SCOPUS 정보 검색 플랫폼

Volumn 1, Issue 2, 2010, Pages 139-144

Discovery of the highly potent PI3K/mTOR dual inhibitor PF-04691502 through structure based drug design

(12) Cheng, Hengmiao a Bagrodia, Shubha a Bailey, Simon a Edwards, Martin a Hoffman, Jacqui a Hu, Qiyue a Kania, Robert a Knighton, Daniel R a Marx, Matthew A a Ninkovic, Sacha a Sun, Shaoxian a Zhang, Eric a

a PFIZER INC (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 8 [4 (2 HYDROXYETHOXY)CYCLOHEXYL] 6 (6 METHOXYPYRIDIN 3 YL) 4 METHYLPYRIDO[2,3 D]PYRIMIDIN 7(8H) ONE; ANTINEOPLASTIC AGENT; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PF 04691502; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CRYSTAL STRUCTURE; DRUG ABSORPTION; DRUG ACTIVITY; DRUG CLEARANCE; DRUG DESIGN; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; GENE MUTATION; HUMAN; IC 50; IN VIVO STUDY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN TARGETING; SOLID TUMOR;

EID: 79851513692 PISSN: 20402503 EISSN: 20402511 Source Type: Journal
DOI: 10.1039/c0md00072h Document Type: Article

Times cited : (70)

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