-
1
-
-
0033948436
-
The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients
-
Firtel R.A., and Chung C.Y. The molecular genetics of chemotaxis: sensing and responding to chemoattractant gradients. Bioessays 22 (2000) 603-615
-
(2000)
Bioessays
, vol.22
, pp. 603-615
-
-
Firtel, R.A.1
Chung, C.Y.2
-
3
-
-
21344464454
-
Signaling to cytoskeletal dynamics during chemotaxis
-
Affolter M., and Weijer C.J. Signaling to cytoskeletal dynamics during chemotaxis. Dev Cell 9 (2005) 19-34
-
(2005)
Dev Cell
, vol.9
, pp. 19-34
-
-
Affolter, M.1
Weijer, C.J.2
-
4
-
-
0033617576
-
A cell's sense of direction
-
Parent C.A., and Devreotes P.N. A cell's sense of direction. Science 284 (1999) 765-770
-
(1999)
Science
, vol.284
, pp. 765-770
-
-
Parent, C.A.1
Devreotes, P.N.2
-
5
-
-
0041327718
-
Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways
-
Merlot S., and Firtel R.A. Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J Cell Sci 116 (2003) 3471-3478
-
(2003)
J Cell Sci
, vol.116
, pp. 3471-3478
-
-
Merlot, S.1
Firtel, R.A.2
-
6
-
-
13544249968
-
In vivo analysis of 3-phosphoinositide dynamics during Dictyostelium phagocytosis and chemotaxis
-
3-binding, PH domain-containing proteins present different spatial and temporal patterns of membrane localization. This suggests that the binding properties of PH domains provide a means to generate distinct responses to one signal.
-
3-binding, PH domain-containing proteins present different spatial and temporal patterns of membrane localization. This suggests that the binding properties of PH domains provide a means to generate distinct responses to one signal.
-
(2004)
J Cell Sci
, vol.117
, pp. 6497-6509
-
-
Dormann, D.1
Weijer, G.2
Dowler, S.3
Weijer, C.J.4
-
7
-
-
0033560747
-
Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
-
Meili R., Ellsworth C., Lee S., Reddy T.B., Ma H., and Firtel R.A. Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J 18 (1999) 2092-2105
-
(1999)
EMBO J
, vol.18
, pp. 2092-2105
-
-
Meili, R.1
Ellsworth, C.2
Lee, S.3
Reddy, T.B.4
Ma, H.5
Firtel, R.A.6
-
8
-
-
0034635513
-
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
-
Servant G., Weiner O.D., Herzmark P., Balla T., Sedat J.W., and Bourne H.R. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science 287 (2000) 1037-1040
-
(2000)
Science
, vol.287
, pp. 1037-1040
-
-
Servant, G.1
Weiner, O.D.2
Herzmark, P.3
Balla, T.4
Sedat, J.W.5
Bourne, H.R.6
-
9
-
-
8444247968
-
Rac regulation of chemotaxis and morphogenesis in Dictyostelium
-
This study demonstrates the presence of a feedback loop controlling RacB activation at the leading edge of chemotactic Dictyostelium cells, implicating the regulation of RacGEF1 by F-actin.
-
Park K.C., Rivero F., Meili R., Lee S., Apone F., and Firtel R.A. Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J 23 (2004) 4177-4189. This study demonstrates the presence of a feedback loop controlling RacB activation at the leading edge of chemotactic Dictyostelium cells, implicating the regulation of RacGEF1 by F-actin.
-
(2004)
EMBO J
, vol.23
, pp. 4177-4189
-
-
Park, K.C.1
Rivero, F.2
Meili, R.3
Lee, S.4
Apone, F.5
Firtel, R.A.6
-
10
-
-
18144378805
-
Vav activation and function as a Rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis
-
Vedham V., Phee H., and Coggeshall K.M. Vav activation and function as a Rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis. Mol Cell Biol 25 (2005) 4211-4220
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4211-4220
-
-
Vedham, V.1
Phee, H.2
Coggeshall, K.M.3
-
11
-
-
17044427681
-
Control of lymphocyte shape and the chemotactic response by the GTP exchange factor Vav
-
Vicente-Manzanares M., Cruz-Adalia A., Martin-Cofreces N.B., Cabrero J.R., Dosil M., Alvarado-Sanchez B., Bustelo X.R., and Sanchez-Madrid F. Control of lymphocyte shape and the chemotactic response by the GTP exchange factor Vav. Blood 105 (2005) 3026-3034
-
(2005)
Blood
, vol.105
, pp. 3026-3034
-
-
Vicente-Manzanares, M.1
Cruz-Adalia, A.2
Martin-Cofreces, N.B.3
Cabrero, J.R.4
Dosil, M.5
Alvarado-Sanchez, B.6
Bustelo, X.R.7
Sanchez-Madrid, F.8
-
12
-
-
27144551936
-
P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils
-
Dong X., Mo Z., Bokoch G., Guo C., Li Z., and Wu D. P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils. Curr Biol 15 (2005) 1874-1879
-
(2005)
Curr Biol
, vol.15
, pp. 1874-1879
-
-
Dong, X.1
Mo, Z.2
Bokoch, G.3
Guo, C.4
Li, Z.5
Wu, D.6
-
13
-
-
27144440346
-
P-Rex1 regulates neutrophil function
-
Welch H.C., Condliffe A.M., Milne L.J., Ferguson G.J., Hill K., Webb L.M., Okkenhaug K., Coadwell W.J., Andrews S.R., Thelen M., et al. P-Rex1 regulates neutrophil function. Curr Biol 15 (2005) 1867-1873
-
(2005)
Curr Biol
, vol.15
, pp. 1867-1873
-
-
Welch, H.C.1
Condliffe, A.M.2
Milne, L.J.3
Ferguson, G.J.4
Hill, K.5
Webb, L.M.6
Okkenhaug, K.7
Coadwell, W.J.8
Andrews, S.R.9
Thelen, M.10
-
14
-
-
14244269335
-
Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gβγ subunits
-
Hill K., Krugmann S., Andrews S.R., Coadwell W.J., Finan P., Welch H.C., Hawkins P.T., and Stephens L.R. Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gβγ subunits. J Biol Chem 280 (2005) 4166-4173
-
(2005)
J Biol Chem
, vol.280
, pp. 4166-4173
-
-
Hill, K.1
Krugmann, S.2
Andrews, S.R.3
Coadwell, W.J.4
Finan, P.5
Welch, H.C.6
Hawkins, P.T.7
Stephens, L.R.8
-
15
-
-
9444297930
-
Dictyostelium PAKc is required for proper chemotaxis
-
Lee S., Rivero F., Park K.C., Huang E., Funamoto S., and Firtel R.A. Dictyostelium PAKc is required for proper chemotaxis. Mol Biol Cell 15 (2004) 5456-5469
-
(2004)
Mol Biol Cell
, vol.15
, pp. 5456-5469
-
-
Lee, S.1
Rivero, F.2
Park, K.C.3
Huang, E.4
Funamoto, S.5
Firtel, R.A.6
-
16
-
-
0035858886
-
Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium
-
Funamoto S., Milan K., Meili R., and Firtel R.A. Role of phosphatidylinositol 3′ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in Dictyostelium. J Cell Biol 153 (2001) 795-810
-
(2001)
J Cell Biol
, vol.153
, pp. 795-810
-
-
Funamoto, S.1
Milan, K.2
Meili, R.3
Firtel, R.A.4
-
17
-
-
0032475863
-
G protein signaling events are activated at the leading edge of chemotactic cells
-
Parent C.A., Blacklock B.J., Froehlich W.M., Murphy D.B., and Devreotes P.N. G protein signaling events are activated at the leading edge of chemotactic cells. Cell 95 (1998) 81-91
-
(1998)
Cell
, vol.95
, pp. 81-91
-
-
Parent, C.A.1
Blacklock, B.J.2
Froehlich, W.M.3
Murphy, D.B.4
Devreotes, P.N.5
-
18
-
-
2342552557
-
3 binding is necessary for WAVE2-induced formation of lamellipodia
-
3 binding is necessary for WAVE2-induced formation of lamellipodia. Nat Cell Biol 6 (2004) 420-426
-
(2004)
Nat Cell Biol
, vol.6
, pp. 420-426
-
-
Oikawa, T.1
Yamaguchi, H.2
Itoh, T.3
Kato, M.4
Ijuin, T.5
Yamazaki, D.6
Suetsugu, S.7
Takenawa, T.8
-
19
-
-
18244378218
-
A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis
-
Myers S.A., Han J.W., Lee Y., Firtel R.A., and Chung C.Y. A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis. Mol Biol Cell 16 (2005) 2191-2206
-
(2005)
Mol Biol Cell
, vol.16
, pp. 2191-2206
-
-
Myers, S.A.1
Han, J.W.2
Lee, Y.3
Firtel, R.A.4
Chung, C.Y.5
-
20
-
-
0035947085
-
Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa
-
Chung C.Y., Potikyan G., and Firtel R.A. Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol Cell 7 (2001) 937-947
-
(2001)
Mol Cell
, vol.7
, pp. 937-947
-
-
Chung, C.Y.1
Potikyan, G.2
Firtel, R.A.3
-
21
-
-
0037205230
-
Tumor suppressor PTEN mediates sensing of chemoattractant gradients
-
Iijima M., and Devreotes P. Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell 109 (2002) 599-610
-
(2002)
Cell
, vol.109
, pp. 599-610
-
-
Iijima, M.1
Devreotes, P.2
-
22
-
-
0037205265
-
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
-
Funamoto S., Meili R., Lee S., Parry L., and Firtel R.A. Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis. Cell 109 (2002) 611-623
-
(2002)
Cell
, vol.109
, pp. 611-623
-
-
Funamoto, S.1
Meili, R.2
Lee, S.3
Parry, L.4
Firtel, R.A.5
-
25
-
-
0030729285
-
Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation
-
Xiao Z., Zhang N., Murphy D.B., and Devreotes P.N. Dynamic distribution of chemoattractant receptors in living cells during chemotaxis and persistent stimulation. J Cell Biol 139 (1997) 365-374
-
(1997)
J Cell Biol
, vol.139
, pp. 365-374
-
-
Xiao, Z.1
Zhang, N.2
Murphy, D.B.3
Devreotes, P.N.4
-
26
-
-
0032911044
-
Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis
-
Servant G., Weiner O.D., Neptune E.R., Sedat J.W., and Bourne H.R. Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell 10 (1999) 1163-1178
-
(1999)
Mol Biol Cell
, vol.10
, pp. 1163-1178
-
-
Servant, G.1
Weiner, O.D.2
Neptune, E.R.3
Sedat, J.W.4
Bourne, H.R.5
-
27
-
-
0034635567
-
Localization of the G protein βγ complex in living cells during chemotaxis
-
Jin T., Zhang N., Long Y., Parent C.A., and Devreotes P.N. Localization of the G protein βγ complex in living cells during chemotaxis. Science 287 (2000) 1034-1036
-
(2000)
Science
, vol.287
, pp. 1034-1036
-
-
Jin, T.1
Zhang, N.2
Long, Y.3
Parent, C.A.4
Devreotes, P.N.5
-
28
-
-
0035955356
-
Single-molecule analysis of chemotactic signaling in Dictyostelium cells
-
Ueda M., Sako Y., Tanaka T., Devreotes P., and Yanagida T. Single-molecule analysis of chemotactic signaling in Dictyostelium cells. Science 294 (2001) 864-867
-
(2001)
Science
, vol.294
, pp. 864-867
-
-
Ueda, M.1
Sako, Y.2
Tanaka, T.3
Devreotes, P.4
Yanagida, T.5
-
29
-
-
0035937571
-
Receptor-mediated activation of heterotrimeric G-proteins in living cells
-
Janetopoulos C., Jin T., and Devreotes P. Receptor-mediated activation of heterotrimeric G-proteins in living cells. Science 291 (2001) 2408-2411
-
(2001)
Science
, vol.291
, pp. 2408-2411
-
-
Janetopoulos, C.1
Jin, T.2
Devreotes, P.3
-
30
-
-
12844268483
-
Quantitative imaging of single live cells reveals spatiotemporal dynamics of multistep signaling events of chemoattractant gradient sensing in Dictyostelium
-
3 response. The authors then suggest the importance of locally controlled components that inhibit PI3K activity.
-
3 response. The authors then suggest the importance of locally controlled components that inhibit PI3K activity.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 676-688
-
-
Xu, X.1
Meier-Schellersheim, M.2
Jiao, X.3
Nelson, L.E.4
Jin, T.5
-
31
-
-
0032823984
-
Orientation of chemotactic cells and growth cones: models and mechanisms
-
Meinhardt H. Orientation of chemotactic cells and growth cones: models and mechanisms. J Cell Sci 112 (1999) 2867-2874
-
(1999)
J Cell Sci
, vol.112
, pp. 2867-2874
-
-
Meinhardt, H.1
-
32
-
-
0033868140
-
Pattern formation by local self-activation and lateral inhibition
-
Meinhardt H., and Gierer A. Pattern formation by local self-activation and lateral inhibition. Bioessays 22 (2000) 753-760
-
(2000)
Bioessays
, vol.22
, pp. 753-760
-
-
Meinhardt, H.1
Gierer, A.2
-
33
-
-
0036219106
-
Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils
-
Levchenko A., and Iglesias P.A. Models of eukaryotic gradient sensing: application to chemotaxis of amoebae and neutrophils. Biophys J 82 (2002) 50-63
-
(2002)
Biophys J
, vol.82
, pp. 50-63
-
-
Levchenko, A.1
Iglesias, P.A.2
-
34
-
-
0037743735
-
Eukaryotic chemotaxis: distinctions between directional sensing and polarization
-
Devreotes P., and Janetopoulos C. Eukaryotic chemotaxis: distinctions between directional sensing and polarization. J Biol Chem 278 (2003) 20445-20448
-
(2003)
J Biol Chem
, vol.278
, pp. 20445-20448
-
-
Devreotes, P.1
Janetopoulos, C.2
-
35
-
-
3442876010
-
Local excitation, global inhibition mechanism for gradient sensing: an interactive applet
-
Kutscher B., Devreotes P., and Iglesias P.A. Local excitation, global inhibition mechanism for gradient sensing: an interactive applet. Sci STKE 2004 (2004) pl3
-
(2004)
Sci STKE
, vol.2004
-
-
Kutscher, B.1
Devreotes, P.2
Iglesias, P.A.3
-
36
-
-
10044250005
-
3 response in Dictyostelium cells
-
3 response that agrees quantitatively with experimentally obtained PH domain distributions in non-polarized cells.
-
3 response that agrees quantitatively with experimentally obtained PH domain distributions in non-polarized cells.
-
(2004)
Biophys J
, vol.87
, pp. 3764-3774
-
-
Ma, L.1
Janetopoulos, C.2
Yang, L.3
Devreotes, P.N.4
Iglesias, P.A.5
-
37
-
-
33646764616
-
Spontaneous polarization in eukaryotic gradient sensing: a mathematical model based on mutual inhibition of frontness and backness pathways
-
10.1016/j.jtbi.2005.10.022
-
Narang A. Spontaneous polarization in eukaryotic gradient sensing: a mathematical model based on mutual inhibition of frontness and backness pathways. J Theor Biol (2005) 10.1016/j.jtbi.2005.10.022
-
(2005)
J Theor Biol
-
-
Narang, A.1
-
38
-
-
0034741649
-
A mathematical model for chemoattractant gradient sensing based on receptor-regulated membrane phospholipid signaling dynamics
-
Narang A., Subramanian K.K., and Lauffenburger D.A. A mathematical model for chemoattractant gradient sensing based on receptor-regulated membrane phospholipid signaling dynamics. Ann Biomed Eng 29 (2001) 677-691
-
(2001)
Ann Biomed Eng
, vol.29
, pp. 677-691
-
-
Narang, A.1
Subramanian, K.K.2
Lauffenburger, D.A.3
-
39
-
-
0034866573
-
A diffusion-translocation model for gradient sensing by chemotactic cells
-
Postma M., and Van Haastert P.J. A diffusion-translocation model for gradient sensing by chemotactic cells. Biophys J 81 (2001) 1314-1323
-
(2001)
Biophys J
, vol.81
, pp. 1314-1323
-
-
Postma, M.1
Van Haastert, P.J.2
-
40
-
-
0036708448
-
Establishing direction during chemotaxis in eukaryotic cells
-
Rappel W.J., Thomas P.J., Levine H., and Loomis W.F. Establishing direction during chemotaxis in eukaryotic cells. Biophys J 83 (2002) 1361-1367
-
(2002)
Biophys J
, vol.83
, pp. 1361-1367
-
-
Rappel, W.J.1
Thomas, P.J.2
Levine, H.3
Loomis, W.F.4
-
41
-
-
0036773899
-
Temporal and spatial regulation of chemotaxis
-
Iijima M., Huang Y.E., and Devreotes P. Temporal and spatial regulation of chemotaxis. Dev Cell 3 (2002) 469-478
-
(2002)
Dev Cell
, vol.3
, pp. 469-478
-
-
Iijima, M.1
Huang, Y.E.2
Devreotes, P.3
-
42
-
-
20244379418
-
Regulation of PTEN by Rho small GTPases
-
Li Z., Dong X., Wang Z., Liu W., Deng N., Ding Y., Tang L., Hla T., Zeng R., Li L., et al. Regulation of PTEN by Rho small GTPases. Nat Cell Biol 7 (2005) 399-404
-
(2005)
Nat Cell Biol
, vol.7
, pp. 399-404
-
-
Li, Z.1
Dong, X.2
Wang, Z.3
Liu, W.4
Deng, N.5
Ding, Y.6
Tang, L.7
Hla, T.8
Zeng, R.9
Li, L.10
-
43
-
-
0034640350
-
A membrane-permeant ester of phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) is an activator of human neutrophil migration
-
Niggli V. A membrane-permeant ester of phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) is an activator of human neutrophil migration. FEBS Lett 473 (2000) 217-221
-
(2000)
FEBS Lett
, vol.473
, pp. 217-221
-
-
Niggli, V.1
-
44
-
-
0036308972
-
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
-
Weiner O.D., Neilsen P.O., Prestwich G.D., Kirschner M.W., Cantley L.C., and Bourne H.R. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol 4 (2002) 509-513
-
(2002)
Nat Cell Biol
, vol.4
, pp. 509-513
-
-
Weiner, O.D.1
Neilsen, P.O.2
Prestwich, G.D.3
Kirschner, M.W.4
Cantley, L.C.5
Bourne, H.R.6
-
45
-
-
0036308458
-
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils
-
Wang F., Herzmark P., Weiner O.D., Srinivasan S., Servant G., and Bourne H.R. Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat Cell Biol 4 (2002) 513-518
-
(2002)
Nat Cell Biol
, vol.4
, pp. 513-518
-
-
Wang, F.1
Herzmark, P.2
Weiner, O.D.3
Srinivasan, S.4
Servant, G.5
Bourne, H.R.6
-
46
-
-
8444221934
-
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement
-
This study highlights the important role of Ras proteins in controlling Dictyostelium chemotaxis. The results suggest that Ras acts upstream of PI3K, first activating a membrane-bound pool of the enzyme leading to F-actin polymerization, which promotes further PI3K translocation and activation through a positive feedback loop.
-
Sasaki A.T., Chun C., Takeda K., and Firtel R.A. Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol 167 (2004) 505-518. This study highlights the important role of Ras proteins in controlling Dictyostelium chemotaxis. The results suggest that Ras acts upstream of PI3K, first activating a membrane-bound pool of the enzyme leading to F-actin polymerization, which promotes further PI3K translocation and activation through a positive feedback loop.
-
(2004)
J Cell Biol
, vol.167
, pp. 505-518
-
-
Sasaki, A.T.1
Chun, C.2
Takeda, K.3
Firtel, R.A.4
-
47
-
-
33644805719
-
Finding the way: directional sensing and cell polarization through Ras signalling
-
Sasaki A.T., and Firtel R.A. Finding the way: directional sensing and cell polarization through Ras signalling. Novartis Found Symp 269 (2005) 73-87
-
(2005)
Novartis Found Symp
, vol.269
, pp. 73-87
-
-
Sasaki, A.T.1
Firtel, R.A.2
-
48
-
-
0344012465
-
Uniform cAMP stimulation of Dictyostelium cells induces localized patches of signal transduction and pseudopodia
-
Postma M., Roelofs J., Goedhart J., Gadella T.W., Visser A.J., and Van Haastert P.J. Uniform cAMP stimulation of Dictyostelium cells induces localized patches of signal transduction and pseudopodia. Mol Biol Cell 14 (2003) 5019-5027
-
(2003)
Mol Biol Cell
, vol.14
, pp. 5019-5027
-
-
Postma, M.1
Roelofs, J.2
Goedhart, J.3
Gadella, T.W.4
Visser, A.J.5
Van Haastert, P.J.6
-
50
-
-
0023688555
-
Actin polymerization and pseudopod extension during amoeboid chemotaxis
-
Condeelis J., Hall A., Bresnick A., Warren V., Hock R., Bennett H., and Ogihara S. Actin polymerization and pseudopod extension during amoeboid chemotaxis. Cell Motil Cytoskeleton 10 (1988) 77-90
-
(1988)
Cell Motil Cytoskeleton
, vol.10
, pp. 77-90
-
-
Condeelis, J.1
Hall, A.2
Bresnick, A.3
Warren, V.4
Hock, R.5
Bennett, H.6
Ogihara, S.7
-
51
-
-
0028329791
-
Actin polymerization, calcium-transients, and phospholipid metabolism in human neutrophils after stimulation with interleukin-8 and N-formyl peptide
-
Norgauer J., Krutmann J., Dobos G.J., Traynor-Kaplan A.E., Oades Z.G., and Schraufstatter I.U. Actin polymerization, calcium-transients, and phospholipid metabolism in human neutrophils after stimulation with interleukin-8 and N-formyl peptide. J Invest Dermatol 102 (1994) 310-314
-
(1994)
J Invest Dermatol
, vol.102
, pp. 310-314
-
-
Norgauer, J.1
Krutmann, J.2
Dobos, G.J.3
Traynor-Kaplan, A.E.4
Oades, Z.G.5
Schraufstatter, I.U.6
-
52
-
-
27144517984
-
Interlinked fast and slow positive feedback loops drive reliable cell decisions
-
With mathematical simulations, the authors demonstrate that interlinked fast and slow positive feedback loops create a 'dual-time' switch that is both rapidly inducible and resistant to noise in the upstream signaling system. This provides an explanation for the fact that various biological processes use multiple interlinked loops rather than single positive feedback loops.
-
Brandman O., Ferrell Jr. J.E., Li R., and Meyer T. Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science 310 (2005) 496-498. With mathematical simulations, the authors demonstrate that interlinked fast and slow positive feedback loops create a 'dual-time' switch that is both rapidly inducible and resistant to noise in the upstream signaling system. This provides an explanation for the fact that various biological processes use multiple interlinked loops rather than single positive feedback loops.
-
(2005)
Science
, vol.310
, pp. 496-498
-
-
Brandman, O.1
Ferrell Jr., J.E.2
Li, R.3
Meyer, T.4
-
53
-
-
2942687012
-
Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton
-
Results in this study suggest that distinct molecular mechanisms control gradient sensing and cell polarity in Dictyostelium, and that signal amplification represents feedback from the cytoskeleton of a polarized cell.
-
Janetopoulos C., Ma L., Devreotes P.N., and Iglesias P.A. Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proc Natl Acad Sci USA 101 (2004) 8951-8956. Results in this study suggest that distinct molecular mechanisms control gradient sensing and cell polarity in Dictyostelium, and that signal amplification represents feedback from the cytoskeleton of a polarized cell.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 8951-8956
-
-
Janetopoulos, C.1
Ma, L.2
Devreotes, P.N.3
Iglesias, P.A.4
-
54
-
-
0042354714
-
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils
-
Xu J., Wang F., Van Keymeulen A., Herzmark P., Straight A., Kelly K., Takuwa Y., Sugimoto N., Mitchison T., and Bourne H.R. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell 114 (2003) 201-214
-
(2003)
Cell
, vol.114
, pp. 201-214
-
-
Xu, J.1
Wang, F.2
Van Keymeulen, A.3
Herzmark, P.4
Straight, A.5
Kelly, K.6
Takuwa, Y.7
Sugimoto, N.8
Mitchison, T.9
Bourne, H.R.10
-
55
-
-
16244377763
-
Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis
-
Janetopoulos C., Borleis J., Vazquez F., Iijima M., and Devreotes P. Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis. Dev Cell 8 (2005) 467-477
-
(2005)
Dev Cell
, vol.8
, pp. 467-477
-
-
Janetopoulos, C.1
Borleis, J.2
Vazquez, F.3
Iijima, M.4
Devreotes, P.5
-
56
-
-
12544249887
-
The PI3K-mediated activation of CRAC independently regulates adenylyl cyclase activation and chemotaxis
-
Comer F.I., Lippincott C.K., Masbad J.J., and Parent C.A. The PI3K-mediated activation of CRAC independently regulates adenylyl cyclase activation and chemotaxis. Curr Biol 15 (2005) 134-139
-
(2005)
Curr Biol
, vol.15
, pp. 134-139
-
-
Comer, F.I.1
Lippincott, C.K.2
Masbad, J.J.3
Parent, C.A.4
-
57
-
-
13344269588
-
A local coupling model and compass parameter for eukaryotic chemotaxis
-
This study suggests that global cell polarization acts independently of the chemotaxis mechanism in migrating primary dendritic cells and fibroblasts.
-
Arrieumerlou C., and Meyer T. A local coupling model and compass parameter for eukaryotic chemotaxis. Dev Cell 8 (2005) 215-227. This study suggests that global cell polarization acts independently of the chemotaxis mechanism in migrating primary dendritic cells and fibroblasts.
-
(2005)
Dev Cell
, vol.8
, pp. 215-227
-
-
Arrieumerlou, C.1
Meyer, T.2
-
58
-
-
4344571626
-
Chemoattractant-induced Ras activation during Dictyostelium aggregation
-
Kae H., Lim C.J., Spiegelman G.B., and Weeks G. Chemoattractant-induced Ras activation during Dictyostelium aggregation. EMBO Rep 5 (2004) 602-606
-
(2004)
EMBO Rep
, vol.5
, pp. 602-606
-
-
Kae, H.1
Lim, C.J.2
Spiegelman, G.B.3
Weeks, G.4
-
59
-
-
0345731237
-
Cell migration: Rho GTPases lead the way
-
Raftopoulou M., and Hall A. Cell migration: Rho GTPases lead the way. Dev Biol 265 (2004) 23-32
-
(2004)
Dev Biol
, vol.265
, pp. 23-32
-
-
Raftopoulou, M.1
Hall, A.2
-
60
-
-
0037415640
-
3 and polarity during neutrophil chemotaxis
-
3 and polarity during neutrophil chemotaxis. J Cell Biol 160 (2003) 375-385
-
(2003)
J Cell Biol
, vol.160
, pp. 375-385
-
-
Srinivasan, S.1
Wang, F.2
Glavas, S.3
Ott, A.4
Hofmann, F.5
Aktories, K.6
Kalman, D.7
Bourne, H.R.8
-
61
-
-
0029278739
-
PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase
-
Hawkins P.T., Eguinoa A., Qiu R.G., Stokoe D., Cooke F.T., Walters R., Wennstrom S., Claesson-Welsh L., Evans T., Symons M., et al. PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr Biol 5 (1995) 393-403
-
(1995)
Curr Biol
, vol.5
, pp. 393-403
-
-
Hawkins, P.T.1
Eguinoa, A.2
Qiu, R.G.3
Stokoe, D.4
Cooke, F.T.5
Walters, R.6
Wennstrom, S.7
Claesson-Welsh, L.8
Evans, T.9
Symons, M.10
-
62
-
-
0033531955
-
Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
-
Benard V., Bohl B.P., and Bokoch G.M. Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J Biol Chem 274 (1999) 13198-13204
-
(1999)
J Biol Chem
, vol.274
, pp. 13198-13204
-
-
Benard, V.1
Bohl, B.P.2
Bokoch, G.M.3
-
63
-
-
0035002333
-
N-WASP, WAVE and Mena play different roles in the organization of actin cytoskeleton in lamellipodia
-
Nakagawa H., Miki H., Ito M., Ohashi K., Takenawa T., and Miyamoto S. N-WASP, WAVE and Mena play different roles in the organization of actin cytoskeleton in lamellipodia. J Cell Sci 114 (2001) 1555-1565
-
(2001)
J Cell Sci
, vol.114
, pp. 1555-1565
-
-
Nakagawa, H.1
Miki, H.2
Ito, M.3
Ohashi, K.4
Takenawa, T.5
Miyamoto, S.6
-
64
-
-
0028338545
-
Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85
-
Zheng Y., Bagrodia S., and Cerione R.A. Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. J Biol Chem 269 (1994) 18727-18730
-
(1994)
J Biol Chem
, vol.269
, pp. 18727-18730
-
-
Zheng, Y.1
Bagrodia, S.2
Cerione, R.A.3
-
65
-
-
0031972690
-
p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase
-
Kobayashi K., Kuroda S., Fukata M., Nakamura T., Nagase T., Nomura N., Matsuura Y., Yoshida-Kubomura N., Iwamatsu A., and Kaibuchi K. p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. J Biol Chem 273 (1998) 291-295
-
(1998)
J Biol Chem
, vol.273
, pp. 291-295
-
-
Kobayashi, K.1
Kuroda, S.2
Fukata, M.3
Nakamura, T.4
Nagase, T.5
Nomura, N.6
Matsuura, Y.7
Yoshida-Kubomura, N.8
Iwamatsu, A.9
Kaibuchi, K.10
-
66
-
-
0034625002
-
Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells
-
Chung C.Y., Lee S., Briscoe C., Ellsworth C., and Firtel R.A. Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells. Proc Natl Acad Sci USA 97 (2000) 5225-5230
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 5225-5230
-
-
Chung, C.Y.1
Lee, S.2
Briscoe, C.3
Ellsworth, C.4
Firtel, R.A.5
-
67
-
-
0033932762
-
Rac1 GTPases control filopodia formation, cell motility, endocytosis, cytokinesis and development in Dictyostelium
-
Dumontier M., Hocht P., Mintert U., and Faix J. Rac1 GTPases control filopodia formation, cell motility, endocytosis, cytokinesis and development in Dictyostelium. J Cell Sci 113 (2000) 2253-2265
-
(2000)
J Cell Sci
, vol.113
, pp. 2253-2265
-
-
Dumontier, M.1
Hocht, P.2
Mintert, U.3
Faix, J.4
-
68
-
-
33646015078
-
Morphological and functional analysis of Rac1B in Dictyostelium discoideum
-
Duleh S.N., Collins J.T., and Pope R.K. Morphological and functional analysis of Rac1B in Dictyostelium discoideum. J Electron Microsc (Tokyo) 54 (2005) 519-528
-
(2005)
J Electron Microsc (Tokyo)
, vol.54
, pp. 519-528
-
-
Duleh, S.N.1
Collins, J.T.2
Pope, R.K.3
-
69
-
-
0036672791
-
The CDM protein DOCK2 in lymphocyte migration
-
Reif K., and Cyster J. The CDM protein DOCK2 in lymphocyte migration. Trends Cell Biol 12 (2002) 368-373
-
(2002)
Trends Cell Biol
, vol.12
, pp. 368-373
-
-
Reif, K.1
Cyster, J.2
-
71
-
-
2942731440
-
Regulation of actin dynamics by WASP and WAVE family proteins
-
Stradal T.E., Rottner K., Disanza A., Confalonieri S., Innocenti M., and Scita G. Regulation of actin dynamics by WASP and WAVE family proteins. Trends Cell Biol 14 (2004) 303-311
-
(2004)
Trends Cell Biol
, vol.14
, pp. 303-311
-
-
Stradal, T.E.1
Rottner, K.2
Disanza, A.3
Confalonieri, S.4
Innocenti, M.5
Scita, G.6
-
72
-
-
4644342865
-
Regulation of WASP/WAVE proteins: making a long story short
-
Bompard G., and Caron E. Regulation of WASP/WAVE proteins: making a long story short. J Cell Biol 166 (2004) 957-962
-
(2004)
J Cell Biol
, vol.166
, pp. 957-962
-
-
Bompard, G.1
Caron, E.2
-
73
-
-
33645742166
-
Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein
-
See Update
-
Matsuoka S., Iijima M., Watanabe T.M., Kuwayama H., Yanagida T., Devreotes P.N., and Ueda M. Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein. J Cell Sci 119 (2006) 1071-1079. See Update
-
(2006)
J Cell Sci
, vol.119
, pp. 1071-1079
-
-
Matsuoka, S.1
Iijima, M.2
Watanabe, T.M.3
Kuwayama, H.4
Yanagida, T.5
Devreotes, P.N.6
Ueda, M.7
|