-
1
-
-
0347357903
-
Looking beyond morphology: Cancer gene expression profiling using DNA microarrays
-
J. Luo, W.B. Isaacs, J.M. Trent, and D.J. Duggan Looking beyond morphology: cancer gene expression profiling using DNA microarrays Cancer Invest 21 2003 937 949
-
(2003)
Cancer Invest
, vol.21
, pp. 937-949
-
-
Luo, J.1
Isaacs, W.B.2
Trent, J.M.3
Duggan, D.J.4
-
2
-
-
3543061612
-
Integrated global profiling of cancer
-
S. Hanash Integrated global profiling of cancer Nat Rev Cancer 4 2004 638 644
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 638-644
-
-
Hanash, S.1
-
3
-
-
4043181214
-
Cancer genes and the pathways they control
-
B. Vogelstein, and K.W. Kinzler Cancer genes and the pathways they control Nat Med 10 2004 789 799
-
(2004)
Nat Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
4
-
-
0344441000
-
Diagnostic and prognostic prediction using gene expression profiles in high-dimensional microarray data
-
R. Simon Diagnostic and prognostic prediction using gene expression profiles in high-dimensional microarray data Br J Cancer 89 2003 1599 1604
-
(2003)
Br J Cancer
, vol.89
, pp. 1599-1604
-
-
Simon, R.1
-
5
-
-
18544365698
-
Gene-expression profiles predict survival of patients with lung adenocarcinomas
-
D.G. Beer, S.L. Kardia, C.C. Huang, T.J. Giordano, A.M. Levin, D.E. Misek, L. Lin, G. Chen, T.G. Gharib, and D.G. Thomas Gene-expression profiles predict survival of patients with lung adenocarcinomas Nat Med 8 2002 816 824
-
(2002)
Nat Med
, vol.8
, pp. 816-824
-
-
Beer, D.G.1
Kardia, S.L.2
Huang, C.C.3
Giordano, T.J.4
Levin, A.M.5
Misek, D.E.6
Lin, L.7
Chen, G.8
Gharib, T.G.9
Thomas, D.G.10
-
6
-
-
2942578063
-
A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen
-
X.J. Ma, Z. Wang, P.D. Ryan, S.J. Isakoff, A. Barmettler, A. Fuller, B. Muir, G. Mohapatra, R. Salunga, and J.T. Tuggle A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen Cancer Cell 5 2004 607 616
-
(2004)
Cancer Cell
, vol.5
, pp. 607-616
-
-
Ma, X.J.1
Wang, Z.2
Ryan, P.D.3
Isakoff, S.J.4
Barmettler, A.5
Fuller, A.6
Muir, B.7
Mohapatra, G.8
Salunga, R.9
Tuggle, J.T.10
-
7
-
-
9244222261
-
Targeted cancer therapy
-
C. Sawyers Targeted cancer therapy Nature 432 2004 294 297
-
(2004)
Nature
, vol.432
, pp. 294-297
-
-
Sawyers, C.1
-
8
-
-
4344623889
-
Imatinib as a paradigm of targeted therapies
-
B.J. Druker Imatinib as a paradigm of targeted therapies Adv Cancer Res 91 2004 1 30
-
(2004)
Adv Cancer Res
, vol.91
, pp. 1-30
-
-
Druker, B.J.1
-
9
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
••].
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
-
10
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
••] demonstrate that the clinical success of the EGFR inhibitor gefitinib correlates with activating mutations of EGFR in human tumors. Such results highlight the utility of identifying genetic alterations in signal transducing genes and the development of individualized therapies for patients whose tumors carry such mutations.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
-
12
-
-
8144225291
-
Association studies for finding cancer-susceptibility genetic variants
-
P.D. Pharoah, A.M. Dunning, B.A. Ponder, and D.F. Easton Association studies for finding cancer-susceptibility genetic variants Nat Rev Cancer 4 2004 850 860
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 850-860
-
-
Pharoah, P.D.1
Dunning, A.M.2
Ponder, B.A.3
Easton, D.F.4
-
14
-
-
0019960812
-
A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene
-
E.P. Reddy, R.K. Reynolds, E. Santos, and M. Barbacid A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene Nature 300 1982 149 152
-
(1982)
Nature
, vol.300
, pp. 149-152
-
-
Reddy, E.P.1
Reynolds, R.K.2
Santos, E.3
Barbacid, M.4
-
15
-
-
0019973408
-
T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes
-
E. Santos, S.R. Tronick, S.A. Aaronson, S. Pulciani, and M. Barbacid T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes Nature 298 1982 343 347
-
(1982)
Nature
, vol.298
, pp. 343-347
-
-
Santos, E.1
Tronick, S.R.2
Aaronson, S.A.3
Pulciani, S.4
Barbacid, M.5
-
16
-
-
0019947771
-
Mechanism of activation of a human oncogene
-
C.J. Tabin, S.M. Bradley, C.I. Bargmann, R.A. Weinberg, A.G. Papageorge, E.M. Scolnick, R. Dhar, D.R. Lowy, and E.H. Chang Mechanism of activation of a human oncogene Nature 300 1982 143 149
-
(1982)
Nature
, vol.300
, pp. 143-149
-
-
Tabin, C.J.1
Bradley, S.M.2
Bargmann, C.I.3
Weinberg, R.A.4
Papageorge, A.G.5
Scolnick, E.M.6
Dhar, R.7
Lowy, D.R.8
Chang, E.H.9
-
17
-
-
7944231535
-
The road to Src
-
G.S. Martin The road to Src Oncogene 23 2004 7910 7917
-
(2004)
Oncogene
, vol.23
, pp. 7910-7917
-
-
Martin, G.S.1
-
18
-
-
1542515338
-
A census of human cancer genes
-
P.A. Futreal, L. Coin, M. Marshall, T. Down, T. Hubbard, R. Wooster, N. Rahman, and M.R. Stratton A census of human cancer genes Nat Rev Cancer 4 2004 177 183
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 177-183
-
-
Futreal, P.A.1
Coin, L.2
Marshall, M.3
Down, T.4
Hubbard, T.5
Wooster, R.6
Rahman, N.7
Stratton, M.R.8
-
19
-
-
0038670241
-
Mutational analysis of the tyrosine kinome in colorectal cancers
-
A. Bardelli, D.W. Parsons, N. Silliman, J. Ptak, S. Szabo, S. Saha, S. Markowitz, J.K. Willson, G. Parmigiani, and K.W. Kinzler Mutational analysis of the tyrosine kinome in colorectal cancers Science 300 2003 949 This study represents the first systematic mutational analysis of any gene family in any human cancer type, identifying novel targets for the individualized analysis and treatment of colorectal tumors.
-
(2003)
Science
, vol.300
, pp. 949
-
-
Bardelli, A.1
Parsons, D.W.2
Silliman, N.3
Ptak, J.4
Szabo, S.5
Saha, S.6
Markowitz, S.7
Willson, J.K.8
Parmigiani, G.9
Kinzler, K.W.10
-
20
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Y. Samuels, Z. Wang, A. Bardelli, N. Silliman, J. Ptak, S. Szabo, H. Yan, A. Gazdar, S.M. Powell, and G.J. Riggins High frequency of mutations of the PIK3CA gene in human cancers Science 304 2004 554 This manuscript describes the discovery of a high frequency of mutations of the PIK3CA gene in human cancers. These results reveal that PIK3CA is one of the most highly mutated oncogenes identified to date, and suggest that additional such alterations remain to be discovered in cancer genomes.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Yan, H.7
Gazdar, A.8
Powell, S.M.9
Riggins, G.J.10
-
21
-
-
2442648882
-
Mutational analysis of the tyrosine phosphatome in colorectal cancers
-
••] and shows that nearly half of colorectal tumors have alterations in genes that control tyrosine phosphorylation.
-
(2004)
Science
, vol.304
, pp. 1164-1166
-
-
Wang, Z.1
Shen, D.2
Parsons, D.W.3
Bardelli, A.4
Sager, J.5
Szabo, S.6
Ptak, J.7
Silliman, N.8
Peters, B.A.9
Van Der Heijden, M.S.10
-
22
-
-
0029937428
-
Hidden Markov models
-
S.R. Eddy Hidden Markov models Curr Opin Struct Biol 6 1996 361 365
-
(1996)
Curr Opin Struct Biol
, vol.6
, pp. 361-365
-
-
Eddy, S.R.1
-
23
-
-
0011542799
-
The Pfam protein families database
-
A. Bateman, E. Birney, L. Cerruti, R. Durbin, L. Etwiller, S.R. Eddy, S. Griffiths-Jones, K.L. Howe, M. Marshall, and E.L. Sonnhammer The Pfam protein families database Nucleic Acids Res 30 2002 276 280
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 276-280
-
-
Bateman, A.1
Birney, E.2
Cerruti, L.3
Durbin, R.4
Etwiller, L.5
Eddy, S.R.6
Griffiths-Jones, S.7
Howe, K.L.8
Marshall, M.9
Sonnhammer, E.L.10
-
24
-
-
0037032835
-
The protein kinase complement of the human genome
-
G. Manning, D.B. Whyte, R. Martinez, T. Hunter, and S. Sudarsanam The protein kinase complement of the human genome Science 298 2002 1912 1934
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
25
-
-
0035902180
-
Oncogenic kinase signalling
-
P. Blume-Jensen, and T. Hunter Oncogenic kinase signalling Nature 411 2001 355 365
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
27
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
H. Davies, G.R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M.J. Garnett, and W. Bottomley Mutations of the BRAF gene in human cancer Nature 417 2002 949 954 The discovery of genetic alterations in BRAF demonstrated that multiple members of a signal transduction pathway can be frequently altered in human cancers.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
-
28
-
-
0037194728
-
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
-
H. Rajagopalan, A. Bardelli, C. Lengauer, K.W. Kinzler, B. Vogelstein, and V.E. Velculescu Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status Nature 418 2002 934
-
(2002)
Nature
, vol.418
, pp. 934
-
-
Rajagopalan, H.1
Bardelli, A.2
Lengauer, C.3
Kinzler, K.W.4
Vogelstein, B.5
Velculescu, V.E.6
-
29
-
-
0035859030
-
The ins and outs of signalling
-
J. Downward The ins and outs of signalling Nature 411 2001 759 762
-
(2001)
Nature
, vol.411
, pp. 759-762
-
-
Downward, J.1
-
30
-
-
0038011429
-
Phosphoregulators: Protein kinases and protein phosphatases of mouse
-
A.R. Forrest, T. Ravasi, D. Taylor, T. Huber, D.A. Hume, and S. Grimmond Phosphoregulators: protein kinases and protein phosphatases of mouse Genome Res 13 2003 1443 1454
-
(2003)
Genome Res
, vol.13
, pp. 1443-1454
-
-
Forrest, A.R.1
Ravasi, T.2
Taylor, D.3
Huber, T.4
Hume, D.A.5
Grimmond, S.6
-
31
-
-
2942581416
-
Protein tyrosine phosphatases in the human genome
-
A. Alonso, J. Sasin, N. Bottini, I. Friedberg, A. Osterman, A. Godzik, T. Hunter, J. Dixon, and T. Mustelin Protein tyrosine phosphatases in the human genome Cell 117 2004 699 711
-
(2004)
Cell
, vol.117
, pp. 699-711
-
-
Alonso, A.1
Sasin, J.2
Bottini, N.3
Friedberg, I.4
Osterman, A.5
Godzik, A.6
Hunter, T.7
Dixon, J.8
Mustelin, T.9
-
32
-
-
0142011466
-
PTEN: From pathology to biology
-
M.L. Sulis, and R. Parsons PTEN: from pathology to biology Trends Cell Biol 13 2003 478 483
-
(2003)
Trends Cell Biol
, vol.13
, pp. 478-483
-
-
Sulis, M.L.1
Parsons, R.2
-
33
-
-
0032227735
-
The role of tyrosine phosphorylation in cell growth and disease
-
T. Hunter The role of tyrosine phosphorylation in cell growth and disease Harvey Lect 94 1998 81 119
-
(1998)
Harvey Lect
, vol.94
, pp. 81-119
-
-
Hunter, T.1
-
34
-
-
0035313868
-
Combinatorial control of the specificity of protein tyrosine phosphatases
-
N.K. Tonks, and B.G. Neel Combinatorial control of the specificity of protein tyrosine phosphatases Curr Opin Cell Biol 13 2001 182 195
-
(2001)
Curr Opin Cell Biol
, vol.13
, pp. 182-195
-
-
Tonks, N.K.1
Neel, B.G.2
-
35
-
-
0038771965
-
The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
-
B.G. Neel, H. Gu, and L. Pao The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling Trends Biochem Sci 28 2003 284 293
-
(2003)
Trends Biochem Sci
, vol.28
, pp. 284-293
-
-
Neel, B.G.1
Gu, H.2
Pao, L.3
-
36
-
-
0347285350
-
A genomic perspective on protein tyrosine phosphatases: Gene structure, pseudogenes, and genetic disease linkage
-
J.N. Andersen, P.G. Jansen, S.M. Echwald, O.H. Mortensen, T. Fukada, R. Del Vecchio, N.K. Tonks, and N.P. Moller A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage FASEB J 18 2004 8 30
-
(2004)
FASEB J
, vol.18
, pp. 8-30
-
-
Andersen, J.N.1
Jansen, P.G.2
Echwald, S.M.3
Mortensen, O.H.4
Fukada, T.5
Del Vecchio, R.6
Tonks, N.K.7
Moller, N.P.8
-
37
-
-
0027401607
-
The multistep nature of cancer
-
B. Vogelstein, and K.W. Kinzler The multistep nature of cancer Trends Genet 9 1993 138 141
-
(1993)
Trends Genet
, vol.9
, pp. 138-141
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
38
-
-
18344378411
-
Prevalence of somatic alterations in the colorectal cancer cell genome
-
T.L. Wang, C. Rago, N. Silliman, J. Ptak, S. Markowitz, J.K. Willson, G. Parmigiani, K.W. Kinzler, B. Vogelstein, and V.E. Velculescu Prevalence of somatic alterations in the colorectal cancer cell genome Proc Natl Acad Sci USA 99 2002 3076 3080
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 3076-3080
-
-
Wang, T.L.1
Rago, C.2
Silliman, N.3
Ptak, J.4
Markowitz, S.5
Willson, J.K.6
Parmigiani, G.7
Kinzler, K.W.8
Vogelstein, B.9
Velculescu, V.E.10
-
39
-
-
4444344330
-
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
-
W. Pao, V. Miller, M. Zakowski, J. Doherty, K. Politi, I. Sarkaria, B. Singh, R. Heelan, V. Rusch, and L. Fulton EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib Proc Natl Acad Sci USA 101 2004 13306 13311
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 13306-13311
-
-
Pao, W.1
Miller, V.2
Zakowski, M.3
Doherty, J.4
Politi, K.5
Sarkaria, I.6
Singh, B.7
Heelan, R.8
Rusch, V.9
Fulton, L.10
-
40
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
B.J. Druker, M. Talpaz, D.J. Resta, B. Peng, E. Buchdunger, J.M. Ford, N.B. Lydon, H. Kantarjian, R. Capdeville, and S. Ohno-Jones Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia N Engl J Med 344 2001 1031 1037
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
-
41
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
-
M.G. Kris, R.B. Natale, R.S. Herbst, T.J. Lynch Jr., D. Prager, C.P. Belani, J.H. Schiller, K. Kelly, H. Spiridonidis, and A. Sandler Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial J Am Med Assoc 290 2003 2149 2158
-
(2003)
J Am Med Assoc
, vol.290
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
Lynch Jr., T.J.4
Prager, D.5
Belani, C.P.6
Schiller, J.H.7
Kelly, K.8
Spiridonidis, H.9
Sandler, A.10
-
42
-
-
0037013143
-
The conformational plasticity of protein kinases
-
M. Huse, and J. Kuriyan The conformational plasticity of protein kinases Cell 109 2002 275 282
-
(2002)
Cell
, vol.109
, pp. 275-282
-
-
Huse, M.1
Kuriyan, J.2
-
43
-
-
16644393213
-
The PIK3CA gene is mutated with high frequency in human breast cancers
-
K.E. Bachman, P. Argani, Y. Samuels, N. Silliman, J. Ptak, S. Szabo, H. Konishi, B. Karakas, B.G. Blair, and C. Lin The PIK3CA gene is mutated with high frequency in human breast cancers Cancer Biol Ther 3 2004 772 775
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 772-775
-
-
Bachman, K.E.1
Argani, P.2
Samuels, Y.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Konishi, H.7
Karakas, B.8
Blair, B.G.9
Lin, C.10
-
44
-
-
3442878125
-
Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas
-
D.K. Broderick, C. Di, T.J. Parrett, Y.R. Samuels, J.M. Cummins, R.E. McLendon, D.W. Fults, V.E. Velculescu, D.D. Bigner, and H. Yan Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas Cancer Res 64 2004 5048 5050
-
(2004)
Cancer Res
, vol.64
, pp. 5048-5050
-
-
Broderick, D.K.1
Di, C.2
Parrett, T.J.3
Samuels, Y.R.4
Cummins, J.M.5
McLendon, R.E.6
Fults, D.W.7
Velculescu, V.E.8
Bigner, D.D.9
Yan, H.10
-
45
-
-
7444250290
-
Mutation of the PIK3CA gene in ovarian and breast cancer
-
I.G. Campbell, S.E. Russell, D.Y. Choong, K.G. Montgomery, M.L. Ciavarella, C.S. Hooi, B.E. Cristiano, R.B. Pearson, and W.A. Phillips Mutation of the PIK3CA gene in ovarian and breast cancer Cancer Res 64 2004 7678 7681
-
(2004)
Cancer Res
, vol.64
, pp. 7678-7681
-
-
Campbell, I.G.1
Russell, S.E.2
Choong, D.Y.3
Montgomery, K.G.4
Ciavarella, M.L.5
Hooi, C.S.6
Cristiano, B.E.7
Pearson, R.B.8
Phillips, W.A.9
-
46
-
-
4944232647
-
Lung cancer: Intragenic ERBB2 kinase mutations in tumours
-
P. Stephens, C. Hunter, G. Bignell, S. Edkins, H. Davies, J. Teague, C. Stevens, S. O'Meara, R. Smith, and A. Parker Lung cancer: intragenic ERBB2 kinase mutations in tumours Nature 431 2004 525 526
-
(2004)
Nature
, vol.431
, pp. 525-526
-
-
Stephens, P.1
Hunter, C.2
Bignell, G.3
Edkins, S.4
Davies, H.5
Teague, J.6
Stevens, C.7
O'Meara, S.8
Smith, R.9
Parker, A.10
|