excitation-resolved fluorescence tomography of quantum dots. Opt. Lett., 2009, 34,16. 2477-2479.
141. Li, C.; Wang, G.; Qi, J.; Cherry, S.R. A three-dimensional multispectral fluorescence optical tomography imaging system for small animals based on a conical mirror design. Opt. Express, 2009, 17(9),7571-7585.
142. Eames, M.E.; Wang, J.; Pogue, B.W.; Dehghani, H. Wavelength band optimization in spectral near-infrared optical tomography improves accuracy while reducing data acquisition and computational burden. J. Biomed. Opt., 2008, 13(5),054037.
143. Hama, Y.; Urano, Y.; Koyama, Y.; Kamiya, M.; Bernardo, M.; Paik, R.S.; Krishna, M.C.; Choyke, P.L.; Kobayashi, H. In vivo spectral fluorescence imaging of submillimeter peritoneal cancer implants using a lectin-targeted optical agent. Neoplasia, 2006, 8(7), 607-612.
144. He, X; Wu, X.; Wang, K.; Shi, B.; Hai, L. Methylene blueencapsulated phosphonate-terminated silica nanoparticles for simultaneous in vivo imaging and photodynamic therapy. Biomaterials, 2009, 30. 5601-5609.
145. Manning, H.C.; Shay, S.D.; Mericle, R.A. Multi-spectral molecular imaging of capillary endothelium to facilitate preoperative endovascular brain mapping. J. Neurosurg. 2009, 110(5),975-980.
146. Schock-Kusch, D.; Sadick, M.; Henninger, N.; Kraenzlin B, Claus G, Kloetzer HM, Weiss C, Pill J, Gretz, N. "Transcutaneous measurement of glomerular filtration rate using FITC-sinistrin in rats. Nephrol. Dial. Transplant, 2009, (10), 2997-3001.
147. Yang, J.; Tang, L. Development of aliphatic biodegradable photoluminescent polymers. Proc. Natl. Acad. Sci. USA, 2009, 106(25), 10086-10091.
148. Nyk, M.; Kumar, R.; Ohulchanskyy, T.Y.; Bergey, E. J.; Prasad, P.N. High contrast in Vitro and in vivo photoluminescence bioimaging using near infrared to near infrared up-conversion in Tm3+ and Yb3+ doped fluoride nanophosphors. Nano Lett., 2008, 11. 3834-3838.
149. Kobayashi, H.; Ogawa, M.; Alford, R.; Choyke, P.L.; Urano, Y. New strategies for fluorescent probe design in medical diagnostic imaging. Chem. Rev., 2010, 110(5), 2620-2640.