Effect of substrate binding loop mutations on the structure, kinetics, and inhibition of enoyl acyl carrier protein reductase from plasmodium falciparum

IUBMB Life

Volumn 63, Issue 1, 2011, Pages 30-41

  Maity, Koustav ^a   Banerjee, Tanushree ^b   Prabakaran, Narayanappa ^a   Surolia, Namita ^c   Surolia, Avadhesha ^a,b   Suguna, Kaza ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^c JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

enoyl ACP reductase; mutant; P. falciparum; salt bridge; substrate binding loop; water bridge

Indexed keywords

ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADH); ENZYME INHIBITOR; METHIONINE; PROTOZOAL PROTEIN; TRICLOSAN; VALINE; WATER;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME KINETICS; ENZYME SUBSTRATE; ESCHERICHIA COLI; MUTANT; NONHUMAN; PLASMODIUM FALCIPARUM;

ANIMALS; CRYSTALLIZATION; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); ENZYME INHIBITORS; ENZYME STABILITY; KINETICS; MODELS, MOLECULAR; PLASMODIUM FALCIPARUM; POINT MUTATION; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; TRICLOSAN;

ESCHERICHIA COLI; PLASMODIUM FALCIPARUM;

EID: 79951979033     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.412     Document Type: Article

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