SCOPUS 정보 검색 플랫폼

Volumn 18, Issue 14, 2010, Pages 5208-5223

Discovery of orally available spirodiketopiperazine-based CCR5 antagonists

(14) Nishizawa, Rena a Nishiyama, Toshihiko a Hisaichi, Katsuya a Hirai, Keisuke a Habashita, Hiromu a Takaoka, Yoshikazu a Tada, Hideaki a Sagawa, Kenji a Shibayama, Shiro a Maeda, Kenji b,c Mitsuya, Hiroaki b,c Nakai, Hisao a Fukushima, Daikichi a Toda, Masaaki a

a ONO PHARMACEUTICAL CO (Japan)

b KUMAMOTO UNIV SCHOOL OF MEDICINE (Japan)

c NATIONAL INSTITUTES OF HEALTH (United States)

Author keywords

Anti HIV; CCR5; Chemokine

Indexed keywords

1 BUTYL 3 (CYCLOHEXYLMETHYL) 9 (4 PHENOXYBENZYL) 1,4,9 TRIAZASPIRO[5.5]UNDECANE 2,5 DIONE; 1 BUTYL 3 ISOBUTYL 9 (4 PHENOXYBENZYL) 1,4,9 TRIAZASPIRO[5.5]UNDECANE 2,5 DIONE; 4 [4 [[1 BUTYL 3 (CYCLOHEXYLMETHYL) 2,5 DIOXO 1,4,9 TRIAZASPIRO[5.5]UNDEC 9 YL]METHYL]PHENOXY]BENZOIC ACID; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CARBOXYLIC ACID DERIVATIVE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; PIPERAZINE DERIVATIVE; PIPERAZINEDIONE; SPIRO COMPOUND; SPIRODIKETOPIPERAZINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG HALF LIFE; DRUG MECHANISM; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; MALE; MAXIMUM PLASMA CONCENTRATION; MEMBRANE PERMEABILITY; NONHUMAN; RAT; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-HIV AGENTS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; HIV INFECTIONS; HIV-1; HUMANS; PIPERAZINES; RATS; RECEPTORS, CCR5;

EID: 77955329654 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2010.05.057 Document Type: Article

Times cited : (17)

References (19)

1
- 72249085764
- Overview of antiretroviral agents
- Hoffmann, C., Rockstroh, J. K., Kamps, B. S., Eds.; Flying Publisher (FlyingPublisher.com): Paris
- Hoffmann, C.; Mulcahy, F. Overview of Antiretroviral Agents. In HIV Medicine 2006; Hoffmann, C., Rockstroh, J. K., Kamps, B. S., Eds.; Flying Publisher (FlyingPublisher.com): Paris, 2006; pp 94.
- (2006) HIV Medicine 2006 , pp. 94
- Hoffmann, C.¹ Mulcahy, F.²

2
- 0036561677
- M.K. Schwarz, and T.N.C. Wells Nat. Rev. Drug Disc. 1 2002 347
- (2002) Nat. Rev. Drug Disc. , vol.1 , pp. 347
- Schwarz, M.K.¹ Wells, T.N.C.²

3
- 0035260881
- C. Gerard, and B.J. Rollins Nat. Immunol. 2 2001 108
- (2001) Nat. Immunol. , vol.2 , pp. 108
- Gerard, C.¹ Rollins, B.J.²

4
- 74849121699
- B. Pirotte, P. Tullio, Q.A. Nguyen, F. Somwes, P. Fraikin, X. Florence, P. Wahl, J.B. Hansen, and P. Lebrun J. Med. Chem. 53 2010 147
- (2010) J. Med. Chem. , vol.53 , pp. 147
- Pirotte, B.¹ Tullio, P.² Nguyen, Q.A.³ Somwes, F.⁴ Fraikin, P.⁵ Florence, X.⁶ Wahl, P.⁷ Hansen, J.B.⁸ Lebrun, P.⁹

5
- 0030002637
- Y. Feng, C.C. Broder, P.E. Kennedy, and E.A. Berger Science 272 1996 872
- (1996) Science , vol.272 , pp. 872
- Feng, Y.¹ Broder, C.C.² Kennedy, P.E.³ Berger, E.A.⁴

6
- 15844419153
- H.K. Deng, R. Liu, W. Ellmeier, S. Choe, D. Unutmaz, M. Burkhart, P.D. Marzio, S. Marmon, R.E. Sutton, C.M. Hill, C.B. Davis, S.C. Peiper, T.J. Schall, D.R. Littman, and N.R. Landau Nature 381 1996 661
- (1996) Nature , vol.381 , pp. 661
- Deng, H.K.¹ Liu, R.² Ellmeier, W.³ Choe, S.⁴ Unutmaz, D.⁵ Burkhart, M.⁶ Marzio, P.D.⁷ Marmon, S.⁸ Sutton, R.E.⁹ Hill, C.M.¹⁰ Davis, C.B.¹¹ Peiper, S.C.¹² Schall, T.J.¹³ Littman, D.R.¹⁴ Landau, N.R.¹⁵

7
- 15844389650
- T. Dragic, V. Litwin, G.P. Allaway, S.R. Martin, Y. Huang, K.A. Nagashima, C. Cayanan, P.J. Maddon, R.A. Koup, J.P. Moore, and W.A. Paxton Nature 381 1996 667
- (1996) Nature , vol.381 , pp. 667
- Dragic, T.¹ Litwin, V.² Allaway, G.P.³ Martin, S.R.⁴ Huang, Y.⁵ Nagashima, K.A.⁶ Cayanan, C.⁷ Maddon, P.J.⁸ Koup, R.A.⁹ Moore, J.P.¹⁰ Paxton, W.A.¹¹

8
- 0030018156
- G. Alkhatib, C. Combadiere, C.C. Broder, Y. Feng, P.E. Kennedy, P.M. Murphy, and E.A. Berger Science 272 1996 1955
- (1996) Science , vol.272 , pp. 1955
- Alkhatib, G.¹ Combadiere, C.² Broder, C.C.³ Feng, Y.⁴ Kennedy, P.E.⁵ Murphy, P.M.⁶ Berger, E.A.⁷

9
- 0033012398
- E.A. Berger, P.M. Murphy, and J.M. Farber Annu. Rev. Immunol. 17 1999 657
- (1999) Annu. Rev. Immunol. , vol.17 , pp. 657
- Berger, E.A.¹ Murphy, P.M.² Farber, J.M.³

10
- 59449093055
- D.J. Caldwell, and J.D. Evans Expert Opin. Pharmacother. 9 2008 3231
- (2008) Expert Opin. Pharmacother. , vol.9 , pp. 3231
- Caldwell, D.J.¹ Evans, J.D.²

11
- 72549118482
- J.T. Leonard, and K. Roy Curr. Med. Chem. 13 2006 91
- (2006) Curr. Med. Chem. , vol.13 , pp. 91
- Leonard, J.T.¹ Roy, K.²

12
- 33746233345
- D.A. Price, D. Armour, M. Groot, D. Leishman, C. Napier, M. Perros, B.L. Stammen, and A. Wood Bioorg. Med. Chem. Lett. 16 2006 4633
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 4633
- Price, D.A.¹ Armour, D.² Groot, M.³ Leishman, D.⁴ Napier, C.⁵ Perros, M.⁶ Stammen, B.L.⁷ Wood, A.⁸

13
- 33745807624
- H. Habashita, M. Kokubo, S. Hamano, N. Hamanaka, M. Toda, S. Shibayama, H. Tada, K. Sagawa, D. Fukushima, K. Maeda, and H. Mitsuya J. Med. Chem. 49 2006 4140
- (2006) J. Med. Chem. , vol.49 , pp. 4140
- Habashita, H.¹ Kokubo, M.² Hamano, S.³ Hamanaka, N.⁴ Toda, M.⁵ Shibayama, S.⁶ Tada, H.⁷ Sagawa, K.⁸ Fukushima, D.⁹ Maeda, K.¹⁰ Mitsuya, H.¹¹

14
- 0035860744
- K. Maeda, K. Yoshimura, S. Shibayama, H. Habashita, H. Tada, K. Sagawa, T. Miyakawa, M. Aoki, D. Fukushima, and H. Mitsuya J. Biol. Chem. 276 2001 35194
- (2001) J. Biol. Chem. , vol.276 , pp. 35194
- Maeda, K.¹ Yoshimura, K.² Shibayama, S.³ Habashita, H.⁴ Tada, H.⁵ Sagawa, K.⁶ Miyakawa, T.⁷ Aoki, M.⁸ Fukushima, D.⁹ Mitsuya, H.¹⁰

15
- 3543144738
- K. Maeda, H. Nakata, Y. Koh, T. Miyakawa, H. Ogata, Y. Takaoka, S. Shibayama, K. Sagawa, D. Fukushima, J. Moravek, Y. Koyanagi, and H. Mitsuya J. Virol. 78 2004 8654
- (2004) J. Virol. , vol.78 , pp. 8654
- Maeda, K.¹ Nakata, H.² Koh, Y.³ Miyakawa, T.⁴ Ogata, H.⁵ Takaoka, Y.⁶ Shibayama, S.⁷ Sagawa, K.⁸ Fukushima, D.⁹ Moravek, J.¹⁰ Koyanagi, Y.¹¹ Mitsuya, H.¹²

16
- 33846354589
- R. Nishizawa, T. Nishiyama, K. Hisaichi, N. Matsunaga, C. Minamoto, H. Habashita, Y. Takaoka, M. Toda, S. Shibayama, H. Tada, K. Sagawa, D. Fukushima, K. Maeda, and H. Mitsuya Bioorg. Med. Chem. Lett. 17 2007 727
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 727
- Nishizawa, R.¹ Nishiyama, T.² Hisaichi, K.³ Matsunaga, N.⁴ Minamoto, C.⁵ Habashita, H.⁶ Takaoka, Y.⁷ Toda, M.⁸ Shibayama, S.⁹ Tada, H.¹⁰ Sagawa, K.¹¹ Fukushima, D.¹² Maeda, K.¹³ Mitsuya, H.¹⁴

17
- 72549086139
- R. Nishizawa, T. Nishiyama, K. Hisaichi, K. Hirai, H. Habashita, Y. Takaoka, H. Tada, K. Sagawa, S. Shibayama, K. Maeda, H. Mitsuya, H. Nakai, D. Fukushima, and M. Toda Bioorg. Med. Chem. Lett. 20 2010 763
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 763
- Nishizawa, R.¹ Nishiyama, T.² Hisaichi, K.³ Hirai, K.⁴ Habashita, H.⁵ Takaoka, Y.⁶ Tada, H.⁷ Sagawa, K.⁸ Shibayama, S.⁹ Maeda, K.¹⁰ Mitsuya, H.¹¹ Nakai, H.¹² Fukushima, D.¹³ Toda, M.¹⁴

18
- 19944399431
- A.S. Kalfutkar, I. Gardner, R.S. Obach, C.L. Shaffer, E. Callegari, K.R. Henne, A.E. Mutlib, D.K. Dalvie, J.S. Lee, Y. Nakai, J.P. O'Donnell, J. Boer, and S.P. Harriman Curr. Drug Metab. 6 2005 161
- (2005) Curr. Drug Metab. , vol.6 , pp. 161
- Kalfutkar, A.S.¹ Gardner, I.² Obach, R.S.³ Shaffer, C.L.⁴ Callegari, E.⁵ Henne, K.R.⁶ Mutlib, A.E.⁷ Dalvie, D.K.⁸ Lee, J.S.⁹ Nakai, Y.¹⁰ O'Donnell, J.P.¹¹ Boer, J.¹² Harriman, S.P.¹³

19
- 77955331828
- Further PK studies of 38 and 39 were not carried out because of the poor AUC after their oral cassette dosing
- Further PK studies of 38 and 39 were not carried out because of the poor AUC after their oral cassette dosing.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.