In-vivo fluorescence imaging with a multivariate curve resolution spectral unmixing technique

Journal of Biomedical Optics

Volumn 14, Issue 6, 2009, Pages

  Xu, Heng ^a   Rice, Brad W ^a  

^a Caliper Life Sciences   (United States)

Author keywords

Autofluorescence; Bioluminescence; Fluorescence; In vivo imaging; Small animals; Spectral imaging; Spectral unmixing

Indexed keywords

AUTOFLUORESCENCE; IN-VIVO IMAGING; SMALL ANIMAL; SPECTRAL IMAGING; SPECTRAL UNMIXING;

ABSORPTION SPECTROSCOPY; ANIMALS; BIOLUMINESCENCE; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; LIGHT EMISSION; PHOSPHORESCENCE; PROBES; SEMICONDUCTOR QUANTUM DOTS; SIGNAL PROCESSING;

FLUOROPHORES;

ANIMALIA;

FLUORESCENT DYE;

ALGORITHM; ANIMAL; ARTICLE; CHEMISTRY; IMAGE QUALITY; METHODOLOGY; MOUSE; MULTIVARIATE ANALYSIS; NUDE MOUSE; REGRESSION ANALYSIS; SPECTROFLUOROMETRY;

ALGORITHMS; ANIMALS; FLUORESCENT DYES; LEAST-SQUARES ANALYSIS; MICE; MICE, NUDE; MULTIVARIATE ANALYSIS; PHANTOMS, IMAGING; SPECTROMETRY, FLUORESCENCE;

EID: 70449758418     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3258838     Document Type: Article

References (27)

1. P. R. Contag, "Whole-animal cellular and molecular imaging to accelerate drug development," Drug Discovery Today 7, 555-562 (2002).
2. B. Ballou, L. A. Ernst, and A. S. Waggoner, "Fluorescence imaging of tumors in vivo," Curr. Med. Chem. 12, 795-805 (2005).
3. V. Ntziachristos, J. Ripoll, L. H. V. Wang, and R. Weissleder, "Looking and listening to light: the evolution of whole-body photonic imaging," Nat. Biotechnol. 23, 313-320 (2005).
4. R. Weissleder and U. Mahmood, "Molecular imaging," Radiology 219, 316-333 (2001).
5. S. T. M. Gammon, W. M. Leevy, S. Gross, G. W Gokel, and D. Piwnica-Worms, "Spectral unmixing of multicolored bioluminescence emitted from heterogeneous biological sources," Anal. Chem. 78, 1520-1527 (2006).
6. J. R. Mansfield, K. W. Gossage, C. C. Hoyt, and R. M. Levenson, "Autofluorescence removal, multiplexing, and automated analysis methods for in-vivo fluorescence imaging," J. Biomed. Opt. 10(21), 041207 (2005).
7. T. Troy, D. Jekic-McMullen, L. Sambucetti, and B. Rice, "Quantitative comparison of the sensitivity of detection of fluorescent and bioluminescent reporters in animal models," Mol. Imaging 3, 9-23 (2004).
8. M. Gao, G. Lewis, G. M. Turner, A. Soubret, and V. Ntziachristos, "Effects of background fluorescence in fluorescence molecular tomography," Appl. Opt. 44, 5468-5474 (2005).
9. N. Keshava and J. F. Mustard, "Spectral unmixing," IEEE Signal Process. Mag. 19, 44-57 (2002).
10. J. H. Jiang and Y. Ozaki, "Self-modeling curve resolution (SMCR): principles, techniques, and applications," Appl. Spectrosc. Rev. 37, 321-345 (2002).
11. R. Tauler, B. Kowalski, and S. Fleming, "Multivariate curve resolution applied to spectral data from multiple runs of an industrialprocess," Anal. Chem. 65, 2040-2047 (1993).
12. P. D. Wentzell, T. K. Karakach, S. Roy, M. J. Martinez, C. P. Allen, and M. Werner-Washburne, "Multivariate curve resolution of time course microarray data," BMC Bioinf. 7, 343 (2006).
13. T. Zimmermann, "Spectral imaging and linear unmixing in light microscopy," Microsc. Res. Tech. 95, 245-265 (2005).
14. E. Schrock, S. du Manoir, T. Veldman, B. Schoell, J. Wienberg, M. A. Ferguson-Smith, Y. Ning, D. H. Ledbetter, I. Bar-Am, D. Soenksen, Y Garini, and T. Ried, "Multicolor spectral karyotyping of human chromosomes," Science 273, 494-497 (1996).
15. R. Lansford, G. Bearman, and S. E. Fraser, "Resolution of multiple green fluorescent protein color variants and dyes using two-photon microscopy and imaging spectroscopy," J. Biomed. Opt. 6(3), 311-318 (2001).
16. E. Fux and C. Mazel, "Unmixing coral fluorescence emission spectra and predicting new spectra under different excitation conditions," Appl. Opt. 38, 486-494 (1999).
17. D. Chorvat, J. Kirchnerova, M. Cagalinec, J. Smolka, A. Mateasik, and A. Chorvatova, "Spectral unmixing of flavin autofluorescence components in cardiac myocytes," Biophys. J. 89, L55-L57 (2005).
18. H. Tsurui, H. Nishimura, S. Hattori, S. Hirose, K. Okumura, and T. Shirai, "Seven-color fluorescence imaging of tissue samples based on Fourier spectroscopy and singular value decomposition," J. Histochem. Cytochem. 48, 653-662 (2000).
19. F. Nadrigny, I. Rivals, P. G. Hirrlinger, A. Koulakoff, L. Personnaz, M. Vernet, M. Allioux, M. Chaumeil, N. Ropert, C. Giaume, F. Kirchhoff', and M. Oheim, "Detecting fluorescent protein expression and co-localisation on single secretory vesicles with linear spectral unmixing," European Biophys. J. Biophys. Lett. 35, 533-547 (2006).
20. L. Duponchel, W Elmi-Rayaleh, C. Ruckebusch, and J. P. Huvenne, "Multivariate curve resolution methods in imaging spectroscopy: influence of extraction methods and instrumentei perturbations," J. Chem Inf. Comput. Sci. 43, 2057-2067 (2003).
21. B. W. Rice, M. D. Cable, and M. B. Nelson, "In vivo imaging of light-emitting probes," J. Biomed. Opt. 6(4), 432-440 (2001).
22. J. A. Timlin, D. M. Haaland, M. B. Sinclair, A. D. Aragon, M. J. Martinez, and M. Werner-Washburne, "Hyperspectral microarray scanning: impact on the accuracy and reliability of gene expression data," BMC Genomics 6, 72 (2005).
23. J. Jaumot, R. Gargallo, A. de Juan, and R. Tauler, "A graphical userfriendly interface for MCR-ALS: a new tool for multivariate curve resolution in MATLAB," Chemom. Intell. Lab. Syst. 76, 101-110 (2005).
24. C. L. Lawson and R. J. Hanson, Solving Least-Squares Problems, Prentice-Hall, Englewood Cliffs, NJ (1974).
25. A. deJuan, Y VanderHeyden, R. Tauler, and D. L. Massart, "Assessment of new constraints applied to the alternating least squares method," Anal. Chim. Acta 346, 307-318 (1997).
26. R. Bro and N. D. Sidiropoulos, "Least squares algorithms under unimodality and non-negativity constraints," J. Chemom. 12, 223-247 (1998).
27. M. H. Van Benthem, M. R. Keenan, and D. M. Haaland, "Application of equality constraints on variables during alternating least squares procedures," J. Chemom. 16, 613-622 (2002).