Atomic force microscopy-based screening of drug-excipient miscibility and stability of solid dispersions

Pharmaceutical Research

Volumn 28, Issue 3, 2011, Pages 572-584

  Lauer, Matthias Eckhard ^a,b   Grassmann, Olaf ^b   Siam, Monira ^b   Tardio, Joseph ^b   Jacob, Laurence ^b   Page, Susanne ^b   Kindt, Johannes Heinrich ^c   Engel, Andreas ^a   Alsenz, Jochem ^b  

^a UNIVERSITY OF BASEL   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c BRUKER DALTONIK GMBH   (Germany)

Author keywords

AFM; amorphous formulation; raman microscopy; solid dispersion; stability prediction

Indexed keywords

1 VINYL 2 PYRROLIDINONE; CHOLESTEROL ESTER TRANSFER PROTEIN INHIBITOR; HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; NEUROKININ 1 RECEPTOR ANTAGONIST; POLYMETHACRYLIC ACID; POVIDONE; VINYL ACETATE;

ARTICLE; ATOMIC FORCE MICROSCOPY; CONTROLLED STUDY; DISPERSION; DRUG DETERMINATION; DRUG FORMULATION; DRUG IDENTIFICATION; DRUG MISCIBILITY; DRUG MIXTURE; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; EXCIPIENT COMPATIBILITY; HUMIDITY; MOLECULAR IMAGING; PHARMACEUTICS; PHASE SEPARATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAMAN SPECTROMETRY; SOLID STATE; TEMPERATURE SENSITIVITY;

DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; EXCIPIENTS; MICROSCOPY, ATOMIC FORCE; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; SURFACE PROPERTIES;

EID: 79851514146     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0306-4     Document Type: Article

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