Spirodiketopiperazine-based CCR5 antagonist: Discovery of an antiretroviral drug candidate

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 4, 2011, Pages 1141-1145

  Nishizawa, Rena ^a   Nishiyama, Toshihiko ^a   Hisaichi, Katsuya ^a   Minamoto, Chiaki ^a   Matsunaga, Naoki ^a   Takaoka, Yoshikazu ^a   Nakai, Hisao ^a   Jenkinson, Stephen ^b   Kazmierski, Wieslaw M ^b   Tada, Hideaki ^a   Sagawa, Kenji ^a   Shibayama, Shiro ^a   Fukushima, Daikichi ^a   Maeda, Kenji ^c,d   Mitsuya, Hiroaki ^c,d  

^a ONO PHARMACEUTICAL CO   (Japan)

^b GLAXOSMITHKLINE   (United States)

^c KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Anti HIV; CCR5; Chemokine

Indexed keywords

CHEMOKINE RECEPTOR CCR5 ANTAGONIST; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; SPIRODIKETOPIPERAZINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; LIVER MICROSOME; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; STEREOCHEMISTRY; STEREOISOMERISM; TISSUE DISTRIBUTION; VIRUS REPLICATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-HIV AGENTS; CELL LINE, TUMOR; DIKETOPIPERAZINES; DRUG EVALUATION, PRECLINICAL; HIV CORE PROTEIN P24; HIV-1; HUMANS; MICROSOMES, LIVER; RATS; RECEPTORS, CCR5; SPIRO COMPOUNDS; STEREOISOMERISM;

EID: 79851510993     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.109     Document Type: Article

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