Receptor-specific functional efficacies of alkyl imidazoles as dual histamine H3/H4 receptor ligands

European Journal of Pharmacology

Volumn 654, Issue 3, 2011, Pages 200-208

  Kottke, Tim ^a   Sander, Kerstin ^a   Weizel, Lilia ^a   Schneider, Erich H ^b   Seifert, Roland ^c   Stark, Holger ^a  

^a GOETHE UNIVERSITY   (Germany)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Agonist; GTP S binding; Histamine receptor; Imidazole; Inflammation; Inverse agonist

Indexed keywords

3 (1H IMIDAZOL 4 YL)PROPYL (CYCLOHEXYLMETHYL)CARBAMATE; 4 [3 (3 PHENYLPROPYLTHIO)PROPYL] 1H IMIDAZOLE; HISTAMINE AGONIST; HISTAMINE H3 RECEPTOR; HISTAMINE H4 RECEPTOR; HISTAMINERGIC RECEPTOR AFFECTING AGENT; N [3 (1H IMIDAZOL 4 YL)PROPYL] 2 CYCLOHEXYLACETAMIDE; OMEGA (1H IMIDAZOL 4 YL)ALKYL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGAND BINDING; PHARMACOPHORE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

HEK293 CELLS; HUMANS; IMIDAZOLES; LIGANDS; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RECEPTORS, HISTAMINE H3; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 79951681782     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.12.033     Document Type: Article

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