Ng-acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the n g-substituent∇

Journal of Medicinal Chemistry

Volumn 52, Issue 8, 2009, Pages 2623-2627

  Igel, Patrick ^a   Schneider, Erich ^a   Schnell, David ^a   Elz, Sigurd ^a   Seifert, Roland ^b   Buschauer, Armin ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 (1H IMIDAZOL 4 YL)PROPYLGUANIDINE; GUANIDINE DERIVATIVE; HISTAMINE 4 RECEPTOR AGONIST; HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR; HISTAMINE H3 RECEPTOR; HISTAMINE H4 RECEPTOR; IMIDAZOLE DERIVATIVE; N1 ACETYL N2 [3 (1H IMIDAZOL 4 YL)PROPYL]GUANIDINE; PARTIAL AGONIST; SKF 91486; UNCLASSIFIED DRUG; UR PI288;

ACYLATION; ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; GUANIDINES; HUMANS; IMIDAZOLES; INSECTS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 65249091015     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9000693     Document Type: Article

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