-
1
-
-
0034804919
-
Lipid biosynthesis as a target for antibacterial agents
-
R.J. Heath, S.W. White, and C.O. Rock Lipid biosynthesis as a target for antibacterial agents Prog. Lipid Res. 40 2001 467 497
-
(2001)
Prog. Lipid Res.
, vol.40
, pp. 467-497
-
-
Heath, R.J.1
White, S.W.2
Rock, C.O.3
-
2
-
-
0035338328
-
Bacterial fatty-acid biosynthesis: A genomics-driven target for antibacterial drug discovery
-
D.J. Payne, P.V. Warren, D.J. Holmes, Y. Ji, and J.T. Lonsdale Bacterial fatty-acid biosynthesis: a genomics-driven target for antibacterial drug discovery Drug Discov. Today 6 2001 537 544
-
(2001)
Drug Discov. Today
, vol.6
, pp. 537-544
-
-
Payne, D.J.1
Warren, P.V.2
Holmes, D.J.3
Ji, Y.4
Lonsdale, J.T.5
-
3
-
-
33749176747
-
Fatty acid synthase-an example of protein evolution by gene fusion
-
A.D. McCarthy, and D.G. Hardie Fatty acid synthase-an example of protein evolution by gene fusion Trends Biochem. Sci. 9 1984 60 63
-
(1984)
Trends Biochem. Sci.
, vol.9
, pp. 60-63
-
-
McCarthy, A.D.1
Hardie, D.G.2
-
4
-
-
0028557012
-
The animal fatty acid synthase: One gene, one polypeptide, seven enzymes
-
S. Smith The animal fatty acid synthase: one gene, one polypeptide, seven enzymes FASEB J. 8 1994 1248 1259
-
(1994)
FASEB J.
, vol.8
, pp. 1248-1259
-
-
Smith, S.1
-
5
-
-
0030581109
-
Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis
-
C.O. Rock, and J.E. Cronan Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis Biochim. Biophys. Acta 1302 1996 1 16
-
(1996)
Biochim. Biophys. Acta
, vol.1302
, pp. 1-16
-
-
Rock, C.O.1
Cronan, J.E.2
-
6
-
-
0028988237
-
Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis
-
A. Dessen, A. Quemard, J.S. Blanchard, W.R. Jacobs Jr, and J.C. Sacchettini Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis Science 267 1995 1638 1641
-
(1995)
Science
, vol.267
, pp. 1638-1641
-
-
Dessen, A.1
Quemard, A.2
Blanchard, J.S.3
Jacobs Jr., W.R.4
Sacchettini, J.C.5
-
7
-
-
0032472224
-
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis
-
D.A. Rozwarski, G.A. Grant, D.H.R. Barton, W.R. Jacobs Jr., and J.C. Sacchettini Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis Science 279 1998 98 102
-
(1998)
Science
, vol.279
, pp. 98-102
-
-
Rozwarski, D.A.1
Grant, G.A.2
Barton, D.H.R.3
Jacobs Jr., W.R.4
Sacchettini, J.C.5
-
8
-
-
0344549379
-
Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum
-
R.F. Waller, P.J. Keeling, R.G. Donald, B. Striepen, E. Handman, and N. Lang-Unnasch Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum Proc. Natl Acad. Sci. USA. 95 1998 12352 12357
-
(1998)
Proc. Natl Acad. Sci. USA.
, vol.95
, pp. 12352-12357
-
-
Waller, R.F.1
Keeling, P.J.2
Donald, R.G.3
Striepen, B.4
Handman, E.5
Lang-Unnasch, N.6
-
9
-
-
0036008554
-
Paradigm shifts in malaria parasite biochemistry and anti-malarial chemotherapy
-
N. Surolia, S.P. Ramachandra Rao, and A. Surola Paradigm shifts in malaria parasite biochemistry and anti-malarial chemotherapy Bioessays 24 2002 192 196
-
(2002)
Bioessays
, vol.24
, pp. 192-196
-
-
Surolia, N.1
Ramachandra Rao, S.P.2
Surola, A.3
-
10
-
-
0142061141
-
Apicoplast fatty acid biosynthesis as a target for medical intervention in apicomplexan parasites
-
P. Gornicki Apicoplast fatty acid biosynthesis as a target for medical intervention in apicomplexan parasites Int. J. Parasitol. 33 2003 885 896
-
(2003)
Int. J. Parasitol.
, vol.33
, pp. 885-896
-
-
Gornicki, P.1
-
11
-
-
0028070318
-
Protein EnvM is the NADH-dependent enoyl-ACP reductase (FabI) of Escherichia coli
-
H. Bergler, P. Wallner, A. Ebeling, B. Leitinger, S. Fuchsbichler, and H. Aschauer Protein EnvM is the NADH-dependent enoyl-ACP reductase (FabI) of Escherichia coli J. Biol. Chem. 269 1994 5493 5496
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5493-5496
-
-
Bergler, H.1
Wallner, P.2
Ebeling, A.3
Leitinger, B.4
Fuchsbichler, S.5
Aschauer, H.6
-
12
-
-
0028855972
-
Enoyl-acyl carrier protein reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli
-
R.J. Heath, and C.O. Rock Enoyl-acyl carrier protein reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli J. Biol. Chem. 270 1995 26538 26542
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 26538-26542
-
-
Heath, R.J.1
Rock, C.O.2
-
13
-
-
0026729159
-
Handwashing in a neonatal intensive care nursery: Product acceptability and effectiveness of chlorhexidine gluconate 4% and triclosan 1%
-
J. Webster Handwashing in a neonatal intensive care nursery: product acceptability and effectiveness of chlorhexidine gluconate 4% and triclosan 1% J. Hosp. Infect. 21 1992 137 141
-
(1992)
J. Hosp. Infect.
, vol.21
, pp. 137-141
-
-
Webster, J.1
-
15
-
-
0032515066
-
Broad-spectrum antimicrobial biocides target the FabI component of fatty acid synthesis
-
R.J. Heath, Y.T. Yu, M.A. Shapiro, E. Olson, and C.O. Rock Broad-spectrum antimicrobial biocides target the FabI component of fatty acid synthesis J. Biol. Chem. 273 1998 30316 30320
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 30316-30320
-
-
Heath, R.J.1
Yu, Y.T.2
Shapiro, M.A.3
Olson, E.4
Rock, C.O.5
-
16
-
-
0033592365
-
Kinetic and structural characteristics of the inhibition of enoyl (acyl carrier protein) reductase by triclosan
-
W.H. Ward, G.A. Holdgate, S. Rowsell, E.G. McLean, R.A. Pauptit, and E. Clayton Kinetic and structural characteristics of the inhibition of enoyl (acyl carrier protein) reductase by triclosan Biochemistry 38 1999 12514 12525
-
(1999)
Biochemistry
, vol.38
, pp. 12514-12525
-
-
Ward, W.H.1
Holdgate, G.A.2
Rowsell, S.3
McLean, E.G.4
Pauptit, R.A.5
Clayton, E.6
-
17
-
-
0033055847
-
Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan
-
L.M. McMurry, P.F. McDermott, and S.B. Levy Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan Antimicrob. Agents Chemother. 43 1999 711 713
-
(1999)
Antimicrob. Agents Chemother.
, vol.43
, pp. 711-713
-
-
McMurry, L.M.1
McDermott, P.F.2
Levy, S.B.3
-
18
-
-
17644436310
-
Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid
-
S.L. Parikh, G. Xiao, and P.J. Tonge Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid Biochemistry 39 2000 7645 7650
-
(2000)
Biochemistry
, vol.39
, pp. 7645-7650
-
-
Parikh, S.L.1
Xiao, G.2
Tonge, P.J.3
-
19
-
-
0035126479
-
Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum
-
N. Surolia, and A. Surolia Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum Nature Med. 7 2001 167 173
-
(2001)
Nature Med.
, vol.7
, pp. 167-173
-
-
Surolia, N.1
Surolia, A.2
-
20
-
-
0037066782
-
Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase
-
R. Perozzo, M. Kuo, A.S. Sidhu, J.T. Valiyaveettil, R. Bittman, and W.R. Jacobs Jr Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase J. Biol. Chem. 277 2002 13106 13114
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 13106-13114
-
-
Perozzo, R.1
Kuo, M.2
Sidhu, A.S.3
Valiyaveettil, J.T.4
Bittman, R.5
Jacobs Jr., W.R.6
-
21
-
-
4344702214
-
Slow-tight-binding inhibition of enoyl-acyl carrier protein reductase from Plasmodium falciparum by triclosan
-
M. Kapoor, C.C. Reddy, M.V. Krishnasastry, N. Surolia, and A. Surolia Slow-tight-binding inhibition of enoyl-acyl carrier protein reductase from Plasmodium falciparum by triclosan Biochem. J. 381 2004 719 724
-
(2004)
Biochem. J.
, vol.381
, pp. 719-724
-
-
Kapoor, M.1
Reddy, C.C.2
Krishnasastry, M.V.3
Surolia, N.4
Surolia, A.5
-
22
-
-
0032721424
-
Molecular basis for triclosan activity involves a flipping loop in the active site
-
X. Qiu, C.A. Janson, R.I. Court, M.G. Smyth, D.J. Payne, and S.S. Abdel-Meguid Molecular basis for triclosan activity involves a flipping loop in the active site Protein Sci. 8 1999 2529 2532
-
(1999)
Protein Sci.
, vol.8
, pp. 2529-2532
-
-
Qiu, X.1
Janson, C.A.2
Court, R.I.3
Smyth, M.G.4
Payne, D.J.5
Abdel-Meguid, S.S.6
-
24
-
-
0029645410
-
Common themes in redox chemistry emerge from the X-ray structure of oilseed rape (Brassica napus) enoyl-acyl carrier protein reductase
-
J.B. Rafferty, J.W. Simon, C. Baldock, P.J. Artymiuk, P.J. Baker, and A.R. Stuitje Common themes in redox chemistry emerge from the X-ray structure of oilseed rape (Brassica napus) enoyl-acyl carrier protein reductase Structure 3 1995 927 938
-
(1995)
Structure
, vol.3
, pp. 927-938
-
-
Rafferty, J.B.1
Simon, J.W.2
Baldock, C.3
Artymiuk, P.J.4
Baker, P.J.5
Stuitje, A.R.6
-
25
-
-
0030452311
-
A mechanism of drug action revealed by structural studies of enoyl reductase
-
C. Baldock, J.B. Rafferty, S.E. Sedelnikova, P.J. Baker, A.R. Stuitje, and A.R. Slabas A mechanism of drug action revealed by structural studies of enoyl reductase Science 274 1996 2107 2110
-
(1996)
Science
, vol.274
, pp. 2107-2110
-
-
Baldock, C.1
Rafferty, J.B.2
Sedelnikova, S.E.3
Baker, P.J.4
Stuitje, A.R.5
Slabas, A.R.6
-
26
-
-
0033607650
-
Crystallographic analysis of triclosan bound to enoyl reductase
-
A. Roujeinikova, C.W. Levy, S. Rowsell, S. Sedelnikova, P.J. Baker, and C.A. Minshull Crystallographic analysis of triclosan bound to enoyl reductase J. Mol. Biol. 294 1999 527 535
-
(1999)
J. Mol. Biol.
, vol.294
, pp. 527-535
-
-
Roujeinikova, A.1
Levy, C.W.2
Rowsell, S.3
Sedelnikova, S.4
Baker, P.J.5
Minshull, C.A.6
-
27
-
-
0038757566
-
Targeting tuberculosis and malaria through inhibition of Enoyl reductase: Compound activity and structural data
-
M.R. Kuo, H.R. Morbidoni, D. Alland, S.F. Sneddon, B.B. Gourlie, and M.M. Staveski Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data J. Biol. Chem. 278 2003 20851 20859
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20851-20859
-
-
Kuo, M.R.1
Morbidoni, H.R.2
Alland, D.3
Sneddon, S.F.4
Gourlie, B.B.5
Staveski, M.M.6
-
29
-
-
0033119057
-
Molecular basis of triclosan activity
-
C.W. Levy, A. Roujeinikova, S. Sedelnikova, P.J. Baker, A.R. Stuitje, and A.R. Slabas Molecular basis of triclosan activity Nature 398 1999 383 384
-
(1999)
Nature
, vol.398
, pp. 383-384
-
-
Levy, C.W.1
Roujeinikova, A.2
Sedelnikova, S.3
Baker, P.J.4
Stuitje, A.R.5
Slabas, A.R.6
-
30
-
-
0033550048
-
Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis
-
S. Parikh, D.P. Moynihan, G. Xiao, and P.J. Tonge Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis Biochemistry 38 1999 13623 13634
-
(1999)
Biochemistry
, vol.38
, pp. 13623-13634
-
-
Parikh, S.1
Moynihan, D.P.2
Xiao, G.3
Tonge, P.J.4
-
31
-
-
0035861962
-
Kinetic determinants of the interaction of enoyl-ACP reductase from Plasmodium falciparum with its substrates and inhibitors
-
M. Kapoor, M.J. Dar, A. Surolia, and N. Surolia Kinetic determinants of the interaction of enoyl-ACP reductase from Plasmodium falciparum with its substrates and inhibitors Biochem. Biophys. Res. Commun. 289 2001 832 837
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.289
, pp. 832-837
-
-
Kapoor, M.1
Dar, M.J.2
Surolia, A.3
Surolia, N.4
-
32
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Z. Otwinowski, and W. Minor Processing of X-ray diffraction data collected in oscillation mode Methods Enzymol. 276 1997 307 326
-
(1997)
Methods Enzymol.
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
33
-
-
84920325457
-
AMoRe: An automated package for molecular replacement
-
J. Navaza AMoRe: an automated package for molecular replacement Acta Crystallog. A 50 1994 157 163
-
(1994)
Acta Crystallog. a
, vol.50
, pp. 157-163
-
-
Navaza, J.1
-
34
-
-
3543012707
-
Crystallography and NMR system: A new software suite for macromolecular structure determination
-
A.T. Brünger, P.D. Adams, G.M. Clore, W.L. DeLano, P. Gros, and R.W. Grosse-Kunstleve Crystallography and NMR system: a new software suite for macromolecular structure determination Acta Crystllog. D 54 1998 905 921
-
(1998)
Acta Crystllog. D
, vol.54
, pp. 905-921
-
-
Brünger, A.T.1
Adams, P.D.2
Clore, G.M.3
Delano, W.L.4
Gros, P.5
Grosse-Kunstleve, R.W.6
-
36
-
-
0001679473
-
ALIGN: A program to superimpose protein coordinates, accounting for insertions and deletions
-
G.H. Cohen ALIGN: a program to superimpose protein coordinates, accounting for insertions and deletions J. Appl. Crystallog. 30 1997 1160 1161
-
(1997)
J. Appl. Crystallog.
, vol.30
, pp. 1160-1161
-
-
Cohen, G.H.1
-
37
-
-
0028103275
-
The CCP4 suite: Programs for protein crystallography
-
Collaborative Computational Project, Number 4
-
Collaborative Computational Project, Number 4 The CCP4 suite: programs for protein crystallography Acta Crystallog. D 50 1994 760 763
-
(1994)
Acta Crystallog. D
, vol.50
, pp. 760-763
-
-
-
38
-
-
0030841587
-
Electron density map interpretation
-
T.A. Jones, and M. Kjeldgaard Electron density map interpretation Methods Enzymol. 277 1997 173 230
-
(1997)
Methods Enzymol.
, vol.277
, pp. 173-230
-
-
Jones, T.A.1
Kjeldgaard, M.2
-
39
-
-
0026244229
-
MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
-
P.J. Kraulis MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures J. Appl. Crystallog. 24 1991 946 950
-
(1991)
J. Appl. Crystallog.
, vol.24
, pp. 946-950
-
-
Kraulis, P.J.1
-
40
-
-
0030815133
-
Raster3D: Photorealistic molecular graphics
-
E.A. Merrit, and D.J. Bacon Raster3D: photorealistic molecular graphics Methods Enzymol. 277 1997 505 524
-
(1997)
Methods Enzymol.
, vol.277
, pp. 505-524
-
-
Merrit, E.A.1
Bacon, D.J.2
-
41
-
-
0030729838
-
An extensively modified version of MolScript that includes greatly enhanced coloring capabilities
-
R. Esnouf An extensively modified version of MolScript that includes greatly enhanced coloring capabilities J. Mol. Graph. 15 1997 132 134
-
(1997)
J. Mol. Graph.
, vol.15
, pp. 132-134
-
-
Esnouf, R.1
|