Specificity of cDNA-expressed human and rodent cytochrome P450s in the oxidative metabolism of the potent carcinogen 7,12-dimethylbenz[a]anthracene

Molecular Carcinogenesis

Volumn 17, Issue 4, 1996, Pages 241-249

  Shou, Magang ^a   Korzekwa, Kenneth R ^a   Krausz, Kristopher W ^a   Buters, Jeroen T M ^a   Grogan, James ^a   Goldfarb, Inna ^a   Hardwick, James P ^b   Gonzalez, Frank J ^a   Gelboin, Harry V ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

Author keywords

7,12 dimethylbenz a anthracene; cDNA expression; cytochrome P450; high performance liquid chromatography; metabolism of polycyclic aromatic hydrocarbons

Indexed keywords

COMPLEMENTARY DNA; CYTOCHROME P450; DIMETHYLBENZ[A]ANTHRACENE;

ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIVER MICROSOME; METABOLIC ACTIVATION; METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; BINDING SITES; BIOTRANSFORMATION; CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; HUMANS; ISOENZYMES; MALE; MICE; MICROSOMES, LIVER; OXIDATION-REDUCTION; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY;

ANIMALIA; ORYCTOLAGUS CUNICULUS; RODENTIA; UNIDENTIFIED BACULOVIRUS; VACCINIA;

EID: 0030461793     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199612)17:4<241::AID-MC8>3.0.CO;2-G     Document Type: Article

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