Chokeberry (Aronia melanocarpa) juice modulates 7,12-dimethylbenz[a]anthracene induced hepatic but not mammary gland phase I and II enzymes in female rats

Environmental Toxicology and Pharmacology

Volumn 31, Issue 2, 2011, Pages 339-346

  Szaefer, Hanna ^a   Krajka Kuźniak, Violetta ^a   Ignatowicz, Ewa ^a   Adamska, Teresa ^a   Baer Dubowska, Wanda ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

7,12 Dimethylbenz a anthracene; Chokeberry juice; Cytochrome P450; Liver; Mammary gland; Phase II enzymes

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; CREATININE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2B; DIMETHYLBENZ[A]ANTHRACENE; ETHOXYRESORUFIN DEETHYLASE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE TRANSFERASE; HERBACEOUS AGENT; IDITOL DEHYDROGENASE; LACTATE DEHYDROGENASE; METHOXYRESORUFIN O DEMETHYLASE; PENTOXYRESORUFIN DEALKYLASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) 1; UNCLASSIFIED DRUG; UNCLASSIFIED ENZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL; CHOKEBERRY JUICE; CONTROLLED STUDY; DETOXIFICATION; DNA DAMAGE; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; FRUIT JUICE; LIVER PARENCHYMA; LIVER TOXICITY; MAMMARY GLAND; METABOLIC ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TISSUE SPECIFICITY; TREATMENT DURATION;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CARCINOGENS; COMET ASSAY; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM; DNA DAMAGE; FEMALE; FRUIT; GLUTATHIONE TRANSFERASE; ISOENZYMES; LIVER; MAMMARY GLANDS, ANIMAL; NAD(P)H DEHYDROGENASE (QUINONE); PHOTINIA; RATS; RATS, SPRAGUE-DAWLEY;

PHOTINIA; PHOTINIA MELANOCARPA; RATTUS;

EID: 79951725680     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2010.12.006     Document Type: Article

References (32)

1. Atanasova-Goranowa V.K., Dimova P.I., Pevicharova G.T. Effect of food products on endogenous generation of N-nitrosamines in rats. Br. J. Nutr. 1997, 78:335-345.
2. Baer-Dubowska W., Szaefer H., Krajka V. Inhibition of murine hepatic cytochrome P450 activities by natural and synthetic phenolic compounds. Xenobiotica 1998, 28:735-743.
3. Benvenuti S., Pellati F., Melegari M., Bertelli D. Polyphenols, anthocyanins, ascorbic acid, and radical scavenging activity of Rubus, Ribes, and Aronia. J. Food Sci. 2004, 69:FCT164-FCT169.
4. Brauze D., Widerak M., Cwykiel J., Szyfter K., Baer-Dubowska W. The effect of aryl hydrocarbon receptor ligands on the expression of AhR, AhRR, ARNT, Hif1α, CYP1A1 and NQO1 genes in rat liver. Toxicology 2006, 167:212-220.
5. Coles B., Ketterer B. The role of glutathione transferases in chemical carcinogenesis. Crit. Rev. Biochem. Mol. Biol. 1999, 25:47-70.
6. Collins A.R. The comet assay for DNA damage and repair: principles, applications and limitations. Mol. Biotechnol. 2004, 26:249-261.
7. Duthie S.J., Jenkinson A.M., Crozier A., Mullen W., Pirie L., Kyle J., Yap L.S., Christen P., Duthie G.G. The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers. Eur. J. Nutr. 2006, 45:113-122.
8. Ga{ogonek}siorowski K., Szyba K., Brokos B., Kołaczyńska B., Jankowiak-Włodarczyk M., Oszmiański J. Antimutagenic activity of anthocyanins isolated from Aronia melanocarpa fruits. Cancer Lett. 1997, 119:37-46.
9. Girolami F., Abbadessa G., Racca S., Spaccamiglio A., Piccione F., Dacasto M., Carletti M., Gardini G., Di Carlo F., Nebbia C. Time-dependent acetylsalicylic acid effects on liver CYP1 and antioxidant enzymes in rat model of 7,12-dimethylbenzanthracene (DMBA)-induced mammary carcinogenesis. Toxicol. Lett. 2008, 181:87-92.
10. Hartmann A., Agurell E., Beevers C., Brendler-Schwaab S., Burlinson B., Clay P., Collins A., Smith A., Speit G., Thybaud V., Tice R.R. Recommendations for conducting the in vivo alkaline Comet assay. Mutagenesis 2003, 8:45-51.
11. Jakobek L., Seruga M., Medvidovic-Kosanovic M., Novak I. Anthocyanin content and antioxidant activity of various red fruit juices. Dtsch. Lebensm. Rundsch. 2007, 103:58-64.
12. Kim H., Hall P., Smith M., Kirk M., Prasain J.K., Barnes S., Grubbs C. Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent. J. Nutr. 2004, 134:3445S-3452S.
13. Kitayar S.K. Grape seed proanthocyanidines and skin cancer prevention: inhibition of oxidative stress and protection of immune system. Mol. Nutr. Food Res. 2008, 52:S71-S76.
14. Kleiner H.E., Vulimiri S.V., Hatten W.B., Reed M.J., Nebert D.W., Jefcoate C.R., DiGiovanni J. Role of cytochrome P4501 family members in the metabolic activation of polycyclic aromatic hydrocarbons in mouse epidermis. Chem. Res. Toxicol. 2004, 17:1667-1674.
15. Köhle C., Bock K.W. Activation of coupled Ah receptor and Nrf2 gene batteries by dietary phytochemicals in relation to chemoprevention. Biochem. Pharmacol. 2006, 72:795-805.
16. Krajka-Kuźniak V., Kaczmarek J., Baer-Dubowska W. Effect of naturally occurring phenolic acids on the expression of glutatione S-transferase isozymes in the rat. Food Chem. Toxicol. 2008, 46:1097-1102.
17. Krajka-Kuźniak V., Szaefer H., Baer-Dubowska W. Modulation of 3-methylcholanthrene-induced rat hepatic and renal cytochrome P450 and phase II enzymes by plant phenols: protocatechuic and tannic acids. Toxicol. Lett. 2004, 152:117-126.
18. Krajka-Kuźniak V., Szaefer H., Ignatowicz E., Adamska T., Oszmiański J., Baer-Dubowska W. Effect of chokeberry (Aronia melanocarpa) juice on the metabolic activation and detoxication of carcinogenic N-nitrosodiethylamine in rat liver. J. Agric. Food Chem. 2009, 57:5071-5077.
19. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
20. Lambard S.E., Burnett A.K., Wolf C.R., Craft J.A. The role of specific cytochromes P450 in the formation of 7,12-dimethylbenz(a)anthracene-protein adducts in rat liver microsomes in vitro. Biochem. Pharmacol. 1991, 42:1529-1535.
21. Lowry O.H., Rosenbrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
22. Nijhoff W.A., Groen G.M., Peters W.H.M. Induction of rat hepatic and intestinal glutathione S-transferases and glutathione by dietary naturally occurring anticarcinogens. Int. J. Oncol. 1993, 3:1131-1139.
23. Oszmiański J., Wojdyło A. Aronia melanocarpa phenolics and their antioxidant activity. Eur. Food Res. Technol. 2005, 221:809-813.
24. Shou M., Korzekwa K.R., Krausz K.W., Buters J.T., Grogan J., Goldfarb I., Hardwick J.P., Gonzalez F.J., Gelboin H.V. Specificity of cDNA-expressed human and rodent cytochrome P450s in the oxidative metabolism of the potent carcinogen 7,12-dimethylbenz[a]anthracene. Mol. Carcinog. 1996, 17:241-249.
25. Strigl A.W., Leitner E., Pfannhauser W. Qualitative und quantitative analyse der anthocyane in schwarzen apfelbeeren (Aronia melanocarpa Michx Ell) mittels TLC, HPLC and UV/VIS-spectrometrie. Z. Lebensm. Unters. Forsch. 1995, 201:266-268.
26. Szaefer H., Cichocki M., Brauze D., Baer-Dubowska W. Alteration in phase I and II enzyme activities and polycyclic aromatic hydrocarbons-DNA adduct formation by plant phenolics in mouse epidermis. Nutr. Cancer 2004, 48:70-77.
27. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyarylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U.S.A. 1979, 76:4350-4354.
28. Tsuchiya Y., Nakajima M., Yokoi T. Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005, 227:115-124.
29. Valcheva-Kuzmanova S., Borisova P., Galunska B., Krasnaliev I., Belcheva A. Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on carbon tetrachloride-induced acute liver damage in rats. Exp. Toxicol. Pathol. 2004, 56:195-201.
30. Vinothini G., Manikandan P., Anandan R., Nagini S. Chemoprevention of rat mammary carcinogenesis by Azadirachta indica leaf fractions: modulation of hormone status, xenobiotic-metabolizing enzymes, oxidative stress, cell proliferation and apoptosis. Food Chem. Toxicol. 2009, 47:1852-1863.
31. Wu X., Gu L., Prior R.L., McKay S. Characterization of anthocyanins and procyanthocyanidins in some cultivars of Ribes, Aronia, and Sambucus and their antioxidant capacity. J. Agric. Food Chem. 2004, 5:7846-7856.
32. Zheng W., Wang S. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J. Agric. Food Chem. 2003, 51:502-509.