Chemoprevention of rat mammary carcinogenesis by Azadirachta indica leaf fractions: Modulation of hormone status, xenobiotic-metabolizing enzymes, oxidative stress, cell proliferation and apoptosis

Food and Chemical Toxicology

Volumn 47, Issue 8, 2009, Pages 1852-1863

  Vinothini, G ^a   Manikandan, P ^a   Anandan, R ^b   Nagini, S ^a  

^a ANNAMALAI UNIVERSITY   (India)

^b CENTRAL INSTITUTE OF FISHERIES TECHNOLOGY   (India)

Author keywords

Apoptosis; Estrogen receptor; Mammary carcinogenesis; Neem; Xenobiotic metabolizing enzymes

Indexed keywords

ACETIC ACID ETHYL ESTER; ANTINEOPLASTIC AGENT; ANTIOXIDANT; AZARDIRACHTA INDICA EXTRACT; BIOLOGICAL MARKER; DIMETHYLBENZ[A]ANTHRACENE; ESTRADIOL RECEPTOR; ESTROGEN RECEPTOR; METHANOL; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AZARDIRACHTA INDICA; BREAST CARCINOGENESIS; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; MEDICINAL PLANT; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PLANT LEAF; RAT;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AZADIRACHTA; BODY WEIGHT; CARCINOGENS; CELL PROLIFERATION; CHROMATOGRAPHY, THIN LAYER; FEMALE; HORMONES; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; LIVER; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; OXIDATIVE STRESS; PLANT LEAVES; PRECANCEROUS CONDITIONS; RATS; RATS, SPRAGUE-DAWLEY; XENOBIOTICS;

AZADIRACHTA INDICA; RATTUS;

EID: 68649113737     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.04.045     Document Type: Article

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