메뉴 건너뛰기




Volumn 48, Issue 6-7, 2011, Pages 973-978

P21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation

Author keywords

CDKN1A; Immunoglobulin variable genes; P21Cip1 Waf1; Proliferating cell nuclear antigen; Somatic hypermutation; Translesional DNA polymerases

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; IMMUNOGLOBULIN; PROTEIN P21;

EID: 79951557931     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2011.01.004     Document Type: Article
Times cited : (1)

References (50)
  • 4
    • 10944251591 scopus 로고    scopus 로고
    • Repair and genetic consequences of endogenous DNA base damage in mammalian cells
    • Barnes D.E., Lindahl T. Repair and genetic consequences of endogenous DNA base damage in mammalian cells. Annu. Rev. Genet. 2004, 38:445-476.
    • (2004) Annu. Rev. Genet. , vol.38 , pp. 445-476
    • Barnes, D.E.1    Lindahl, T.2
  • 5
    • 0037388165 scopus 로고    scopus 로고
    • Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
    • Bransteitter R., Pham P., Scharff M.D., Goodman M.F. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:4102-4107.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 4102-4107
    • Bransteitter, R.1    Pham, P.2    Scharff, M.D.3    Goodman, M.F.4
  • 7
    • 33846404877 scopus 로고    scopus 로고
    • DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse
    • Delbos F., Aoufouchi S., Faili A., Weill J.C., Reynaud C.A. DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse. J. Exp. Med. 2007, 204:17-23.
    • (2007) J. Exp. Med. , vol.204 , pp. 17-23
    • Delbos, F.1    Aoufouchi, S.2    Faili, A.3    Weill, J.C.4    Reynaud, C.A.5
  • 8
    • 18244401095 scopus 로고    scopus 로고
    • Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse
    • Delbos F., De Smet A., Faili A., Aoufouchi S., Weill J.C., Reynaud C.A. Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse. J. Exp. Med. 2005, 201:1191-1196.
    • (2005) J. Exp. Med. , vol.201 , pp. 1191-1196
    • Delbos, F.1    De Smet, A.2    Faili, A.3    Aoufouchi, S.4    Weill, J.C.5    Reynaud, C.A.6
  • 9
    • 0035399804 scopus 로고    scopus 로고
    • Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta
    • Diaz M., Verkoczy L.K., Flajnik M.F., Klinman N.R. Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta. J. Immunol. 2001, 167:327-335.
    • (2001) J. Immunol. , vol.167 , pp. 327-335
    • Diaz, M.1    Verkoczy, L.K.2    Flajnik, M.F.3    Klinman, N.R.4
  • 10
    • 0037561998 scopus 로고    scopus 로고
    • AID mediates hypermutation by deaminating single stranded DNA
    • Dickerson S.K., Market E., Besmer E., Papavasiliou F.N. AID mediates hypermutation by deaminating single stranded DNA. J. Exp. Med. 2003, 197:1291-1296.
    • (2003) J. Exp. Med. , vol.197 , pp. 1291-1296
    • Dickerson, S.K.1    Market, E.2    Besmer, E.3    Papavasiliou, F.N.4
  • 11
    • 70249089736 scopus 로고    scopus 로고
    • Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats
    • Eccleston J., Schrader C.E., Yuan K., Stavnezer J., Selsing E. Class switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats. J. Immunol. 2009, 183:1222-1228.
    • (2009) J. Immunol. , vol.183 , pp. 1222-1228
    • Eccleston, J.1    Schrader, C.E.2    Yuan, K.3    Stavnezer, J.4    Selsing, E.5
  • 12
    • 0037206851 scopus 로고    scopus 로고
    • Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota
    • Faili A., Aoufouchi S., Flatter E., Gueranger Q., Reynaud C.A., Weill J.C. Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota. Nature 2002, 419:944-947.
    • (2002) Nature , vol.419 , pp. 944-947
    • Faili, A.1    Aoufouchi, S.2    Flatter, E.3    Gueranger, Q.4    Reynaud, C.A.5    Weill, J.C.6
  • 13
    • 0027364313 scopus 로고
    • Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes
    • Gonzalez-Fernandez A., Milstein C. Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:9862-9866.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 9862-9866
    • Gonzalez-Fernandez, A.1    Milstein, C.2
  • 14
    • 0030592544 scopus 로고    scopus 로고
    • Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA
    • Gulbis J.M., Kelman Z., Hurwitz J., O'Donnell M., Kuriyan J. Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA. Cell 1996, 87:297-306.
    • (1996) Cell , vol.87 , pp. 297-306
    • Gulbis, J.M.1    Kelman, Z.2    Hurwitz, J.3    O'Donnell, M.4    Kuriyan, J.5
  • 15
    • 34447617375 scopus 로고    scopus 로고
    • Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors
    • Han J.H., Akira S., Calame K., Beutler B., Selsing E., Imanishi-Kari T. Class switch recombination and somatic hypermutation in early mouse B cells are mediated by B cell and Toll-like receptors. Immunity 2007, 27:64-75.
    • (2007) Immunity , vol.27 , pp. 64-75
    • Han, J.H.1    Akira, S.2    Calame, K.3    Beutler, B.4    Selsing, E.5    Imanishi-Kari, T.6
  • 16
    • 33344468484 scopus 로고    scopus 로고
    • Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice
    • Jansen J.G., Langerak P., Tsaalbi-Shtylik A., van den Berk P., Jacobs H., de Wind N. Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice. J. Exp. Med. 2006, 203:319-323.
    • (2006) J. Exp. Med. , vol.203 , pp. 319-323
    • Jansen, J.G.1    Langerak, P.2    Tsaalbi-Shtylik, A.3    van den Berk, P.4    Jacobs, H.5    de Wind, N.6
  • 17
    • 2442417331 scopus 로고    scopus 로고
    • Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage
    • Kannouche P.L., Wing J., Lehmann A.R. Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage. Mol. Cell 2004, 14:491-500.
    • (2004) Mol. Cell , vol.14 , pp. 491-500
    • Kannouche, P.L.1    Wing, J.2    Lehmann, A.R.3
  • 18
    • 33847621554 scopus 로고    scopus 로고
    • Uracil in DNA - general mutagen, but normal intermediate in acquired immunity
    • Kavli B., Otterlei M., Slupphaug G., Krokan H.E. Uracil in DNA - general mutagen, but normal intermediate in acquired immunity. DNA Repair (Amst) 2007, 6:505-516.
    • (2007) DNA Repair (Amst) , vol.6 , pp. 505-516
    • Kavli, B.1    Otterlei, M.2    Slupphaug, G.3    Krokan, H.E.4
  • 19
    • 2342419732 scopus 로고    scopus 로고
    • DNA replication fidelity
    • Kunkel T.A. DNA replication fidelity. J. Biol. Chem. 2004, 279:16895-16898.
    • (2004) J. Biol. Chem. , vol.279 , pp. 16895-16898
    • Kunkel, T.A.1
  • 20
    • 34547797940 scopus 로고    scopus 로고
    • A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification
    • Langerak P., Nygren A.O., Krijger P.H., van den Berk P.C., Jacobs H. A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification. J. Exp. Med. 2007, 204:1989-1998.
    • (2007) J. Exp. Med. , vol.204 , pp. 1989-1998
    • Langerak, P.1    Nygren, A.O.2    Krijger, P.H.3    van den Berk, P.C.4    Jacobs, H.5
  • 22
    • 56549125517 scopus 로고    scopus 로고
    • SHMTool: a webserver for comparative analysis of somatic hypermutation datasets
    • Maccarthy T., Roa S., Scharff M.D., Bergman A. SHMTool: a webserver for comparative analysis of somatic hypermutation datasets. DNA Repair (Amst) 2009, 8:137-141.
    • (2009) DNA Repair (Amst) , vol.8 , pp. 137-141
    • Maccarthy, T.1    Roa, S.2    Scharff, M.D.3    Bergman, A.4
  • 24
    • 20444427642 scopus 로고    scopus 로고
    • DNA polymerase eta contributes to strand bias of mutations of A versus T in immunoglobulin genes
    • Mayorov V.I., Rogozin I.B., Adkison L.R., Gearhart P.J. DNA polymerase eta contributes to strand bias of mutations of A versus T in immunoglobulin genes. J. Immunol. 2005, 174:7781-7786.
    • (2005) J. Immunol. , vol.174 , pp. 7781-7786
    • Mayorov, V.I.1    Rogozin, I.B.2    Adkison, L.R.3    Gearhart, P.J.4
  • 26
    • 34249066085 scopus 로고    scopus 로고
    • PCNA, the maestro of the replication fork
    • Moldovan G.L., Pfander B., Jentsch S. PCNA, the maestro of the replication fork. Cell 2007, 129:665-679.
    • (2007) Cell , vol.129 , pp. 665-679
    • Moldovan, G.L.1    Pfander, B.2    Jentsch, S.3
  • 27
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 2000, 102:553-563.
    • (2000) Cell , vol.102 , pp. 553-563
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 29
    • 0037019315 scopus 로고    scopus 로고
    • AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
    • Petersen-Mahrt S.K., Harris R.S., Neuberger M.S. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 2002, 418:99-103.
    • (2002) Nature , vol.418 , pp. 99-103
    • Petersen-Mahrt, S.K.1    Harris, R.S.2    Neuberger, M.S.3
  • 30
    • 27144462049 scopus 로고    scopus 로고
    • BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells
    • Phan R.T., Saito M., Basso K., Niu H., Dalla-Favera R. BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells. Nat. Immunol. 2005, 6:1054-1060.
    • (2005) Nat. Immunol. , vol.6 , pp. 1054-1060
    • Phan, R.T.1    Saito, M.2    Basso, K.3    Niu, H.4    Dalla-Favera, R.5
  • 31
    • 6344256944 scopus 로고    scopus 로고
    • Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
    • Rada C., Di Noia J.M., Neuberger M.S. Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation. Mol. Cell 2004, 16:163-171.
    • (2004) Mol. Cell , vol.16 , pp. 163-171
    • Rada, C.1    Di Noia, J.M.2    Neuberger, M.S.3
  • 32
    • 0032127804 scopus 로고    scopus 로고
    • Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
    • Rada C., Ehrenstein M.R., Neuberger M.S., Milstein C. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity 1998, 9:135-141.
    • (1998) Immunity , vol.9 , pp. 135-141
    • Rada, C.1    Ehrenstein, M.R.2    Neuberger, M.S.3    Milstein, C.4
  • 33
    • 0037108463 scopus 로고    scopus 로고
    • Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
    • Rada C., Williams G.T., Nilsen H., Barnes D.E., Lindahl T., Neuberger M.S. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 2002, 12:1748-1755.
    • (2002) Curr. Biol. , vol.12 , pp. 1748-1755
    • Rada, C.1    Williams, G.T.2    Nilsen, H.3    Barnes, D.E.4    Lindahl, T.5    Neuberger, M.S.6
  • 34
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky K. Clonal selection and learning in the antibody system. Nature 1996, 381:751-758.
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 35
    • 78649335719 scopus 로고    scopus 로고
    • The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated
    • Ratnam S., Bozek G., Nicolae D., Storb U. The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated. Mol. Immunol. 2010, 47:2611-2618.
    • (2010) Mol. Immunol. , vol.47 , pp. 2611-2618
    • Ratnam, S.1    Bozek, G.2    Nicolae, D.3    Storb, U.4
  • 37
    • 33644543730 scopus 로고    scopus 로고
    • The catalytic activity of REV1 is employed during immunoglobulin gene diversification in DT40
    • Ross A.L., Sale J.E. The catalytic activity of REV1 is employed during immunoglobulin gene diversification in DT40. Mol. Immunol. 2006, 43:1587-1594.
    • (2006) Mol. Immunol. , vol.43 , pp. 1587-1594
    • Ross, A.L.1    Sale, J.E.2
  • 38
    • 24944541376 scopus 로고    scopus 로고
    • Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination
    • Rush J.S., Liu M., Odegard V.H., Unniraman S., Schatz D.G. Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:13242-13247.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 13242-13247
    • Rush, J.S.1    Liu, M.2    Odegard, V.H.3    Unniraman, S.4    Schatz, D.G.5
  • 39
    • 63049129975 scopus 로고    scopus 로고
    • Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability
    • Schenten D., Kracker S., Esposito G., Franco S., Klein U., Murphy M., Alt F.W., Rajewsky K. Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability. J. Exp. Med. 2009, 206:477-490.
    • (2009) J. Exp. Med. , vol.206 , pp. 477-490
    • Schenten, D.1    Kracker, S.2    Esposito, G.3    Franco, S.4    Klein, U.5    Murphy, M.6    Alt, F.W.7    Rajewsky, K.8
  • 40
    • 60049083259 scopus 로고    scopus 로고
    • The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch
    • Schrader C.E., Guikema J.E., Wu X., Stavnezer J. The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch. Phil. Trans. R. Soc. Lond. B: Biol. Sci. 2009, 364:645-652.
    • (2009) Phil. Trans. R. Soc. Lond. B: Biol. Sci. , vol.364 , pp. 645-652
    • Schrader, C.E.1    Guikema, J.E.2    Wu, X.3    Stavnezer, J.4
  • 41
    • 33749519393 scopus 로고    scopus 로고
    • Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice
    • Shen H.M., Tanaka A., Bozek G., Nicolae D., Storb U. Somatic hypermutation and class switch recombination in Msh6(-/-)Ung(-/-) double-knockout mice. J. Immunol. 2006, 177:5386-5392.
    • (2006) J. Immunol. , vol.177 , pp. 5386-5392
    • Shen, H.M.1    Tanaka, A.2    Bozek, G.3    Nicolae, D.4    Storb, U.5
  • 42
    • 33646156444 scopus 로고    scopus 로고
    • P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation
    • Soria G., Podhajcer O., Prives C., Gottifredi V. P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation. Oncogene 2006, 25:2829-2838.
    • (2006) Oncogene , vol.25 , pp. 2829-2838
    • Soria, G.1    Podhajcer, O.2    Prives, C.3    Gottifredi, V.4
  • 43
    • 55449119244 scopus 로고    scopus 로고
    • P21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation
    • Soria G., Speroni J., Podhajcer O.L., Prives C., Gottifredi V. p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation. J. Cell Sci. 2008, 121:3271-3282.
    • (2008) J. Cell Sci. , vol.121 , pp. 3271-3282
    • Soria, G.1    Speroni, J.2    Podhajcer, O.L.3    Prives, C.4    Gottifredi, V.5
  • 44
    • 0141831006 scopus 로고    scopus 로고
    • Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation
    • Stelter P., Ulrich H.D. Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature 2003, 425:188-191.
    • (2003) Nature , vol.425 , pp. 188-191
    • Stelter, P.1    Ulrich, H.D.2
  • 45
    • 6344288785 scopus 로고    scopus 로고
    • Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination
    • Watanabe K., Tateishi S., Kawasuji M., Tsurimoto T., Inoue H., Yamaizumi M. Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination. EMBO J. 2004, 23:3886-3896.
    • (2004) EMBO J. , vol.23 , pp. 3886-3896
    • Watanabe, K.1    Tateishi, S.2    Kawasuji, M.3    Tsurimoto, T.4    Inoue, H.5    Yamaizumi, M.6
  • 46
    • 0034614916 scopus 로고    scopus 로고
    • Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern
    • Wiesendanger M., Kneitz B., Edelmann W., Scharff M.D. Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern. J. Exp. Med. 2000, 191:579-584.
    • (2000) J. Exp. Med. , vol.191 , pp. 579-584
    • Wiesendanger, M.1    Kneitz, B.2    Edelmann, W.3    Scharff, M.D.4
  • 49
    • 0035005241 scopus 로고    scopus 로고
    • The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation
    • Zan H., Komori A., Li Z., Cerutti A., Schaffer A., Flajnik M.F., Diaz M., Casali P. The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation. Immunity 2001, 14:643-653.
    • (2001) Immunity , vol.14 , pp. 643-653
    • Zan, H.1    Komori, A.2    Li, Z.3    Cerutti, A.4    Schaffer, A.5    Flajnik, M.F.6    Diaz, M.7    Casali, P.8
  • 50
    • 0035377269 scopus 로고    scopus 로고
    • DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
    • Zeng X., Winter D.B., Kasmer C., Kraemer K.H., Lehmann A.R., Gearhart P.J. DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nat. Immunol. 2001, 2:537-541.
    • (2001) Nat. Immunol. , vol.2 , pp. 537-541
    • Zeng, X.1    Winter, D.B.2    Kasmer, C.3    Kraemer, K.H.4    Lehmann, A.R.5    Gearhart, P.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.