Predicting the formation and stability of amorphous small molecule binary mixtures from computationally determined flory-huggins interaction parameter and phase diagram

Molecular Pharmaceutics

Volumn 7, Issue 3, 2010, Pages 795-804

  Pajula, Katja ^a   Taskinen, Markku ^a   Lehto, Vesa Pekka ^a   Ketolainen, Jarkko ^a   Korhonen, Ossi ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Amorphous; Flory Huggins; Miscibility; Solid dispersion; Stabilization

Indexed keywords

ACETYLSALICYLIC ACID; BENZOCAINE; CAPTOPRIL; CHLORPROPAMIDE; DIFLUNISAL; FENBUFEN; FLURBIPROFEN; FLUTAMIDE; IBUPROFEN; KETOPROFEN; MEFENAMIC ACID; NABUMETONE; NAPROXEN; NIMESULIDE; PARACETAMOL; PERPHENAZINE; PIROXICAM; PRIMIDONE; PYRAZINAMIDE; SACCHARIN; SALICYLAMIDE; SALICYLIC ACID; SULFADIMIDINE; SULFAMERAZINE; SULFAMETHOXAZOLE; SULFANILAMIDE; THIOSALICYLIC ACID; TOLBUTAMIDE; TOLFENAMIC ACID; UNINDEXED DRUG;

ARTICLE; CRYSTALLIZATION; DISPERSION; DRUG STABILITY; FLORY HUGGIN INTERACTION; MICROSCOPY; MISCIBILITY; MOLECULAR INTERACTION; PHASE SEPARATION; POLARIZATION; PREDICTOR VARIABLE; PRIORITY JOURNAL; SOLID; THERMODYNAMICS; VALIDITY;

COMPUTER SIMULATION; CRYSTALLIZATION; DRUG STABILITY; EXCIPIENTS; MICROSCOPY; MODELS, MOLECULAR; POLYMERS; SOLUBILITY; THERMODYNAMICS;

EID: 77953236977     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp900304p     Document Type: Article

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