메뉴 건너뛰기




Volumn 97, Issue 3, 2006, Pages 631-640

Amyloid beta peptide increases DP5 expression via activation of neutral sphingomyelinase and JNK in oligodendrocytes

Author keywords

Amyloid beta peptide; Ceramide; DP5; Jun N terminal kinase; Neutral sphingomyelinase; Oligodendrocyte

Indexed keywords

AMYLOID BETA PROTEIN; APOPTOTIC PROTEIN 1; CERAMIDE; CYTOCHROME C; PROAPOPTOTIC PROTEIN DP5 HRK; PROTEIN; SMALL INTERFERING RNA; SPHINGOMYELIN PHOSPHODIESTERASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

EID: 33645858245     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.03774.x     Document Type: Article
Times cited : (37)

References (70)
  • 1
    • 0027283310 scopus 로고
    • Expression of c-fos and c-jun family genes after focal cerebral ischemia
    • An G. Lin T. N. Liu J. S. Xue J. J. He Y. Y. Hsu C. Y. 1993 Expression of c-fos and c-jun family genes after focal cerebral ischemia. Ann. Neurol. 33 457 464.
    • (1993) Ann. Neurol. , vol.33 , pp. 457-464
    • An, G.1    Lin, T.N.2    Liu, J.S.3    Xue, J.J.4    He, Y.Y.5    Hsu, C.Y.6
  • 3
  • 4
    • 0032411879 scopus 로고    scopus 로고
    • Stress signals for apoptosis: Ceramide and c-Jun kinase
    • Basu S. Kolesnick R. 1998 Stress signals for apoptosis: ceramide and c-Jun kinase. Oncogene 17 3277 3285.
    • (1998) Oncogene , vol.17 , pp. 3277-3285
    • Basu, S.1    Kolesnick, R.2
  • 5
    • 1542511200 scopus 로고    scopus 로고
    • Interactions of Alzheimer amyloid peptides with cultured cells and brain tissue, and their biological consequences
    • Bateman D. A. Chakrabartty A. 2004 Interactions of Alzheimer amyloid peptides with cultured cells and brain tissue, and their biological consequences. Biopolymers 76 4 14.
    • (2004) Biopolymers , vol.76 , pp. 4-14
    • Bateman, D.A.1    Chakrabartty, A.2
  • 6
    • 0028207907 scopus 로고
    • Amyloid beta peptide induces necrosis rather than apoptosis
    • Behl C. Davis J. B. Klier F. G. Schubert D. 1994 Amyloid beta peptide induces necrosis rather than apoptosis. Brain Res. 645 253 264.
    • (1994) Brain Res. , vol.645 , pp. 253-264
    • Behl, C.1    Davis, J.B.2    Klier, F.G.3    Schubert, D.4
  • 7
    • 0029148660 scopus 로고
    • Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
    • Bose R. Verheij M. Haimovitz-Friedman A. Scotto K. Fuks Z. Kolesnick R. 1995 Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 82 405 414.
    • (1995) Cell , vol.82 , pp. 405-414
    • Bose, R.1    Verheij, M.2    Haimovitz-Friedman, A.3    Scotto, K.4    Fuks, Z.5    Kolesnick, R.6
  • 8
    • 0035019371 scopus 로고    scopus 로고
    • CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis
    • Bozyczko-Coyne D. O'Kane T. M. Wu Z. L. Dobrzanski P. Murthy S. Vaught J. L. Scott R. W. 2001 CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis. J. Neurochem. 77 849 863.
    • (2001) J. Neurochem. , vol.77 , pp. 849-863
    • Bozyczko-Coyne, D.1    O'Kane, T.M.2    Wu, Z.L.3    Dobrzanski, P.4    Murthy, S.5    Vaught, J.L.6    Scott, R.W.7
  • 11
    • 0022572209 scopus 로고
    • A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study
    • Brun A. Englund E. 1986 A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study. Ann. Neurol. 19 253 262.
    • (1986) Ann. Neurol. , vol.19 , pp. 253-262
    • Brun, A.1    Englund, E.2
  • 12
    • 0035977067 scopus 로고    scopus 로고
    • FAS activation induces dephosphorylation of SR proteins; Dependence on the de novo generation of ceramide and activation of protein phosphatase 1
    • Chalfant C. E. Ogretmen B. Galadari S. Kroesen B. J. Pettus B. J. Hannun Y. A. 2001 FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1. J. Biol. Chem. 276 44 848 44 855.
    • (2001) J. Biol. Chem. , vol.276 , pp. 44848-44855
    • Chalfant, C.E.1    Ogretmen, B.2    Galadari, S.3    Kroesen, B.J.4    Pettus, B.J.5    Hannun, Y.A.6
  • 13
    • 0037066727 scopus 로고    scopus 로고
    • De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1
    • Chalfant C. E. Rathman K. Pinkerman R. L. Wood R. E. Obeid L. M. Ogretmen B. Hannun Y. A. 2002 De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J. Biol. Chem. 277 12 587 12 595.
    • (2002) J. Biol. Chem. , vol.277 , pp. 12587-12595
    • Chalfant, C.E.1    Rathman, K.2    Pinkerman, R.L.3    Wood, R.E.4    Obeid, L.M.5    Ogretmen, B.6    Hannun, Y.A.7
  • 14
    • 1542723736 scopus 로고    scopus 로고
    • The structural requirements for ceramide activation of serine-threonine protein phosphatases
    • Chalfant C. E. Szulc Z. Roddy P. Bielawska A. Hannun Y. A. 2004 The structural requirements for ceramide activation of serine-threonine protein phosphatases. J. Lipid Res. 45 496 506.
    • (2004) J. Lipid Res. , vol.45 , pp. 496-506
    • Chalfant, C.E.1    Szulc, Z.2    Roddy, P.3    Bielawska, A.4    Hannun, Y.A.5
  • 15
    • 0041846404 scopus 로고    scopus 로고
    • Quantitative assessment of DNA fragmentation and beta-amyloid deposition in insular cortex and midfrontal gyrus from patients with Alzheimer's disease
    • Colurso G. J. Nilson J. E. Vervoort L. G. 2003 Quantitative assessment of DNA fragmentation and beta-amyloid deposition in insular cortex and midfrontal gyrus from patients with Alzheimer's disease. Life Sci. 73 1795 1803.
    • (2003) Life Sci. , vol.73 , pp. 1795-1803
    • Colurso, G.J.1    Nilson, J.E.2    Vervoort, L.G.3
  • 16
    • 0028983336 scopus 로고
    • Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells
    • Davis-Salinas J. Saporito-Irwin S. M. Cotman C. W. Van Nostrand W. E. 1995 Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells. J. Neurochem. 65 931 934.
    • (1995) J. Neurochem. , vol.65 , pp. 931-934
    • Davis-Salinas, J.1    Saporito-Irwin, S.M.2    Cotman, C.W.3    Van Nostrand, W.E.4
  • 17
    • 0001551049 scopus 로고    scopus 로고
    • Signal transduction and the regulation of apoptosis: Roles of ceramide
    • Dbaibo G. S. Hannun Y. A. 1998 Signal transduction and the regulation of apoptosis: roles of ceramide. Apoptosis 3 317 334.
    • (1998) Apoptosis , vol.3 , pp. 317-334
    • Dbaibo, G.S.1    Hannun, Y.A.2
  • 19
    • 0030478489 scopus 로고    scopus 로고
    • Membrane components separate early-onset Alzheimer's disease from senile dementia of the Alzheimer type
    • Gottfries C. G. Karlsson I. Svennerholm L. 1996 Membrane components separate early-onset Alzheimer's disease from senile dementia of the Alzheimer type. Int. Psychogeriatr 8 365 372.
    • (1996) Int. Psychogeriatr , vol.8 , pp. 365-372
    • Gottfries, C.G.1    Karlsson, I.2    Svennerholm, L.3
  • 21
    • 0036677303 scopus 로고    scopus 로고
    • Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: Potential role in disease pathogenesis
    • Han X. Holtzman D. M.,q42 McKeel D. W. Jr. Kelley J. Morris J. C. 2002 Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis. J. Neurochem. 82 809 818.
    • (2002) J. Neurochem. , vol.82 , pp. 809-818
    • Han, X.1    Holtzman, D.M.2    McKeel Jr., D.W.3    Kelley, J.4    Morris, J.C.5
  • 22
    • 0035851204 scopus 로고    scopus 로고
    • BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons
    • Harris C. A. Johnson E. M. Jr. 2001 BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons. J. Biol. Chem. 276 37 754 37 760.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37754-37760
    • Harris, C.A.1    Johnson Jr., E.M.2
  • 23
    • 0036845266 scopus 로고    scopus 로고
    • Identification of JNK-dependent and - Independent components of cerebellar granule neuron apoptosis
    • Harris C. Maroney A. C. Johnson E. M. Jr. 2002 Identification of JNK-dependent and - independent components of cerebellar granule neuron apoptosis. J. Neurochem. 83 992 1001.
    • (2002) J. Neurochem. , vol.83 , pp. 992-1001
    • Harris, C.1    Maroney, A.C.2    Johnson Jr., E.M.3
  • 24
    • 15644376284 scopus 로고    scopus 로고
    • Amyloid beta-peptide possesses a transforming growth factor-beta activity
    • Huang S. S. Huang F. W. Xu J. Chen S. Hsu C. Y. Huang J. S. 1998 Amyloid beta-peptide possesses a transforming growth factor-beta activity. J. Biol. Chem. 273 27 640 27 644.
    • (1998) J. Biol. Chem. , vol.273 , pp. 27640-27644
    • Huang, S.S.1    Huang, F.W.2    Xu, J.3    Chen, S.4    Hsu, C.Y.5    Huang, J.S.6
  • 26
    • 0033583218 scopus 로고    scopus 로고
    • The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein
    • Imaizumi K. Morihara T. Mori Y. Katayama T. Tsuda M. Furuyama T. Wanaka A. Takeda M. Tohyama M. 1999 The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein. J. Biol. Chem. 274 7975 7981.
    • (1999) J. Biol. Chem. , vol.274 , pp. 7975-7981
    • Imaizumi, K.1    Morihara, T.2    Mori, Y.3    Katayama, T.4    Tsuda, M.5    Furuyama, T.6    Wanaka, A.7    Takeda, M.8    Tohyama, M.9
  • 27
    • 0028246298 scopus 로고
    • Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells
    • Joseph C. K. Wright S. D. Bornmann W. G. Randolph J. T. Kumar E. R. Bittman R. Liu J. Kolesnick R. N. 1994 Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells. J. Biol. Chem. 269 17 606 17 610.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17606-17610
    • Joseph, C.K.1    Wright, S.D.2    Bornmann, W.G.3    Randolph, J.T.4    Kumar, E.R.5    Bittman, R.6    Liu, J.7    Kolesnick, R.N.8
  • 30
    • 0031919157 scopus 로고    scopus 로고
    • Regulation of ceramide production and apoptosis
    • Kolesnick R. N. Kronke M. 1998 Regulation of ceramide production and apoptosis. Annu. Rev. Physiol. 60 643 665.
    • (1998) Annu. Rev. Physiol. , vol.60 , pp. 643-665
    • Kolesnick, R.N.1    Kronke, M.2
  • 31
    • 0034847176 scopus 로고    scopus 로고
    • Neurodegenerative changes associated with beta-amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes
    • Kurt M. A. Davies D. C. Kidd M. Duff K. Rolph S. C. Jennings K. H. Howlett D. R. 2001 Neurodegenerative changes associated with beta-amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes. Exp Neurol. 171 59 71.
    • (2001) Exp Neurol. , vol.171 , pp. 59-71
    • Kurt, M.A.1    Davies, D.C.2    Kidd, M.3    Duff, K.4    Rolph, S.C.5    Jennings, K.H.6    Howlett, D.R.7
  • 33
    • 0032484194 scopus 로고    scopus 로고
    • Impaired ionizing radiation-induced activation of a nuclear signal essential for phosphorylation of c-Jun by dually phosphorylated c-Jun amino-terminal kinases in ataxia telangiectasia fibroblasts
    • Lee S. A. Dritschilo A. Jung M. 1998 Impaired ionizing radiation-induced activation of a nuclear signal essential for phosphorylation of c-Jun by dually phosphorylated c-Jun amino-terminal kinases in ataxia telangiectasia fibroblasts. J. Biol. Chem. 273 32 889 32 894.
    • (1998) J. Biol. Chem. , vol.273 , pp. 32889-32894
    • Lee, S.A.1    Dritschilo, A.2    Jung, M.3
  • 34
    • 0347122965 scopus 로고    scopus 로고
    • Amyloid-{beta} peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway
    • Lee J. T. Xu J. Lee J. M. Ku G. Han X. Yang D. I. Chen S. Hsu C. Y. 2004 Amyloid-{beta} peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway. J. Cell Biol. 164 123 131.
    • (2004) J. Cell Biol. , vol.164 , pp. 123-131
    • Lee, J.T.1    Xu, J.2    Lee, J.M.3    Ku, G.4    Han, X.5    Yang, D.I.6    Chen, S.7    Hsu, C.Y.8
  • 35
    • 0037418238 scopus 로고    scopus 로고
    • JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
    • Lei K. Davis R. J. 2003 JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc. Natl Acad. Sci. U S A 100 2432 2437.
    • (2003) Proc. Natl Acad. Sci. U S a , vol.100 , pp. 2432-2437
    • Lei, K.1    Davis, R.J.2
  • 36
    • 0036269755 scopus 로고    scopus 로고
    • The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH (2)-terminal kinase
    • Lei K. Nimnual A. Zong W. X. Kennedy N. J. Flavell R. A. Thompson C. B. Bar-Sagi D. Davis R. J. 2002 The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH (2)-terminal kinase. Mol Cell Biol. 22 4929 4942.
    • (2002) Mol Cell Biol. , vol.22 , pp. 4929-4942
    • Lei, K.1    Nimnual, A.2    Zong, W.X.3    Kennedy, N.J.4    Flavell, R.A.5    Thompson, C.B.6    Bar-Sagi, D.7    Davis, R.J.8
  • 37
    • 0344349001 scopus 로고    scopus 로고
    • Signalling sphingomyelinases: Which, where, how and why?
    • Levade T. Jaffrezou J. P. 1999 Signalling sphingomyelinases: which, where, how and why? Biochim. Biophys. Acta 1438 1 17.
    • (1999) Biochim. Biophys. Acta , vol.1438 , pp. 1-17
    • Levade, T.1    Jaffrezou, J.P.2
  • 38
    • 12144286502 scopus 로고    scopus 로고
    • Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients
    • Li R. Lindholm K. Yang L. B et al. 2004 Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients. Proc. Natl Acad. Sci. U S A 101 3632 3637.
    • (2004) Proc. Natl Acad. Sci. U S a , vol.101 , pp. 3632-3637
    • Li, R.1    Lindholm, K.2    Yang, L.B.3
  • 41
    • 1942533609 scopus 로고    scopus 로고
    • Identification of two RNA cis-elements that function to regulate the 5′ splice site selection of Bcl-x pre-mRNA in response to ceramide
    • Massiello A. Salas A. Pinkerman R. L. Roddy P. Roesser J. R. Chalfant C. E. 2004 Identification of two RNA cis-elements that function to regulate the 5′ splice site selection of Bcl-x pre-mRNA in response to ceramide. J. Biol. Chem. 279 15 799 15 804.
    • (2004) J. Biol. Chem. , vol.279 , pp. 15799-15804
    • Massiello, A.1    Salas, A.2    Pinkerman, R.L.3    Roddy, P.4    Roesser, J.R.5    Chalfant, C.E.6
  • 42
    • 0025889011 scopus 로고
    • Characterization of a ceramide-activated protein kinase: Stimulation by tumor necrosis factor alpha
    • Mathias S. Dressler K. A. Kolesnick R. N. 1991 Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha. Proc. Natl Acad. Sci. U S A 88 10 009 10 013.
    • (1991) Proc. Natl Acad. Sci. U S a , vol.88 , pp. 10009-10013
    • Mathias, S.1    Dressler, K.A.2    Kolesnick, R.N.3
  • 44
    • 1342275412 scopus 로고    scopus 로고
    • The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling
    • Nateri A. S. Riera-Sans L. Da Costa C. Behrens A. 2004 The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science 303 1374 1378.
    • (2004) Science , vol.303 , pp. 1374-1378
    • Nateri, A.S.1    Riera-Sans, L.2    Da Costa, C.3    Behrens, A.4
  • 45
    • 0347695003 scopus 로고    scopus 로고
    • Ceramide pathways modulate ethanol-induced cell death in astrocytes
    • Pascual M. Valles S. L. Renau-Piqueras J. Guerri C. 2003 Ceramide pathways modulate ethanol-induced cell death in astrocytes. J. Neurochem. 87 1535 1545.
    • (2003) J. Neurochem. , vol.87 , pp. 1535-1545
    • Pascual, M.1    Valles, S.L.2    Renau-Piqueras, J.3    Guerri, C.4
  • 46
    • 0037203342 scopus 로고    scopus 로고
    • Ceramide in apoptosis: An overview and current perspectives
    • Pettus B. J. Chalfant C. E. Hannun Y. A. 2002 Ceramide in apoptosis: an overview and current perspectives. Biochim. Biophys. Acta 1585 114 125.
    • (2002) Biochim. Biophys. Acta , vol.1585 , pp. 114-125
    • Pettus, B.J.1    Chalfant, C.E.2    Hannun, Y.A.3
  • 47
    • 18544386562 scopus 로고    scopus 로고
    • Increased a beta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease
    • Roher A. E. Weiss N. Kokjohn T. A. et al. 2002 Increased A beta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease. Biochemistry 41 11 080 11 090.
    • (2002) Biochemistry , vol.41 , pp. 11080-11090
    • Roher, A.E.1    Weiss, N.2    Kokjohn, T.A.3
  • 48
    • 0034882639 scopus 로고    scopus 로고
    • Ceramide regulates cellular homeostasis via diverse stress signaling pathways
    • Ruvolo P. P. 2001 Ceramide regulates cellular homeostasis via diverse stress signaling pathways. Leukemia 15 1153 1160.
    • (2001) Leukemia , vol.15 , pp. 1153-1160
    • Ruvolo, P.P.1
  • 49
    • 0033575320 scopus 로고    scopus 로고
    • Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A
    • Ruvolo P. P. Deng X. Ito T. Carr B. K. May W. S. 1999 Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. J. Biol. Chem. 274 20 296 20 300.
    • (1999) J. Biol. Chem. , vol.274 , pp. 20296-20300
    • Ruvolo, P.P.1    Deng, X.2    Ito, T.3    Carr, B.K.4    May, W.S.5
  • 50
    • 0033600274 scopus 로고    scopus 로고
    • Translating cell biology into therapeutic advances in Alzheimer's disease
    • Selkoe D. J. 1999 Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399 A23 A31.
    • (1999) Nature , vol.399
    • Selkoe, D.J.1
  • 51
    • 0029949938 scopus 로고    scopus 로고
    • PrICE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2
    • Smyth M. J. Perry D. K. Zhang J. Poirier G. G. Hannun Y. A. Obeid L. M. 1996 prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem. J. 316 25 28.
    • (1996) Biochem. J. , vol.316 , pp. 25-28
    • Smyth, M.J.1    Perry, D.K.2    Zhang, J.3    Poirier, G.G.4    Hannun, Y.A.5    Obeid, L.M.6
  • 52
    • 0026732790 scopus 로고
    • Lipid composition in different regions of the brain in Alzheimer's disease/senile dementia of Alzheimer's type
    • Soderberg M. Edlund C. Alafuzoff I. Kristensson K. Dallner G. 1992 Lipid composition in different regions of the brain in Alzheimer's disease/senile dementia of Alzheimer's type. J. Neurochem. 59 1646 1653.
    • (1992) J. Neurochem. , vol.59 , pp. 1646-1653
    • Soderberg, M.1    Edlund, C.2    Alafuzoff, I.3    Kristensson, K.4    Dallner, G.5
  • 53
    • 1842588702 scopus 로고    scopus 로고
    • Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition
    • Song S. K. Kim J. H. Lin S. J. Brendza R. P. Holtzman D. M. 2004 Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition. Neurobiol. Dis 15 640 647.
    • (2004) Neurobiol. Dis , vol.15 , pp. 640-647
    • Song, S.K.1    Kim, J.H.2    Lin, S.J.3    Brendza, R.P.4    Holtzman, D.M.5
  • 54
    • 0029862561 scopus 로고    scopus 로고
    • Sphingolipid metabolism and cell growth regulation
    • Spiegel S. Merrill A. H. Jr. 1996 Sphingolipid metabolism and cell growth regulation. Faseb J. 10 1388 1397.
    • (1996) Faseb J. , vol.10 , pp. 1388-1397
    • Spiegel, S.1    Merrill Jr., A.H.2
  • 55
    • 0038079348 scopus 로고    scopus 로고
    • Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death
    • Su J. H. Anderson A. J. Cribbs D. H. Tu C. Tong L. Kesslack P. Cotman C. W. 2003 Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death. Neurobiol. Dis 12 182 193.
    • (2003) Neurobiol. Dis , vol.12 , pp. 182-193
    • Su, J.H.1    Anderson, A.J.2    Cribbs, D.H.3    Tu, C.4    Tong, L.5    Kesslack, P.6    Cotman, C.W.7
  • 56
    • 0036550597 scopus 로고    scopus 로고
    • Significance of intracellular Abeta42 accumulation in Alzheimer's disease
    • Tabira T. Chui D. H. Kuroda S. 2002 Significance of intracellular Abeta42 accumulation in Alzheimer's disease. Front Biosci. 7 44 49.
    • (2002) Front Biosci. , vol.7 , pp. 44-49
    • Tabira, T.1    Chui, D.H.2    Kuroda, S.3
  • 57
    • 0031457783 scopus 로고    scopus 로고
    • Age-induced white matter changes in the human brain: A stereological investigation
    • q43
    • Tang Y. Nyengaard J. R. Pakkenberg B. Gundersen H. J. 1997 Age-induced white matter changes in the human brain: a stereological investigation. Neurobiol. Aging 18 609 615. q43
    • (1997) Neurobiol. Aging , vol.18 , pp. 609-615
    • Tang, Y.1    Nyengaard, J.R.2    Pakkenberg, B.3    Gundersen, H.J.4
  • 58
    • 0030473287 scopus 로고    scopus 로고
    • Sphingomyelin breakdown and cell fate
    • Testi R. 1996 Sphingomyelin breakdown and cell fate. Trends Biochem. Sci. 21 468 471.
    • (1996) Trends Biochem. Sci. , vol.21 , pp. 468-471
    • Testi, R.1
  • 59
    • 0029670094 scopus 로고    scopus 로고
    • Beta-Amyloid-mediated vasoactivity and vascular endothelial damage
    • Thomas T. Thomas G. McLendon C. Sutton T. Mullan M. 1996 beta-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature 380 168 171.
    • (1996) Nature , vol.380 , pp. 168-171
    • Thomas, T.1    Thomas, G.2    McLendon, C.3    Sutton, T.4    Mullan, M.5
  • 60
    • 0030778933 scopus 로고    scopus 로고
    • The role of amyloid in the pathogenesis of Alzheimer's disease
    • Verbeek M. M. Ruiter D. J. de Waal R. M. 1997 The role of amyloid in the pathogenesis of Alzheimer's disease. Biol. Chem. 378 937 950.
    • (1997) Biol. Chem. , vol.378 , pp. 937-950
    • Verbeek, M.M.1    Ruiter, D.J.2    De Waal, R.M.3
  • 61
    • 0038400952 scopus 로고    scopus 로고
    • C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis
    • Willaime-Morawek S. Brami-Cherrier K. Mariani J. Caboche J. Brugg B. 2003 C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis. Neuroscience 119 387 397.
    • (2003) Neuroscience , vol.119 , pp. 387-397
    • Willaime-Morawek, S.1    Brami-Cherrier, K.2    Mariani, J.3    Caboche, J.4    Brugg, B.5
  • 62
    • 0028122397 scopus 로고
    • Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction
    • Wolff R. A. Dobrowsky R. T. Bielawska A. Obeid L. M. Hannun Y. A. 1994 Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J. Biol. Chem. 269 19 605 19 609.
    • (1994) J. Biol. Chem. , vol.269 , pp. 19605-19609
    • Wolff, R.A.1    Dobrowsky, R.T.2    Bielawska, A.3    Obeid, L.M.4    Hannun, Y.A.5
  • 64
    • 0032568836 scopus 로고    scopus 로고
    • Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death
    • Xu J. Yeh C. H. Chen S. He L. Sensi S. L. Canzoniero L. M. Choi D. W. Hsu C. Y. 1998 Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death. J. Biol. Chem. 273 16 521 16 526.
    • (1998) J. Biol. Chem. , vol.273 , pp. 16521-16526
    • Xu, J.1    Yeh, C.H.2    Chen, S.3    He, L.4    Sensi, S.L.5    Canzoniero, L.M.6    Choi, D.W.7    Hsu, C.Y.8
  • 65
    • 0030745012 scopus 로고    scopus 로고
    • Interrelationship between beta-amyloid deposition and complement-activated oligodendroglia
    • Yamada T. Tsuboi Y. Takahashi M. 1997 Interrelationship between beta-amyloid deposition and complement-activated oligodendroglia. Dement Geriatr Cogn Disord 8 267 272.
    • (1997) Dement Geriatr Cogn Disord , vol.8 , pp. 267-272
    • Yamada, T.1    Tsuboi, Y.2    Takahashi, M.3
  • 68
    • 0004491134 scopus 로고    scopus 로고
    • Enhancement of outward potassium current may participate in beta-amyloid peptide-induced cortical neuronal death
    • Yu S. P. Farhangrazi Z. S. Ying H. S. Yeh C. H. Choi D. W. 1998 Enhancement of outward potassium current may participate in beta-amyloid peptide-induced cortical neuronal death. Neurobiol. Dis 5 81 88.
    • (1998) Neurobiol. Dis , vol.5 , pp. 81-88
    • Yu, S.P.1    Farhangrazi, Z.S.2    Ying, H.S.3    Yeh, C.H.4    Choi, D.W.5
  • 69
    • 23244468383 scopus 로고    scopus 로고
    • Amyloid-beta peptide enhances tumor necrosis factor-alpha-induced iNOS through neutral sphingomyelinase/ceramide pathway in oligodendrocytes
    • Zeng C. Lee J. T. Chen H. Chen S. Hsu C. Y. Xu J. 2005 Amyloid-beta peptide enhances tumor necrosis factor-alpha-induced iNOS through neutral sphingomyelinase/ceramide pathway in oligodendrocytes. J. Neurochem. 2005 August 94 703 712.
    • (2005) J. Neurochem. 2005 August , vol.94 , pp. 703-712
    • Zeng, C.1    Lee, J.T.2    Chen, H.3    Chen, S.4    Hsu, C.Y.5    Xu, J.6
  • 70
    • 0033616730 scopus 로고    scopus 로고
    • Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity
    • Zhang S. C. Ge B. Duncan I. D. 1999 Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity. Proc. Natl Acad. Sci. U S A 96 4089 4094.
    • (1999) Proc. Natl Acad. Sci. U S a , vol.96 , pp. 4089-4094
    • Zhang, S.C.1    Ge, B.2    Duncan, I.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.